Engineering responsive and biomimetic hydrogels for biomedical therapeutic and diagnostic applications

Resultado final

5 day Summer School to focus TP8: general skills (iv-x)

A Blogspot will be incorporated into the BIOGEL website to provide a place where ESRs can communicate and share their challenges and knowledge.

Workshop 4

3 day Workshop 4: TP3: Biomimetic hydrogels

Design BIOGEL Website

Communicate the projects and results to the public and the other participants

Workshop 1

2 day Workshop 1: TP8: general skills (i-iii)

Workshop 3

3 day Workshop 3: TP2: Mechanical characterization

Workshop 2

3 day Workshop 2: TP1: Synthesis

Ambassador Day

All ESRs will act as Marie Skłodowska-Curie Ambassadors and visit schools, universities, community organizations

International conference

3 day international conference organized by BIOGEL

Workshop 7

3 day Workshop 7: TP7: Imaging

Workshop 6

4 day Workshop 6: TP5-6: in vitro, ex vivo, and in vivo models

Workshop 5

3 day Workshop 5: TP4: Coatings and sensors

Open ITN day

All participants will open their door to inform the public one day

Newsletters

Bi-annual newsletters to announce training events and scientific results

14 (anticipated) PhD diplomas

Awarding (anticipated) doctoral degrees by all partners

Bicyclic peptides

Different improved biological bicyclic peptides with integrin binding domains and proteolytic cleavage sites

Optical characterization methods

Characterization of thin film hydrogels by optical waveguide spectroscopy (OWS) and surface plasmon resonance (SPR)

Completion of Recruitment

All individual projects will have started by month 12

Publicaciones

Fibrous Hydrogels under Multi-Axial Deformation: Persistence Length as the Main Determinant of Compression Softening

Autores: Paula de Almeida, Paul A. Janmey, Paul H. J. Kouwer
Publicado en: Advanced Functional Materials, 2021, ISSN 1616-301X
Editor: John Wiley & Sons Ltd.
DOI: 10.1002/adfm.202010527

Nanofibrillar Cellulose as an Enzymatically and Flow Driven Degradable Scaffold for Three-Dimensional Tissue Engineering

Autores: Melanie Krüger, Bart Spee, Andreas Walther, Laura De Laporte, Linda M. Kock
Publicado en: ASME. ASME J of Medical Diagnostics, 2019, ISSN 2572-7958
Editor: ASME
DOI: 10.1115/1.4044473

Biomimetic Cell-Laden MeHA Hydrogels for the Regeneration of Cartilage Tissue

Autores: Evgenia Tsanaktsidou, Olga Kammona, Norina Labude, Sabine Neuss, Melanie Krüger, Linda Kock, Costas Kiparissides
Publicado en: Polymers, 2020, ISSN 2073-4360
Editor: MDPI
DOI: 10.3390/polym12071598

Cellulose Nanofibril Hydrogel Promotes Hepatic Differentiation of Human Liver Organoids

Autores: Melanie Krüger, Loes A. Oosterhoff, Monique E. van Wolferen, Simon A. Schiele, Andreas Walther, Niels Geijsen, Laura De Laporte, Luc J. W. van der Laan, Linda M. Kock, Bart Spee
Publicado en: Advanced Healthcare Materials, 2020, ISSN 2192-2659
Editor: World Scientific
DOI: 10.1002/adhm.201901658

Cell Encapsulation in Soft, Anisometric Poly(ethylene) Glycol Microgels Using a Novel Radical-Free Microfluidic System

Autores: Luis P. B. Guerzoni, Jonas C. Rose, David B. Gehlen, Alexander Jans, Tamàs Haraszti, Matthias Wessling, Alexander J. C. Kuehne, Laura De Laporte
Publicado en: Small, 2019, ISSN 1613-6829
Editor: Wiley-VCH GmbH
DOI: 10.1002/smll.201900692

Hydrophobic Cholesteryl Moieties Trigger Substrate Cell−Membrane Interaction of Elastin−Mimetic Protein Coatings in Vitro

Autores: Leander Poocza, Filippo Cipriani, Matilde Alonso, José Carlos Rodríguez-Cabello
Publicado en: ACS Omega, 2019, ISSN 2470-1343
Editor: ACS Publications
DOI: 10.1021/acsomega.9b00548

Thin-Film Polyisocyanide-Based Hydrogels for Affinity Biosensors

Autores: Daria Kotlarek, Kaizheng Liu, Nestor G. Quilis, Dominik Bernhagen, Peter Timmerman, Paul Kouwer, Jakub Dostalek
Publicado en: The Journal of Physical Chemistry C, 2021, ISSN 1932-7447
Editor: American Chemical Society
DOI: 10.1021/acs.jpcc.1c02489

Actively Tunable Collective Localized Surface Plasmons by Responsive Hydrogel Membrane

Autores: Nestor Gisbert Quilis, Marcel van Dongen, Priyamvada Venugopalan, Daria Kotlarek, Christian Petri, Alberto Moreno Cencerrado, Sorin Stanescu, Jose Luis Toca Herrera, Ulrich Jonas, Martin Möller, Ahmed Mourran, Jakub Dostalek
Publicado en: Advanced Optical Materials, 2019, ISSN 2195-1071
Editor: WILEY VCH Verlag GmbH & Co. KGaA, Weinheim
DOI: 10.1002/adom.201900342

Bicyclic RGD Peptides with Exquisite Selectivity for the Integrin α v β 3 Receptor Using a “Random Design” Approach

Autores: Dominik Bernhagen, Vanessa Jungbluth, Nestor Gisbert Quilis, Jakub Dostalek, Paul B. White, Kees Jalink, Peter Timmerman
Publicado en: ACS Combinatorial Science, 2019, ISSN 2156-8952
Editor: American Chemical Society
DOI: 10.1021/acscombsci.8b00144

Cytoskeletal stiffening in synthetic hydrogels

Autores: Paula de Almeida, Maarten Jaspers, Sarah Vaessen, Oya Tagit, Giuseppe Portale, Alan E. Rowan, Paul H. J. Kouwer
Publicado en: Nature Communications, Edición 10/1, 2019, Página(s) 609, ISSN 2041-1723
Editor: Nature Publishing Group
DOI: 10.1038/s41467-019-08569-4

Synthetic Extracellular Matrices with Nonlinear Elasticity Regulate Cellular Organization

Autores: Kaizheng Liu, Silvia M. Mihaila, Alan Rowan, Egbert Oosterwijk, Paul H. J. Kouwer
Publicado en: Biomacromolecules, Edición 20/2, 2019, Página(s) 826-834, ISSN 1525-7797
Editor: American Chemical Society
DOI: 10.1021/acs.biomac.8b01445

Controlling the gelation temperature of biomimetic polyisocyanides

Autores: Paul H.J. Kouwer, Paula de Almeida, Onno ven den Boomen, Zaskia H. Eksteen-Akeroyd, Roel Hammink, Maarten Jaspers, Stijn Kragt, Mathijs F.J. Mabesoone, Roeland J.M. Nolte, Alan E. Rowan, Martin G.T.A. Rutten, Vincent A.A. Le Sage, Daniël C. Schoenmakers, Chengfen Xing, Jialiang Xu
Publicado en: Chinese Chemical Letters, Edición 29/2, 2018, Página(s) 281-284, ISSN 1001-8417
Editor: Institute of Materia Medica
DOI: 10.1016/j.cclet.2017.11.002

Polymer Brush-Functionalized Chitosan Hydrogels as Antifouling Implant Coatings

Autores: Irene Buzzacchera, Mariia Vorobii, Nina Yu. Kostina, Andres de los Santos Pereira, Tomáš Riedel, Michael Bruns, Wojciech Ogieglo, Martin Möller, Christopher J. Wilson, Cesar Rodriguez-Emmenegger
Publicado en: Biomacromolecules, Edición 18/6, 2017, Página(s) 1983-1992, ISSN 1525-7797
Editor: American Chemical Society
DOI: 10.1021/acs.biomac.7b00516

Screening Libraries of Amphiphilic Janus Dendrimers Based on Natural Phenolic Acids to Discover Monodisperse Unilamellar Dendrimersomes

Autores: Irene Buzzacchera, Qi Xiao, Hong Han, Khosrow Rahimi, Shangda Li, Nina Yu. Kostina, B. Jelle Toebes, Samantha E. Wilner, Martin Möller, Cesar Rodriguez-Emmenegger, Tobias Baumgart, Daniela A. Wilson, Christopher J. Wilson, Michael L. Klein, Virgil Percec
Publicado en: Biomacromolecules, Edición 20/2, 2019, Página(s) 712-727, ISSN 1525-7797
Editor: American Chemical Society
DOI: 10.1021/acs.biomac.8b01405

Microfluidic fabrication of polyethylene glycol microgel capsules with tailored properties for the delivery of biomolecules

Autores: Luis P. B. Guerzoni, Jan Bohl, Alexander Jans, Jonas C. Rose, Jens Koehler, Alexander J. C. Kuehne, Laura De Laporte
Publicado en: Biomaterials Science, Edición 5/8, 2017, Página(s) 1549-1557, ISSN 2047-4830
Editor: Royal Society of Chemistry
DOI: 10.1039/c7bm00322f

Clinical Evidence for Use of a Noninvasive Biosensor for Tear Glucose as an Alternative to Painful Finger-Prick for Diabetes Management Utilizing a Biopolymer Coating

Autores: Alicja E. Kownacka, Dovile Vegelyte, Maurits Joosse, Nicoleta Anton, B. Jelle Toebes, Jan Lauko, Irene Buzzacchera, Katarzyna Lipinska, Daniela A. Wilson, Nel Geelhoed-Duijvestijn, Christopher J. Wilson
Publicado en: Biomacromolecules, Edición 19/11, 2018, Página(s) 4504-4511, ISSN 1525-7797
Editor: American Chemical Society
DOI: 10.1021/acs.biomac.8b01429

On the synthesis and characterization of biofunctional hyaluronic acid based injectable hydrogels for the repair of cartilage lesions

Autores: Evgenia Tsanaktsidou, Olga Kammona, Costas Kiparissides
Publicado en: European Polymer Journal, Edición 114, 2019, Página(s) 47-56, ISSN 0014-3057
Editor: Pergamon Press Ltd.
DOI: 10.1016/j.eurpolymj.2019.02.024

Tunable laser interference lithography preparation of plasmonic nanoparticle arrays tailored for SERS

Autores: Nestor Gisbert Quilis, Médéric Lequeux, Priyamvada Venugopalan, Imran Khan, Wolfgang Knoll, Souhir Boujday, Marc Lamy de la Chapelle, Jakub Dostalek
Publicado en: Nanoscale, Edición 10/21, 2018, Página(s) 10268-10276, ISSN 2040-3364
Editor: Royal Society of Chemistry
DOI: 10.1039/c7nr08905h

Encoding biological recognition in a bicomponent cell-membrane mimic

Autores: Cesar Rodriguez-Emmenegger, Qi Xiao, Nina Yu. Kostina, Samuel E. Sherman, Khosrow Rahimi, Benjamin E. Partridge, Shangda Li, Dipankar Sahoo, Aracelee M. Reveron Perez, Irene Buzzacchera, Hong Han, Meir Kerzner, Ishita Malhotra, Martin Möller, Christopher J. Wilson, Matthew C. Good, Mark Goulian, Tobias Baumgart, Michael L. Klein, Virgil Percec
Publicado en: Proceedings of the National Academy of Sciences, 2017, Página(s) 201821924, ISSN 0027-8424
Editor: National Academy of Sciences
DOI: 10.1073/pnas.1821924116

High-Affinity RGD-Knottin Peptide as a New Tool for Rapid Evaluation of the Binding Strength of Unlabeled RGD-Peptides to α v β 3 , α v β 5 , and α 5 β 1 Integrin Receptors

Autores: Dominik Bernhagen, Laura De Laporte, Peter Timmerman
Publicado en: Analytical Chemistry, Edición 89/11, 2017, Página(s) 5991-5997, ISSN 0003-2700
Editor: American Chemical Society
DOI: 10.1021/acs.analchem.7b00554

SET-LRP in biphasic mixtures of fluorinated alcohols with water

Autores: Adrian Moreno, Tong Liu, Liang Ding, Irene Buzzacchera, Marina Galià, Martin Möller, Christopher J. Wilson, Gerard Lligadas, Virgil Percec
Publicado en: Polymer Chemistry, Edición 9/17, 2018, Página(s) 2313-2327, ISSN 1759-9954
Editor: Royal Society of Chemistry
DOI: 10.1039/c8py00062j

Exploring functional pairing between surface glycoconjugates and human galectins using programmable glycodendrimersomes

Autores: Qi Xiao, Anna-Kristin Ludwig, Cecilia Romanò, Irene Buzzacchera, Samuel E. Sherman, Maria Vetro, Sabine Vértesy, Herbert Kaltner, Ellen H. Reed, Martin Möller, Christopher J. Wilson, Daniel A. Hammer, Stefan Oscarson, Michael L. Klein, Hans-Joachim Gabius, Virgil Percec
Publicado en: Proceedings of the National Academy of Sciences, Edición 115/11, 2018, Página(s) E2509-E2518, ISSN 0027-8424
Editor: National Academy of Sciences
DOI: 10.1073/pnas.1720055115

Cartilage Regeneration in Preannealed Silk Elastin-Like Co-Recombinamers Injectable Hydrogel Embedded with Mature Chondrocytes in an Ex Vivo Culture Platform

Autores: Filippo Cipriani, Melanie Krüger, Israel Gonzalez de Torre, Luis Quintanilla Sierra, Matilde Alonso Rodrigo, Linda Kock, José Carlos Rodriguez-Cabello
Publicado en: Biomacromolecules, Edición 19/11, 2018, Página(s) 4333-4347, ISSN 1525-7797
Editor: American Chemical Society
DOI: 10.1021/acs.biomac.8b01211

Bicyclic RGD peptides with high integrin αvβ3 and α5β1 affinity promote cell adhesion on elastin-like recombinamers

Autores: Filippo Cipriani, Dominik Bernhagen, Carmen Garcia-Arévalo, Israel González de Torre, Peter Timmerman, Jose Carlos Rodriguez-Cabello
Publicado en: Biomedical Materials, 2019, ISSN 1748-6041
Editor: Institute of Physics Publishing
DOI: 10.1088/1748-605x/aafd83

Sensor Devices Inspired by the Five Senses: A Review

Autores: Mila I. Svechtarova, Irene Buzzacchera, B. Jelle Toebes, Jan Lauko, Nicoleta Anton, Christopher J. Wilson
Publicado en: Electroanalysis, 2016, ISSN 1040-0397
Editor: Wiley - V C H Verlag GmbbH & Co.
DOI: 10.1002/elan.201600047

Charge Density as a Molecular Modulator of Nanostructuration in Intrinsically Disordered Protein Polymers

Autores: Sergio Acosta, Leander Poocza, Luis Quintanilla-Sierra, José Carlos Rodríguez-Cabello
Publicado en: Biomacromolecules, 2021, ISSN 1525-7797
Editor: American Chemical Society
DOI: 10.1021/acs.biomac.0c00934

A Layer-by-Layer Single-Cell Coating Technique To Produce Injectable Beating Mini Heart Tissues via Microfluidics

Autores: Luis P. B. Guerzoni, Yoshinari Tsukamoto, David B. Gehlen, Dirk Rommel, Tamás Haraszti, Mitsuru Akashi, Laura De Laporte
Publicado en: Biomacromolecules, 2019, ISSN 1525-7797
Editor: American Chemical Society
DOI: 10.1021/acs.biomac.9b00786

Cell-matrix reciprocity in 3D culture models with nonlinear elasticity

Autores: Kaizheng Liu, Maury Wiendels, Hongbo Yuan, Changshun Ruan, Paul H.J. Kouwer
Publicado en: Bioactive Materials, 2022, ISSN 2452-199X
Editor: Elsevier B.V. on behalf of KeAi Communications Co. Ltd.
DOI: 10.1016/j.bioactmat.2021.08.002

Structural characterization of fibrous synthetic hydrogels using fluorescence microscopy

Autores: Johannes Vandaele, Boris Louis, Kaizheng Liu, Rafael Camacho, Paul H. J. Kouwer, Susana Rocha
Publicado en: Soft Matter, 2020, ISSN 1744-683X
Editor: Royal Society of Chemistry
DOI: 10.1039/c9sm01828j

Actuated plasmonic nanohole arrays for sensing and optical spectroscopy applications

Autores: Daria Kotlarek, Stefan Fossati,Priyamvada Venugopalan, Nestor Gisbert Quilis, Jiří Slabý, Jiří Homola, Médéric Lequeux, Frédéric Amiard,Marc Lamy de la Chapelle, Ulrich Jonas, Jakub Dostálek
Publicado en: Nanoscale, 2020, ISSN 2040-3372
Editor: Royal Society of Chemistry
DOI: 10.1039/d0nr00761g

Bicyclic RGD peptides enhance nerve growth in synthetic PEG-based Anisogels

Autores: Sitara Vedaraman, Dominik Bernhagen, Tamas Haraszti, Christopher Licht, Arturo Castro Nava, Abdolrahman Omidinia Anarkoli, Peter Timmerman, Laura De Laporte
Publicado en: Biomaterials Science, 2021, ISSN 2397-1401
Editor: Royal Society of Chemistry
DOI: 10.1039/d0bm02051f

Compact Grating-Coupled Biosensor for the Analysis of Thrombin

Autores: Daria Kotlarek, Mariia Vorobii, Wojciech Ogieglo, Wolfgang Knoll, Cesar Rodriguez-Emmenegger, Jakub Dostálek
Publicado en: ACS Sensors, 2019, ISSN 2379-3694
Editor: American Chemical Society
DOI: 10.1021/acssensors.9b00827

Cellular responses to beating hydrogels to investigate mechanotransduction

Autores: Yashoda Chandorkar, Arturo Castro Nava, Sjören Schweizerhof, Marcel Van Dongen, Tamás Haraszti, Jens Köhler, Hang Zhang, Reinhard Windoffer, Ahmed Mourran, Martin Möller, Laura De Laporte
Publicado en: Nature Communications, 2019, ISSN 2041-1723
Editor: Nature Publishing Group
DOI: 10.1038/s41467-019-11475-4

Synthetic Extracellular Matrices as a Toolbox to Tune Stem CellSecretome

Autores: Kaizheng Liu, Tomas Veenendaal, Maury Wiendels, Alejandra M. Ruiz-Zapata, Justin van Laar, Rafail Kyranas, Hilde Enting, Bram van Cranenbroek, Hans J. P. M. Koenen, Silvia M. Mihaila, Egbert Oosterwijk, Paul H. J. Kouwer
Publicado en: ACS Applied Materials and Interfaces, 2020, ISSN 1944-8244
Editor: American Chemical Society
DOI: 10.1021/acsami.0c16208

Anisometric Microstructures to Determine Minimal Critical Physical Cues Required for Neurite Alignment

Autores: Sitara Vedaraman, Amaury Perez-Tirado, Tamas Haraszti, Jose Gerardo-Nava, Akihiro Nishiguchi, Laura De Laporte
Publicado en: Advanced Healthcare Materials, 2021, ISSN 2192-2659
Editor: World Scientific
DOI: 10.1002/adhm.202100874

Encapsulation of hydrophobic components in dendrimersomes and decoration of their surface with proteins and nucleic acids

Autores: Paola Torre, Qi Xiao, Irene Buzzacchera, Samuel E. Sherman, Khosrow Rahimi, Nina Yu. Kostina, Cesar Rodriguez-Emmenegger, Martin Möller, Christopher J. Wilson, Michael L. Klein, Matthew C. Good, Virgil Percec
Publicado en: Proceedings of the National Academy of Sciences (PNAS), 2019, ISSN 1091-6490
Editor: National Academy of Sciences
DOI: 10.1073/pnas.1904868116

Responsive polymer networks and brushes for active plasmonics

Autores: N. G. Quilis, N. Sharma, S. Fossati, W. Knoll, J. Dostalek
Publicado en: in Polymer and Biopolymer Brushes: Fundamentals and Applications in Materials Science and Biotechnology, 2018, ISBN 1118928903
Editor: John Wiley & Sons, Ltd.
DOI: 10.1002/9781119455042.ch24

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