Personalized Nanomedicines for Leukemia Patients

Informazioni relative al progetto

PNANOMED

ID dell’accordo di sovvenzione: 638035

DOI 10.3030/638035

Progetto chiuso

Data della firma CE 15 Giugno 2015

Data di avvio 1 Luglio 2015

Data di completamento 30 Giugno 2020

Finanziato da

• EXCELLENT SCIENCE - European Research Council (ERC)

Costo totale € 1 499 750,00

Contributo UE € 1 499 750,00

Coordinato da

MEDIZINISCHE HOCHSCHULE HANNOVER
Germany

Pubblicazioni

Peer reviewed articles (18)

Measurable residual disease monitoring by NGS before allogeneic hematopoietic cell transplantation in AML

Autori: Felicitas Thol, Razif Gabdoulline, Alessandro Liebich, Piroska Klement, Johannes Schiller, Christian Kandziora, Lothar Hambach, Michael Stadler, Christian Koenecke, Madita Flintrop, Mira Pankratz, Martin Wichmann, Blerina Neziri, Konstantin Büttner, Bennet Heida, Sabrina Klesse, Anuhar Chaturvedi, Arnold Kloos, Gudrun Göhring, Brigitte Schlegelberger, Verena I. Gaidzik, Lars Bullinger, Walter Fi
Pubblicato in: Blood, Numero 132/16, 2018, Pagina/e 1703-1713, ISSN 0006-4971
Editore: American Society of Hematology
DOI: 10.1182/blood-2018-02-829911

Effective drug treatment identified by in vivo screening in a transplantable patient-derived xenograft model of chronic myelomonocytic leukemia

Autori: Arnold Kloos, Konstantinos Mintzas, Lina Winckler, Razif Gabdoulline, Yasmine Alwie, Nidhi Jyotsana, Nadine Kattre, Renate Schottmann, Michaela Scherr, Charu Gupta, Felix F. Adams, Adrian Schwarzer, Dirk Heckl, Axel Schambach, Suzan Imren, R. Keith Humphries, Arnold Ganser, Felicitas Thol, Michael Heuser
Pubblicato in: Leukemia, 2020, ISSN 0887-6924
Editore: Nature Publishing Group
DOI: 10.1038/s41375-020-0929-3

Lipid nanoparticle-mediated siRNA delivery for safe targeting of human CML in vivo

Autori: Nidhi Jyotsana, Amit Sharma, Anuhar Chaturvedi, Ramachandramouli Budida, Michaela Scherr, Florian Kuchenbauer, Robert Lindner, Fatih Noyan, Kurt-Wolfram Sühs, Martin Stangel, Denis Grote-Koska, Korbinian Brand, Hans-Peter Vornlocher, Matthias Eder, Felicitas Thol, Arnold Ganser, R. Keith Humphries, Euan Ramsay, Pieter Cullis, Michael Heuser
Pubblicato in: Annals of Hematology, Numero 98/8, 2019, Pagina/e 1905-1918, ISSN 0939-5555
Editore: Springer Verlag
DOI: 10.1007/s00277-019-03713-y

Synergistic activity of IDH1 inhibitor BAY1436032 with azacitidine in IDH1 mutant acute myeloid leukemia

Autori: Anuhar Chaturvedi, Charu Gupta, Razif Gabdoulline, Nora M. Borchert, Ramya Goparaju, Stefan Kaulfuss, Kerstin Görlich, Renate Schottmann, Basem Othman, Julia Welzenbach, Olaf Panknin, Markus Wagner, Robert Geffers, Arnold Ganser, Felicitas Thol, Michael Jeffers, Andrea Haegebarth, Michael Heuser
Pubblicato in: Haematologica, 2020, Pagina/e haematol.2019.236992, ISSN 0390-6078
Editore: Ferrata Storti Foundation
DOI: 10.3324/haematol.2019.236992

Targeted Inhibition of the NUP98-NSD1 Fusion Oncogene in Acute Myeloid Leukemia

Autori: Sagarajit Mohanty, Nidhi Jyotsana, Amit Sharma, Arnold Kloos, Razif Gabdoulline, Basem Othman, Courteney K. Lai, Renate Schottmann, Madhvi Mandhania, Johannes Schmoellerl, Florian Grebien, Euan Ramsay, Anitha Thomas, Hans-Peter Vornlocher, Arnold Ganser, Felicitas Thol, Michael Heuser
Pubblicato in: Cancers, Numero 12/10, 2020, Pagina/e 2766, ISSN 2072-6694
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/cancers12102766

Combination treatment of an IDH1 inhibitor with chemotherapy in IDH1 mutant acute myeloid leukemia

Autori: Charu Gupta, Stefan Kaulfuss, Kerstin Görlich, Basem Othman, Anuhar Chaturvedi, Michael Heuser
Pubblicato in: Annals of Hematology, Numero 99/6, 2020, Pagina/e 1415-1417, ISSN 0939-5555
Editore: Springer Verlag
DOI: 10.1007/s00277-020-04001-w

Risk of tumor lysis syndrome in patients with acute myeloid leukemia treated with venetoclax-containing regimens without dose ramp-up

Autori: Rabia Shahswar, Gernot Beutel, Razif Gabdoulline, Christian Koenecke, Dominik Markel, Matthias Eder, Michael Stadler, Gudrun Gohring, Brigitte Schlegelberger, Arne Trummer, Juergen Krauter, Felicitas Thol, Michael Heuser
Pubblicato in: Annals of Hematology, 2020, ISSN 0939-5555
Editore: Springer Verlag
DOI: 10.1007/s00277-020-04181-5

Exploiting differential RNA splicing patterns: a potential new group of therapeutic targets in cancer

Autori: Nidhi Jyotsana, Michael Heuser
Pubblicato in: Expert Opinion on Therapeutic Targets, Numero 22/2, 2017, Pagina/e 107-121, ISSN 1472-8222
Editore: Ashley Publications Ltd.
DOI: 10.1080/14728222.2018.1417390

Individual outcome prediction for myelodysplastic syndrome (MDS) and secondary acute myeloid leukemia from MDS after allogeneic hematopoietic cell transplantation

Autori: Michael Heuser, Razif Gabdoulline, Patrick Löffeld, Vera Dobbernack, Henriette Kreimeyer, Mira Pankratz, Madita Flintrop, Alessandro Liebich, Sabrina Klesse, Victoria Panagiota, Michael Stadler, Martin Wichmann, Rabia Shahswar, Uwe Platzbecker, Christian Thiede, Thomas Schroeder, Guido Kobbe, Robert Geffers, Brigitte Schlegelberger, Gudrun Göhring, Hans-Heinrich Kreipe, Ulrich Germing, Arnold Ga
Pubblicato in: Annals of Hematology, Numero 96/8, 2017, Pagina/e 1361-1372, ISSN 0939-5555
Editore: Springer Verlag
DOI: 10.1007/s00277-017-3027-5

Therapy-related myeloid neoplasms: does knowing the origin help to guide treatment?

Autori: M. Heuser
Pubblicato in: Hematology, Numero 2016/1, 2016, Pagina/e 24-32, ISSN 1520-4391
Editore: American Society of Hematology
DOI: 10.1182/asheducation-2016.1.24

Epigenetics in myelodysplastic syndromes

Autori: Michael Heuser, Haiyang Yun, Felicitas Thol
Pubblicato in: Seminars in Cancer Biology, 2017, ISSN 1044-579X
Editore: Academic Press
DOI: 10.1016/j.semcancer.2017.07.009

Enantiomer-specific and paracrine leukemogenicity of mutant IDH metabolite 2-hydroxyglutarate

Autori: A Chaturvedi, M M Araujo Cruz, N Jyotsana, A Sharma, R Goparaju, A Schwarzer, K Görlich, R Schottmann, E A Struys, E E Jansen, C Rohde, C Müller-Tidow, R Geffers, G Göhring, A Ganser, F Thol, M Heuser
Pubblicato in: Leukemia, Numero 30/8, 2016, Pagina/e 1708-1715, ISSN 0887-6924
Editore: Nature Publishing Group
DOI: 10.1038/leu.2016.71

Pan-mutant-IDH1 inhibitor BAY1436032 is highly effective against human IDH1 mutant acute myeloid leukemia in vivo

Autori: A Chaturvedi, L Herbst, S Pusch, L Klett, R Goparaju, D Stichel, S Kaulfuss, O Panknin, K Zimmermann, L Toschi, R Neuhaus, A Haegebarth, H Rehwinkel, H Hess-Stumpp, M Bauser, T Bochtler, E A Struys, A Sharma, A Bakkali, R Geffers, M M Araujo-Cruz, F Thol, R Gabdoulline, A Ganser, A D Ho, A von Deimling, K Rippe, M Heuser, A Krämer
Pubblicato in: Leukemia, Numero 31/10, 2017, Pagina/e 2020-2028, ISSN 0887-6924
Editore: Nature Publishing Group
DOI: 10.1038/leu.2017.46

Acute myeloid leukemia derived from lympho-myeloid clonal hematopoiesis

Autori: F Thol, S Klesse, L Köhler, R Gabdoulline, A Kloos, A Liebich, M Wichmann, A Chaturvedi, J Fabisch, V I Gaidzik, P Paschka, L Bullinger, G Bug, H Serve, G Göhring, B Schlegelberger, M Lübbert, H Kirchner, M Wattad, D Kraemer, B Hertenstein, G Heil, W Fiedler, J Krauter, R F Schlenk, K Döhner, H Döhner, A Ganser, M Heuser
Pubblicato in: Leukemia, Numero 31/6, 2017, Pagina/e 1286-1295, ISSN 0887-6924
Editore: Nature Publishing Group
DOI: 10.1038/leu.2016.345

RNA interference efficiently targets human leukemia driven by a fusion oncogene in vivo

Autori: N Jyotsana, A Sharma, A Chaturvedi, M Scherr, F Kuchenbauer, L Sajti, A Barchanski, R Lindner, F Noyan, K-W Sühs, D Grote-Koska, K Brand, H-P Vornlocher, M Stanulla, B Bornhauser, J-P Bourquin, M Eder, F Thol, A Ganser, R K Humphries, E Ramsay, P Cullis, M Heuser
Pubblicato in: Leukemia, Numero 32/1, 2017, Pagina/e 224-226, ISSN 0887-6924
Editore: Nature Publishing Group
DOI: 10.1038/leu.2017.269

Meningioma 1 is indispensable for mixed lineage leukemia-rearranged acute myeloid leukemia

Autori: Amit Sharma, Nidhi Jyotsana, Razif Gabdoulline, Dirk Heckl, Florian Kuchenbauer, Robert K. Slany, Arnold Ganser, Michael Heuser
Pubblicato in: Haematologica, Numero 105/5, 2020, Pagina/e 1294-1305, ISSN 0390-6078
Editore: Ferrata Storti Foundation
DOI: 10.3324/haematol.2018.211201

In vivo efficacy of mutant IDH1 inhibitor HMS-101 and structural resolution of distinct binding site

Autori: Anuhar Chaturvedi, Ramya Goparaju, Charu Gupta, Julia Weder, Thomas Klünemann, Michelle Maria Araujo Cruz, Arnold Kloos, Kerstin Goerlich, Renate Schottmann, Basem Othman, Eduard A. Struys, Heike Bähre, Denis Grote-Koska, Korbinian Brand, Arnold Ganser, Matthias Preller, Michael Heuser
Pubblicato in: Leukemia, Numero 34/2, 2020, Pagina/e 416-426, ISSN 0887-6924
Editore: Nature Publishing Group
DOI: 10.1038/s41375-019-0582-x

FLA‐IDA salvage chemotherapy combined with a seven‐day course of venetoclax (FLAVIDA) in patients with relapsed/refractory acute leukaemia

Autori: Rabia Shahswar, Gernot Beutel, Piroska Klement, Alina Rehberg, Razif Gabdoulline, Christian Koenecke, Dominik Markel, Hendrik Eggers, Matthias Eder, Michael Stadler, Lothar Hambach, Steve Ehrlich, Gudrun Göhring, Brigitte Schlegelberger, Elke Dammann, Marlene Reuter, Martin Wichmann, Blerina Neziri, Arnold Ganser, Felicitas Thol, Michael Heuser
Pubblicato in: British Journal of Haematology, Numero 188/3, 2019, ISSN 0007-1048
Editore: Blackwell Publishing Inc.
DOI: 10.1111/bjh.16268

Diritti di proprietà intellettuale

Patent (2)

COMBINATION OF MIDH1 INHIBITORS AND DNA HYPOMETHYLATING AGENTS (HMA)

Numero candidatura/pubblicazione: 18 742521
Data: 2018-07-25

MEANS AND METHODS FOR TREATING CANCER

Numero candidatura/pubblicazione: 14 724722
Data: 2014-05-14