Optoelectrical Dynamics of Ion channel Activation in Calcium Nanodomains

Project Information

NANOPDICS

Grant agreement ID: 648936

DOI 10.3030/648936

Project closed

EC signature date 8 June 2015

Start date 1 September 2015

End date 31 August 2021

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost € 1 999 742,00

EU contribution € 1 999 742,00

Coordinated by

UNIVERSIDAD DE LA LAGUNA
Spain

Publications

Peer reviewed articles (10)

Kv1.3 channel inhibition partially reverts uremia-induced calcification in human aortic vascular smooth muscle cells

Author(s): Violeta Cazaña-Pérez, Pilar Cidad-Velasco, Juan F. Navarro-González, Frederic Jaisser, José R. López-López, Diego Alvarez de la Rosa, Teresa Giraldez*, M. Teresa Pérez-García*.
Published in: Function, 2021, ISSN 2633-8823
Publisher: Oxford Academic
DOI: 10.1093/function/zqaa036

Understanding the conformational motions of RCK gating rings

Author(s): Teresa Giraldez, Brad S. Rothberg
Published in: The Journal of General Physiology, Issue 149/4, 2017, Page(s) 431-441, ISSN 0022-1295
Publisher: Rockefeller University Press
DOI: 10.1085/jgp.201611726

Functional validation of Ca 2+ -binding residues from the crystal structure of the BK ion channel

Author(s): Aravind S. Kshatri, Alberto J. Gonzalez-Hernandez, Teresa Giraldez
Published in: Biochimica et Biophysica Acta (BBA) - Biomembranes, Issue 1860/4, 2018, Page(s) 943-952, ISSN 0005-2736
Publisher: Elsevier BV
DOI: 10.1016/j.bbamem.2017.09.023

Interactions of divalent cations with calcium binding sites of BK channels reveal independent motions within the gating ring

Author(s): Pablo Miranda, Teresa Giraldez, Miguel Holmgren
Published in: Proceedings of the National Academy of Sciences, Issue 113/49, 2016, Page(s) 14055-14060, ISSN 0027-8424
Publisher: National Academy of Sciences
DOI: 10.1073/pnas.1611415113

The GoSlo family of BK channel activators: A no-go for γ subunits?

Author(s): Teresa Giraldez
Published in: Channels, 2016, Page(s) 1-2, ISSN 1933-6950
Publisher: Landes Bioscience
DOI: 10.1080/19336950.2016.1263136

Voltage-dependent dynamics of the BK channel cytosolic gating ring are coupled to the membrane-embedded voltage sensor

Author(s): Pablo Miranda, Miguel Holmgren, Teresa Giraldez
Published in: eLife, Issue 7, 2018, ISSN 2050-084X
Publisher: eLife Sciences Publications
DOI: 10.7554/elife.40664

Physiological Roles and Therapeutic Potential of Ca2+ Activated Potassium Channels in the Nervous System

Author(s): Aravind S. Kshatri, Alberto Gonzalez-Hernandez, Teresa Giraldez
Published in: Frontiers in Molecular Neuroscience, Issue 11, 2018, ISSN 1662-5099
Publisher: Frontiers Research Foundation
DOI: 10.3389/fnmol.2018.00258

SGK1.1 Reduces Kainic Acid-Induced Seizure Severity and Leads to Rapid Termination of Seizures

Author(s): Natalia Armas-Capote, Laura E Maglio, Leonel Pérez-Atencio, Elva Martin-Batista, Antonio Reboreda, Juan A Barios, Guadalberto Hernandez, Diego Alvarez de la Rosa, José Antonio Lamas, Luis C Barrio, Teresa Giraldez
Published in: Cerebral Cortex, 2019, ISSN 1047-3211
Publisher: Oxford University Press
DOI: 10.1093/cercor/bhz302

Differential regulation of BK channels by fragile X mental retardation protein

Author(s): A. Kshatri1,2, A. Cerrada1,2, R. Gimeno1,2, D. Bartolomé-Martín1,2, P. Rojas3 and T. Giraldez
Published in: The Journal of General Physiology, 2020, ISSN 1540-7748
Publisher: Rockefeller U Press
DOI: 10.1085/jgp.201912502

Activation of SGK1.1 up-regulates the M-current in the presence of epilepsy mutations

Author(s): Elva Martin-Batista, Rían W. Manville, Belinda Rivero-Pérez, David Bartolomé-Martín, Diego Alvarez de la Rosa, Geoffrey W. Abbott, Teresa Giraldez
Published in: Frontiers in Molecular Neuroscience, 2021, ISSN 1662-5099
Publisher: Frontiers Research Foundation
DOI: 10.3389/fnmol.2021.798261

Conference proceedings (2)

Generating new tools for the study of structure-function of ion channels using unnatural amino acids.

Author(s): Ariadna Rubio-Cancio, Alberto J. Gonzalez-Hernandez, Teresa Giraldez, Diego Alvarez de la Rosa
Published in: 2015
Publisher: RECI-Annual Meeting Abstract

Molecular basis of BK activation by Ca2+ studied using photoactivatable unnatural aminoacid BzF

Author(s): Alberto J. Gonzalez-Hernandez, Diego Alvarez de la Rosa, Teresa Giraldez
Published in: 2016
Publisher: The Biophysical Society

Book chapters (1)

Calcium-gated potassium channels

Author(s): Alberto Gonzalez-Hernandez Aravind Kshatri Teresa Giraldez
Published in: Calcium Signals: From single molecules to physiology, 2022
Publisher: IOP-Science

Thesis and dissertations (3)

Role of NMDAR-NR2B subunit in the functionality of supramolecular NMDAR-BK complexes

Author(s): Rebeca Martinez-Lazaro
Published in: 2018
Publisher: FH Campus Wien University of Applied Sciences

Optoelectrical dynamics of ion channels and calcium nanodomains

Author(s): Alberto Gonzalez-Hernandez
Published in: 2021
Publisher: Universidad de La Laguna

Novel neuronal Ca2+ sensors based on the BK channel.

Author(s): Roger Gimeno Llobet
Published in: 2019
Publisher: Universidad de La Laguna

Other (2)

Cereblon Regulates BK Channel Expression at Presynaptic and Postsynaptic Sites in Excitatory Synapses

Author(s): Ricardo Gomez Laura E Maglio Alberto Gonzalez-Hernandez
Published in: The Journal of Neuroscience, 2018
Publisher: Society for Neuroscience
DOI: 10.1523/jneurosci.1402-18.2018

Neuronal kinase SGK1.1 protects against brain damage after status epilepticus

Author(s): Elva Martin-Batista Laura E. Maglio Natalia Armas-Capote Guadalberto Hernandez Diego Alvarez de la Rosa Teresa Giraldez
Published in: BioRxiv, 2020
Publisher: BioRxiv
DOI: 10.1101/2020.04.03.024067