Objectif Cognitive control regulates our thoughts and actions, helping us avoid impulsive behaviours that are inappropriate, costly or dangerous. In recent years, evidence has emerged that training in behavioural tasks that promote response inhibition or avoidance of specific stimuli can enhance cognitive control, reducing overeating and alcohol consumption. Despite the promising nature of cognitive control training (CCT), we know little about which CCT methods are most effective, how individual differences determine training outcomes, whether CCT produces benefits for real-life behaviour, and how CCT alters – and is determined by – the structure and function of the brain. My aim is to discover what works in CCT and how the effects of training relate to neurophysiology. Subproject 1 will be the largest ever trial on the effectiveness of different CCT methods for achieving weight loss, recruiting 36,000 participants worldwide to complete an internet-based training programme via the Guardian. This study will reveal, with high statistical power, which CCT methods are the most effective and which individual differences are most important for producing real-life benefits. Subproject 2 will investigate how CCT influences neurobiology, and how individual differences in neurobiology influence CCT outcomes. In Subproject 2a, I will focus on theoretically predicted changes to GABAergic systems in prefrontal and motor cortex, and I will test the effect of GABAergic brain stimulation on training outcomes. In Subproject 2b, I will use concurrent brain stimulation (TMS) and brain imaging (fMRI) to test how CCT alters top-down coupling between prefrontal cortex and remote regions that mediate reward and emotion. I will also study how CCT alters, and is altered by, white matter microstructure. This project promises to advance understanding of the causal determinants and moderators of CCT, with implications for its suitability as a clinical adjunct in addiction therapy and behaviour change. Champ scientifique natural sciencesbiological sciencesneurobiologysocial sciencespsychologynatural scienceschemical sciencesorganic chemistryalcohols Mots‑clés cognitive control response inhibition cognitive training brain stimulation neuroimaging transcranial magnetic stimulation functional magnetic resonance imaging Programme(s) H2020-EU.1.1. - EXCELLENT SCIENCE - European Research Council (ERC) Main Programme Thème(s) ERC-CoG-2014 - ERC Consolidator Grant Appel à propositions ERC-2014-CoG Voir d’autres projets de cet appel Régime de financement ERC-COG - Consolidator Grant Institution d’accueil CARDIFF UNIVERSITY Contribution nette de l'UE € 1 998 305,00 Adresse NEWPORT ROAD 30 36 CF24 0DE Cardiff Royaume-Uni Voir sur la carte Région Wales East Wales Cardiff and Vale of Glamorgan Type d’activité Higher or Secondary Education Establishments Liens Contacter l’organisation Opens in new window Site web Opens in new window Participation aux programmes de R&I de l'UE Opens in new window Réseau de collaboration HORIZON Opens in new window Coût total € 1 998 305,00 Bénéficiaires (1) Trier par ordre alphabétique Trier par contribution nette de l'UE Tout développer Tout réduire CARDIFF UNIVERSITY Royaume-Uni Contribution nette de l'UE € 1 998 305,00 Adresse NEWPORT ROAD 30 36 CF24 0DE Cardiff Voir sur la carte Région Wales East Wales Cardiff and Vale of Glamorgan Type d’activité Higher or Secondary Education Establishments Liens Contacter l’organisation Opens in new window Site web Opens in new window Participation aux programmes de R&I de l'UE Opens in new window Réseau de collaboration HORIZON Opens in new window Coût total € 1 998 305,00