Modulation of the Ubiquitin Proteasome System During Multiple Stages of the Poxvirus Lifecycle

Project Information

UbiProPox

Grant agreement ID: 649101

DOI 10.3030/649101

Project closed

EC signature date 26 March 2015

Start date 1 September 2015

End date 31 August 2021

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost € 2 270 000,00

EU contribution € 2 270 000,00

Coordinated by

THE UNIVERSITY OF BIRMINGHAM
United Kingdom

Publications

Peer reviewed articles (14)

Acrylamide inhibits vaccinia virus through vimentin‐independent anti‐viral granule formation

Author(s): Jennifer J. Wood, Ian J. White, Jerzy Samolej, Jason Mercer
Published in: Cellular Microbiology, Issue 23/8, 2021, ISSN 1462-5814
Publisher: Blackwell Publishing Inc.
DOI: 10.1111/cmi.13334

Vaccinia virus hijacks ESCRT-mediated multivesicular body formation for virus egress

Author(s): Moona Huttunen, Jerzy Samolej, Robert J Evans, Artur Yakimovich, Ian J White, Janos Kriston-Vizi, Juan Martin-Serrano, Wesley I Sundquist, Eva-Maria Frickel, Jason Mercer
Published in: Life Science Alliance, Issue 4/8, 2021, Page(s) e202000910, ISSN 2575-1077
Publisher: LSA
DOI: 10.26508/lsa.202000910

The zebrafish as a novel model for the in vivo study of Toxoplasma gondii replication and interaction with macrophages

Author(s): Nagisa Yoshida, Marie-Charlotte Domart, Christopher J. Peddie, Artur Yakimovich, Maria J. Mazon-Moya, Thomas A. Hawkins, Lucy Collinson, Jason Mercer, Eva-Maria Frickel, Serge Mostowy
Published in: Disease Models & Mechanisms, Issue 13/7, 2020, ISSN 1754-8403
Publisher: The Company of Biologists Ltd.
DOI: 10.1242/dmm.043091

NanoJ-SQUIRREL: quantitative mapping and minimisation of super-resolution optical imaging artefacts

Author(s): Mercer, Jason; Leterrier, Christophe; Pereira, Pedro; Henriques, Ricardo; Culley, Siân; Albrecht, David; Jacobs, Caron
Published in: Nature Methods, Issue 15(4), 2018, ISSN 1548-7091
Publisher: Nature Publishing Group
DOI: 10.1101/158279

Open-source Single-particle Analysis for Super-resolution Microscopy with VirusMapper

Author(s): Robert D. M. Gray, Jason Mercer, Ricardo Henriques
Published in: Journal of Visualized Experiments, Issue 122, 2017, ISSN 1940-087X
Publisher: MYJoVE Corporation
DOI: 10.3791/55471

Inhibition of Poxvirus Gene Expression and Genome Replication by Bisbenzimide Derivatives

Author(s): Yakimovich, Artur; Huttunen, Moona; Zehnder, Benno; Coulter, Lesley J.; Gould, Victoria; Schneider, Christoph; Kopf, Manfred; McInnes, Colin J.; Greber, Urs F.; Mercer, Jason
Published in: Journal of Virology, Issue 91(18), 2017, ISSN 0022-538X
Publisher: American Society for Microbiology
DOI: 10.3929/ethz-b-000177326

Proteotype profiling unmasks a viral signalling network essential for poxvirus assembly and transcriptional competence

Author(s): Karel Novy, Samuel Kilcher, Ulrich Omasits, Christopher Karl Ernst Bleck, Corina Beerli, Jakob Vowinckel, Caroline K. Martin, Mohammedyaseen Syedbasha, Alessio Maiolica, Ian White, Jason Mercer, Bernd Wollscheid
Published in: Nature Microbiology, Issue 3/5, 2018, Page(s) 588-599, ISSN 2058-5276
Publisher: Nature Publishing Group
DOI: 10.1038/s41564-018-0142-6

VirusMapper: open-source nanoscale mapping of viral architecture through super-resolution microscopy

Author(s): Gray, Robert D.M.; Ricardo Henriques; Jerzy Samolej; Christopher Karl Ernst Bleck; Kathrin Maria Scherer; Pedro Matos Pereira; Corina Beerli; Jason Mercer
Published in: Scientific Reports , 6 , Article 29132. (2016), Issue 1, 2016, ISSN 2045-2322
Publisher: Nature Publishing Group
DOI: 10.1038/srep29132

Vaccinia virus hijacks EGFR signalling to enhance virus spread through rapid and directed infected cell motility

Author(s): Corina Beerli, Artur Yakimovich, Samuel Kilcher, Glennys V. Reynoso, Gotthold Fläschner, Daniel J. Müller, Heather D. Hickman, Jason Mercer
Published in: Nature Microbiology, Issue 4/2, 2019, Page(s) 216-225, ISSN 2058-5276
Publisher: Nature Publishing Group
DOI: 10.1038/s41564-018-0288-2

Nanoscale polarization of the entry fusion complex of vaccinia virus drives efficient fusion

Author(s): Robert D. M. Gray, David Albrecht, Corina Beerli, Moona Huttunen, Gary H. Cohen, Ian J. White, Jemima J. Burden, Ricardo Henriques, Jason Mercer
Published in: Nature Microbiology, Issue 4/10, 2019, Page(s) 1636-1644, ISSN 2058-5276
Publisher: Nature Publishing Group
DOI: 10.1038/s41564-019-0488-4

Fix Your Membrane Receptor Imaging: Actin Cytoskeleton and CD4 Membrane Organization Disruption by Chemical Fixation

Author(s): Pedro M. Pereira, David Albrecht, Siân Culley, Caron Jacobs, Mark Marsh, Jason Mercer, Ricardo Henriques
Published in: Frontiers in Immunology, Issue 10, 2019, ISSN 1664-3224
Publisher: Frontiers Media SA
DOI: 10.3389/fimmu.2019.00675

Defining host–pathogen interactions employing an artificial intelligence workflow

Author(s): Daniel Fisch, Artur Yakimovich, Barbara Clough, Joseph Wright, Monique Bunyan, Michael Howell, Jason Mercer, Eva Frickel
Published in: eLife, Issue 8, 2019, ISSN 2050-084X
Publisher: eLife Sciences Publications
DOI: 10.7554/eLife.40560

Modulation of Early Host Innate Immune Response by an Avipox Vaccine Virus’ Lateral Body Protein

Author(s): Efstathios S. Giotis, Stephen M. Laidlaw, Susanna R. Bidgood, David Albrecht, Jemima J. Burden, Rebecca C. Robey, Jason Mercer, Michael A. Skinner
Published in: Biomedicines, Issue 8/12, 2020, Page(s) 634, ISSN 2227-9059
Publisher: MDPI
DOI: 10.3390/biomedicines8120634

Mimicry Embedding Facilitates Advanced Neural Network Training for Image-Based Pathogen Detection

Author(s): Artur Yakimovich, Moona Huttunen, Jerzy Samolej, Barbara Clough, Nagisa Yoshida, Serge Mostowy, Eva-Maria Frickel, Jason Mercer
Published in: mSphere, Issue 5/5, 2020, ISSN 2379-5042
Publisher: ASM
DOI: 10.1128/msphere.00836-20

Book chapters (1)

Image-Based Quantitation of Host Cell–Toxoplasma gondii Interplay Using HRMAn: A Host Response to Microbe Analysis Pipeline

Author(s): Daniel Fisch, Artur Yakimovich, Barbara Clough, Jason Mercer, Eva-Maria Frickel
Published in: Toxoplasma gondii - Methods and Protocols, Issue 2071, 2020, Page(s) 411-433, ISBN 978-1-4939-9856-2
Publisher: Springer US
DOI: 10.1007/978-1-4939-9857-9_21

Non-peer reviewed articles (2)

mSphere of Influence: the Rise of Artificial Intelligence in Infection Biology

Author(s): Artur Yakimovich
Published in: mSphere, Issue 4/3, 2019, ISSN 2379-5042
Publisher: ASM Journals
DOI: 10.1128/mSphere.00315-19

NanoJ: a high-performance open-source super-resolution microscopy toolbox

Author(s): Romain F Laine, Kalina L Tosheva, Nils Gustafsson, Robert D M Gray, Pedro Almada, David Albrecht, Gabriel T Risa, Fredrik Hurtig, Ann-Christin Lindås, Buzz Baum, Jason Mercer, Christophe Leterrier, Pedro M Pereira, Siân Culley, Ricardo Henriques
Published in: Journal of Physics D: Applied Physics, Issue 52/16, 2019, Page(s) 163001, ISSN 0022-3727
Publisher: Institute of Physics Publishing
DOI: 10.1088/1361-6463/ab0261