Optoelectrical Dynamics of Ion channel Activation in Calcium Nanodomains

Project Information

NANOPDICS

Grant agreement ID: 648936

DOI

10.3030/648936

Project closed

EC signature date 8 June 2015

Start date 1 September 2015

End date 31 August 2021

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost

€ 1 999 742,00

EU contribution

€ 1 999 742,00

Coordinated by

UNIVERSIDAD DE LA LAGUNA
Spain

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Publications

Peer reviewed articles (10)

Kv1.3 channel inhibition partially reverts uremia-induced calcification in human aortic vascular smooth muscle cells

Author(s): Violeta Cazaña-Pérez, Pilar Cidad-Velasco, Juan F. Navarro-González, Frederic Jaisser, José R. López-López, Diego Alvarez de la Rosa, Teresa Giraldez*, M. Teresa Pérez-García*.
Published in: Function, 2021, ISSN 2633-8823
Publisher: Oxford Academic
DOI: 10.1093/function/zqaa036

Understanding the conformational motions of RCK gating rings

Author(s): Teresa Giraldez, Brad S. Rothberg
Published in: The Journal of General Physiology, Issue 149/4, 2017, Page(s) 431-441, ISSN 0022-1295
Publisher: Rockefeller University Press
DOI: 10.1085/jgp.201611726

Functional validation of Ca 2+ -binding residues from the crystal structure of the BK ion channel

Author(s): Aravind S. Kshatri, Alberto J. Gonzalez-Hernandez, Teresa Giraldez
Published in: Biochimica et Biophysica Acta (BBA) - Biomembranes, Issue 1860/4, 2018, Page(s) 943-952, ISSN 0005-2736
Publisher: Elsevier BV
DOI: 10.1016/j.bbamem.2017.09.023

Interactions of divalent cations with calcium binding sites of BK channels reveal independent motions within the gating ring

Author(s): Pablo Miranda, Teresa Giraldez, Miguel Holmgren
Published in: Proceedings of the National Academy of Sciences, Issue 113/49, 2016, Page(s) 14055-14060, ISSN 0027-8424
Publisher: National Academy of Sciences
DOI: 10.1073/pnas.1611415113

The GoSlo family of BK channel activators: A no-go for γ subunits?

Author(s): Teresa Giraldez
Published in: Channels, 2016, Page(s) 1-2, ISSN 1933-6950
Publisher: Landes Bioscience
DOI: 10.1080/19336950.2016.1263136

Voltage-dependent dynamics of the BK channel cytosolic gating ring are coupled to the membrane-embedded voltage sensor

Author(s): Pablo Miranda, Miguel Holmgren, Teresa Giraldez
Published in: eLife, Issue 7, 2018, ISSN 2050-084X
Publisher: eLife Sciences Publications
DOI: 10.7554/elife.40664

Physiological Roles and Therapeutic Potential of Ca2+ Activated Potassium Channels in the Nervous System

Author(s): Aravind S. Kshatri, Alberto Gonzalez-Hernandez, Teresa Giraldez
Published in: Frontiers in Molecular Neuroscience, Issue 11, 2018, ISSN 1662-5099
Publisher: Frontiers Research Foundation
DOI: 10.3389/fnmol.2018.00258

SGK1.1 Reduces Kainic Acid-Induced Seizure Severity and Leads to Rapid Termination of Seizures

Author(s): Natalia Armas-Capote, Laura E Maglio, Leonel Pérez-Atencio, Elva Martin-Batista, Antonio Reboreda, Juan A Barios, Guadalberto Hernandez, Diego Alvarez de la Rosa, José Antonio Lamas, Luis C Barrio, Teresa Giraldez
Published in: Cerebral Cortex, 2019, ISSN 1047-3211
Publisher: Oxford University Press
DOI: 10.1093/cercor/bhz302

Differential regulation of BK channels by fragile X mental retardation protein

Author(s): A. Kshatri1,2, A. Cerrada1,2, R. Gimeno1,2, D. Bartolomé-Martín1,2, P. Rojas3 and T. Giraldez
Published in: The Journal of General Physiology, 2020, ISSN 1540-7748
Publisher: Rockefeller U Press
DOI: 10.1085/jgp.201912502

Activation of SGK1.1 up-regulates the M-current in the presence of epilepsy mutations

Author(s): Elva Martin-Batista, Rían W. Manville, Belinda Rivero-Pérez, David Bartolomé-Martín, Diego Alvarez de la Rosa, Geoffrey W. Abbott, Teresa Giraldez
Published in: Frontiers in Molecular Neuroscience, 2021, ISSN 1662-5099
Publisher: Frontiers Research Foundation
DOI: 10.3389/fnmol.2021.798261

Conference proceedings (2)

Generating new tools for the study of structure-function of ion channels using unnatural amino acids.

Author(s): Ariadna Rubio-Cancio, Alberto J. Gonzalez-Hernandez, Teresa Giraldez, Diego Alvarez de la Rosa
Published in: 2015
Publisher: RECI-Annual Meeting Abstract

Molecular basis of BK activation by Ca2+ studied using photoactivatable unnatural aminoacid BzF

Author(s): Alberto J. Gonzalez-Hernandez, Diego Alvarez de la Rosa, Teresa Giraldez
Published in: 2016
Publisher: The Biophysical Society

Book chapters (1)

Calcium-gated potassium channels

Author(s): Alberto Gonzalez-Hernandez Aravind Kshatri Teresa Giraldez
Published in: Calcium Signals: From single molecules to physiology, 2022
Publisher: IOP-Science

Thesis and dissertations (3)

Role of NMDAR-NR2B subunit in the functionality of supramolecular NMDAR-BK complexes

Author(s): Rebeca Martinez-Lazaro
Published in: 2018
Publisher: FH Campus Wien University of Applied Sciences

Optoelectrical dynamics of ion channels and calcium nanodomains

Author(s): Alberto Gonzalez-Hernandez
Published in: 2021
Publisher: Universidad de La Laguna

Novel neuronal Ca2+ sensors based on the BK channel.

Author(s): Roger Gimeno Llobet
Published in: 2019
Publisher: Universidad de La Laguna

Other (2)

Cereblon Regulates BK Channel Expression at Presynaptic and Postsynaptic Sites in Excitatory Synapses

Author(s): Ricardo Gomez Laura E Maglio Alberto Gonzalez-Hernandez
Published in: The Journal of Neuroscience, 2018
Publisher: Society for Neuroscience
DOI: 10.1523/jneurosci.1402-18.2018

Neuronal kinase SGK1.1 protects against brain damage after status epilepticus

Author(s): Elva Martin-Batista Laura E. Maglio Natalia Armas-Capote Guadalberto Hernandez Diego Alvarez de la Rosa Teresa Giraldez
Published in: BioRxiv, 2020
Publisher: BioRxiv
DOI: 10.1101/2020.04.03.024067