Endoscopic Comprehensive Optical Multimodal Molecular Intelligent Imaging

Informazioni relative al progetto

ENCOMOLE-2i

ID dell’accordo di sovvenzione: 646669

DOI 10.3030/646669

Progetto chiuso

Data della firma CE 22 Giugno 2015

Data di avvio 1 Gennaio 2016

Data di completamento 31 Dicembre 2020

Finanziato da

• EXCELLENT SCIENCE - European Research Council (ERC)

Costo totale € 1 998 530,00

Contributo UE € 1 998 530,00

Coordinato da

UNIVERSITAET zu LUEBECK
Germany

Pubblicazioni

Conference proceedings (10)

Towards combined optical coherence tomography and multi-spectral imaging with MHz a-scan rates for endoscopy

Autori: Madita Göb, Tom Pfeiffer, Robert Huber
Pubblicato in: Optical Coherence Imaging Techniques and Imaging in Scattering Media III, 2019, Pagina/e 33, ISBN 9781510628502
Editore: SPIE
DOI: 10.1117/12.2526796

Zero roll-off retinal MHz-OCT using an FDML-laser

Autori: Julian Klee, Jan Philip Kolb, Christin Grill, Wolfgang Draxinger, Tom Pfeiffer, Robert Huber
Pubblicato in: Optical Coherence Imaging Techniques and Imaging in Scattering Media III, 2019, Pagina/e 27, ISBN 9781510628502
Editore: SPIE
DOI: 10.1117/12.2527034

Short pulse laser induced thermo-elastic deformation imaging

Autori: Tianshi Wang, Tom Pfeiffer, Min Wu, Wolfgang Wieser, Wolfgang Draxinger, Antonius F. W. van der Steen, Robert Huber, Gijs van Soest
Pubblicato in: Optical Interactions with Tissue and Cells XXVIII, 2017, Pagina/e 100620C
Editore: SPIE
DOI: 10.1117/12.2251502

Analysis of FDML lasers with meter range coherence

Autori: Tom Pfeiffer, Wolfgang Draxinger, Wolfgang Wieser, Thomas Klein, Markus Petermann, Robert Huber
Pubblicato in: Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XXI, 2017, Pagina/e 100531T
Editore: SPIE
DOI: 10.1117/12.2254792

Pulse-to-pulse wavelength switching of diode based fiber laser for multi-color multi-photon imaging

Autori: Matthias Eibl, Sebastian Karpf, Hubertus Hakert, Daniel Weng, Torben Blömker, Robert Huber
Pubblicato in: Fiber Lasers XIV: Technology and Systems, 2017, Pagina/e 100831C
Editore: SPIE
DOI: 10.1117/12.2251965

Feature tracking for automated volume of interest stabilization on 4D-OCT images

Autori: Max-Heinrich Laves, Andreas Schoob, Lüder A. Kahrs, Tom Pfeiffer, Robert Huber, Tobias Ortmaier
Pubblicato in: Medical Imaging 2017: Image-Guided Procedures, Robotic Interventions, and Modeling, 2017, Pagina/e 101350W
Editore: SPIE
DOI: 10.1117/12.2255090

Flexible A-scan rate MHz OCT: computational downscaling by coherent averaging

Autori: Tom Pfeiffer, Wolfgang Wieser, Thomas Klein, Markus Petermann, Jan-Phillip Kolb, Matthias Eibl, Robert Huber
Pubblicato in: Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XX, 2016, Pagina/e 96970S
Editore: SPIE
DOI: 10.1117/12.2214788

Megahertz FDML laser with up to 143nm sweep range for ultrahigh resolution OCT at 1050nm

Autori: Jan Philip Kolb, Thomas Klein, Matthias Eibl, Tom Pfeiffer, Wolfgang Wieser, Robert Huber
Pubblicato in: Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XX, 2016, Pagina/e 969703
Editore: SPIE
DOI: 10.1117/12.2214758

Two-photon-excited fluorescence (TPEF) and fluorescence lifetime imaging (FLIM) with sub-nanosecond pulses and a high analog bandwidth signal detection

Autori: Matthias Eibl, Sebastian Karpf, Hubertus Hakert, Daniel Weng, Robert Huber
Pubblicato in: Multiphoton Microscopy in the Biomedical Sciences XVII, 2017, Pagina/e 100691F
Editore: SPIE
DOI: 10.1117/12.2250831

Virtual HE histology by fiber-based picosecond two-photon microscopy

Autori: Wolfgang Draxinger, Jan Philip Kolb, Daniel Weng, Hubertus Hakert, Sebastian Nino Karpf, Robert Huber, Jürgen Popp, Tobias Meyer, Jens Limpert, Thomas Gottschall, Matthias Eibl, Ralf Brinkmann, Reginald Birngruber
Pubblicato in: Multiphoton Microscopy in the Biomedical Sciences XIX, 2019, Pagina/e 83, ISBN 9781510624078
Editore: SPIE
DOI: 10.1117/12.2507866

Peer reviewed articles (22)

Time-encoded stimulated Raman scattering microscopy of tumorous human pharynx tissue in the fingerprint region from 1500-1800 cm-1.

Autori: Hubertus Hakert; Matthias Eibl; Marie Tillich; Ralph Pries; Gereon Hüttmann; Ralf Brinkmann; Barbara Wollenberg; Karl-Ludwig Bruchhage; Sebastian Karpf; Robert Huber
Pubblicato in: Optics Letters, Numero 1, 2021, Pagina/e 3456-3459, ISSN 0146-9592
Editore: Optical Society of America
DOI: 10.1364/ol.424726

Wavelength agile multi-photon microscopy with a fiber amplified diode laser

Autori: Matthias Eibl, Daniel Weng, Hubertus Hakert, Jan Philip Kolb, Tom Pfeiffer, Jennifer E. Hundt, Robert Huber, Sebastian Karpf
Pubblicato in: Biomedical Optics Express, Numero 9/12, 2018, Pagina/e 6273, ISSN 2156-7085
Editore: The Optical Society
DOI: 10.1364/boe.9.006273

Pulse-to-pulse wavelength switching of a nanosecond fiber laser by four-wave mixing seeded stimulated Raman amplification

Autori: Matthias Eibl, Sebastian Karpf, Hubertus Hakert, Torben Blömker, Jan Philip Kolb, Christian Jirauschek, Robert Huber
Pubblicato in: Optics Letters, Numero 42/21, 2017, Pagina/e 4406, ISSN 0146-9592
Editore: Optical Society of America
DOI: 10.1364/ol.42.004406

Simultaneous Morphological and Flow Imaging Enabled by Megahertz Intravascular Doppler Optical Coherence Tomography

Autori: Tianshi Wang, Tom Pfeiffer, Joost Daemen, Frits Mastik, Wolfgang Wieser, A. F. W. van der Steen, Robert Huber, Gijs van Soest
Pubblicato in: IEEE Transactions on Medical Imaging, Numero 39/5, 2020, Pagina/e 1535-1544, ISSN 0278-0062
Editore: Institute of Electrical and Electronics Engineers
DOI: 10.1109/tmi.2019.2948258

Cavity length control for Fourier domain mode locked (FDML) lasers with µm precision.

Autori: Simon Lotz; Christin Grill; Madita Göb; Wolfgang Draxinger; Jan Philip Kolb; Robert Huber
Pubblicato in: Biomedical Optics Express, Numero 2, 2021, Pagina/e 2604-2616, ISSN 2156-7085
Editore: The Optical Society
DOI: 10.1364/boe.422898

Ultra low noise Fourier domain mode locked laser for high quality megahertz optical coherence tomography

Autori: Tom Pfeiffer, Markus Petermann, Wolfgang Draxinger, Christian Jirauschek, Robert Huber
Pubblicato in: Biomedical Optics Express, Numero 9/9, 2018, Pagina/e 4130, ISSN 2156-7085
Editore: The Optical Society
DOI: 10.1364/boe.9.004130

Flexible A-scan rate MHz-OCT: efficient computational downscaling by coherent averaging

Autori: Tom Pfeiffer, Madita Göb, Wolfgang Draxinger, Sebastian Karpf, Jan Philip Kolb, Robert Huber
Pubblicato in: Biomedical Optics Express, Numero 11/11, 2020, Pagina/e 6799, ISSN 2156-7085
Editore: The Optical Society
DOI: 10.1364/boe.402477

Important factors for cell-membrane permeabilization by gold nanoparticles activated by nanosecond-laser irradiation

Autori: Cuiping Yao, Florian Rudnitzki, Gereon Hüttmann, Zhenxi Zhang, Ramtin Rahmanzadeh
Pubblicato in: International Journal of Nanomedicine, Numero Volume 12, 2017, Pagina/e 5659-5672, ISSN 1178-2013
Editore: Dovepress
DOI: 10.2147/IJN.S140620

Thermo-elastic optical coherence tomography

Autori: Tianshi Wang, Tom Pfeiffer, Min Wu, Wolfgang Wieser, Gaetano Amenta, Wolfgang Draxinger, Antonius F. W. van der Steen, Robert Huber, Gijs van Soest
Pubblicato in: Optics Letters, Numero 42/17, 2017, Pagina/e 3466, ISSN 0146-9592
Editore: Optical Society of America
DOI: 10.1364/ol.42.003466

High-speed fiber scanning endoscope for volumetric multi-megahertz optical coherence tomography

Autori: Hinnerk Schulz-Hildebrandt, Tom Pfeiffer, Tim Eixmann, Sabrina Lohmann, Martin Ahrens, Joshua Rehra, Wolfgang Draxinger, Peter König, Robert Huber, Gereon Hüttmann
Pubblicato in: Optics Letters, Numero 43/18, 2018, Pagina/e 4386, ISSN 0146-9592
Editore: Optical Society of America
DOI: 10.1364/ol.43.004386

Single pulse two photon fluorescence lifetime imaging (SP-FLIM) with MHz pixel rate

Autori: Matthias Eibl, Sebastian Karpf, Daniel Weng, Hubertus Hakert, Tom Pfeiffer, Jan Philip Kolb, Robert Huber
Pubblicato in: Biomedical Optics Express, Numero 8/7, 2017, Pagina/e 3132, ISSN 2156-7085
Editore: The Optical Society
DOI: 10.1364/BOE.8.003132

Efficient simulation of the swept-waveform polarization dynamics in fiber spools and Fourier domain mode-locked (FDML) lasers

Autori: Christian Jirauschek, Robert Huber
Pubblicato in: Journal of the Optical Society of America B, Numero 34/6, 2017, Pagina/e 1135, ISSN 0740-3224
Editore: Optical Society of America
DOI: 10.1364/JOSAB.34.001135

Shot-Noise Limited Time-Encoded Raman Spectroscopy

Autori: Sebastian Karpf, Matthias Eibl, Wolfgang Wieser, Thomas Klein, Robert Huber
Pubblicato in: Journal of Spectroscopy, Numero 2017, 2017, Pagina/e 1-6, ISSN 2314-4920
Editore: Hindawi Publishing Corporation
DOI: 10.1155/2017/9253475

Two-photon microscopy using fiber-based nanosecond excitation

Autori: Sebastian Karpf, Matthias Eibl, Benjamin Sauer, Fred Reinholz, Gereon Hüttmann, Robert Huber
Pubblicato in: Biomedical Optics Express, Numero 7/7, 2016, Pagina/e 2432, ISSN 2156-7085
Editore: The Optical Society
DOI: 10.1364/BOE.7.002432

High-speed OCT light sources and systems [Invited]

Autori: Thomas Klein, Robert Huber
Pubblicato in: Biomedical Optics Express, Numero 8/2, 2017, Pagina/e 828, ISSN 2156-7085
Editore: The Optical Society
DOI: 10.1364/BOE.8.000828

Heartbeat OCT and Motion-Free 3D In Vivo Coronary Artery Microscopy

Autori: Tianshi Wang, Tom Pfeiffer, Evelyn Regar, Wolfgang Wieser, Heleen van Beusekom, Charles T. Lancee, Geert Springeling, Ilona Krabbendam-Peters, Antonius F.W. van der Steen, Robert Huber, Gijs van Soest
Pubblicato in: JACC: Cardiovascular Imaging, Numero 9/5, 2016, Pagina/e 622-623, ISSN 1936-878X
Editore: Elsevier BV
DOI: 10.1016/j.jcmg.2015.08.010

Beyond Vibrationally Mediated Electron Transfer: Coherent Phenomena Induced by Ultrafast Charge Separation

Autori: Robert Huber, Lars Dworak, Jacques E. Moser, Michael Grätzel, Josef Wachtveitl
Pubblicato in: The Journal of Physical Chemistry C, Numero 120/16, 2016, Pagina/e 8534-8539, ISSN 1932-7447
Editore: American Chemical Society
DOI: 10.1021/acs.jpcc.6b02012

Self-stabilization mechanism in ultra-stable Fourier domain mode-locked (FDML) lasers

Autori: Mark Schmidt, Tom Pfeiffer, Christin Grill, Robert Huber, Christian Jirauschek
Pubblicato in: OSA Continuum, Numero 3/6, 2020, Pagina/e 1589, ISSN 2578-7519
Editore: Optical Society of America
DOI: 10.1364/osac.389972

Live video rate volumetric OCT imaging of the retina with multi-MHz A-scan rates

Autori: Jan Philip Kolb, Wolfgang Draxinger, Julian Klee, Tom Pfeiffer, Matthias Eibl, Thomas Klein, Wolfgang Wieser, Robert Huber
Pubblicato in: PLOS ONE, Numero 14/3, 2019, Pagina/e e0213144, ISSN 1932-6203
Editore: Public Library of Science
DOI: 10.1371/journal.pone.0213144

In-vitro and in-vivo imaging of coronary artery stents with Heartbeat OCT

Autori: Leonardo Cecchetti, Tianshi Wang, Ayla Hoogendoorn, Karen T. Witberg, Jurgen M. R. Ligthart, Joost Daemen, Heleen M. M. van Beusekom, Tom Pfeiffer, Robert A. Huber, Jolanda J. Wentzel, Antonius F. W. van der Steen, Gijs van Soest
Pubblicato in: The International Journal of Cardiovascular Imaging, Numero 36/6, 2020, Pagina/e 1021-1029, ISSN 1569-5794
Editore: Kluwer Academic Publishers
DOI: 10.1007/s10554-020-01796-7

Motorized capsule for shadow-free OCT imaging and synchronous beam control

Autori: Antonio López-Marín, Geert Springeling, Robert Beurskens, Heleen van Beusekom, Antonius F. W. van der Steen, Arjun D. Koch, Brett E. Bouma, Robert Huber, Gijs van Soest, Tianshi Wang
Pubblicato in: Optics Letters, Numero 44/15, 2019, Pagina/e 3641, ISSN 0146-9592
Editore: Optical Society of America
DOI: 10.1364/ol.44.003641

Intensity pattern types in broadband Fourier domain mode-locked (FDML) lasers operating beyond the ultra-stable regime

Autori: Mark Schmidt; Christin Grill; Simon Lotz; Tom Pfeiffer; Robert Huber; Christian Jirauschek
Pubblicato in: Applied Physics B, Numero 1, 2021, ISSN 0946-2171
Editore: Springer Verlag
DOI: 10.1007/s00340-021-07600-1

Diritti di proprietà intellettuale

Patent (1)

METHOD FOR MONITORING TIME-DEPENDENT PROPERTIES OF LIGHT IN SCANNING SWEPT-SOURCE OPTICAL COHERENCE TOMOGRAPHY

Numero candidatura/pubblicazione: 20 19069473
Data: 2019-07-19
Candidato/i: UNIVERSITAET zu LUEBECK