Functions of the X chromosome in the mammalian germ line

Informazioni relative al progetto

XChromosome

ID dell’accordo di sovvenzione: 647971

DOI 10.3030/647971

Progetto chiuso

Data della firma CE 26 Agosto 2015

Data di avvio 1 Novembre 2015

Data di completamento 30 Aprile 2022

Finanziato da

• EXCELLENT SCIENCE - European Research Council (ERC)

Costo totale € 1 912 369,00

Contributo UE € 1 912 369,00

Coordinato da

THE FRANCIS CRICK INSTITUTE LIMITED
United Kingdom

Pubblicazioni

Peer reviewed articles (14)

CRISPR-Cas9 effectors facilitate generation of single-sex litters and sex-specific phenotypes

Autori: Charlotte Douglas, Valdone Maciulyte, Jasmin Zohren, Daniel M. Snell, Shantha K. Mahadevaiah, Obah A. Ojarikre, Peter J. I. Ellis & James M. A. Turner
Pubblicato in: Nature Communications, 2021, ISSN 2041-1723
Editore: Nature Publishing Group
DOI: 10.1038/s41467-021-27227-2

A single-cell transcriptome atlas of marsupial embryogenesis and X inactivation

Autori: Shantha K. Mahadevaiah, Mahesh N. Sangrithi, Takayuki Hirota, James M. A. Turner
Pubblicato in: Nature, Numero 586/7830, 2020, Pagina/e 612-617, ISSN 0028-0836
Editore: Nature Publishing Group
DOI: 10.1038/s41586-020-2629-6

Epigenetics drive the evolution of sex chromosomes in animals and plants

Autori: Aline Muyle, Doris Bachtrog, Gabriel A. B. Marais, James M. A. Turner
Pubblicato in: Philosophical Transactions of the Royal Society B: Biological Sciences, Numero 376/1826, 2021, Pagina/e 20200124, ISSN 0962-8436
Editore: Royal Society of London
DOI: 10.1098/rstb.2020.0124

Frequent loss of heterozygosity in CRISPR-Cas9–edited early human embryos

Autori: Gregorio Alanis-Lobato, Jasmin Zohren, Afshan McCarthy, Norah M. E. Fogarty, Nada Kubikova, Emily Hardman, Maria Greco, Dagan Wells, James M. A. Turner, Kathy K. Niakan
Pubblicato in: Proceedings of the National Academy of Sciences, Numero 118/22, 2021, Pagina/e e2004832117, ISSN 0027-8424
Editore: National Academy of Sciences
DOI: 10.1073/pnas.2004832117

Human Embryogenesis: A Comparative Perspective

Autori: Claudia Gerri, Sergio Menchero, Shantha K. Mahadevaiah, James M.A. Turner, Kathy K. Niakan
Pubblicato in: Annual Review of Cell and Developmental Biology, Numero 36/1, 2020, Pagina/e 411-440, ISSN 1081-0706
Editore: Annual Reviews, Inc.
DOI: 10.1146/annurev-cellbio-022020-024900

DNA damage response protein TOPBP1 regulates X chromosome silencing in the mammalian germ line

Autori: Elias ElInati, Helen R. Russell, Obah A. Ojarikre, Mahesh Sangrithi, Takayuki Hirota, Dirk G. de Rooij, Peter J. McKinnon, James M. A. Turner
Pubblicato in: Proceedings of the National Academy of Sciences, Numero 114/47, 2017, Pagina/e 12536-12541, ISSN 0027-8424
Editore: National Academy of Sciences
DOI: 10.1073/pnas.1712530114

Fertile offspring from sterile sex chromosome trisomic mice

Autori: Takayuki Hirota, Hiroshi Ohta, Benjamin E. Powell, Shantha K. Mahadevaiah, Obah A. Ojarikre, Mitinori Saitou, James M. A. Turner
Pubblicato in: Science, Numero 357/6354, 2017, Pagina/e 932-935, ISSN 0036-8075
Editore: American Association for the Advancement of Science
DOI: 10.1126/science.aam9046

Mammalian X Chromosome Dosage Compensation: Perspectives From the Germ Line

Autori: Mahesh N. Sangrithi, James M. A. Turner
Pubblicato in: BioEssays, Numero 40/6, 2018, Pagina/e 1800024, ISSN 0265-9247
Editore: John Wiley & Sons Inc.
DOI: 10.1002/bies.201800024

SETDB1 Links the Meiotic DNA Damage Response to Sex Chromosome Silencing in Mice

Autori: Takayuki Hirota, Paul Blakeley, Mahesh N. Sangrithi, Shantha K. Mahadevaiah, Vesela Encheva, Ambrosius P. Snijders, Elias ElInati, Obah A. Ojarikre, Dirk G. de Rooij, Kathy K. Niakan, James M.A. Turner
Pubblicato in: Developmental Cell, Numero 47/5, 2018, Pagina/e 645-659.e6, ISSN 1534-5807
Editore: Cell Press
DOI: 10.1016/j.devcel.2018.10.004

Meiotic Silencing in Mammals

Autori: James M.A. Turner
Pubblicato in: Annual Review of Genetics, Numero 49/1, 2015, Pagina/e 395-412, ISSN 0066-4197
Editore: Annual Reviews, Inc.
DOI: 10.1146/annurev-genet-112414-055145

Non-Canonical and Sexually Dimorphic X Dosage Compensation States in the Mouse and Human Germline

Autori: Mahesh N. Sangrithi, Helene Royo, Shantha K. Mahadevaiah, Obah Ojarikre, Leena Bhaw, Abdul Sesay, Antoine H.F.M. Peters, Michael Stadler, James M.A. Turner
Pubblicato in: Developmental Cell, Numero 40/3, 2017, Pagina/e 289-301.e3, ISSN 1534-5807
Editore: Cell Press
DOI: 10.1016/j.devcel.2016.12.023

The BCL-2 pathway preserves mammalian genome integrity by eliminating recombination-defective oocytes

Autori: Elias ElInati, Agata P. Zielinska, Afshan McCarthy, Nada Kubikova, Valdone Maciulyte, Shantha Mahadevaiah, Mahesh N. Sangrithi, Obah Ojarikre, Dagan Wells, Kathy K. Niakan, Melina Schuh, James M. A. Turner
Pubblicato in: Nature Communications, Numero 11/1, 2020, ISSN 2041-1723
Editore: Nature Publishing Group
DOI: 10.1038/s41467-020-16441-z

ATR is a multifunctional regulator of male mouse meiosis

Autori: Alexander Widger, Shantha K. Mahadevaiah, Julian Lange, Elias ElInati, Jasmin Zohren, Takayuki Hirota, Sarai Pacheco, Andros Maldonado-Linares, Marcello Stanzione, Obah Ojarikre, Valdone Maciulyte, Dirk G. de Rooij, Attila Tóth, Ignasi Roig, Scott Keeney, James M.A. Turner
Pubblicato in: Nature Communications, Numero 9/1, 2018, ISSN 2041-1723
Editore: Nature Publishing Group
DOI: 10.1038/s41467-018-04850-0

Author Correction: Scalable and robust SARS-CoV-2 testing in an academic center

Autori: Jim Aitken, Karen Ambrose, Sam Barrell, Rupert Beale, Ganka Bineva-Todd, Dhruva Biswas, Richard Byrne, Simon Caidan, Peter Cherepanov, Laura Churchward, Graham Clark, Margaret Crawford, Laura Cubitt, Vicky Dearing, Christopher Earl, Amelia Edwards, Chris Ekin, Efthymios Fidanis, Alessandra Gaiba, Steve Gamblin, Sonia Gandhi, Jacki Goldman, Robert Goldstone, Paul R. Grant, Maria Greco, Judith Heane
Pubblicato in: Nature Biotechnology, Numero 38/8, 2020, Pagina/e 1000-1000, ISSN 1087-0156
Editore: Nature Publishing Group
DOI: 10.1038/s41587-020-0623-z