Objetivo Excitotoxicity contributes significantly to neuronal cell death in a number of neurological conditions including stroke, head trauma, and Huntington's disease. The recent discovery of the proteins that anchor and interact with glutamate receptors opens for a new strategical approach to cytoprotective therapy. The present project aims at exploiting this conceptual advance to provide a platform for cytoprotective therapies that do not interfere unduly with synaptic transmission.Glutamate receptor interacting proteins (interactors) serve dual purpose. They determine the level and site of glutamate receptor expression within the cells and connect the receptors to specific intracellular signalling pathways. Both roles are interesting from a therapeutical perspective. Thus, excitotoxicity might be alleviated by modulation of the surface expression of glutamate receptors, as well as by interfering with their downstream signalling.The first part of the project aims at providing a more complete picture of the functional roles of interactors (WP1-3). It is envisaged that we will be able to identify novel interactors and that we will be in a position to understand, at a molecular level, how the different interactors connect with glutamate receptors and with each other. This part of the project will also elucidate the principles that govern the turnover and surface expression of glutamate receptors and the mechanisms that couple the individual receptors to specific downstream effectors of excitotoxicity.The second part (WP4 and 5) aims at exploiting the increased insight obtained through the first part of the project to design ways to alleviate excitotoxicity in different model systems. In designing these experiments the complex of glutamate receptor interacting proteins will be viewed as a 'nodal point' in orchestrating the surface expression of receptors and in activating appropriate and inappropriate (excitotoxic) signalling pathways. Ámbito científico natural sciencesbiological sciencesneurobiologynatural sciencesbiological sciencescell biologycell signalingnatural sciencesbiological sciencesbiochemistrybiomoleculesproteinsmedical and health sciencesbasic medicineneurologystroke Palabras clave CREB glutamate receptors interacting proteins ischemia pro-survival genes Programa(s) FP6-LIFESCIHEALTH - Life sciences, genomics and biotechnology for health: Thematic Priority 1 under the Focusing and Integrating Community Research programme 2002-2006. Tema(s) LSH-2003-2.1.3-6 - Excitotoxic neuronal cell death Convocatoria de propuestas FP6-2003-LIFESCIHEALTH-I Consulte otros proyectos de esta convocatoria Régimen de financiación STREP - Specific Targeted Research Project Coordinador UNIVERSITY OF OSLO Aportación de la UE Sin datos Dirección Problemveien 57 1073 OSLO Noruega Ver en el mapa Enlaces Sitio web Opens in new window Coste total Sin datos Participantes (7) Ordenar alfabéticamente Ordenar por aportación de la UE Ampliar todo Contraer todo UNIVERSITY OF BRISTOL Reino Unido Aportación de la UE Sin datos Dirección Senate House, Tyndall Avenue BRISTOL Ver en el mapa Enlaces Sitio web Opens in new window Coste total Sin datos NEUROSEARCH A/S Dinamarca Aportación de la UE Sin datos Dirección Pederstrupvej 93 BALLERUP Ver en el mapa Enlaces Sitio web Opens in new window Coste total Sin datos INSTYTUT BIOLOGII DOSWIADCZALNEJ IM. M. NENCKIEGO PAN Polonia Aportación de la UE Sin datos Dirección Pasteura 3 WARSAW Ver en el mapa Enlaces Sitio web Opens in new window Coste total Sin datos RUPRECHT-KARLS-UNIVERSITÄT HEIDELBERG Alemania Aportación de la UE Sin datos Dirección Seminarstr. 2 HEIDELBERG Ver en el mapa Enlaces Sitio web Opens in new window Coste total Sin datos FLUOFARMA SA Francia Aportación de la UE Sin datos Dirección 2, Rue Robert Escarpit PESSAC Ver en el mapa Enlaces Sitio web Opens in new window Coste total Sin datos UNIVERSITY OF SOUTHERN DENMARK Dinamarca Aportación de la UE Sin datos Dirección Campusvej 55 ODENSE M Ver en el mapa Enlaces Sitio web Opens in new window Coste total Sin datos CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE Francia Aportación de la UE Sin datos Dirección 3 rue Michel Ange PARIS Ver en el mapa Enlaces Sitio web Opens in new window Coste total Sin datos