Objetivo This project is designed to provide answers to questions not yet covered in the literature regarding hyperthermia cancer therapy based on the activation of magnetic and/or plasmonic nanomaterials. It aims at understanding and measuring nanoparticle-based heat-generating potential in environments that gradually approach the in vivo situation. The originality of the approach proposed is to combine in-depth physical studies (magnetic, plasmonic) of nanomaterials in biological environment while exploring new therapeutic modalities. Two main issues will be addressed: (1) the influence of magnetic or plasmonic nanoparticle confinement inside cells on heat-generating potential; (2) the possible synergism between magnetic and plasmonic hyperthermia, with a view to combined therapy, and their cumulative efficacy in solution, in vitro cell models, and in vivo tumour models. These issues will be addressed at several levels, ranging from materials chemistry to antitumoral applications in living animals, by exploiting multiple disciplines. To open the way to new therapeutic tools, it will be necessary to test a wide variety of nanoparticles with different compositions, shapes and sizes, provided by leading teams in nanomaterials synthesis, as well as to develop appropriate nanometrologic methods to detect, quantify and characterize the different nanostructures in their biological environment. Ámbito científico medical and health sciencesclinical medicineoncologyengineering and technologynanotechnologynano-materials Programa(s) FP7-PEOPLE - Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013) Tema(s) FP7-PEOPLE-2013-IEF - Marie-Curie Action: "Intra-European fellowships for career development" Convocatoria de propuestas FP7-PEOPLE-2013-IEF Consulte otros proyectos de esta convocatoria Régimen de financiación MC-IEF - Intra-European Fellowships (IEF) Coordinador Université Paris Diderot-Paris 7 Aportación de la UE € 194 046,60 Dirección Rue Thomas Mann F-75205 / 13 Paris Francia Ver en el mapa Tipo de actividad Higher or Secondary Education Establishments Contacto administrativo Eleonora Zuolo (Ms.) Enlaces Contactar con la organización Opens in new window Sitio web Opens in new window Coste total Sin datos
