Is your heart aging well? A systems biology approach to characterize cardiac aging from the cell to the body surface

Pubblicazioni

Inhomogeneous Heart Rate Variability Spectral Complexity: A Preliminary Evaluation With Gravitational Stimuli Under Selective Autonomic Blockade

Autori: Bolea Juan, Gaetano Valenza, Raquel Bailón, Esther Pueyo, Riccardo Barbieri
Pubblicato in: 2018 Computing in Cardiology Conference (CinC), 2018, ISBN 978-1-7281-0958-9
Editore: Computing in Cardiology
DOI: 10.22489/cinc.2018.312

In silico Electrophysiological Evaluation of Scaffold Geometries for Cardiac Tissue Engineering.

Autori: R. Rosales, K. Mountris, M. Doblaré, E. Pueyo
Pubblicato in: Proc. XLVIII International Conference on Computing in Cardiology, 2021, Pagina/e pp. 1-4
Editore: Computing in Cardiology

SK Channel Block and Adrenergic Stimulation Counteract Acetylcholine-Induced Arrhythmogenic Effects in Human Atria

Autori: Chiara Celotto, Carlos Sanchez, Konstantinos A. Mountris, Pablo Laguna, Esther Pueyo
Pubblicato in: 2020 42nd Annual International Conference of the IEEE Engineering in Medicine & Biology Society (EMBC), 2020, Pagina/e 2303-2306, ISBN 978-1-7281-1990-8
Editore: IEEE
DOI: 10.1109/embc44109.2020.9175886

Potassium Monitoring from Multilead T-wave Morphology Changes during Hemodyalisis: Periodic versus Principal Component Analysis

Autori: Flavio Palmieri, Pedro Gomis, José Esteban Ruiz, Dina Ferreira, Alba Martin, Esther Pueyo, Pablo Laguna, Juan Pablo Martínez, Julia Ramírez
Pubblicato in: 2020 Computing in Cardiology Conference (CinC), 2020, ISBN 978-1-7281-7382-5
Editore: Computing in Cardiology
DOI: 10.22489/cinc.2020.199

Adaptation mechanisms of the QT interval during stress test and its dependency with adrenergic stimulation: a simulation study

Autori: R.Cebollada, C. Pérez, K. Mountris, P.Laguna, J.P. Martínez, E. Pueyo
Pubblicato in: Proc. XLVIII International Conference on Computing in Cardiology, 2021, Pagina/e pp. 1-4
Editore: Computing in Cardiology

Microgravity Exposure Alters Sympathetic Modulation of Ventricular Repolarization Quantified From the ECG via Periodic Repolarization Dynamics

Autori: Saúl Palacios, Enrico Caiani, Juan Pablo Martínez, Esther Pueyo
Pubblicato in: 2018 Computing in Cardiology Conference (CinC), 2018, ISBN 978-1-7281-0958-9
Editore: Computing in Cardiology
DOI: 10.22489/cinc.2018.358

A Novel Paradigm for In Silico Simulation of Cardiac Electrophysiology Through the Mixed Collocation Meshless Petrov-Galerkin Method

Autori: Konstantinos Mountris, Carlos Sanchez, Esther Pueyo
Pubblicato in: 2019 Computing in Cardiology Conference (CinC), 2019, ISBN 978-1-7281-6936-1
Editore: Computing in Cardiology
DOI: 10.22489/cinc.2019.382

Relationship between Atrial Oscillatory Acetylcholine Release Pattern and f-wave Frequency Modulation: a Computational and Experimental Study

Autori: Chiara Celotto, Carlos Sánchez, Konstantinos Mountris, Mostafa Abdollahpur, Frida Sandberg, Pablo Laguna, Esther Pueyo
Pubblicato in: 2020 Computing in Cardiology Conference (CinC), 2020, ISBN 978-1-7281-7382-5
Editore: Computing in Cardiology
DOI: 10.22489/cinc.2020.303

Sudden Cardiac Death Prediction in Chronic Heart Failure Patients by Periodic Repolarization Dynamics

Autori: Saúl Palacios, Iwona Cygankiewicz, Antoni Bayés-de-Luna, Juan Pablo Martínez, Esther Pueyo
Pubblicato in: 2020 Computing in Cardiology Conference (CinC), 2020, ISBN 978-1-7281-7382-5
Editore: Computing in Cardiology
DOI: 10.22489/cinc.2020.209

Influence of the Stimulation Current on the Differences between Cell and Tissue Electrophysiological Simulations

Autori: Violeta Monasterio, Esther Pueyo, José Félix Rodríguez-Matas, Jesús Carro
Pubblicato in: 2019 Computing in Cardiology Conference (CinC), 2019, ISBN 978-1-7281-6936-1
Editore: Computing in Cardiology
DOI: 10.22489/cinc.2019.104

Ventilatory Thresholds Estimation Based on ECG-derived Respiratory Rate

Autori: D. García, S. Kontaxis, A. Hernández-Vicente, D. Hernando, J. Milagro, E. Pueyo, N. Garatachea, R. Bailón, J. Lazaro
Pubblicato in: Proc. XLVIII International Conference on Computing in Cardiology, 2021, Pagina/e pp. 1-4
Editore: Computing in Cardiology

Weighted Time Warping T-wave Analysis Robust to Delineation Errors: Clinical Implications.

Autori: F. Palmieri, P. Gomis, J.E. Ruiz, D. Ferreira, E. Pueyo, J.P. Martínez, P. Laguna, J. Ramírez.
Pubblicato in: Proc. XLVIII International Conference on Computing in Cardiology, 2021, Pagina/e pp. 1-4
Editore: Computing in Cardiology

Changes in QRS and T-wave Loops Subsequent to an Increase in Left Ventricle Globularity as in Intrauterine Growth Restriction: a Simulation Study

Autori: Freddy L Bueno-Palomeque, Konstantinos Mountris, Ana Minchole, Nuria Ortigosa, Raquel Bailón, Esther Pueyo, Pablo Laguna
Pubblicato in: 2020 Computing in Cardiology Conference (CinC), 2020, ISBN 978-1-7281-7382-5
Editore: Computing in Cardiology
DOI: 10.22489/cinc.2020.438

Rotor Termination in Cholinergic Paroxysmal Atrial Fibrillation by Small-Calcium-Activated K+ Channels Inhibition and Isoproterenol: a Computational Study

Autori: C. Celotto, C. Sánchez, K. Mountris, P. Laguna, E. Pueyo
Pubblicato in: Proc. XLVIII International Conference on Computing in Cardiology, 2021, Pagina/e pp. 1-4
Editore: Computing in Cardiology

Next-generation in-silico Cardiac Electrophysiology through Immersed Grid Meshfree Modelling: Application to Simulation of Myocardial Infarction

Autori: Konstantinos Mountris, Esther Pueyo
Pubblicato in: 2020 Computing in Cardiology Conference (CinC), 2020, ISBN 978-1-7281-7382-5
Editore: Computing in Cardiology
DOI: 10.22489/cinc.2020.254

Response of Ventricular Repolarization to Simulated Microgravity Measured by Periodic Repolarization Dynamics Using Phase-Rectified Signal Averaging

Autori: Saúl Palacios, Enrico Caiani, Esther Pueyo, Juan Pablo Martínez
Pubblicato in: 2019 Computing in Cardiology Conference (CinC), 2019, ISBN 978-1-7281-6936-1
Editore: Computing in Cardiology
DOI: 10.22489/cinc.2019.169

Transmural Ventricular Heterogeneities Play a Major Role in Determining T-Wave Morphology at Different Extracellular Potassium Levels

Autori: Syed Hassaan Ahmed Bukhari, Flavio Palmieri, Dina Ferreira, Mark Potse, Julia Ramırez, Pablo Laguna, Carlos Sanchez, Esther Pueyo
Pubblicato in: 2019 Computing in Cardiology Conference (CinC), 2019, ISBN 978-1-7281-6936-1
Editore: Computing in Cardiology
DOI: 10.22489/cinc.2019.404

Calcium-Activated Potassium Channel Inhibition in Autonomically Stimulated Human Atrial Myocytes.

Autori: Chiara Celotto, Carlos Sánchez, Pablo Laguna, Esther Pueyo
Pubblicato in: 2019 Computing in Cardiology Conference (CinC), 2019, ISBN 978-1-7281-6936-1
Editore: Computing in Cardiology
DOI: 10.22489/cinc.2019.334

Improved Methods for Processing Optical Mapping Signals From Human Left Ventricular Tissues at Baseline and Following Adrenergic Stimulation

Autori: María Pérez-Zabalza, Emiliano Raúl Diez, Julia Rhyins, Konstantinos Mountris, Jose María Vallejo-Gil, Pedro Carlos Fresneda-Roldán, Javier Fañanás-Mastral, Marta Matamala-Adell, Fernando Sorribas-Berjón, Manuel Vázquez-Sancho, Carlos Ballester-Cuenca, Margarita Segovia-Roldán, Aida Oliván-Viguera, Esther Pueyo
Pubblicato in: 2020 Computing in Cardiology Conference (CinC), 2020, ISBN 978-1-7281-7382-5
Editore: Computing in Cardiology
DOI: 10.22489/cinc.2020.427

Characterization of impaired repolarization by quantification of the QT delay in response to heart rate changes from stress test recordings

Autori: Cristina Perez, Esther Pueyo, Juan Pablo Martinez, Pablo Laguna
Pubblicato in: 2020 11th Conference of the European Study Group on Cardiovascular Oscillations (ESGCO), 2020, Pagina/e 1-2, ISBN 978-1-7281-5751-1
Editore: IEEE
DOI: 10.1109/esgco49734.2020.9158186

Quantification of T-wave Morphological Variability Using Time-warping Methods

Autori: Julia Ramírez, Michele Orini, Esther Pueyo, Pablo Laguna
Pubblicato in: IFMBE Proceedings, Numero 65, 2017, Pagina/e 478-481, ISBN 978-981-10-5121-0
Editore: Springer Singapore
DOI: 10.1007/978-981-10-5122-7_120

An Index for T:wave Pointwise Amplitude Variability Quantification

Autori: Julia Ramirez, Michele Orini, J. Derek Tucker, Esther Pueyo, Pablo Laguna
Pubblicato in: 2016 Computing in Cardiology Conference (CinC), Numero 43, 2016, ISBN 978-1-5090-0895-7
Editore: Computing in Cardiology
DOI: 10.22489/CinC.2016.016-137

T-wave Morphology Restitution Dependency with Heart Rate Range and Its Association with Sudden Cardiac Death in Chronic Heart Failure

Autori: Julia Ram�rez, Michele Orini, Esther Pueyo, Pablo Laguna
Pubblicato in: 2017 Computing in Cardiology Conference (CinC), Numero 44, 2017, ISBN 978-1-5386-6630-2
Editore: Computing in Cardiology
DOI: 10.22489/CinC.2017.221-009

Comparison of ECG T-wave Duration and Morphology Restitution Markers for Sudden Cardiac Death Prediction in Chronic Heart Failure

Identification of Parameters describing Phenomenological Cardiac Action Potential Models using Sigma-point Methods

Autori: Jesus Fernandez-Bes, David Adolfo Sampedro-Puente, Esther Pueyo
Pubblicato in: 2017 Computing in Cardiology Conference (CinC), Numero 44, 2017, ISBN 978-1-5386-6630-2
Editore: Computing in Cardiology
DOI: 10.22489/CinC.2017.060-109

Differential Responses to Beta-Adrenergic Stimulation in the Long QT Syndrome Type 1: Characterization and Mechanisms

Autori: David Adolfo Sampedro-Puente, Jesus Fernandez-Bes, Esther Pueyo
Pubblicato in: 2017 Computing in Cardiology Conference (CinC), Numero 44, 2017, ISBN 978-1-5386-6630-2
Editore: Computing in Cardiology
DOI: 10.22489/CinC.2017.250-453

Age-Associated Changes in Myocardial Fibrosis Amount and Distribution Quantified from Nonlinear Optical Microscopy Images

Autori: M. Pérez, L. García, K. Mountris, L. Ordovás, E. Pueyo
Pubblicato in: Proc. XLVIII International Conference on Computing in Cardiology, 2021, Pagina/e pp. 1-4
Editore: Computing in Cardiology

QRS Slopes for Potassium and Calcium Monitoring in End-Stage Renal Disease Patients

Autori: H.A. Bukhari, P. Laguna, M. Potse, C. Sánchez, E. Pueyo.
Pubblicato in: Proc. XLVIII International Conference on Computing in Cardiology, 2021, Pagina/e pp. 1-4
Editore: Computing in Cardiology

T-Wave Morphology Changes as Surrogate for Blood Potassium Concentration in Hemodialysis Patients

Autori: Flavio Palmieri, Pedro Gomis, José Esteban Ruiz, Beatriz Bergasa, Ferreira Dina, Alba Martin, Syed Hassaan Ahamed, Esther Pueyo, Juan Pablo Martínez, Julia Ramírez, Pablo Laguna
Pubblicato in: 2019 Computing in Cardiology Conference (CinC), 2019, Pagina/e pp. 1-4, ISBN 978-1-7281-6936-1
Editore: Computing in Cardiology
DOI: 10.22489/cinc.2019.109

In Silico Characterization of Repolarization Duration and Variability in the LQT1 Syndrome Under β-Adrenergic Stimulation

Autori: David Adolfo Sampedro-Puente, Fabien Raphel, Jesus Fernandez-Bes, Pablo Laguna, Damiano Lombardi, Esther Pueyo
Pubblicato in: 2020 Computing in Cardiology Conference (CinC), 2020, ISBN 978-1-7281-7382-5
Editore: Computing in Cardiology
DOI: 10.22489/cinc.2020.430

Analysis of T Wave Nonlinear Dynamics for Serum Potassium Monitoring in End-Stage Renal Disease Patients

Autori: SABARATHINAM SRINIVASAN, Syed Hassaan Ahmed Bukhari, Pablo Laguna, Carlos Sánchez, Esther Pueyo
Pubblicato in: 2020 Computing in Cardiology Conference (CinC), 2020, ISBN 978-1-7281-7382-5
Editore: Computing in Cardiology
DOI: 10.22489/cinc.2020.461

Assessing a Warping Methodology for the Identification of Increased Cardiovascular Risk Based on the HR Profile Morphology

Autori: Julia Ramírez, Stefan van Duijvenboden, Pablo Laguna, Esther Pueyo, Andrew Tinker, Pier Lambiase, Patricia Munroe, Michele Orini
Pubblicato in: 2018 Computing in Cardiology Conference (CinC), 2018, ISBN 978-1-7281-0958-9
Editore: Computing in Cardiology
DOI: 10.22489/cinc.2018.039

KCa3.1 Transgene Induction in Murine Intestinal Epithelium Causes Duodenal Chyme Accumulation and Impairs Duodenal Contractility

Autori: Marta Sofía Valero, Mariano Ramón-Gimenez, Javier Lozano-Gerona, Pablo Delgado-Wicke, Pilar Calmarza, Aida Oliván-Viguera, Víctor López, Ángel-Luis Garcia-Otín, Salvador Valero, Esther Pueyo, Kirk L. Hamilton, Hiroto Miura, Ralf Köhler
Pubblicato in: International Journal of Molecular Sciences, Numero 20/5, 2019, Pagina/e 1193, ISSN 1422-0067
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms20051193

Automatic Quantification of Cardiomyocyte Dimensions and Connexin 43 Lateralization in Fluorescence Images

Autori: Antoni Oliver-Gelabert, Laura García-Mendívil, José María Vallejo-Gil, Pedro Carlos Fresneda-Roldán, Katarína Andelová, Javier Fañanás-Mastral, Manuel Vázquez-Sancho, Marta Matamala-Adell, Fernando Sorribas-Berjón, Carlos Ballester-Cuenca, Narcisa Tribulova, Laura Ordovás, Emiliano Raúl Diez, Esther Pueyo
Pubblicato in: Biomolecules, Numero 10/9, 2020, Pagina/e 1334, ISSN 2218-273X
Editore: Multidisciplinary Digital Publishing Institute
DOI: 10.3390/biom10091334

Characterization of T Wave Amplitude, Duration and Morphology Changes During Hemodialysis: Relationship With Serum Electrolyte Levels and Heart Rate

Autori: Hassaan A. Bukhari, Flavio Palmieri, Julia Ramirez, Pablo Laguna, Jose Esteban Ruiz, Dina Ferreira, Mark Potse, Carlos Sanchez, Esther Pueyo
Pubblicato in: IEEE Transactions on Biomedical Engineering, Numero 68/8, 2021, Pagina/e 2467-2478, ISSN 0018-9294
Editore: Institute of Electrical and Electronics Engineers
DOI: 10.1109/tbme.2020.3043844

Nonlinear T-Wave Time Warping-Based Sensing Model for Non-Invasive Personalised Blood Potassium Monitoring in Hemodialysis Patients: A Pilot Study

Autori: Flavio Palmieri, Pedro Gomis, José Esteban Ruiz, Dina Ferreira, Alba Martín-Yebra, Esther Pueyo, Juan Pablo Martínez, Julia Ramírez, Pablo Laguna
Pubblicato in: Sensors, Numero 21/8, 2021, Pagina/e 2710, ISSN 1424-8220
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/s21082710

Long-Term Microgravity Exposure Increases ECG Repolarization Instability Manifested by Low-Frequency Oscillations of T-Wave Vector

Autori: Saúl Palacios, Enrico G. Caiani, Federica Landreani, Juan Pablo Martínez, Esther Pueyo
Pubblicato in: Frontiers in Physiology, Numero 10, 2019, ISSN 1664-042X
Editore: Frontiers Research Foundation
DOI: 10.3389/fphys.2019.01510

Pulse Rate and Transit Time Analysis to Predict Hypotension Events After Spinal Anesthesia During Programmed Cesarean Labor

Autori: Juan Bolea, Jesús Lázaro, Eduardo Gil, Eva Rovira, José M. Remartínez, Pablo Laguna, Esther Pueyo, Augusto Navarro, Raquel Bailón
Pubblicato in: Annals of Biomedical Engineering, Numero 45/9, 2017, Pagina/e 2253-2263, ISSN 0090-6964
Editore: Kluwer Academic Publishers
DOI: 10.1007/s10439-017-1864-y

Emerging evidence for a mechanistic link between low-frequency oscillation of ventricular repolarization measured from the electrocardiogram T-wave vector and arrhythmia

Autori: Peter Taggart, Esther Pueyo, Stefan van Duijvenboden, Bradley Porter, Martin Bishop, David A Sampedro-Puente, M Orini, B Hanson, Christopher A Rinaldi, Jaswinder S Gill, Pier Lambiase
Pubblicato in: EP Europace, Numero 23/9, 2021, Pagina/e 1350-1358, ISSN 1099-5129
Editore: Oxford University Press
DOI: 10.1093/europace/euab009

Characterization of Spatio-Temporal Cardiac Action Potential Variability at Baseline and Under $\beta$-Adrenergic Stimulation by Combined Unscented Kalman Filter and Double Greedy Dimension Reduction

Autori: David Adolfo Sampedro-Puente, Fabien Raphel, Jesus Fernandez-Bes, Pablo Laguna, Damiano Lombardi, Esther Pueyo
Pubblicato in: IEEE Journal of Biomedical and Health Informatics, Numero 25/1, 2021, Pagina/e 276-288, ISSN 2168-2194
Editore: Institute of Electrical and Electronics Engineers Inc.
DOI: 10.1109/jbhi.2020.2984647

ECG Ventricular Repolarization Dynamics during Exercise: Temporal Profile, Relation to Heart Rate Variability and Effects of Age and Physical Health

Autori: Adrián Hernández-Vicente, David Hernando, Germán Vicente-Rodríguez, Raquel Bailón, Nuria Garatachea, Esther Pueyo
Pubblicato in: International Journal of Environmental Research and Public Health, Numero 18/18, 2021, Pagina/e 9497, ISSN 1660-4601
Editore: Multidisciplinary Digital Publishing Institute
DOI: 10.3390/ijerph18189497

Editorial: Perspectives of Antiarrhythmic Drug Therapy: Disappointing Past, Current Efforts, and Faint Hopes

Autori: Péter P. Nánási, Esther Pueyo, László Virág
Pubblicato in: Frontiers in Pharmacology, Numero 11, 2020, ISSN 1663-9812
Editore: Frontiers Media S.A.
DOI: 10.3389/fphar.2020.01116

Heart Rate Variability and Exceptional Longevity

Autori: Adrián Hernández-Vicente, David Hernando, Alejandro Santos-Lozano, Gabriel Rodríguez-Romo, Germán Vicente-Rodríguez, Esther Pueyo, Raquel Bailón, Nuria Garatachea
Pubblicato in: Frontiers in Physiology, Numero 11, 2020, ISSN 1664-042X
Editore: Frontiers Research Foundation
DOI: 10.3389/fphys.2020.566399

Monitoring blood potassium concentration in hemodialysis patients by quantifying T-wave morphology dynamics

Autori: Flavio Palmieri, Pedro Gomis, Dina Ferreira, José Esteban Ruiz, Beatriz Bergasa, Alba Martín-Yebra, Hassaan A. Bukhari, Esther Pueyo, Juan Pablo Martínez, Julia Ramírez, Pablo Laguna
Pubblicato in: Scientific Reports, Numero 11/1, 2021, ISSN 2045-2322
Editore: Nature Publishing Group
DOI: 10.1038/s41598-021-82935-5

Time Course of Low-Frequency Oscillatory Behavior in Human Ventricular Repolarization Following Enhanced Sympathetic Activity and Relation to Arrhythmogenesis

Autori: David Adolfo Sampedro-Puente, Jesus Fernandez-Bes, Norbert Szentandrássy, Péter Nánási, Peter Taggart, Esther Pueyo
Pubblicato in: Frontiers in Physiology, Numero 10, 2020, ISSN 1664-042X
Editore: Frontiers Research Foundation
DOI: 10.3389/fphys.2019.01547

Estimation of the second ventilatory threshold through ventricular repolarization profile analysis

Autori: Javier Milagro, Adrián Hernández‐Vicente, David Hernando, José A. Casajús, Nuria Garatachea, Raquel Bailón, Esther Pueyo
Pubblicato in: Scandinavian Journal of Medicine & Science in Sports, Numero 31/2, 2021, Pagina/e 339-349, ISSN 0905-7188
Editore: Blackwell Publishing Inc.
DOI: 10.1111/sms.13849

Cardiac computational modelling

Autori: Jean R. Bragard, Oscar Camara, Blas Echebarria, Luca Gerardo Giorda, Esther Pueyo, Javier Saiz, Rafael Sebastián, Eduardo Soudah, Mariano Vázquez
Pubblicato in: Revista Española de Cardiología (English Edition), Numero 74/1, 2021, Pagina/e 65-71, ISSN 1885-5857
Editore: Elsevier
DOI: 10.1016/j.rec.2020.05.024

Reperfusion Arrhythmias Increase after Superior Cervical Ganglionectomy Due to Conduction Disorders and Changes in Repolarization

Autori: Natalia Jorgelina Prado, Estela Maris Muñoz, Luz Estefanía Farias Altamirano, Francisco Aguiar, Amira Zulma Ponce Zumino, Francisco Javier Sánchez, Roberto Miguel Miatello, Esther Pueyo, Emiliano Raúl Diez
Pubblicato in: International Journal of Molecular Sciences, Numero 21/5, 2020, Pagina/e 1804, ISSN 1422-0067
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms21051804

ECG-based monitoring of blood potassium concentration: Periodic versus principal component as lead transformation for biomarker robustness

Autori: Flavio Palmieri, Pedro Gomis, José Esteban Ruiz, Dina Ferreira, Alba Martín-Yebra, Esther Pueyo, Juan Pablo Martínez, Julia Ramírez, Pablo Laguna
Pubblicato in: Biomedical Signal Processing and Control, Numero 68, 2021, Pagina/e 102719, ISSN 1746-8094
Editore: Elsevier BV
DOI: 10.1016/j.bspc.2021.102719

Minimally invasive system to reliably characterize ventricular electrophysiology from living donors

Autori: Aida Oliván-Viguera, María Pérez-Zabalza, Laura García-Mendívil, Konstantinos A. Mountris, Sofía Orós-Rodrigo, Estel Ramos-Marquès, José María Vallejo-Gil, Pedro Carlos Fresneda-Roldán, Javier Fañanás-Mastral, Manuel Vázquez-Sancho, Marta Matamala-Adell, Fernando Sorribas-Berjón, Javier André Bellido-Morales, Francisco Javier Mancebón-Sierra, Alexánder Sebastián Vaca-Núñez, Ca
Pubblicato in: Scientific Reports, Numero 10/1, 2020, ISSN 2045-2322
Editore: Nature Publishing Group
DOI: 10.1038/s41598-020-77076-0

Data-Driven Identification of Stochastic Model Parameters and State Variables: Application to the Study of Cardiac Beat-to-Beat Variability

Autori: David Adolfo Sampedro-Puente, Jesus Fernandez-Bes, Laszlo Virag, Andras Varro, Esther Pueyo
Pubblicato in: IEEE Journal of Biomedical and Health Informatics, Numero 24/3, 2020, Pagina/e 693-704, ISSN 2168-2194
Editore: Institute of Electrical and Electronics Engineers Inc.
DOI: 10.1109/jbhi.2019.2921881

A dual adaptive explicit time integration algorithm for efficiently solving the cardiac monodomain equation

Autori: Konstantinos A. Mountris, Esther Pueyo
Pubblicato in: International Journal for Numerical Methods in Biomedical Engineering, Numero 37/7, 2021, ISSN 2040-7939
Editore: John Wiley & Sons Ltd.
DOI: 10.1002/cnm.3461

Bifurcations and Slow-Fast Analysis in a Cardiac Cell Model for Investigation of Early Afterdepolarizations

Autori: Roberto Barrio, M. Angeles Martínez, Lucía Pérez, Esther Pueyo
Pubblicato in: Mathematics, Numero 8/6, 2020, Pagina/e 880, ISSN 2227-7390
Editore: Multidisciplinary Digital Publishing Institute
DOI: 10.3390/math8060880

The ‘Digital Twin’ to enable the vision of precision cardiology

Autori: Jorge Corral-Acero, Francesca Margara, Maciej Marciniak, Cristobal Rodero, Filip Loncaric, Yingjing Feng, Andrew Gilbert, Joao F Fernandes, Hassaan A Bukhari, Ali Wajdan, Manuel Villegas Martinez, Mariana Sousa Santos, Mehrdad Shamohammdi, Hongxing Luo, Philip Westphal, Paul Leeson, Paolo DiAchille, Viatcheslav Gurev, Manuel Mayr, Liesbet Geris, Pras Pathmanathan, Tina Morrison, Richard Cornelusse
Pubblicato in: European Heart Journal, Numero 41/48, 2020, Pagina/e 4556-4564, ISSN 0195-668X
Editore: Oxford University Press
DOI: 10.1093/eurheartj/ehaa159

Pharmacological activation of TRPV4 produces immediate cell damage and induction of apoptosis in human melanoma cells and HaCaT keratinocytes

Autori: Aida Olivan-Viguera, Angel Luis Garcia-Otin, Javier Lozano-Gerona, Edgar Abarca-Lachen, Ana J. Garcia-Malinis, Kirk L. Hamilton, Yolanda Gilaberte, Esther Pueyo, Ralf Köhler
Pubblicato in: PLOS ONE, Numero 13/1, 2018, Pagina/e e0190307, ISSN 1932-6203
Editore: Public Library of Science
DOI: 10.1371/journal.pone.0190307

Sudden cardiac death and pump failure death prediction in chronic heart failure by combining ECG and clinical markers in an integrated risk model

Autori: Julia Ramírez, Michele Orini, Ana Mincholé, Violeta Monasterio, Iwona Cygankiewicz, Antonio Bayés de Luna, Juan Pablo Martínez, Pablo Laguna, Esther Pueyo
Pubblicato in: PLOS ONE, Numero 12/10, 2017, Pagina/e e0186152, ISSN 1932-6203
Editore: Public Library of Science
DOI: 10.1371/journal.pone.0186152

Atrial Fibrillation Dynamics and Ionic Block Effects in Six Heterogeneous Human 3D Virtual Atria with Distinct Repolarization Dynamics

Autori: Carlos Sánchez, Alfonso Bueno-Orovio, Esther Pueyo, Blanca Rodríguez
Pubblicato in: Frontiers in Bioengineering and Biotechnology, Numero 5, 2017, ISSN 2296-4185
Editore: Frontiers Media S.A.
DOI: 10.3389/fbioe.2017.00029

A Time-Varying Non-Parametric Methodology for Assessing Changes in QT Variability Unrelated to Heart Rate Variability

Autori: michele orini, Esther Pueyo, Pablo Laguna, Raquel Bailon
Pubblicato in: IEEE Transactions on Biomedical Engineering, 2017, Pagina/e 1-1, ISSN 0018-9294
Editore: Institute of Electrical and Electronics Engineers
DOI: 10.1109/TBME.2017.2758925

Variability of Ventricular Repolarization Dispersion Quantified by Time-Warping the Morphology of the T-Waves

Autori: Julia Ramirez, Michele Orini, J. Derek Tucker, Esther Pueyo, Pablo Laguna
Pubblicato in: IEEE Transactions on Biomedical Engineering, Numero 64/7, 2017, Pagina/e 1619-1630, ISSN 0018-9294
Editore: Institute of Electrical and Electronics Engineers
DOI: 10.1109/TBME.2016.2614899

Limitations in electrophysiological model development and validation caused by differences between simulations and experimental protocols

Autori: Jesús Carro, José F. Rodríguez-Matas, Violeta Monasterio, Esther Pueyo
Pubblicato in: Progress in Biophysics and Molecular Biology, Numero 129, 2017, Pagina/e 53-64, ISSN 0079-6107
Editore: Pergamon Press Ltd.
DOI: 10.1016/j.pbiomolbio.2016.11.006

T‐Wave Morphology Restitution Predicts Sudden Cardiac Death in Patients With Chronic Heart Failure

Autori: Julia Ramírez, Michele Orini, Ana Mincholé, Violeta Monasterio, Iwona Cygankiewicz, Antonio Bayés de Luna, Juan Pablo Martínez, Esther Pueyo, Pablo Laguna
Pubblicato in: Journal of the American Heart Association, Numero 6/5, 2017, Pagina/e e005310, ISSN 2047-9980
Editore: Wiley-Blackwell
DOI: 10.1161/JAHA.116.005310

Influence of Heart Rate in Non-linear HRV Indices as a Sampling Rate Effect Evaluated on Supine and Standing

Autori: Juan Bolea, Esther Pueyo, Michele Orini, Raquel Bailón
Pubblicato in: Frontiers in Physiology, Numero 7, 2016, Pagina/e 00501(12pp), ISSN 1664-042X
Editore: Frontiers Research Foundation
DOI: 10.3389/fphys.2016.00501

Electrocardiographic Biomarkers for Detection of Drug-Induced Late Sodium Current Block

Autori: Jose Vicente, Lars Johannesen, Meisam Hosseini, Jay W. Mason, Philip T. Sager, Esther Pueyo, David G. Strauss
Pubblicato in: PLOS ONE, Numero 11/12, 2016, Pagina/e e0163619, ISSN 1932-6203
Editore: Public Library of Science
DOI: 10.1371/journal.pone.0163619

Interactive effect of beta-adrenergic stimulation and mechanical stretch on low-frequency oscillations of ventricular action potential duration in humans

Autori: Esther Pueyo, Michele Orini, José F. Rodríguez, Peter Taggart
Pubblicato in: Journal of Molecular and Cellular Cardiology, Numero 97, 2016, Pagina/e 93-105, ISSN 0022-2828
Editore: Academic Press
DOI: 10.1016/j.yjmcc.2016.05.003

Experimentally-Based Computational Investigation into Beat-To-Beat Variability in Ventricular Repolarization and Its Response to Ionic Current Inhibition

Autori: E. Pueyo, C. E. Dangerfield, O. J. Britton, L. Virág, K. Kistamás, N. Szentandrássy, N. Jost, A. Varró, P. P. Nánási, K. Burrage, B. Rodríguez
Pubblicato in: PLOS ONE, Numero 11/3, 2016, Pagina/e e0151461, ISSN 1932-6203
Editore: Public Library of Science
DOI: 10.1371/journal.pone.0151461

Techniques for Ventricular Repolarization Instability Assessment From the ECG

Autori: Pablo Laguna, Juan Pablo Martinez Cortes, Esther Pueyo
Pubblicato in: Proceedings of the IEEE, Numero 104/2, 2016, Pagina/e 392-415, ISSN 0018-9219
Editore: Institute of Electrical and Electronics Engineers
DOI: 10.1109/JPROC.2015.2500501

A response surface optimization approach to adjust ionic current conductances of cardiac electrophysiological models. Application to the study of potassium level changes

Autori: Jesús Carro, Esther Pueyo, José F. Rodríguez Matas
Pubblicato in: PLOS ONE, Numero 13/10, 2018, Pagina/e e0204411, ISSN 1932-6203
Editore: Public Library of Science
DOI: 10.1371/journal.pone.0204411

On the Standardization of Approximate Entropy: Multidimensional Approximate Entropy Index Evaluated on Short-Term HRV Time Series

Autori: Juan Bolea, Raquel Bailón, Esther Pueyo
Pubblicato in: Complexity, Numero 2018, 2018, Pagina/e 1-15, ISSN 1076-2787
Editore: John Wiley & Sons Inc.
DOI: 10.1155/2018/4953273

A Methodology to Improve Human Ventricular Models for the Investigation of Cardiac Arrhythmias

Autori: Jesús Carro, José F Rodríguez-Matas, Esther Pueyo
Pubblicato in: Biophysical Journal, Numero 112/3, 2017, Pagina/e 403a, ISSN 0006-3495
Editore: Biophysical Society
DOI: 10.1016/j.bpj.2016.11.2183

Getting to the Heart of Safety Pharmacology

Autori: Eleonora Grandi, Stefano Morotti, Esther Pueyo, Blanca Rodríguez
Pubblicato in: Frontiers in Physiology, 2018, ISSN 1664-042X
Editore: Frontiers Research Foundation
DOI: 10.3389/fphys.2018.00678

Correction: Experimentally-Based Computational Investigation into Beat-To-Beat Variability in Ventricular Repolarization and Its Response to Ionic Current Inhibition

Autori: E. Pueyo, C. E. Dangerfield, O. J. Britton, L. Virág, K. Kistamás, N. Szentandrássy, N. Jost, A. Varró, P. P. Nánási, K. Burrage, B. Rodríguez
Pubblicato in: PLOS ONE, Numero 13/5, 2018, Pagina/e e0197871, ISSN 1932-6203
Editore: Public Library of Science
DOI: 10.1371/journal.pone.0197871

Correction: Electrocardiographic Biomarkers for Detection of Drug-Induced Late Sodium Current Block

Autori: Jose Vicente, Lars Johannesen, Meisam Hosseini, Jay W. Mason, Philip T. Sager, Esther Pueyo, David G. Strauss
Pubblicato in: PLOS ONE, Numero 13/5, 2018, Pagina/e e0197952, ISSN 1932-6203
Editore: Public Library of Science
DOI: 10.1371/journal.pone.0197952

Corrigendum: Influence of Heart Rate in Non-linear HRV Indices as a Sampling Rate Effect Evaluated on Supine and Standing

Autori: Juan Bolea, Esther Pueyo, Michele Orini, Raquel Bailón
Pubblicato in: Frontiers in Physiology, Numero 9, 2018, ISSN 1664-042X
Editore: Frontiers Research Foundation
DOI: 10.3389/fphys.2018.00620

Corrigendum to “Limitations in electrophysiological model development and validation caused by differences between simulations and experimental protocols” [Prog. Biophys. Mol. Biol. 129 (2017) 53–64]

Autori: Jesús Carro, José F. Rodríguez-Matas, Violeta Monasterio, Esther Pueyo
Pubblicato in: Progress in Biophysics and Molecular Biology, 2018, ISSN 0079-6107
Editore: Pergamon Press Ltd.
DOI: 10.1016/j.pbiomolbio.2018.11.001

Correction: T‐Wave Morphology Restitution Predicts Sudden Cardiac Death in Patients With Chronic Heart Failure

Corrigendum to “Interactive effect of beta-adrenergic stimulation and mechanical stretch on low-frequency oscillations of ventricular action potential duration in humans” [J. Mol. Cell. Cardiol. 97 (2016) 93–105]

Autori: Esther Pueyo, Michele Orini, José F. Rodríguez, Peter Taggart
Pubblicato in: Journal of Molecular and Cellular Cardiology, Numero 121, 2018, Pagina/e 305, ISSN 0022-2828
Editore: Academic Press
DOI: 10.1016/j.yjmcc.2018.05.006

Conditional KCa3.1-Transgene Induction in Murine Skin Produces Pruritic Eczematous Dermatitis With Severe Epidermal Hyperplasia and Hyperkeratosis

Autori: Javier Lozano-Gerona; Aida Oliván-Viguera; Pablo Delgado-Wicke; Vikrant Singh; Brandon M. Brown; Elena Tapia-Casellas; Esther Pueyo; Marta Sofía Valero; Ángel Luis García-Otín; Pilar Giraldo; Edgar Abarca-Lachen; Joaquín C. Surra; Jesús Osada; Kirk L. Hamilton; Siba P. Raychaudhuri; Miguel Marigil; Angeles Juarranz; Heike Wulff; Hiroto Miura; Yolanda Gilaberte; Ralf Köhler
Pubblicato in: PLoS ONE, Numero 1, 2020, ISSN 1932-6203
Editore: Public Library of Science
DOI: 10.1101/759274

Location of Parasympathetic Innervation Regions From Electrograms to Guide Atrial Fibrillation Ablation Therapy: An in silico Modeling Study

Autori: Chiara Celotto, Carlos Sánchez, Konstantinos A. Mountris, Pablo Laguna, Esther Pueyo
Pubblicato in: Frontiers in Physiology, Numero 12, 2021, ISSN 1664-042X
Editore: Frontiers Research Foundation
DOI: 10.3389/fphys.2021.674197

Mechanisms Underlying Interactions Between Low-Frequency Oscillations and Beat-to-Beat Variability of Celullar Ventricular Repolarization in Response to Sympathetic Stimulation: Implications for Arrhythmogenesis

Autori: David Adolfo Sampedro-Puente, Jesus Fernandez-Bes, Bradley Porter, Stefan van Duijvenboden, Peter Taggart, Esther Pueyo
Pubblicato in: Frontiers in Physiology, Numero 10, 2019, ISSN 1664-042X
Editore: Frontiers Research Foundation
DOI: 10.3389/fphys.2019.00916

Excitable dynamics in neural and cardiac systems

Autori: Roberto Barrio, Stephen Coombes, Mathieu Desroches, Flavio Fenton, Stefan Luther, Esther Pueyo
Pubblicato in: Communications in Nonlinear Science and Numerical Simulation, Numero 86, 2020, Pagina/e 105275, ISSN 1007-5704
Editore: Elsevier BV
DOI: 10.1016/j.cnsns.2020.105275

Chronological and biological aging of the human left ventricular myocardium: Analysis of microRNAs contribution

Autori: Estel Ramos‐Marquès, Laura García‐Mendívil, María Pérez‐Zabalza, Hazel Santander‐Badules, Sabarathinam Srinivasan, Juan Carlos Oliveros, Rafael Torres‐Pérez, Alberto Cebollada, José María Vallejo‐Gil, Pedro Carlos Fresneda‐Roldán, Javier Fañanás‐Mastral, Manuel Vázquez‐Sancho, Marta Matamala‐Adell, Juan Fernando Sorribas‐Berjón, Javier André Bellido‑Morales, F
Pubblicato in: Aging Cell, Numero 20/7, 2021, ISSN 1474-9718
Editore: Blackwell Publishing Inc.
DOI: 10.1111/acel.13383

QT variability unrelated to RR variability during stress testing for identification of coronary artery disease

Autori: Marta González del Castillo, David Hernando, Michele Orini, Pablo Laguna, Jari Viik, Raquel Bailón, Esther Pueyo
Pubblicato in: Philosophical Transactions of the Royal Society A: Mathematical, Physical and Engineering Sciences, Numero 379/2212, 2021, ISSN 1364-503X
Editore: Royal Society of London
DOI: 10.1098/rsta.2020.0261

Ischemia detection from morphological QRS angle changes

Autori: Daniel Romero, Juan Pablo Martínez, Pablo Laguna, Esther Pueyo
Pubblicato in: Physiological Measurement, Numero 37/7, 2016, Pagina/e 1004-1023, ISSN 0967-3334
Editore: Institute of Physics Publishing
DOI: 10.1088/0967-3334/37/7/1004

The radial point interpolation mixed collocation method for the solution of transient diffusion problems

Autori: Konstantinos A. Mountris, Esther Pueyo
Pubblicato in: Engineering Analysis with Boundary Elements, Numero 121, 2020, Pagina/e 207-216, ISSN 0955-7997
Editore: Pergamon Press Ltd.
DOI: 10.1016/j.enganabound.2020.10.005

Cell‐based maximum entropy approximants for three‐dimensional domains: Application in large strain elastodynamics using the meshless total Lagrangian explicit dynamics method

Autori: Konstantinos A. Mountris, George C. Bourantas, Daniel Millán, Grand R. Joldes, Karol Miller, Esther Pueyo, Adam Wittek
Pubblicato in: International Journal for Numerical Methods in Engineering, Numero 121/3, 2020, Pagina/e 477-491, ISSN 0029-5981
Editore: John Wiley & Sons Inc.
DOI: 10.1002/nme.6218

Complex Interaction Between Low-Frequency APD Oscillations and Beat-to-Beat APD Variability in Humans Is Governed by the Sympathetic Nervous System

Autori: Stefan Van Duijvenboden, Bradley Porter, Esther Pueyo, David Adolfo Sampedro-Puente, Jesus Fernandez-Bes, Baldeep Sidhu, Justin Gould, Michele Orini, Martin J. Bishop, Ben Hanson, Pier Lambiase, Reza Razavi, Christopher A. Rinaldi, Jaswinder S. Gill, Peter Taggart
Pubblicato in: Frontiers in Physiology, Numero 10, 2020, ISSN 1664-042X
Editore: Frontiers Research Foundation
DOI: 10.3389/fphys.2019.01582

Dynamical analysis of early afterdepolarization patterns in a biophysically detailed cardiac model

Autori: Roberto Barrio, M. Ángeles Martínez, Esther Pueyo, Sergio Serrano
Pubblicato in: Chaos: An Interdisciplinary Journal of Nonlinear Science, Numero 31/7, 2021, Pagina/e 073137, ISSN 1054-1500
Editore: American Institute of Physics
DOI: 10.1063/5.0055965

Atrial Dyssynchrony Measured by Strain Echocardiography as a Marker of Proarrhythmic Remodeling and Oxidative Stress in Cardiac Surgery Patients

Autori: Francisco J. Sánchez, Valeria A. Gonzalez, Martin Farrando, Ariel O. Baigorria Jayat, Margarita Segovia-Roldan, Laura García-Mendívil, Laura Ordovás, Natalia J. Prado, Esther Pueyo, Emiliano R. Diez
Pubblicato in: Oxidative Medicine and Cellular Longevity, Numero 2020, 2020, Pagina/e 1-14, ISSN 1942-0900
Editore: Landes Bioscience
DOI: 10.1155/2020/8895078

Cardiovascular Predictive Value and Genetic Basis of Ventricular Repolarization Dynamics

Autori: Julia Ramírez, Stefan van Duijvenboden, Nay Aung, Pablo Laguna, Esther Pueyo, Andrew Tinker, Pier D. Lambiase, Michele Orini, Patricia B. Munroe
Pubblicato in: Circulation: Arrhythmia and Electrophysiology, Numero 12/10, 2019, ISSN 1941-3149
Editore: Lippincott Williams & Wilkins Ltd.
DOI: 10.1161/circep.119.007549

Melatonin to Rescue the Aged Heart: Antiarrhythmic and Antioxidant Benefits

Autori: Margarita Segovia-Roldan, Emiliano Raúl Diez, Esther Pueyo
Pubblicato in: Oxidative Medicine and Cellular Longevity, Numero 2021, 2021, Pagina/e 1-18, ISSN 1942-0900
Editore: Landes Bioscience
DOI: 10.1155/2021/8876792

Periodic repolarization dynamics as predictor of risk for sudden cardiac death in chronic heart failure patients

Autori: Saúl Palacios, Iwona Cygankiewicz, Antoni Bayés de Luna, Esther Pueyo, Juan Pablo Martínez
Pubblicato in: Scientific Reports, Numero 11/1, 2021, ISSN 2045-2322
Editore: Nature Publishing Group
DOI: 10.1038/s41598-021-99861-1

Validity of the Polar H7 Heart Rate Sensor for Heart Rate Variability Analysis during Exercise in Different Age, Body Composition and Fitness Level Groups

Autori: Adrián Hernández-Vicente, David Hernando, Jorge Marín-Puyalto, Germán Vicente-Rodríguez, Nuria Garatachea, Esther Pueyo, Raquel Bailón
Pubblicato in: Sensors, Numero 21/3, 2021, Pagina/e 902, ISSN 1424-8220
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/s21030902

Prediction of Cardiac Death Risk by Analysis of Ventricular Repolarization Restitution from the Electrocardiogram Signal

Autori: Julia Ramírez, Esther Pueyo (Supervisor), Pablo Laguna (Supervisor)
Pubblicato in: Doctoral Thesis, 2017, ISSN 2254-7606
Editore: University of Zaragoza

Novel electrocardiographic biomarkers for proarrhythmic assessment of drugs

Autori: José Vicente Ruiz, David G. Strauss (Supervisor), Esther Pueyo (Supervisor)
Pubblicato in: Doctoral Thesis, 2016
Editore: University of Zaragoza

Time-frequency analysis of heart rate variability for characterization of autonomic impairments

Autori: Juan Bolea, Raquel Bailón (Supervisor), Esther Pueyo (Supervisor)
Pubblicato in: Doctoral Thesis, 2018
Editore: University of Zaragoza

New methodologies for the development and validation of cardiac electrophysiological models

Autori: Jesús Carro, José F. Rodríguez (Supervisor), Esther Pueyo (Supervisor)
Pubblicato in: Doctoral Thesis, 2018
Editore: University of Zaragoza

Theoretical analysis of the effects of the Autonomic Nervous System on human cardiac electrophysiology and its relation to arrhythmic risk

Autori: David Sampedro, Esther Pueyo (Supervisor)
Pubblicato in: Doctoral Thesis, 2019
Editore: University of Zaragoza

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