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Maintaining synaptic function for a healthy brain: Membrane trafficking and autophagy in neurodegeneration

Publications

Synaptogyrin-3 Mediates Presynaptic Dysfunction Induced by Tau

Author(s): Joseph McInnes, Keimpe Wierda, An Snellinx, Laura Bounti, Yu-Chun Wang, Ilie-Cosmin Stancu, Nuno Apóstolo, Kris Gevaert, Ilse Dewachter, Tara L. Spires-Jones, Bart De Strooper, Joris De Wit, Lujia Zhou, Patrik Verstreken
Published in: Neuron, Issue 97/4, 2018, Page(s) 823-835.e8, ISSN 0896-6273
DOI: 10.1016/j.neuron.2018.01.022

A Single-Cell Transcriptome Atlas of the Aging Drosophila Brain

Author(s): Kristofer Davie, Jasper Janssens, Duygu Koldere, Maxime De Waegeneer, Uli Pech, Łukasz Kreft, Sara Aibar, Samira Makhzami, Valerie Christiaens, Carmen Bravo González-Blas, Suresh Poovathingal, Gert Hulselmans, Katina I. Spanier, Thomas Moerman, Bram Vanspauwen, Sarah Geurs, Thierry Voet, Jeroen Lammertyn, Bernard Thienpont, Sha Liu, Nikos Konstantinides, Mark Fiers, Patrik Verstreken, Stein Aert
Published in: Cell, 2018, ISSN 0092-8674
DOI: 10.1016/j.cell.2018.05.057

Reprogramming neurodegeneration in the big data era

Author(s): Lujia Zhou, Patrik Verstreken
Published in: Current Opinion in Neurobiology, Issue 48, 2018, Page(s) 167-173, ISSN 0959-4388
DOI: 10.1016/j.conb.2017.12.015

α-Synuclein and Tau: Mitochondrial Kill Switches

Author(s): Ulrike Pech, Patrik Verstreken
Published in: Neuron, Issue 97/1, 2018, Page(s) 3-4, ISSN 0896-6273
DOI: 10.1016/j.neuron.2017.12.024

p13 protects against Parkinson's disease

Author(s): Jorge S Valadas, Patrik Verstreken
Published in: EMBO reports, Issue 19/3, 2018, Page(s) e45900, ISSN 1469-221X
DOI: 10.15252/embr.201845900

ER Lipid Defects in Neuropeptidergic Neurons Impair Sleep Patterns in Parkinson’s Disease

Author(s): Jorge S. Valadas, Giovanni Esposito, Dirk Vandekerkhove, Katarzyna Miskiewicz, Liesbeth Deaulmerie, Susanna Raitano, Philip Seibler, Christine Klein, Patrik Verstreken
Published in: Neuron, Issue 98/6, 2018, Page(s) 1155-1169.e6, ISSN 0896-6273
DOI: 10.1016/j.neuron.2018.05.022

Tau association with synaptic vesicles causes presynaptic dysfunction

Author(s): Lujia Zhou, Joseph McInnes, Keimpe Wierda, Matthew Holt, Abigail G. Herrmann, Rosemary J. Jackson, Yu-Chun Wang, Jef Swerts, Jelle Beyens, Katarzyna Miskiewicz, Sven Vilain, Ilse Dewachter, Diederik Moechars, Bart De Strooper, Tara L. Spires-Jones, Joris De Wit, Patrik Verstreken
Published in: Nature Communications, Issue 8, 2017, Page(s) 15295, ISSN 2041-1723
DOI: 10.1038/ncomms15295

Shawn, the Drosophila Homolog of SLC25A39/40, Is a Mitochondrial Carrier That Promotes Neuronal Survival

Author(s): J. R. Slabbaert, S. Kuenen, J. Swerts, I. Maes, V. Uytterhoeven, J. Kasprowicz, A. C. Fernandes, R. Blust, P. Verstreken
Published in: Journal of Neuroscience, Issue 36/6, 2016, Page(s) 1914-1929, ISSN 0270-6474
DOI: 10.1523/JNEUROSCI.3432-15.2016

Membrane Lipids in Presynaptic Function and Disease

Author(s): Elsa Lauwers, Rose Goodchild, Patrik Verstreken
Published in: Neuron, Issue 90/1, 2016, Page(s) 11-25, ISSN 0896-6273
DOI: 10.1016/j.neuron.2016.02.033

Torsins Are Essential Regulators of Cellular Lipid Metabolism

Author(s): Micheline Grillet, Beatriz Dominguez Gonzalez, Adria Sicart, Maria Pöttler, Ana Cascalho, Karolien Billion, Sergio Hernandez Diaz, Jef Swerts, Teresa V. Naismith, Natalia V. Gounko, Patrik Verstreken, Phyllis I. Hanson, Rose E. Goodchild
Published in: Developmental Cell, Issue 38/3, 2016, Page(s) 235-247, ISSN 1534-5807
DOI: 10.1016/j.devcel.2016.06.017

Mitochondrial uncouplers inhibit clathrin-mediated endocytosis largely through cytoplasmic acidification

Author(s): Wim Dejonghe, Sabine Kuenen, Evelien Mylle, Mina Vasileva, Olivier Keech, Corrado Viotti, Jef Swerts, Matyáš Fendrych, Fausto Andres Ortiz-Morea, Kiril Mishev, Simon Delang, Stefan Scholl, Xavier Zarza, Mareike Heilmann, Jiorgos Kourelis, Jaroslaw Kasprowicz, Le Son Long Nguyen, Andrzej Drozdzecki, Isabelle Van Houtte, Anna-Mária Szatmári, Mateusz Majda, Gary Baisa, Sebastian York Bednarek, St
Published in: Nature Communications, Issue 7, 2016, Page(s) 11710, ISSN 2041-1723
DOI: 10.1038/ncomms11710

Loss of Bin1 Promotes the Propagation of Tau Pathology

Author(s): Sara Calafate, William Flavin, Patrik Verstreken, Diederik Moechars
Published in: Cell Reports, Issue 17/4, 2016, Page(s) 931-940, ISSN 2211-1247
DOI: 10.1016/j.celrep.2016.09.063

Endophilin-A Deficiency Induces the Foxo3a-Fbxo32 Network in the Brain and Causes Dysregulation of Autophagy and the Ubiquitin-Proteasome System

Author(s): John D. Murdoch, Christine M. Rostosky, Sindhuja Gowrisankaran, Amandeep S. Arora, Sandra-Fausia Soukup, Ramon Vidal, Vincenzo Capece, Siona Freytag, Andre Fischer, Patrik Verstreken, Stefan Bonn, Nuno Raimundo, Ira Milosevic
Published in: Cell Reports, Issue 17/4, 2016, Page(s) 1071-1086, ISSN 2211-1247
DOI: 10.1016/j.celrep.2016.09.058

A LRRK2-Dependent EndophilinA Phosphoswitch Is Critical for Macroautophagy at Presynaptic Terminals

Author(s): Sandra-Fausia Soukup, Sabine Kuenen, Roeland Vanhauwaert, Julia Manetsberger, Sergio Hernández-Díaz, Jef Swerts, Nils Schoovaerts, Sven Vilain, Natalia V. Gounko, Katlijn Vints, Ann Geens, Bart De Strooper, Patrik Verstreken
Published in: Neuron, Issue 92/4, 2016, Page(s) 829-844, ISSN 0896-6273
DOI: 10.1016/j.neuron.2016.09.037

EndoA/Endophilin-A creates docking stations for autophagic proteins at synapses

Author(s): Sandra-Fausia Soukup, Patrik Verstreken
Published in: Autophagy, Issue 13/5, 2017, Page(s) 971-972, ISSN 1554-8627
DOI: 10.1080/15548627.2017.1286440

In vivo single-molecule imaging of syntaxin1A reveals polyphosphoinositide- and activity-dependent trapping in presynaptic nanoclusters

Author(s): Adekunle T. Bademosi, Elsa Lauwers, Pranesh Padmanabhan, Lorenzo Odierna, Ye Jin Chai, Andreas Papadopulos, Geoffrey J. Goodhill, Patrik Verstreken, Bruno van Swinderen, Frédéric A. Meunier
Published in: Nature Communications, Issue 8, 2017, Page(s) 13660, ISSN 2041-1723
DOI: 10.1038/ncomms13660

Cardiolipin promotes electron transport between ubiquinone and complex I to rescue PINK1 deficiency

Author(s): Melissa Vos, Ann Geens, Claudia Böhm, Liesbeth Deaulmerie, Jef Swerts, Matteo Rossi, Katleen Craessaerts, Elvira P. Leites, Philip Seibler, Aleksandar Rakovic, Thora Lohnau, Bart De Strooper, Sarah-Maria Fendt, Vanessa A. Morais, Christine Klein, Patrik Verstreken
Published in: The Journal of Cell Biology, Issue 216/3, 2017, Page(s) 695-708, ISSN 0021-9525
DOI: 10.1083/jcb.201511044

Neurons eat glutamate to stay alive

Author(s): Sarah-Maria Fendt, Patrik Verstreken
Published in: The Journal of Cell Biology, Issue 216/4, 2017, Page(s) 863-865, ISSN 0021-9525
DOI: 10.1083/jcb.201702003

The SAC1 domain in synaptojanin is required for autophagosome maturation at presynaptic terminals

Author(s): Roeland Vanhauwaert, Sabine Kuenen, Roy Masius, Adekunle Bademosi, Julia Manetsberger, Nils Schoovaerts, Laura Bounti, Serguei Gontcharenko, Jef Swerts, Sven Vilain, Marina Picillo, Paolo Barone, Shashini T Munshi, Femke MS de Vrij, Steven A Kushner, Natalia V Gounko, Wim Mandemakers, Vincenzo Bonifati, Frederic A Meunier, Sandra‐Fausia Soukup, Patrik Verstreken
Published in: The EMBO Journal, Issue 36/10, 2017, Page(s) 1392-1411, ISSN 0261-4189
DOI: 10.15252/embj.201695773

Presynaptic protein homeostasis and neuronal function


Published in: ISSN 0959-437X
DOI: 10.1016/j.gde.2017.01.015

Autophagy in the presynaptic compartment in health and disease

Author(s): Vinoy Vijayan, Patrik Verstreken
Published in: The Journal of Cell Biology, Issue 216/7, 2017, Page(s) 1895-1906, ISSN 0021-9525
DOI: 10.1083/jcb.201611113

Trapping of Syntaxin1a in Presynaptic Nanoclusters by a Clinically Relevant General Anesthetic

Author(s): Adekunle T. Bademosi, James Steeves, Shanker Karunanithi, Oressia H. Zalucki, Rachel S. Gormal, Shu Liu, Elsa Lauwers, Patrik Verstreken, Victor Anggono, Frederic A. Meunier, Bruno van Swinderen
Published in: Cell Reports, Issue 22/2, 2018, Page(s) 427-440, ISSN 2211-1247
DOI: 10.1016/j.celrep.2017.12.054

Deficiency of parkin and PINK1 impairs age-dependent mitophagy in Drosophila

Author(s): Tom Cornelissen, Sven Vilain, Katlijn Vints, Natalia Gounko, Patrik Verstreken, Wim Vandenberghe
Published in: eLife, Issue 7, 2018, ISSN 2050-084X
DOI: 10.7554/elife.35878

Hsp90 Mediates Membrane Deformation and Exosome Release

Author(s): Elsa Lauwers, Yu-Chun Wang, Rodrigo Gallardo, Rob Van der Kant, Emiel Michiels, Jef Swerts, Pieter Baatsen, Samantha S. Zaiter, Shelli R. McAlpine, Natalia V. Gounko, Frederic Rousseau, Joost Schymkowitz, Patrik Verstreken
Published in: Molecular Cell, Issue 71/5, 2018, Page(s) 689-702.e9, ISSN 1097-2765
DOI: 10.1016/j.molcel.2018.07.016

Parkinson's disease: convergence on synaptic homeostasis

Author(s): Sandra‐Fausia Soukup, Roeland Vanhauwaert, Patrik Verstreken
Published in: The EMBO Journal, Issue 37/18, 2018, ISSN 0261-4189
DOI: 10.15252/embj.201898960

Imaging mitophagy in the fruit fly

Author(s): Tom Cornelissen, Patrik Verstreken, Wim Vandenberghe
Published in: Autophagy, Issue 14/9, 2018, Page(s) 1656-1657, ISSN 1554-8627
DOI: 10.1080/15548627.2018.1496720

Need for speed: Super-resolving the dynamic nanoclustering of syntaxin-1 at exocytic fusion sites

Author(s): Pranesh Padmanabhan, Adekunle T. Bademosi, Ravikiran Kasula, Elsa Lauwers, Patrik Verstreken, Frédéric A. Meunier
Published in: Neuropharmacology, Issue 169, 2020, Page(s) 107554, ISSN 0028-3908
DOI: 10.1016/j.neuropharm.2019.02.036

TBC1D24-TLDc-related epilepsy exercise-induced dystonia: rescue by antioxidants in a disease model

Author(s): Kevin Lüthy, Davide Mei, Baptiste Fischer, Maurizio De Fusco, Jef Swerts, Jone Paesmans, Elena Parrini, Naomi Lubarr, Inge A Meijer, Katherine M Mackenzie, Wang-Tso Lee, Davide Cittaro, Paolo Aridon, Nils Schoovaerts, Wim Versées, Patrik Verstreken, Giorgio Casari, Renzo Guerrini
Published in: Brain, Issue 142/8, 2019, Page(s) 2319-2335, ISSN 0006-8950
DOI: 10.1093/brain/awz175

Mitochondria Re-set Epilepsy

Author(s): Valerie Uytterhoeven, Natalie Kaempf, Patrik Verstreken
Published in: Neuron, Issue 102/5, 2019, Page(s) 907-910, ISSN 0896-6273
DOI: 10.1016/j.neuron.2019.05.023

Excess Lipin enzyme activity contributes to TOR1A recessive disease and DYT-TOR1A dystonia

Author(s): Ana Cascalho, Joyce Foroozandeh, Lise Hennebel, Jef Swerts, Christine Klein, Stef Rous, Beatriz Dominguez Gonzalez, Antonio Pisani, Maria Meringolo, Sandra F Gallego, Patrik Verstreken, Philip Seibler, Rose E Goodchild
Published in: Brain, Issue 143/6, 2020, Page(s) 1746-1765, ISSN 0006-8950
DOI: 10.1093/brain/awaa139

Assaying Mutants of Clathrin-Mediated Endocytosis in the Fly Eye

Author(s): Elsa Lauwers, Patrik Verstreken
Published in: Clathrin-Mediated Endocytosis - Methods and Protocols, Issue 1847, 2018, Page(s) 109-119
DOI: 10.1007/978-1-4939-8719-1_9