Publications Peer reviewed articles (37) Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition) Author(s): Daniel J. Klionsky, Amal Kamal Abdel-Aziz, Sara Abdelfatah, Mahmoud Abdellatif, Asghar Abdoli, Steffen Abel, Hagai Abeliovich, Marie H. Abildgaard, Yakubu Princely Abudu, Abraham Acevedo-Arozena, Iannis E. Adamopoulos, Khosrow Adeli, Timon E. Adolph, Annagrazia Adornetto, Elma Aflaki, Galila Agam, Anupam Agarwal, Bharat B. Aggarwal, Maria Agnello, Patrizia Agostinis, Javed N. Agrewala, Alexander A Published in: Autophagy, Issue 17(12), 2021, Page(s) 1-382, ISSN 1554-8627 Publisher: Landes Bioscience DOI: 10.1080/15548627.2020.1797280 Presynaptic Autophagy and the Connection With Neurotransmission Author(s): Marianna Decet, Patrik Verstreken Published in: Frontiers in Cell and Developmental Biology, Issue 9, 2022, Page(s) 790721, ISSN 2296-634X Publisher: Frontiers Media SA DOI: 10.3389/fcell.2021.790721 Torsin and NEP1R1-CTDNEP1 phosphatase affect interphase nuclear pore complex insertion by lipid-dependent and lipid-independent mechanisms Author(s): Julie Jacquemyn, Joyce Foroozandeh, Katlijn Vints, Jef Swerts, Patrik Verstreken, Natalia V Gounko, Sandra F Gallego, Rose Goodchild Published in: The EMBO Journal, Issue 40(17), 2021, Page(s) e106914, ISSN 0261-4189 Publisher: Nature Publishing Group DOI: 10.15252/embj.2020106914 MAPRE2 mutations result in altered human cranial neural crest migration, underlying craniofacial malformations in CSC-KT syndrome Author(s): Cedric Thues, Jorge S. Valadas, Liesbeth Deaulmerie, Ann Geens, Amit K. Chouhan, Ramon Duran-Romaña, Joost Schymkowitz, Frederic Rousseau, Michaela Bartusel, Rizwan Rehimi, Alvaro Rada-Iglesias, Patrik Verstreken & Hilde Van Esch Published in: Scientific Reports, Issue 11(1), 2021, Page(s) 4976, ISSN 2045-2322 Publisher: Nature Publishing Group DOI: 10.1038/s41598-021-83771-3 A structure of substrate-bound Synaptojanin1 provides new insights in its mechanism and the effect of disease mutations Author(s): Jone Paesmans, Ella Martin, Babette Deckers, Marjolijn Berghmans, Ritika Sethi, Yannick Loeys, Els Pardon, Jan Steyaert, Patrik Verstreken, Christian Galicia, Wim Versées Published in: eLife, Issue 9, 2020, Page(s) e64922, ISSN 2050-084X Publisher: eLife Sciences Publications DOI: 10.7554/elife.64922 Molecule-to-Circuit Disease Mechanisms of a Synaptic SNAREopathy Author(s): Roman Praschberger, Julie Jacquemyn, Patrik Verstreken Published in: Neuron, Issue 109(1), 2021, Page(s) 1-3, ISSN 0896-6273 Publisher: Cell Press DOI: 10.1016/j.neuron.2020.12.009 Endophilin-B regulates autophagy during synapse development and neurodegeneration Author(s): Sergio Hernandez-Diaz, Saurav Ghimire, Irene Sanchez-Mirasierra, Carla Montecinos-Oliva, Jef Swerts, Sabine Kuenen, Patrik Verstreken, Sandra-Fausia Soukup Published in: Neurobiology of Disease, Issue 163, 2022, Page(s) 105595, ISSN 0969-9961 Publisher: Academic Press DOI: 10.1016/j.nbd.2021.105595 Synaptic proteostasis in Parkinson’s disease Author(s): Eliana Nachman, Patrik Verstreken Published in: Current Opinion in Neurobiology, Issue 72, 2021, Page(s) 72-79, ISSN 0959-4388 Publisher: Elsevier BV DOI: 10.1016/j.conb.2021.09.001 The Alzheimer susceptibility gene BIN1 induces isoform-dependent neurotoxicity through early endosome defects. Author(s): Erwan Lambert, Orthis Saha, Bruna Soares Landeira, Ana Raquel Melo de Farias, Xavier Hermant, Arnaud Carrier, Alexandre Pelletier, Johanna Gadaut, Lindsay Davoine, Cloé Dupont, Philippe Amouyel, Amélie Bonnefond, Frank Lafont, Farida Abdelfettah, Patrik Verstreken, Julien Chapuis, Nicolas Barois, Fabien Delahaye, Bart Dermaut, Jean-Charles Lambert, Marcos R. Costa & Pierre Dourlen Published in: Acta Neuropathologica Communications, Issue 10(1), 2022, Page(s) 4, ISSN 2051-5960 Publisher: BioMed Central DOI: 10.1186/s40478-021-01285-5 Maturation of neuronal AD-tau pathology involves site-specific phosphorylation of cytoplasmic and synaptic tau preceding conformational change and fibril formation Author(s): Luis Aragão Gomes, Valerie Uytterhoeven, Diego Lopez-Sanmartin, Sandra O. Tomé, Thomas Tousseyn, Rik Vandenberghe, Mathieu Vandenbulcke, Christine A. F. von Arnim, Patrik Verstreken, Dietmar Rudolf Thal Published in: Acta Neuropathologica, Issue 141, 2021, Page(s) 173-192, ISSN 0001-6322 Publisher: Springer Verlag DOI: 10.1007/s00401-020-02251-6 Synaptogyrin-3 Mediates Presynaptic Dysfunction Induced by Tau Author(s): Joseph McInnes, Keimpe Wierda, An Snellinx, Laura Bounti, Yu-Chun Wang, Ilie-Cosmin Stancu, Nuno Apóstolo, Kris Gevaert, Ilse Dewachter, Tara L. Spires-Jones, Bart De Strooper, Joris De Wit, Lujia Zhou, Patrik Verstreken Published in: Neuron, Issue 97/4, 2018, Page(s) 823-835.e8, ISSN 0896-6273 Publisher: Cell Press DOI: 10.1016/j.neuron.2018.01.022 A Single-Cell Transcriptome Atlas of the Aging Drosophila Brain Author(s): Kristofer Davie, Jasper Janssens, Duygu Koldere, Maxime De Waegeneer, Uli Pech, Łukasz Kreft, Sara Aibar, Samira Makhzami, Valerie Christiaens, Carmen Bravo González-Blas, Suresh Poovathingal, Gert Hulselmans, Katina I. Spanier, Thomas Moerman, Bram Vanspauwen, Sarah Geurs, Thierry Voet, Jeroen Lammertyn, Bernard Thienpont, Sha Liu, Nikos Konstantinides, Mark Fiers, Patrik Verstreken, Stein Aert Published in: Cell, 2018, ISSN 0092-8674 Publisher: Cell Press DOI: 10.1016/j.cell.2018.05.057 Reprogramming neurodegeneration in the big data era Author(s): Lujia Zhou, Patrik Verstreken Published in: Current Opinion in Neurobiology, Issue 48, 2018, Page(s) 167-173, ISSN 0959-4388 Publisher: Elsevier BV DOI: 10.1016/j.conb.2017.12.015 p13 protects against Parkinson's disease Author(s): Jorge S Valadas, Patrik Verstreken Published in: EMBO reports, Issue 19/3, 2018, Page(s) e45900, ISSN 1469-221X Publisher: Nature Publishing Group DOI: 10.15252/embr.201845900 ER Lipid Defects in Neuropeptidergic Neurons Impair Sleep Patterns in Parkinson’s Disease Author(s): Jorge S. Valadas, Giovanni Esposito, Dirk Vandekerkhove, Katarzyna Miskiewicz, Liesbeth Deaulmerie, Susanna Raitano, Philip Seibler, Christine Klein, Patrik Verstreken Published in: Neuron, Issue 98/6, 2018, Page(s) 1155-1169.e6, ISSN 0896-6273 Publisher: Cell Press DOI: 10.1016/j.neuron.2018.05.022 Tau association with synaptic vesicles causes presynaptic dysfunction Author(s): Lujia Zhou, Joseph McInnes, Keimpe Wierda, Matthew Holt, Abigail G. Herrmann, Rosemary J. Jackson, Yu-Chun Wang, Jef Swerts, Jelle Beyens, Katarzyna Miskiewicz, Sven Vilain, Ilse Dewachter, Diederik Moechars, Bart De Strooper, Tara L. Spires-Jones, Joris De Wit, Patrik Verstreken Published in: Nature Communications, Issue 8, 2017, Page(s) 15295, ISSN 2041-1723 Publisher: Nature Publishing Group DOI: 10.1038/ncomms15295 Shawn, the Drosophila Homolog of SLC25A39/40, Is a Mitochondrial Carrier That Promotes Neuronal Survival Author(s): J. R. Slabbaert, S. Kuenen, J. Swerts, I. Maes, V. Uytterhoeven, J. Kasprowicz, A. C. Fernandes, R. Blust, P. Verstreken Published in: Journal of Neuroscience, Issue 36/6, 2016, Page(s) 1914-1929, ISSN 0270-6474 Publisher: Society for Neuroscience DOI: 10.1523/JNEUROSCI.3432-15.2016 Torsins Are Essential Regulators of Cellular Lipid Metabolism Author(s): Micheline Grillet, Beatriz Dominguez Gonzalez, Adria Sicart, Maria Pöttler, Ana Cascalho, Karolien Billion, Sergio Hernandez Diaz, Jef Swerts, Teresa V. Naismith, Natalia V. Gounko, Patrik Verstreken, Phyllis I. Hanson, Rose E. Goodchild Published in: Developmental Cell, Issue 38/3, 2016, Page(s) 235-247, ISSN 1534-5807 Publisher: Cell Press DOI: 10.1016/j.devcel.2016.06.017 Mitochondrial uncouplers inhibit clathrin-mediated endocytosis largely through cytoplasmic acidification Author(s): Wim Dejonghe, Sabine Kuenen, Evelien Mylle, Mina Vasileva, Olivier Keech, Corrado Viotti, Jef Swerts, Matyáš Fendrych, Fausto Andres Ortiz-Morea, Kiril Mishev, Simon Delang, Stefan Scholl, Xavier Zarza, Mareike Heilmann, Jiorgos Kourelis, Jaroslaw Kasprowicz, Le Son Long Nguyen, Andrzej Drozdzecki, Isabelle Van Houtte, Anna-Mária Szatmári, Mateusz Majda, Gary Baisa, Sebastian York Bednarek, St Published in: Nature Communications, Issue 7, 2016, Page(s) 11710, ISSN 2041-1723 Publisher: Nature Publishing Group DOI: 10.1038/ncomms11710 Loss of Bin1 Promotes the Propagation of Tau Pathology Author(s): Sara Calafate, William Flavin, Patrik Verstreken, Diederik Moechars Published in: Cell Reports, Issue 17/4, 2016, Page(s) 931-940, ISSN 2211-1247 Publisher: Cell Press DOI: 10.1016/j.celrep.2016.09.063 Skywalker-TBC1D24 has a lipid-binding pocket mutated in epilepsy and required for synaptic function Author(s): Baptiste Fischer, Kevin Lüthy, Jone Paesmans, Charlotte De Koninck, Ine Maes, Jef Swerts, Sabine Kuenen, Valerie Uytterhoeven, Patrik Verstreken, Wim Versées Published in: Nature Structural & Molecular Biology, Issue 23/11, 2016, Page(s) 965-973, ISSN 1545-9993 Publisher: Nature Publishing Group DOI: 10.1038/nsmb.3297 Endophilin-A Deficiency Induces the Foxo3a-Fbxo32 Network in the Brain and Causes Dysregulation of Autophagy and the Ubiquitin-Proteasome System Author(s): John D. Murdoch, Christine M. Rostosky, Sindhuja Gowrisankaran, Amandeep S. Arora, Sandra-Fausia Soukup, Ramon Vidal, Vincenzo Capece, Siona Freytag, Andre Fischer, Patrik Verstreken, Stefan Bonn, Nuno Raimundo, Ira Milosevic Published in: Cell Reports, Issue 17/4, 2016, Page(s) 1071-1086, ISSN 2211-1247 Publisher: Cell Press DOI: 10.1016/j.celrep.2016.09.058 A LRRK2-Dependent EndophilinA Phosphoswitch Is Critical for Macroautophagy at Presynaptic Terminals Author(s): Sandra-Fausia Soukup, Sabine Kuenen, Roeland Vanhauwaert, Julia Manetsberger, Sergio Hernández-Díaz, Jef Swerts, Nils Schoovaerts, Sven Vilain, Natalia V. Gounko, Katlijn Vints, Ann Geens, Bart De Strooper, Patrik Verstreken Published in: Neuron, Issue 92/4, 2016, Page(s) 829-844, ISSN 0896-6273 Publisher: Cell Press DOI: 10.1016/j.neuron.2016.09.037 EndoA/Endophilin-A creates docking stations for autophagic proteins at synapses Author(s): Sandra-Fausia Soukup, Patrik Verstreken Published in: Autophagy, Issue 13/5, 2017, Page(s) 971-972, ISSN 1554-8627 Publisher: Landes Bioscience DOI: 10.1080/15548627.2017.1286440 In vivo single-molecule imaging of syntaxin1A reveals polyphosphoinositide- and activity-dependent trapping in presynaptic nanoclusters Author(s): Adekunle T. Bademosi, Elsa Lauwers, Pranesh Padmanabhan, Lorenzo Odierna, Ye Jin Chai, Andreas Papadopulos, Geoffrey J. Goodhill, Patrik Verstreken, Bruno van Swinderen, Frédéric A. Meunier Published in: Nature Communications, Issue 8, 2017, Page(s) 13660, ISSN 2041-1723 Publisher: Nature Publishing Group DOI: 10.1038/ncomms13660 Cardiolipin promotes electron transport between ubiquinone and complex I to rescue PINK1 deficiency Author(s): Melissa Vos, Ann Geens, Claudia Böhm, Liesbeth Deaulmerie, Jef Swerts, Matteo Rossi, Katleen Craessaerts, Elvira P. Leites, Philip Seibler, Aleksandar Rakovic, Thora Lohnau, Bart De Strooper, Sarah-Maria Fendt, Vanessa A. Morais, Christine Klein, Patrik Verstreken Published in: The Journal of Cell Biology, Issue 216/3, 2017, Page(s) 695-708, ISSN 0021-9525 Publisher: Rockefeller University Press DOI: 10.1083/jcb.201511044 Neurons eat glutamate to stay alive Author(s): Sarah-Maria Fendt, Patrik Verstreken Published in: The Journal of Cell Biology, Issue 216/4, 2017, Page(s) 863-865, ISSN 0021-9525 Publisher: Rockefeller University Press DOI: 10.1083/jcb.201702003 The SAC1 domain in synaptojanin is required for autophagosome maturation at presynaptic terminals Author(s): Roeland Vanhauwaert, Sabine Kuenen, Roy Masius, Adekunle Bademosi, Julia Manetsberger, Nils Schoovaerts, Laura Bounti, Serguei Gontcharenko, Jef Swerts, Sven Vilain, Marina Picillo, Paolo Barone, Shashini T Munshi, Femke MS de Vrij, Steven A Kushner, Natalia V Gounko, Wim Mandemakers, Vincenzo Bonifati, Frederic A Meunier, Sandra‐Fausia Soukup, Patrik Verstreken Published in: The EMBO Journal, Issue 36/10, 2017, Page(s) 1392-1411, ISSN 0261-4189 Publisher: Nature Publishing Group DOI: 10.15252/embj.201695773 Presynaptic protein homeostasis and neuronal function Author(s): Yu-Chun Wang, Elsa Lauwers, Patrik Verstreken Published in: Current Opinion in Genetics & Development, Issue 44, 2017, Page(s) 38-46, ISSN 0959-437X Publisher: Elsevier BV DOI: 10.1016/j.gde.2017.01.015 Autophagy in the presynaptic compartment in health and disease Author(s): Vinoy Vijayan, Patrik Verstreken Published in: The Journal of Cell Biology, Issue 216/7, 2017, Page(s) 1895-1906, ISSN 0021-9525 Publisher: Rockefeller University Press DOI: 10.1083/jcb.201611113 Trapping of Syntaxin1a in Presynaptic Nanoclusters by a Clinically Relevant General Anesthetic Author(s): Adekunle T. Bademosi, James Steeves, Shanker Karunanithi, Oressia H. Zalucki, Rachel S. Gormal, Shu Liu, Elsa Lauwers, Patrik Verstreken, Victor Anggono, Frederic A. Meunier, Bruno van Swinderen Published in: Cell Reports, Issue 22/2, 2018, Page(s) 427-440, ISSN 2211-1247 Publisher: Cell Press DOI: 10.1016/j.celrep.2017.12.054 Deficiency of parkin and PINK1 impairs age-dependent mitophagy in Drosophila Author(s): Tom Cornelissen, Sven Vilain, Katlijn Vints, Natalia Gounko, Patrik Verstreken, Wim Vandenberghe Published in: eLife, Issue 7, 2018, ISSN 2050-084X Publisher: eLife Sciences Publications DOI: 10.7554/elife.35878 Hsp90 Mediates Membrane Deformation and Exosome Release Author(s): Elsa Lauwers, Yu-Chun Wang, Rodrigo Gallardo, Rob Van der Kant, Emiel Michiels, Jef Swerts, Pieter Baatsen, Samantha S. Zaiter, Shelli R. McAlpine, Natalia V. Gounko, Frederic Rousseau, Joost Schymkowitz, Patrik Verstreken Published in: Molecular Cell, Issue 71/5, 2018, Page(s) 689-702.e9, ISSN 1097-2765 Publisher: Cell Press DOI: 10.1016/j.molcel.2018.07.016 Parkinson's disease: convergence on synaptic homeostasis Author(s): Sandra‐Fausia Soukup, Roeland Vanhauwaert, Patrik Verstreken Published in: The EMBO Journal, Issue 37/18, 2018, ISSN 0261-4189 Publisher: Nature Publishing Group DOI: 10.15252/embj.201898960 Excess Lipin enzyme activity contributes to TOR1A recessive disease and DYT-TOR1A dystonia Author(s): Ana Cascalho, Joyce Foroozandeh, Lise Hennebel, Jef Swerts, Christine Klein, Stef Rous, Beatriz Dominguez Gonzalez, Antonio Pisani, Maria Meringolo, Sandra F Gallego, Patrik Verstreken, Philip Seibler, Rose E Goodchild Published in: Brain, Issue 143/6, 2020, Page(s) 1746-1765, ISSN 0006-8950 Publisher: Oxford University Press DOI: 10.1093/brain/awaa139 LifeTime and improving European healthcare through cell-based interceptive medicine Author(s): Nikolaus Rajewsky, Geneviève Almouzni, Stanislaw A Gorski, Stein Aerts, Ido Amit, Michela G Bertero, Christoph Bock, Annelien L Bredenoord, Giacomo Cavalli, Susanna Chiocca, Hans Clevers, Bart De Strooper, Angelika Eggert, Jan Ellenberg, Xosé M Fernández, Marek Figlerowicz, Susan M Gasser, Norbert Hubner, Jørgen Kjems, Jürgen A Knoblich, Grietje Krabbe, Peter Lichter, Sten Linnarsson, Jean-Ch Published in: Nature, Issue 587 (7834), 2020, Page(s) 377-386, ISSN 0028-0836 Publisher: Nature Publishing Group DOI: 10.1038/s41586-020-2715-9 Lowering Synaptogyrin-3 expression rescues Tau-induced memory defects and synaptic loss in the presence of microglial activation Author(s): Pablo Largo-Barrientos, Nuno Apóstolo, Eline Creemers, Zsuzsanna Callaerts-Vegh, Jef Swerts, Caitlin Davies, Joseph McInnes, Keimpe Wierda, Bart De Strooper, Tara Spires-Jones, Joris de Wit, Valerie Uytterhoeven, Patrik Verstreken Published in: Neuron, Issue 109(5), 2021, Page(s) 767-777, ISSN 0896-6273 Publisher: Cell Press DOI: 10.1016/j.neuron.2020.12.016 Other (6) α-Synuclein and Tau: Mitochondrial Kill Switches Author(s): Ulrike Pech, Patrik Verstreken Published in: Neuron, Issue 97/1, 2018, Page(s) 3-4, ISSN 0896-6273 Publisher: Cell Press DOI: 10.1016/j.neuron.2017.12.024 Membrane Lipids in Presynaptic Function and Disease Author(s): Elsa Lauwers, Rose Goodchild, Patrik Verstreken Published in: Neuron, Issue 90/1, 2016, Page(s) 11-25, ISSN 0896-6273 Publisher: Cell Press DOI: 10.1016/j.neuron.2016.02.033 Imaging mitophagy in the fruit fly Author(s): Tom Cornelissen, Patrik Verstreken, Wim Vandenberghe Published in: Autophagy, Issue 14/9, 2018, Page(s) 1656-1657, ISSN 1554-8627 Publisher: Landes Bioscience DOI: 10.1080/15548627.2018.1496720 Need for speed: Super-resolving the dynamic nanoclustering of syntaxin-1 at exocytic fusion sites Author(s): Pranesh Padmanabhan, Adekunle T. Bademosi, Ravikiran Kasula, Elsa Lauwers, Patrik Verstreken, Frédéric A. Meunier Published in: Neuropharmacology, Issue 169, 2020, Page(s) 107554, ISSN 0028-3908 Publisher: Pergamon Press Ltd. DOI: 10.1016/j.neuropharm.2019.02.036 TBC1D24-TLDc-related epilepsy exercise-induced dystonia: rescue by antioxidants in a disease model Author(s): Kevin Lüthy, Davide Mei, Baptiste Fischer, Maurizio De Fusco, Jef Swerts, Jone Paesmans, Elena Parrini, Naomi Lubarr, Inge A Meijer, Katherine M Mackenzie, Wang-Tso Lee, Davide Cittaro, Paolo Aridon, Nils Schoovaerts, Wim Versées, Patrik Verstreken, Giorgio Casari, Renzo Guerrini Published in: Brain, Issue 142/8, 2019, Page(s) 2319-2335, ISSN 0006-8950 Publisher: Oxford University Press DOI: 10.1093/brain/awz175 Mitochondria Re-set Epilepsy Author(s): Valerie Uytterhoeven, Natalie Kaempf, Patrik Verstreken Published in: Neuron, Issue 102/5, 2019, Page(s) 907-910, ISSN 0896-6273 Publisher: Cell Press DOI: 10.1016/j.neuron.2019.05.023 Book chapters (1) Assaying Mutants of Clathrin-Mediated Endocytosis in the Fly Eye Author(s): Elsa Lauwers, Patrik Verstreken Published in: Clathrin-Mediated Endocytosis - Methods and Protocols, Issue 1847, 2018, Page(s) 109-119, ISBN 978-1-4939-8717-7 Publisher: Springer New York DOI: 10.1007/978-1-4939-8719-1_9 Searching for OpenAIRE data... 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