Endoscopic Comprehensive Optical Multimodal Molecular Intelligent Imaging

Project Information

ENCOMOLE-2i

Grant agreement ID: 646669

DOI 10.3030/646669

Project closed

EC signature date 22 June 2015

Start date 1 January 2016

End date 31 December 2020

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost € 1 998 530,00

EU contribution € 1 998 530,00

Coordinated by

UNIVERSITAET zu LUEBECK
Germany

Publications

Conference proceedings (10)

Towards combined optical coherence tomography and multi-spectral imaging with MHz a-scan rates for endoscopy

Author(s): Madita Göb, Tom Pfeiffer, Robert Huber
Published in: Optical Coherence Imaging Techniques and Imaging in Scattering Media III, 2019, Page(s) 33, ISBN 9781510628502
Publisher: SPIE
DOI: 10.1117/12.2526796

Zero roll-off retinal MHz-OCT using an FDML-laser

Author(s): Julian Klee, Jan Philip Kolb, Christin Grill, Wolfgang Draxinger, Tom Pfeiffer, Robert Huber
Published in: Optical Coherence Imaging Techniques and Imaging in Scattering Media III, 2019, Page(s) 27, ISBN 9781510628502
Publisher: SPIE
DOI: 10.1117/12.2527034

Short pulse laser induced thermo-elastic deformation imaging

Author(s): Tianshi Wang, Tom Pfeiffer, Min Wu, Wolfgang Wieser, Wolfgang Draxinger, Antonius F. W. van der Steen, Robert Huber, Gijs van Soest
Published in: Optical Interactions with Tissue and Cells XXVIII, 2017, Page(s) 100620C
Publisher: SPIE
DOI: 10.1117/12.2251502

Analysis of FDML lasers with meter range coherence

Author(s): Tom Pfeiffer, Wolfgang Draxinger, Wolfgang Wieser, Thomas Klein, Markus Petermann, Robert Huber
Published in: Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XXI, 2017, Page(s) 100531T
Publisher: SPIE
DOI: 10.1117/12.2254792

Pulse-to-pulse wavelength switching of diode based fiber laser for multi-color multi-photon imaging

Author(s): Matthias Eibl, Sebastian Karpf, Hubertus Hakert, Daniel Weng, Torben Blömker, Robert Huber
Published in: Fiber Lasers XIV: Technology and Systems, 2017, Page(s) 100831C
Publisher: SPIE
DOI: 10.1117/12.2251965

Feature tracking for automated volume of interest stabilization on 4D-OCT images

Author(s): Max-Heinrich Laves, Andreas Schoob, Lüder A. Kahrs, Tom Pfeiffer, Robert Huber, Tobias Ortmaier
Published in: Medical Imaging 2017: Image-Guided Procedures, Robotic Interventions, and Modeling, 2017, Page(s) 101350W
Publisher: SPIE
DOI: 10.1117/12.2255090

Flexible A-scan rate MHz OCT: computational downscaling by coherent averaging

Author(s): Tom Pfeiffer, Wolfgang Wieser, Thomas Klein, Markus Petermann, Jan-Phillip Kolb, Matthias Eibl, Robert Huber
Published in: Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XX, 2016, Page(s) 96970S
Publisher: SPIE
DOI: 10.1117/12.2214788

Megahertz FDML laser with up to 143nm sweep range for ultrahigh resolution OCT at 1050nm

Author(s): Jan Philip Kolb, Thomas Klein, Matthias Eibl, Tom Pfeiffer, Wolfgang Wieser, Robert Huber
Published in: Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XX, 2016, Page(s) 969703
Publisher: SPIE
DOI: 10.1117/12.2214758

Two-photon-excited fluorescence (TPEF) and fluorescence lifetime imaging (FLIM) with sub-nanosecond pulses and a high analog bandwidth signal detection

Author(s): Matthias Eibl, Sebastian Karpf, Hubertus Hakert, Daniel Weng, Robert Huber
Published in: Multiphoton Microscopy in the Biomedical Sciences XVII, 2017, Page(s) 100691F
Publisher: SPIE
DOI: 10.1117/12.2250831

Virtual HE histology by fiber-based picosecond two-photon microscopy

Author(s): Wolfgang Draxinger, Jan Philip Kolb, Daniel Weng, Hubertus Hakert, Sebastian Nino Karpf, Robert Huber, Jürgen Popp, Tobias Meyer, Jens Limpert, Thomas Gottschall, Matthias Eibl, Ralf Brinkmann, Reginald Birngruber
Published in: Multiphoton Microscopy in the Biomedical Sciences XIX, 2019, Page(s) 83, ISBN 9781510624078
Publisher: SPIE
DOI: 10.1117/12.2507866

Peer reviewed articles (22)

Time-encoded stimulated Raman scattering microscopy of tumorous human pharynx tissue in the fingerprint region from 1500-1800 cm-1.

Author(s): Hubertus Hakert; Matthias Eibl; Marie Tillich; Ralph Pries; Gereon Hüttmann; Ralf Brinkmann; Barbara Wollenberg; Karl-Ludwig Bruchhage; Sebastian Karpf; Robert Huber
Published in: Optics Letters, Issue 1, 2021, Page(s) 3456-3459, ISSN 0146-9592
Publisher: Optical Society of America
DOI: 10.1364/ol.424726

Wavelength agile multi-photon microscopy with a fiber amplified diode laser

Author(s): Matthias Eibl, Daniel Weng, Hubertus Hakert, Jan Philip Kolb, Tom Pfeiffer, Jennifer E. Hundt, Robert Huber, Sebastian Karpf
Published in: Biomedical Optics Express, Issue 9/12, 2018, Page(s) 6273, ISSN 2156-7085
Publisher: The Optical Society
DOI: 10.1364/boe.9.006273

Pulse-to-pulse wavelength switching of a nanosecond fiber laser by four-wave mixing seeded stimulated Raman amplification

Author(s): Matthias Eibl, Sebastian Karpf, Hubertus Hakert, Torben Blömker, Jan Philip Kolb, Christian Jirauschek, Robert Huber
Published in: Optics Letters, Issue 42/21, 2017, Page(s) 4406, ISSN 0146-9592
Publisher: Optical Society of America
DOI: 10.1364/ol.42.004406

Simultaneous Morphological and Flow Imaging Enabled by Megahertz Intravascular Doppler Optical Coherence Tomography

Author(s): Tianshi Wang, Tom Pfeiffer, Joost Daemen, Frits Mastik, Wolfgang Wieser, A. F. W. van der Steen, Robert Huber, Gijs van Soest
Published in: IEEE Transactions on Medical Imaging, Issue 39/5, 2020, Page(s) 1535-1544, ISSN 0278-0062
Publisher: Institute of Electrical and Electronics Engineers
DOI: 10.1109/tmi.2019.2948258

Cavity length control for Fourier domain mode locked (FDML) lasers with µm precision.

Author(s): Simon Lotz; Christin Grill; Madita Göb; Wolfgang Draxinger; Jan Philip Kolb; Robert Huber
Published in: Biomedical Optics Express, Issue 2, 2021, Page(s) 2604-2616, ISSN 2156-7085
Publisher: The Optical Society
DOI: 10.1364/boe.422898

Ultra low noise Fourier domain mode locked laser for high quality megahertz optical coherence tomography

Author(s): Tom Pfeiffer, Markus Petermann, Wolfgang Draxinger, Christian Jirauschek, Robert Huber
Published in: Biomedical Optics Express, Issue 9/9, 2018, Page(s) 4130, ISSN 2156-7085
Publisher: The Optical Society
DOI: 10.1364/boe.9.004130

Flexible A-scan rate MHz-OCT: efficient computational downscaling by coherent averaging

Author(s): Tom Pfeiffer, Madita Göb, Wolfgang Draxinger, Sebastian Karpf, Jan Philip Kolb, Robert Huber
Published in: Biomedical Optics Express, Issue 11/11, 2020, Page(s) 6799, ISSN 2156-7085
Publisher: The Optical Society
DOI: 10.1364/boe.402477

Important factors for cell-membrane permeabilization by gold nanoparticles activated by nanosecond-laser irradiation

Author(s): Cuiping Yao, Florian Rudnitzki, Gereon Hüttmann, Zhenxi Zhang, Ramtin Rahmanzadeh
Published in: International Journal of Nanomedicine, Issue Volume 12, 2017, Page(s) 5659-5672, ISSN 1178-2013
Publisher: Dovepress
DOI: 10.2147/IJN.S140620

Thermo-elastic optical coherence tomography

Author(s): Tianshi Wang, Tom Pfeiffer, Min Wu, Wolfgang Wieser, Gaetano Amenta, Wolfgang Draxinger, Antonius F. W. van der Steen, Robert Huber, Gijs van Soest
Published in: Optics Letters, Issue 42/17, 2017, Page(s) 3466, ISSN 0146-9592
Publisher: Optical Society of America
DOI: 10.1364/ol.42.003466

High-speed fiber scanning endoscope for volumetric multi-megahertz optical coherence tomography

Author(s): Hinnerk Schulz-Hildebrandt, Tom Pfeiffer, Tim Eixmann, Sabrina Lohmann, Martin Ahrens, Joshua Rehra, Wolfgang Draxinger, Peter König, Robert Huber, Gereon Hüttmann
Published in: Optics Letters, Issue 43/18, 2018, Page(s) 4386, ISSN 0146-9592
Publisher: Optical Society of America
DOI: 10.1364/ol.43.004386

Single pulse two photon fluorescence lifetime imaging (SP-FLIM) with MHz pixel rate

Author(s): Matthias Eibl, Sebastian Karpf, Daniel Weng, Hubertus Hakert, Tom Pfeiffer, Jan Philip Kolb, Robert Huber
Published in: Biomedical Optics Express, Issue 8/7, 2017, Page(s) 3132, ISSN 2156-7085
Publisher: The Optical Society
DOI: 10.1364/BOE.8.003132

Efficient simulation of the swept-waveform polarization dynamics in fiber spools and Fourier domain mode-locked (FDML) lasers

Author(s): Christian Jirauschek, Robert Huber
Published in: Journal of the Optical Society of America B, Issue 34/6, 2017, Page(s) 1135, ISSN 0740-3224
Publisher: Optical Society of America
DOI: 10.1364/JOSAB.34.001135

Shot-Noise Limited Time-Encoded Raman Spectroscopy

Author(s): Sebastian Karpf, Matthias Eibl, Wolfgang Wieser, Thomas Klein, Robert Huber
Published in: Journal of Spectroscopy, Issue 2017, 2017, Page(s) 1-6, ISSN 2314-4920
Publisher: Hindawi Publishing Corporation
DOI: 10.1155/2017/9253475

Two-photon microscopy using fiber-based nanosecond excitation

Author(s): Sebastian Karpf, Matthias Eibl, Benjamin Sauer, Fred Reinholz, Gereon Hüttmann, Robert Huber
Published in: Biomedical Optics Express, Issue 7/7, 2016, Page(s) 2432, ISSN 2156-7085
Publisher: The Optical Society
DOI: 10.1364/BOE.7.002432

High-speed OCT light sources and systems [Invited]

Author(s): Thomas Klein, Robert Huber
Published in: Biomedical Optics Express, Issue 8/2, 2017, Page(s) 828, ISSN 2156-7085
Publisher: The Optical Society
DOI: 10.1364/BOE.8.000828

Heartbeat OCT and Motion-Free 3D In Vivo Coronary Artery Microscopy

Author(s): Tianshi Wang, Tom Pfeiffer, Evelyn Regar, Wolfgang Wieser, Heleen van Beusekom, Charles T. Lancee, Geert Springeling, Ilona Krabbendam-Peters, Antonius F.W. van der Steen, Robert Huber, Gijs van Soest
Published in: JACC: Cardiovascular Imaging, Issue 9/5, 2016, Page(s) 622-623, ISSN 1936-878X
Publisher: Elsevier BV
DOI: 10.1016/j.jcmg.2015.08.010

Beyond Vibrationally Mediated Electron Transfer: Coherent Phenomena Induced by Ultrafast Charge Separation

Author(s): Robert Huber, Lars Dworak, Jacques E. Moser, Michael Grätzel, Josef Wachtveitl
Published in: The Journal of Physical Chemistry C, Issue 120/16, 2016, Page(s) 8534-8539, ISSN 1932-7447
Publisher: American Chemical Society
DOI: 10.1021/acs.jpcc.6b02012

Self-stabilization mechanism in ultra-stable Fourier domain mode-locked (FDML) lasers

Author(s): Mark Schmidt, Tom Pfeiffer, Christin Grill, Robert Huber, Christian Jirauschek
Published in: OSA Continuum, Issue 3/6, 2020, Page(s) 1589, ISSN 2578-7519
Publisher: Optical Society of America
DOI: 10.1364/osac.389972

Live video rate volumetric OCT imaging of the retina with multi-MHz A-scan rates

Author(s): Jan Philip Kolb, Wolfgang Draxinger, Julian Klee, Tom Pfeiffer, Matthias Eibl, Thomas Klein, Wolfgang Wieser, Robert Huber
Published in: PLOS ONE, Issue 14/3, 2019, Page(s) e0213144, ISSN 1932-6203
Publisher: Public Library of Science
DOI: 10.1371/journal.pone.0213144

In-vitro and in-vivo imaging of coronary artery stents with Heartbeat OCT

Author(s): Leonardo Cecchetti, Tianshi Wang, Ayla Hoogendoorn, Karen T. Witberg, Jurgen M. R. Ligthart, Joost Daemen, Heleen M. M. van Beusekom, Tom Pfeiffer, Robert A. Huber, Jolanda J. Wentzel, Antonius F. W. van der Steen, Gijs van Soest
Published in: The International Journal of Cardiovascular Imaging, Issue 36/6, 2020, Page(s) 1021-1029, ISSN 1569-5794
Publisher: Kluwer Academic Publishers
DOI: 10.1007/s10554-020-01796-7

Motorized capsule for shadow-free OCT imaging and synchronous beam control

Author(s): Antonio López-Marín, Geert Springeling, Robert Beurskens, Heleen van Beusekom, Antonius F. W. van der Steen, Arjun D. Koch, Brett E. Bouma, Robert Huber, Gijs van Soest, Tianshi Wang
Published in: Optics Letters, Issue 44/15, 2019, Page(s) 3641, ISSN 0146-9592
Publisher: Optical Society of America
DOI: 10.1364/ol.44.003641

Intensity pattern types in broadband Fourier domain mode-locked (FDML) lasers operating beyond the ultra-stable regime

Author(s): Mark Schmidt; Christin Grill; Simon Lotz; Tom Pfeiffer; Robert Huber; Christian Jirauschek
Published in: Applied Physics B, Issue 1, 2021, ISSN 0946-2171
Publisher: Springer Verlag
DOI: 10.1007/s00340-021-07600-1

Intellectual Property Rights

Patent (2)

METHOD FOR MONITORING TIME-DEPENDENT PROPERTIES OF LIGHT IN SCANNING SWEPT-SOURCE OPTICAL COHERENCE TOMOGRAPHY

Application/Publication number: 20 19069473
Date: 2019-07-19
Applicant(s): UNIVERSITAET zu LUEBECK

METHOD FOR MONITORING TIME-DEPENDENT PROPERTIES OF LIGHT IN SCANNING SWEPT-SOURCE OPTICAL COHERENCE TOMOGRAPHY

Application/Publication number: 20 19069473
Date: 2019-07-19