GENOMIC, CELLULAR AND DEVELOPMENTAL RECONSTRUCTION OF INFANT MLL-AF4+ ACUTE LYMPHOBLASTIC LEUKEMIA

Publicaciones

Aneuploidy in Cancer: Lessons from Acute Lymphoblastic Leukemia

Autores: Oscar Molina, Maria Alba Abad, Francesc Solé, Pablo Menéndez
Publicado en: Trends in Cancer, Edición 7/1, 2021, Página(s) 37-47, ISSN 2405-8033
Editor: [Cambridge, MA] : Cell Press, [2015]
DOI: 10.1016/j.trecan.2020.08.008

In vivo CRISPR/Cas9 targeting of fusion oncogenes for selective elimination of cancer cells

Autores: M. Martinez-Lage, R. Torres-Ruiz, P. Puig-Serra, P. Moreno-Gaona, M. C. Martin, F. J. Moya, O. Quintana-Bustamante, S. Garcia-Silva, A. M. Carcaboso, P. Petazzi, C. Bueno, J. Mora, H. Peinado, J. C. Segovia, P. Menendez, S. Rodriguez-Perales
Publicado en: Nature Communications, Edición 11/1, 2020, ISSN 2041-1723
Editor: Nature Publishing Group
DOI: 10.1038/s41467-020-18875-x

Genetic Rescue of Mitochondrial and Skeletal Muscle Impairment in an Induced Pluripotent Stem Cells Model of Coenzyme Q 10 Deficiency

Autores: Damià Romero-Moya, Carlos Santos-Ocaña, Julio Castaño, Gloria Garrabou, José A. Rodríguez-Gómez, Vanesa Ruiz-Bonilla, Clara Bueno, Patricia González-Rodríguez, Alessandra Giorgetti, Eusebio Perdiguero, Cristina Prieto, Constanza Moren-Nuñez, Daniel J. Fernández-Ayala, Maria Victoria Cascajo, Iván Velasco, Josep Maria Canals, Raquel Montero, Delia Yubero, Cristina Jou, José López-Barne
Publicado en: STEM CELLS, Edición 35/7, 2017, Página(s) 1687-1703, ISSN 1066-5099
Editor: AlphaMed Press Inc
DOI: 10.1002/stem.2634

Generation and characterization of a human iPSC cell line expressing inducible Cas9 in the “safe harbor” AAVS1 locus

Autores: Julio Castaño, Clara Bueno, Senda Jiménez-Delgado, Heleia Roca-Ho, Mario F. Fraga, Agustín F. Fernandez, Mahito Nakanishi, Raúl Torres-Ruiz, Sandra Rodríguez-Perales, Pablo Menéndez
Publicado en: Stem Cell Research, Edición 21, 2017, Página(s) 137-140, ISSN 1873-5061
Editor: Elsevier
DOI: 10.1016/j.scr.2017.04.011

Detailed Characterization of Mesenchymal Stem/Stromal Cells from a Large Cohort of AML Patients Demonstrates a Definitive Link to Treatment Outcomes

Autores: Rafael Diaz de la Guardia, Belen Lopez-Millan, Jessie R. Lavoie, Clara Bueno, Julio Castaño, Maite Gómez-Casares, Susana Vives, Laura Palomo, Manel Juan, Julio Delgado, Maria L. Blanco, Josep Nomdedeu, Alberto Chaparro, Jose Luis Fuster, Eduardo Anguita, Michael Rosu-Myles, Pablo Menéndez
Publicado en: Stem Cell Reports, Edición 8/6, 2017, Página(s) 1573-1586, ISSN 2213-6711
Editor: Cell Press
DOI: 10.1016/j.stemcr.2017.04.019

Chemical exposure and infant leukaemia: development of an adverse outcome pathway (AOP) for aetiology and risk assessment research

Autores: Olavi Pelkonen, Andrea Terron, Antonio F. Hernandez, Pablo Menendez, Susanne Hougaard Bennekou
Publicado en: Archives of Toxicology, Edición 91/8, 2017, Página(s) 2763-2780, ISSN 0340-5761
Editor: Springer Verlag
DOI: 10.1007/s00204-017-1986-x

Modeling mixed-lineage-rearranged leukemia initiation in CD34 + cells: a “CRISPR” solution

Autores: Raúl Torres-Ruiz, Sandra Rodriguez-Perales, Clara Bueno, Pablo Menendez
Publicado en: Haematologica, Edición 102/9, 2017, Página(s) 1467-1468, ISSN 0390-6078
Editor: Ferrata Storti Foundation
DOI: 10.3324/haematol.2017.173740

RUNX1c Regulates Hematopoietic Differentiation of Human Pluripotent Stem Cells Possibly in Cooperation with Proinflammatory Signaling

Autores: Oscar Navarro-Montero, Veronica Ayllon, Mar Lamolda, Lourdes López-Onieva, Rosa Montes, Clara Bueno, Elizabeth Ng, Xiomara Guerrero-Carreno, Tamara Romero, Damià Romero-Moya, Ed Stanley, Andrew Elefanty, Verónica Ramos-Mejia, Pablo Menendez, Pedro J. Real
Publicado en: STEM CELLS, Edición 35/11, 2017, Página(s) 2253-2266, ISSN 1066-5099
Editor: AlphaMed Press Inc
DOI: 10.1002/stem.2700

NG2 antigen is involved in leukemia invasiveness and central nervous system infiltration in MLL-rearranged infant B-ALL

Autores: C Prieto, B López-Millán, H Roca-Ho, R W Stam, D Romero-Moya, F J Rodríguez-Baena, A Sanjuan-Pla, V Ayllón, M Ramírez, M Bardini, P De Lorenzo, M G Valsecchi, M Stanulla, M Iglesias, P Ballerini, Á M Carcaboso, J Mora, F Locatelli, A Bertaina, L Padilla, J Carlos Rodríguez-Manzaneque, C Bueno, P Menéndez
Publicado en: Leukemia, Edición 32/3, 2017, Página(s) 633-644, ISSN 0887-6924
Editor: Nature Publishing Group
DOI: 10.1038/leu.2017.294

Cellular Ontogeny and Hierarchy Influence the Reprogramming Efficiency of Human B Cells into Induced Pluripotent Stem Cells

Autores: Álvaro Muñoz-López, Eddy. H.J. van Roon, Damià Romero-Moya, Belén López-Millan, Ronald W. Stam, Dolors Colomer, Mahito Nakanishi, Clara Bueno, Pablo Menendez
Publicado en: STEM CELLS, Edición 34/3, 2016, Página(s) 581-587, ISSN 1066-5099
Editor: AlphaMed Press Inc
DOI: 10.1002/stem.2303

Proinflammatory signals are insufficient to drive definitive hematopoietic specification of human HSCs in vitro

Autores: Alessandra Giorgetti, Julio Castaño, Clara Bueno, Rafael Díaz de la Guardia, Mario Delgado, Anna Bigas, Lluis Espinosa, Pablo Menendez
Publicado en: Experimental Hematology, Edición 45, 2017, Página(s) 85-93.e2, ISSN 0301-472X
Editor: Elsevier BV
DOI: 10.1016/j.exphem.2016.09.007

Generation, genome edition and characterization of iPSC lines from a patient with coenzyme Q 10 deficiency harboring a heterozygous mutation in COQ4 gene

Autores: Damià Romero-Moya, Julio Castaño, Carlos Santos-Ocaña, Plácido Navas, Pablo Menendez
Publicado en: Stem Cell Research, Edición 24, 2017, Página(s) 144-147, ISSN 1873-5061
Editor: Elsevier
DOI: 10.1016/j.scr.2016.09.007

Development Refractoriness of MLL-Rearranged Human B Cell Acute Leukemias to Reprogramming into Pluripotency

Autores: Alvaro Muñoz-López, Damià Romero-Moya, Cristina Prieto, Verónica Ramos-Mejía, Antonio Agraz-Doblas, Ignacio Varela, Marcus Buschbeck, Anna Palau, Xonia Carvajal-Vergara, Alessandra Giorgetti, Anthony Ford, Majlinda Lako, Isabel Granada, Neus Ruiz-Xivillé, Sandra Rodríguez-Perales, Raul Torres-Ruíz, Ronald W. Stam, Jose Luis Fuster, Mario F. Fraga, Mahito Nakanishi, Gianni Cazzaniga, Mic
Publicado en: Stem Cell Reports, Edición 7/4, 2016, Página(s) 602-618, ISSN 2213-6711
Editor: Cell Press
DOI: 10.1016/j.stemcr.2016.08.013

Intra-Bone Marrow Transplantation Confers Superior Multilineage Engraftment of Murine Aorta-Gonad Mesonephros Cells Over Intravenous Transplantation

Autores: Alejandra Sanjuan-Pla, Damia Romero-Moya, Cristina Prieto, Clara Bueno, Anna Bigas, Pablo Menendez
Publicado en: Stem Cells and Development, Edición 25/3, 2016, Página(s) 259-265, ISSN 1547-3287
Editor: Mary Ann Liebert Inc.
DOI: 10.1089/scd.2015.0309

Engineered LINE-1 retrotransposition in nondividing human neurons

Autores: Angela Macia, Thomas J. Widmann, Sara R. Heras, Veronica Ayllon, Laura Sanchez, Meriem Benkaddour-Boumzaouad, Martin Muñoz-Lopez, Alejandro Rubio, Suyapa Amador-Cubero, Eva Blanco-Jimenez, Javier Garcia-Castro, Pablo Menendez, Philip Ng, Alysson R. Muotri, John L. Goodier, Jose L. Garcia-Perez
Publicado en: Genome Research, Edición 27/3, 2017, Página(s) 335-348, ISSN 1088-9051
Editor: Cold Spring Harbor Laboratory Press
DOI: 10.1101/gr.206805.116

The European Hematology Association Roadmap for European Hematology Research: a consensus document

Autores: A. Engert, C. Balduini, A. Brand, B. Coiffier, C. Cordonnier, H. Dohner, T. D. de Wit, S. Eichinger, W. Fibbe, T. Green, F. de Haas, A. Iolascon, T. Jaffredo, F. Rodeghiero, G. Salles, J. J. Schuringa, J. J. Schuringa, T. Jaffredo, B. Coiffier, G. Salles, H. Dohner, A. Iolascon, C. Balduini, S. Eichinger, A. Brand, C. Cordonnier, W. Fibbe
Publicado en: Haematologica, Edición 101/2, 2016, Página(s) 115-208, ISSN 0390-6078
Editor: Ferrata Storti Foundation
DOI: 10.3324/haematol.2015.136739

Human acute leukemia induced pluripotent stem cells: a unique model for investigating disease development and pathogenesis

Autores: Clara Bueno, Pablo Menendez
Publicado en: Stem Cell Investigation, Edición 4/7, 2017, Página(s) 55-55, ISSN 2313-0792
Editor: Stem Cell Investigation
DOI: 10.21037/sci.2017.05.12

The AF4-MLL fusion transiently augments multilineage hematopoietic engraftment but is not sufficient to initiate leukemia in cord blood CD34<sup>+</sup> cells

Autores: Cristina Prieto, Rolf Marschalek, Alessa Kühn, Adelheid Bursen, Clara Bueno, Pablo Menéndez
Publicado en: Oncotarget, Edición 8/47, 2017, ISSN 1949-2553
Editor: Impact Journals
DOI: 10.18632/oncotarget.19567

The “Never-Ending” Mouse Models for MLL-Rearranged Acute Leukemia Are Still Teaching Us

Autores: Katrin Ottersbach, Alejandra Sanjuan-Pla, Raúl Torres-Ruíz, Clara Bueno, Talia Velasco-Hernández, Pablo Menendez
Publicado en: HemaSphere, Edición 2/4, 2018, Página(s) e57, ISSN 2572-9241
Editor: Wolters Kluwer Health Inc
DOI: 10.1097/HS9.0000000000000057

Activated KRAS Cooperates with MLL-AF4 to Promote Extramedullary Engraftment and Migration of Cord Blood CD34 + HSPC But Is Insufficient to Initiate Leukemia

Autores: Cristina Prieto, Ronald W. Stam, Antonio Agraz-Doblas, Paola Ballerini, Mireia Camos, Julio Castaño, Rolf Marschalek, Aldeheid Bursen, Ignacio Varela, Clara Bueno, Pablo Menendez
Publicado en: Cancer Research, Edición 76/8, 2016, Página(s) 2478-2489, ISSN 0008-5472
Editor: American Association for Cancer Research
DOI: 10.1158/0008-5472.CAN-15-2769

Intratumoral heterogeneity and clonal evolution in blood malignancies and solid tumors

Autores: Ignacio Varela, Pablo Menendez, Alejandra Sanjuan-Pla
Publicado en: Oncotarget, Edición 8/39, 2017, ISSN 1949-2553
Editor: Impact Journals
DOI: 10.18632/oncotarget.20279

IMiDs mobilize acute myeloid leukemia blasts to peripheral blood through downregulation of CXCR4 but fail to potentiate AraC/Idarubicin activity in preclinical models of non del5q/5q- AML

Autores: Belen Lopez-Millan, Rafael Diaz de la Guardia, Heleia Roca-Ho, Eduardo Anguita, Abul B. M. M. K. Islam, Damia Romero-Moya, Cristina Prieto, Francisco Gutierrez-Agüera, Jose Antonio Bejarano-Garcia, Jose Antonio Perez-Simon, Paula Costales, Montse Rovira, Pedro Marín, Silvia Menendez, Mar Iglesias, Jose Luis Fuster, Alvaro Urbano-Ispizua, Fernando Anjos-Afonso, Clara Bueno, Pablo Menendez
Publicado en: OncoImmunology, 2018, Página(s) 1-14, ISSN 2162-402X
Editor: Taylor & Francis
DOI: 10.1080/2162402x.2018.1477460

BM-Mscs From Risk-Stratified AML Patients Support Normal Hematopoiesis and are Anti-Inflammatory in in Vivo Preclinical Models of Hematopoietic Reconstitution and Severe Colitis

Autores: Pablo Menendez, Rafael Diaz de la Guardia, Belen Lopez-Millan
Publicado en: Experimental Hematology, Edición 64, 2018, Página(s) S85, ISSN 0301-472X
Editor: Elsevier BV
DOI: 10.1016/j.exphem.2018.06.091

Expression of MLL-AF4 or AF4-MLL fusions does not impact the efficiency of DNA damage repair

Autores: Julio Castaño, Ana B. Herrero, Aldeheid Bursen, Federico González, Rolf Marschalek, Norma C. Gutiérrez, Pablo Menendez
Publicado en: Oncotarget, Edición 7/21, 2016, ISSN 1949-2553
Editor: Impact Journals
DOI: 10.18632/oncotarget.8938

Bone Marrow Clonogenic Myeloid Progenitors from NPM1-Mutated AML Patients Do Not Harbor the NPM1 Mutation: Implication for the Cell-Of-Origin of NPM1+ AML

Autores: Rafael Diaz de la Guardia, Laura González-Silva, Belén López-Millán, Juan José Rodríguez-Sevilla, Matteo L. Baroni, Clara Bueno, Eduardo Anguita, Susana Vives, Laura Palomo, Helene Lapillonne, Ignacio Varela, Pablo Menendez
Publicado en: Genes, Edición 11/1, 2020, Página(s) 73, ISSN 2073-4425
Editor: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/genes11010073

GATA2 Promotes Hematopoietic Development and Represses Cardiac Differentiation of Human Mesoderm

Autores: Julio Castaño, Sergi Aranda, Clara Bueno, Fernando J. Calero-Nieto, Eva Mejia-Ramirez, Jose Luis Mosquera, Enrique Blanco, Xiaonan Wang, Cristina Prieto, Lorea Zabaleta, Elisabetta Mereu, Meritxell Rovira, Senda Jiménez-Delgado, Daniel R. Matson, Holger Heyn, Emery H. Bresnick, Berthold Göttgens, Luciano Di Croce, Pablo Menendez, Angel Raya, Alessandra Giorgetti
Publicado en: Stem Cell Reports, Edición 13/3, 2019, Página(s) 515-529, ISSN 2213-6711
Editor: Cell Press
DOI: 10.1016/j.stemcr.2019.07.009

Unraveling the cellular origin and clinical prognostic markers of infant B-cell acute lymphoblastic leukemia using genome-wide analysis

Autores: Antonio Agraz-Doblas, Clara Bueno, Rachael Bashford-Rogers, Anindita Roy, Pauline Schneider, Michela Bardini, Paola Ballerini, Gianni Cazzaniga, Thaidy Moreno, Carlos Revilla, Marta Gut, Maria G. Valsecchi, Irene Roberts, Rob Pieters, Paola De Lorenzo, Ignacio Varela, Pablo Menendez, Ronald W. Stam
Publicado en: Haematologica, Edición 104/6, 2019, Página(s) 1176-1188, ISSN 0390-6078
Editor: Ferrata Storti Foundation
DOI: 10.3324/haematol.2018.206375

Daratumumab displays in vitro and in vivo anti-tumor activity in models of B cell non-Hodgkin lymphoma and improves responses to standard chemo-immunotherapy regimens

Autores: Anna Vidal-Crespo, Alba Matas-Céspedes, Vanina Rodriguez, Cédric Rossi, Juan G. Valero, Neus Serrat, Alejandra Sanjuan Pla, Pablo Menéndez, Gaël Roué, Armando López-Guillermo, Eva Giné, Elías Campo, Dolors Colomer, Christine Bezombes, Jeroen Lammerts van Bueren, Christopher Chiu, Parul Doshi, Patricia Pérez-Galán
Publicado en: Haematologica, Edición 11th July 2019, 2019, Página(s) haematol.2018.211904, ISSN 0390-6078
Editor: Ferrata Storti Foundation
DOI: 10.3324/haematol.2018.211904

Natural history and cell of origin of TCF3-ZNF384 and PTPN11 mutations in monozygotic twins with concordant BCP-ALL

Autores: Clara Bueno, J. Ramón Tejedor, Rachael Bashford-Rogers, Laura González-Silva, Rafael Valdés-Mas, Antonio Agraz-Doblás, Rafael Díaz de la Guardia, Jordi Ribera, Lurdes Zamora, Chrystele Bilhou-Nabera, Nassera Abermil, Hélène Guermouche, Elodie Gouache, Guy Leverger, Mario F. Fraga, Agustín F. Fernández, Paola Ballerini, Ignacio Varela, Pablo Menendez
Publicado en: Blood, Edición 134/11, 2019, Página(s) 900-905, ISSN 0006-4971
Editor: American Society of Hematology
DOI: 10.1182/blood.2019000893

Fratricide-resistant CD1a-specific CAR T cells for the treatment of cortical T-cell acute lymphoblastic leukemia

Autores: Diego Sánchez-Martínez, Matteo L. Baroni, Francisco Gutierrez-Agüera, Heleia Roca-Ho, Oscar Blanch-Lombarte, Sara González-García, Montserrat Torrebadell, Jordi Junca, Manuel Ramírez-Orellana, Talía Velasco-Hernández, Clara Bueno, José Luís Fuster, Julia G. Prado, Julien Calvo, Benjamin Uzan, Jan Cools, Mireia Camos, Françoise Pflumio, María Luisa Toribio, Pablo Menéndez
Publicado en: Blood, Edición 133/21, 2019, Página(s) 2291-2304, ISSN 0006-4971
Editor: American Society of Hematology
DOI: 10.1182/blood-2018-10-882944

Discovery of a CD10-negative B-progenitor in human fetal life identifies unique ontogeny-related developmental programs

Autores: Sorcha O’Byrne, Natalina Elliott, Siobhan Rice, Gemma Buck, Nicholas Fordham, Catherine Garnett, Laura Godfrey, Nicholas T. Crump, Gary Wright, Sarah Inglott, Peng Hua, Bethan Psaila, Benjamin Povinelli, David J. H. F. Knapp, Antonio Agraz-Doblas, Clara Bueno, Ignacio Varela, Phillip Bennett, Hashem Koohy, Suzanne M. Watt, Anastasios Karadimitris, Adam J. Mead, Phillip Ancliff, Paresh Vyas, Pabl
Publicado en: Blood, Edición 134/13, 2019, Página(s) 1059-1071, ISSN 0006-4971
Editor: American Society of Hematology
DOI: 10.1182/blood.2019001289

Enhanced hemato-endothelial specification during human embryonic differentiation through developmental cooperation between AF4-MLL and MLL-AF4 fusions

Autores: Clara Bueno, Fernando J Calero-Nieto, Xiaonan Wang, Rafael Valdés-Mas, Francisco Gutiérrez-Agüera, Heleia Roca-Ho, Veronica Ayllon, Pedro J Real, David Arambilet, Lluis Espinosa, Raul Torres-Ruiz, Antonio Agraz-Doblas, Ignacio Varela, Jasper de Boer, Anna Bigas, Bertie Gottgens, Rolf Marschalek, Pablo Menendez
Publicado en: Haematologica, Edición 104/6, 2019, Página(s) 1189-1201, ISSN 0390-6078
Editor: Ferrata Storti Foundation
DOI: 10.3324/haematol.2018.202044

Chromatin regulation by Histone H4 acetylation at Lysine 16 during cell death and differentiation in the myeloid compartment

Autores: Rocio G Urdinguio, Virginia Lopez, Gustavo F Bayón, Rafael Diaz de la Guardia, Marta I Sierra, Estela García-Toraño, Raúl F Perez, María G García, Antonella Carella, Patricia C Pruneda, Cristina Prieto, Marija Dmitrijeva, Pablo Santamarina, Thalía Belmonte, Cristina Mangas, Elena Diaconu, Cecilia Ferrero, Juan Ramón Tejedor, Juan Luis Fernandez-Morera, Cristina Bravo, Clara Bueno, Aleja
Publicado en: Nucleic Acids Research, Edición 47/10, 2019, Página(s) 5016-5037, ISSN 0305-1048
Editor: Oxford University Press
DOI: 10.1093/nar/gkz195

Reprogramming human B cells into induced pluripotent stem cells and its enhancement by C/EBPα

Autores: C Bueno, J L Sardina, B Di Stefano, D Romero-Moya, A Muñoz-López, L Ariza, M C Chillón, A Balanzategui, J Castaño, A Herreros, M F Fraga, A Fernández, I Granada, O Quintana-Bustamante, J C Segovia, K Nishimura, M Ohtaka, M Nakanishi, T Graf, P Menendez
Publicado en: Leukemia, Edición 30/3, 2015, Página(s) 674-682, ISSN 0887-6924
Editor: Nature Publishing Group
DOI: 10.1038/leu.2015.294

Immunophenotypic analysis and quantification of B-1 and B-2 B cells during human fetal hematopoietic development

Autores: C Bueno, E H J van Roon, A Muñoz-López, A Sanjuan-Pla, M Juan, A Navarro, R W Stam, P Menendez
Publicado en: Leukemia, Edición 30/7, 2015, Página(s) 1603-1606, ISSN 0887-6924
Editor: Nature Publishing Group
DOI: 10.1038/leu.2015.362

Linking Pesticide Exposure with Pediatric Leukemia: Potential Underlying Mechanisms

Autores: Antonio Hernández, Pablo Menéndez
Publicado en: International Journal of Molecular Sciences, Edición 17/4, 2016, Página(s) 461, ISSN 1422-0067
Editor: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms17040461

Enforced sialyl‐Lewis‐X (sLeX) display in E‐selectin ligands by exofucosylation is dispensable for CD19‐CAR T‐cell activity and bone marrow homing

Autores: Diego Sánchez‐Martínez, Francisco Gutiérrez‐Agüera, Paola Romecin, Meritxell Vinyoles, Marta Palomo, Néstor Tirado, Samanta Romina Zanetti, Manel Juan, Michela Carlet, Irmela Jeremias, Pablo Menéndez
Publicado en: Clinical and Translational Medicine, Edición 11/2, 2021, Página(s) e280, ISSN 2001-1326
Editor: Springer Verlag
DOI: 10.1002/ctm2.280

Integrative methylome-transcriptome analysis unravels cancer cell vulnerabilities in infant MLL-rearranged B-cell acute lymphoblastic leukemia

Autores: J. Ramon Tejedor, Clara Bueno, Meritxell Vinyoles, Paolo Petazzi, Antonio Agraz-Doblas, Isabel Cobo, Raúl Torres-Ruiz, Gustavo F. Bayón, Raúl F. Pérez, Sara López-Tamargo, Francisco Gutierrez-Agüera, Pablo Santamarina-Ojeda, Manuel Ramírez-Orellana, Michela Bardini, Giovanni Cazzaniga, Paola Ballerini, Pauline Schneider, Ronald W. Stam, Ignacio Varela, Mario F. Fraga, Agustín F. Fernández
Publicado en: Journal of Clinical Investigation, Edición Twenty-four issues a year, 2021, 2021, Página(s) 138833, ISSN 1558-8238
Editor: New Haven [etc.] American Society for Clinical Investigation.
DOI: 10.1172/jci138833

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