A systematic characterization of human regulatory architectures and their determinants of regulatory activity

Informazioni relative al progetto

SCORA

ID dell’accordo di sovvenzione: 638273

DOI 10.3030/638273

Progetto chiuso

Data della firma CE 15 Aprile 2015

Data di avvio 1 Maggio 2015

Data di completamento 31 Gennaio 2021

Finanziato da

• EXCELLENT SCIENCE - European Research Council (ERC)

Costo totale € 1 436 292,50

Contributo UE € 1 436 292,50

Coordinato da

KOBENHAVNS UNIVERSITET
Denmark

Pubblicazioni

Peer reviewed articles (12)

Determinants of enhancer and promoter activities of regulatory elements

Autori: Robin Andersson, Albin Sandelin
Pubblicato in: Nature Reviews Genetics, Numero 21/2, 2020, Pagina/e 71-87, ISSN 1471-0056
Editore: Nature Publishing Group
DOI: 10.1038/s41576-019-0173-8

Transcriptional decomposition reveals active chromatin architectures and cell specific regulatory interactions

Autori: Sarah Rennie, Maria Dalby, Lucas van Duin, Robin Andersson
Pubblicato in: Nature Communications, Numero 9/1, 2018, ISSN 2041-1723
Editore: Nature Publishing Group
DOI: 10.1038/s41467-017-02798-1

Regulating retrotransposon activity through the use of alternative transcription start sites

Autori: Jenna Persson, Babett Steglich, Agata Smialowska, Mette Boyd, Jette Bornholdt, Robin Andersson, Catherine Schurra, Benoit Arcangioli, Albin Sandelin, Olaf Nielsen, Karl Ekwall
Pubblicato in: EMBO reports, Numero 17/5, 2016, Pagina/e 753-768, ISSN 1469-221X
Editore: Nature Publishing Group
DOI: 10.15252/embr.201541866

Loss-of-function variants in ADCY3 increase risk of obesity and type 2 diabetes

Autori: Niels Grarup, Ida Moltke, Mette K. Andersen, Maria Dalby, Kristoffer Vitting-Seerup, Timo Kern, Yuvaraj Mahendran, Emil Jørsboe, Christina V. L. Larsen, Inger K. Dahl-Petersen, Arthur Gilly, Daniel Suveges, George Dedoussis, Eleftheria Zeggini, Oluf Pedersen, Robin Andersson, Peter Bjerregaard, Marit E. Jørgensen, Anders Albrechtsen, Torben Hansen
Pubblicato in: Nature Genetics, Numero 50/2, 2018, Pagina/e 172-174, ISSN 1061-4036
Editore: Nature Publishing Group
DOI: 10.1038/s41588-017-0022-7

Shared activity patterns arising at genetic susceptibility loci reveal underlying genomic and cellular architecture of human disease

Autori: J. Kenneth Baillie, Andrew Bretherick, Christopher S. Haley, Sara Clohisey, Alan Gray, Lucile P. A. Neyton, Jeffrey Barrett, Eli A. Stahl, Albert Tenesa, Robin Andersson, J. Ben Brown, Geoffrey J. Faulkner, Marina Lizio, Ulf Schaefer, Carsten Daub, Masayoshi Itoh, Naoto Kondo, Timo Lassmann, Jun Kawai, Damian Mole, Vladimir B. Bajic, Peter Heutink, Michael Rehli, Hideya Kawaji, Albin Sandelin, Har
Pubblicato in: PLOS Computational Biology, Numero 14/3, 2018, Pagina/e e1005934, ISSN 1553-7358
Editore: Public Library of Science
DOI: 10.1371/journal.pcbi.1005934

Transcription start site analysis reveals widespread divergent transcription in D. melanogaster and core promoter-encoded enhancer activities

Autori: Sarah Rennie, Maria Dalby, Marta Lloret-Llinares, Stylianos Bakoulis, Christian Dalager Vaagensø, Torben Heick Jensen, Robin Andersson
Pubblicato in: Nucleic Acids Research, 2018, ISSN 0305-1048
Editore: Oxford University Press
DOI: 10.1093/nar/gky244

Characterization of the enhancer and promoter landscape of inflammatory bowel disease from human colon biopsies

Autori: Mette Boyd, Malte Thodberg, Morana Vitezic, Jette Bornholdt, Kristoffer Vitting-Seerup, Yun Chen, Mehmet Coskun, Yuan Li, Bobby Zhao Sheng Lo, Pia Klausen, Pawel Jan Schweiger, Anders Gorm Pedersen, Nicolas Rapin, Kerstin Skovgaard, Katja Dahlgaard, Robin Andersson, Thilde Bagger Terkelsen, Berit Lilje, Jesper Thorvald Troelsen, Andreas Munk Petersen, Kim Bak Jensen, Ismail Gögenur, Peter Thielse
Pubblicato in: Nature Communications, Numero 9/1, 2018, ISSN 2041-1723
Editore: Nature Publishing Group
DOI: 10.1038/s41467-018-03766-z

A unified architecture of transcriptional regulatory elements

Autori: Robin Andersson, Albin Sandelin, Charles G. Danko
Pubblicato in: Trends in Genetics, Numero 31/8, 2015, Pagina/e 426-433, ISSN 0168-9525
Editore: Elsevier BV
DOI: 10.1016/j.tig.2015.05.007

Principles for RNA metabolism and alternative transcription initiation within closely spaced promoters

Autori: Yun Chen, Athma A Pai, Jan Herudek, Michal Lubas, Nicola Meola, Aino I Järvelin, Robin Andersson, Vicent Pelechano, Lars M Steinmetz, Torben Heick Jensen, Albin Sandelin
Pubblicato in: Nature Genetics, Numero 48/9, 2016, Pagina/e 984-994, ISSN 1061-4036
Editore: Nature Publishing Group
DOI: 10.1038/ng.3616

Human Gene Promoters Are Intrinsically Bidirectional

Autori: Robin Andersson, Yun Chen, Leighton Core, John T. Lis, Albin Sandelin, Torben Heick Jensen
Pubblicato in: Molecular Cell, Numero 60/3, 2015, Pagina/e 346-347, ISSN 1097-2765
Editore: Cell Press
DOI: 10.1016/j.molcel.2015.10.015

MCM2 promotes symmetric inheritance of modified histones during DNA replication

Autori: Nataliya Petryk, Maria Dalby, Alice Wenger, Caroline B. Stromme, Anne Strandsby, Robin Andersson, Anja Groth
Pubblicato in: Science, Numero 361/6409, 2018, Pagina/e 1389-1392, ISSN 0036-8075
Editore: American Association for the Advancement of Science
DOI: 10.1126/science.aau0294

The Transcriptional Network That Controls Growth Arrest and Macrophage Differentiation in the Human Myeloid Leukemia Cell Line THP-1

Autori: Iveta Gažová, Lucas Lefevre, Stephen J. Bush, Sara Clohisey, Erik Arner, Michiel de Hoon, Jessica Severin, Lucas van Duin, Robin Andersson, Andreas Lengeling, David A. Hume, Kim M. Summers
Pubblicato in: Frontiers in Cell and Developmental Biology, Numero 8, 2020, ISSN 2296-634X
Editore: Frontiers Media S.A.
DOI: 10.3389/fcell.2020.00498