Periodic Reporting for period 5 - CCT (The psychology and neurobiology of cognitive control training in humans) Période du rapport: 2021-11-01 au 2022-10-31 Résumé du contexte et des objectifs généraux du projet Cognitive control regulates our thoughts and actions, helping us avoid impulsive behaviours that are inappropriate, costly or dangerous. In recent years, evidence has emerged that training in behavioural tasks that promote response inhibition or avoidance of specific stimuli can enhance cognitive control, reducing overeating and alcohol consumption. Despite the promising nature of cognitive control training (CCT), we know little about which CCT methods are most effective, how individual differences determine training outcomes, whether CCT produces benefits for real-life behaviour, and how CCT alters – and is determined by – the structure and function of the brain. My aim is to discover what works in CCT and how the effects of training relate to neurophysiology. Subproject 1 is a randomised trial on the effectiveness of different CCT methods for achieving weight loss, recruiting thousands of participants worldwide to complete an app-based training programme called 'Restrain'. In Subproject 2a, I focus on theoretically predicted changes to GABAergic systems in prefrontal and motor cortex, testing the effect of GABAergic brain stimulation on training outcomes. In Subproject 2b, we focus on policy implications of cognitive control training and creating freely available open-source tools, including the Restrain food database, to facilitate future research in this area. Travail effectué depuis le début du projet jusqu’à la fin de la période considérée dans le rapport et principaux résultats atteints jusqu’à présent * Launch of the Restrain trial (nearing completion)* Validation and publication of the Restrain food database* Consultation of UK academics on evidence-based policy, with a view toward informing health-related policy* Theoretical and methodological advances in understanding whether, and how, cognitive control training and brain stimulation influence cognitive control Progrès au-delà de l’état des connaissances et impact potentiel prévu (y compris l’impact socio-économique et les conséquences sociétales plus larges du projet jusqu’à présent) Remaining publications will focus on the results of the Restrain trial, which are currently in preparation and will be submitted by the end of 2023. restrain.jpg