Obiettivo To find a therapy alternative to cART for life is one of the hot topics of investigation in HIV field. Therapeutic vaccination seems to be the best option. We have reported in a double-blind placebo controlled study some of the best, most solid data showing that HIV-1 specific immune responses elicited by therapeutic dendritic cell (DC) vaccines pulsed ex vivo with inactivated autologous whole virus could significantly change pVL set-point (mean peak drop of -1.2 log10 copies/ml). Similar efficacy has been found in a preliminary non controlled clinical trial using DC electroporated with mRNA encoding autologous HIV-1 antigens. However, the logistics of developing a specific vaccine by ex vivo manipulating autologous DC for each patient may be prohibitive. Therefore, we propose that in vivo targeting of DC by direct administration of a rational designed HIV mRNA encoding immunomodulating proteins might be an attractive alternative to target DCs in situ. Our candidate is highly innovative: 1. It is a mRNA based immunogen: it is expected to have a good safety profile, it is classified as nongene therapy by the American and German authorities, is easier to produce and to store regardless of the encoded antigen and is not restricted to a defined HLA type of individuals. 2. The HIV antigen encoded by mRNA has been selected with a rational design: based on our previous works selecting viral targets of protective HIV-1 specific T cell responses in 3 large cohorts of HIV infected individuals. 3. The candidate includes TriMix to target DC in vivo: our data suggest that mRNA encoding a mixture of antigen presenting cells activation molecules (CD40L, a constitutive active variant of TLR4 and CD70) significantly enhanced the induction of antigen-specific T cells. If this candidate would be able to obtain the functional cure in at least a proportion of patients it could be applicable to developing countries and would improve the care and cost of HIV infection. Campo scientifico natural sciencesbiological sciencesmicrobiologyvirologynatural sciencesbiological sciencesbiochemistrybiomoleculesproteinsmedical and health sciencesbasic medicineimmunologymedical and health scienceshealth sciencesinfectious diseasesRNA virusesHIVmedical and health sciencesbasic medicinepharmacology and pharmacypharmaceutical drugsvaccines Programma(i) FP7-HEALTH - Specific Programme "Cooperation": Health Argomento(i) HEALTH.2013.1.3-3 - Safety and efficacy of therapeutic vaccines Invito a presentare proposte FP7-HEALTH-2013-INNOVATION-1 Vedi altri progetti per questo bando Meccanismo di finanziamento CP-FP - Small or medium-scale focused research project Coordinatore CONSORCI INSTITUT D'INVESTIGACIONS BIOMEDIQUES AUGUST PI I SUNYER Contributo UE € 1 114 220,00 Indirizzo CALLE ROSSELLO 149 PUERTA BJS 08036 Barcelona Spagna Mostra sulla mappa Regione Este Cataluña Barcelona Tipo di attività Other Contatto amministrativo Rosa Vilavella I Gasull (Dr.) Collegamenti Contatta l’organizzazione Opens in new window Sito web Opens in new window Costo totale Nessun dato Partecipanti (7) Classifica in ordine alfabetico Classifica per Contributo UE Espandi tutto Riduci tutto INSTITUUT VOOR TROPISCHE GENEESKUNDE Belgio Contributo UE € 798 560,00 Indirizzo NATIONALESTRAAT 155 2000 ANTWERPEN Mostra sulla mappa Regione Vlaams Gewest Prov. Antwerpen Arr. Antwerpen Tipo di attività Higher or Secondary Education Establishments Contatto amministrativo Nadine Van Peer (Ms.) Collegamenti Contatta l’organizzazione Opens in new window Sito web Opens in new window Costo totale Nessun dato VRIJE UNIVERSITEIT BRUSSEL Belgio Contributo UE € 303 220,00 Indirizzo PLEINLAAN 2 1050 Bruxelles / Brussel Mostra sulla mappa Regione Région de Bruxelles-Capitale/Brussels Hoofdstedelijk Gewest Région de Bruxelles-Capitale/ Brussels Hoofdstedelijk Gewest Arr. de Bruxelles-Capitale/Arr. Brussel-Hoofdstad Tipo di attività Higher or Secondary Education Establishments Contatto amministrativo Nik Claesen (Prof.) Collegamenti Contatta l’organizzazione Opens in new window Sito web Opens in new window Costo totale Nessun dato ETHERNA IMMUNOTHERAPIES Belgio Contributo UE € 1 718 520,00 Indirizzo GALILEILAAN 19 2845 Niel Mostra sulla mappa Regione Vlaams Gewest Prov. Antwerpen Arr. Antwerpen Tipo di attività Private for-profit entities (excluding Higher or Secondary Education Establishments) Contatto amministrativo Hilde Van Raemdonck (Mrs.) Collegamenti Contatta l’organizzazione Opens in new window Sito web Opens in new window Costo totale Nessun dato ERASMUS UNIVERSITAIR MEDISCH CENTRUM ROTTERDAM Paesi Bassi Contributo UE € 932 800,00 Indirizzo DR MOLEWATERPLEIN 40 3015 GD Rotterdam Mostra sulla mappa Regione West-Nederland Zuid-Holland Groot-Rijnmond Tipo di attività Higher or Secondary Education Establishments Contatto amministrativo Wim Leep (Mr.) Collegamenti Contatta l’organizzazione Opens in new window Sito web Opens in new window Costo totale Nessun dato FUNDACIO PRIVADA INSTITUT DE RECERCA DE LA SIDA-CAIXA Spagna Contributo UE € 648 200,00 Indirizzo CARRETERA DE CANYET 08916 Barcelona Mostra sulla mappa Regione Este Cataluña Barcelona Tipo di attività Research Organisations Contatto amministrativo Lourdes Grau (Ms.) Collegamenti Contatta l’organizzazione Opens in new window Sito web Opens in new window Costo totale Nessun dato SYNAPSE RESEARCH MANAGEMENT PARTNERS SL Spagna Contributo UE € 308 800,00 Indirizzo CALLE VELAZQUEZ 94 PLANTA 1 28006 Madrid Mostra sulla mappa Regione Comunidad de Madrid Comunidad de Madrid Madrid Tipo di attività Private for-profit entities (excluding Higher or Secondary Education Establishments) Contatto amministrativo Sandra Pla (Ms.) Collegamenti Contatta l’organizzazione Opens in new window Sito web Opens in new window Costo totale Nessun dato ASPHALION SL Spagna Contributo UE € 160 400,00 Indirizzo CALLE TARRAGONA, NUMEROS 151-157, PLANTA 10, BLOQU 08014 Barcelona Mostra sulla mappa Regione Este Cataluña Barcelona Tipo di attività Private for-profit entities (excluding Higher or Secondary Education Establishments) Contatto amministrativo Montse Perez (Mrs.) Collegamenti Contatta l’organizzazione Opens in new window Sito web Opens in new window Costo totale Nessun dato