Deliverables
A white paper that will address the direct tension between the privacy-by-design principal and the need to establish situation awareness. Our ethics and governance panel will be tasked to oversee this activity and comment on the project’s findings on design standards, ethical guidelines, codes of practice and professional standards for emergency CBRN responses within ethnically and culturally highly heterogeneous communities. • Key Headings will include: • Processes • Communication protocols • Consented and non-consented physical and virtual interventions
Guidelines for the care and triage of vulnerable groups in crises-management operationsA report with design and operational guidelines for the triage and management of casualties with: cognitive impairment, mobility impairment, sensory impairment, clinical complications (bariatric patients, cardiac, respiratory, diabetes, liver, kidney diseases, immune compromised and casualties with cancer), pregnancy, lone children, and finally casualties impaired from alcohol and recreational drug use.
Annual reports, with restricted technical annexesSix monthly activity and financial reports supported by summaries of milestones and deliverables will be produced and highlighted in our bulletin. These will be compiled, indexed and summarised for the annual reports and review. Furthermore formal and detailed presentation supported by appropriate technical specialists will be given by the co-ordinator to the annual conferences and project reviews.
Report on the Clinical trialsResearch Papers reporting on the findings from the clinical studies undertaken in Norway, Scotland, and Sri-Lanka on the diagnosis and identification of poisoning.
Messages for Clear and compelling communication during crises managementA systematically catalogued and indexed lexicon of timely and compelling instructions, briefings and prepared messages for all types of media and stake-holders
Triage verification facilityLaboratory infrastructure and SOPs for the evaluation of C-, B-, R/N triage systems challenged by pesticides, chlorine, chloropicrin, sarin, VX- nerve agents, ricin, and the N42 34 ANSI isotope list. A range of matrices including: food, water, clothing (PPE) and building materials under a range of environmental conditions will be included.
The public's interface to the Project
Promotional campaign trade exhibitions with press and media eventsA dissemination strategy and delivery timetable for three annual campaigns supporting commercial development of TOXI-triage outcomes involving press releases; social media, trade conferences, publications; research conferences; training materials and events. Scheduling and logistical planning to integrate meetings, workshops, reviews and field trials into the dissemination and marketing plan. A secondary and equally significant dissemination pathway will be the co-ordination of our activity, followed by the transfer of know-how and methodologies into CBRN research programmes undertaken by government laboratories, such as Dstl and Bundeswehr Institute of Pharmacology and Toxicology.
Data and publication repositoryThe repository will also include all PU dissemination level deliverables from TOXI-triage. (All subject to security clearance evaluation) TOXI-triage will provide immediate, unrestricted, on-line access to published output of publically funded research; often referred to as the ‘gold’ route. Supporting data will also be lodged in the repository.
A data base will consolidate, and link to other metabolomics repositories, the outcomes of: • In-clinic metabolomic definition studies describing markers of injury, prognosis, and recovery for OP pesticides (study based at SATRC), toxic alcohol adulterants of drink (Oslo University Hospital, Norway, and Royal Infirmary of Edinburgh, UK,) and radiation injury (Edinburgh Cancer Research Centre, UK). • In-vitro studies presenting data from liver-liposomes and infused organ (animal, pig, ) challenges by live agents chemical (chlorine, chloropicrin, sarin and VX-nerve agents), biological (ricin), and radiation exposures.
Social media data for crises management operations implementationICT tools for distributed knowledge extraction, dynamic semantic modelling and embedded reasoning recovered from social network data streams. This deliverable will use proven techniques that have resulted in the highly effective Natural Language Processing E-mail Knowledge Extraction (EKE) system.
Business plans and commercialisation outcomesA high-level strategy and manifesto for the realisation of: • An effective dissemination strategy. • Integration with CBRN networks established through previous initiatives • Compliance with current standards. • Realise opportunities for commercial exploitation in other sectors, with special emphasis on emergency medicine, environmental protection and fire and rescue. • an approach to the European Medicines Agency to propose registration of the methodologies and any biomarkers of CBRN injury.
Presentation of optimized prototypes ( sampling, analytics, data-flows, and patient stratification) by studying patients with exposure to OP pesticides, toxic alcohol adulterants, and radiation, as well as exposure to unknown chemicals.
Prototype sampling system for reproducible non-invasive Clinical sampling.Devices, systems and SOPs for the non-invasive sampling from suspected casualties with breath, skin and saliva variants.
Publications
Author(s):
L Criado-García, D M Ruszkiewicz, G A Eiceman, C L P Thomas
Published in:
Journal of Breath Research, Issue 10/1, 2016, Page(s) 017101, ISSN 1752-7163
Publisher:
IOP Publishing Ltd
DOI:
10.1088/1752-7155/10/1/017101
Author(s):
Graham Hancox, Sue Hignett, Hilary Pillin, Spyros Kintzios, Jyri Silmäri, C.L. Paul Thomas
Published in:
International Journal of Emergency Services, Issue 7/2, 2018, Page(s) 111-119, ISSN 2047-0894
Publisher:
Emera;ld
DOI:
10.1108/ijes-08-2017-0044
Author(s):
Ivan Vučković, Marja-Leena Rapinoja, Matti Vaismaa, Paula Vanninen, Harri Koskela
Published in:
Phytochemical Analysis, Issue 27/1, 2016, Page(s) 64-72, ISSN 0958-0344
Publisher:
John Wiley & Sons Inc.
DOI:
10.1002/pca.2600
Author(s):
Liam M Heaney, Dorota M Ruszkiewicz, Kayleigh L Arthur, Andria Hadjithekli, Clive Aldcroft, Martin R Lindley, CL Paul Thomas, Matthew A Turner, James C Reynolds
Published in:
Bioanalysis, Issue 8/13, 2016, Page(s) 1325-1336, ISSN 1757-6180
Publisher:
Future Science
DOI:
10.4155/bio-2016-0045
Author(s):
Mia Halme, Maija Pesonen, Heta Salo, Martin Söderström, Markku Pasanen, Kirsi Vähäkangas, Paula Vanninen
Published in:
Journal of Chromatography B, Issue 1009-1010, 2016, Page(s) 17-24, ISSN 1570-0232
Publisher:
Elsevier BV
DOI:
10.1016/j.jchromb.2015.11.042
Author(s):
S Kang, C L Paul Thomas
Published in:
Journal of Breath Research, Issue 10/2, 2016, Page(s) 026011, ISSN 1752-7163
Publisher:
IOP Publishing Ltd
DOI:
10.1088/1752-7155/10/2/026011
Author(s):
Brigitte G. Dorner, Reinhard Zeleny, Kirsi Harju, Jacques-Antoine Hennekinne, Paula Vanninen, Heinz Schimmel, Andreas Rummel
Published in:
TrAC Trends in Analytical Chemistry, Issue 85, 2016, Page(s) 89-102, ISSN 0165-9936
Publisher:
Elsevier BV
DOI:
10.1016/j.trac.2016.05.024
Author(s):
H J Martin, M A Turner, S Bandelow, L Edwards, Svetlana Riazanskaia, C L P Thomas
Published in:
Journal of Breath Research, Issue 10/4, 2016, Page(s) 046012, ISSN 1752-7163
Publisher:
IOP Publishing Ltd
DOI:
10.1088/1752-7155/10/4/046012
Author(s):
Jeevan Dhanarisi, Fathima Shihana, Kirsi Harju, Fahim Mohamed, Vasundhara Verma, Seyed Shahmy, Paula Vanninen, Olli Kostiainen, Indika Gawarammana, Michael Eddleston
Published in:
Clinical Toxicology, 2019, Page(s) 1-8, ISSN 1556-3650
Publisher:
Taylor & Francis
DOI:
10.1080/15563650.2019.1643467
Author(s):
André Ahrens, Moritz Hitzemann, Stefan Zimmermann
Published in:
International Journal for Ion Mobility Spectrometry, Issue 22/2, 2019, Page(s) 77-83, ISSN 1435-6163
Publisher:
Springer Verlag
DOI:
10.1007/s12127-019-00248-w
Author(s):
Mashaalah Zarejousheghani, Wilhelm Lorenz, Paula Vanninen, Taher Alizadeh, Malcolm Cämmerer, Helko Borsdorf
Published in:
Polymers, Issue 11/5, 2019, Page(s) 888, ISSN 2073-4360
Publisher:
MDPI AG Basel, Switzerland
DOI:
10.3390/polym11050888
Author(s):
Thomas Mayer, Malcolm Cämmerer, Helko Borsdorf
Published in:
International Journal for Ion Mobility Spectrometry, Issue June 2019, 2019, Page(s) pp 1-10, ISSN 1435-6163
Publisher:
Springer Verlag
DOI:
10.1007/s12127-019-00252-0
Author(s):
Angelika Skarysz, Yaser Alkhalifah, Kareen Darnley, Michael Eddleston, Yang Hu, Duncan B McLaren, William H Nailon, Dahlia Salman, Martin Sykora, C L Paul Thomas, Andrea Soltoggio
Published in:
2018 International Joint Conference on Neural Networks (IJCNN), 2018, Page(s) 1-8, ISBN 978-1-5090-6014-6
Publisher:
IEEE
DOI:
10.1109/IJCNN.2018.8489539
Author(s):
Hignett, S., Hancox, G., Pillin, H., Silmäri, J., O’Leary, A., Brodrick, E.
Published in:
HEPS 2019, 2019, Page(s) p 49-53
Publisher:
Healthcare Ergonomics & Patient Safety (HEPS) International Conference
Author(s):
Amelunxen, C., Rupp, N. & Sander, J. I.,
Published in:
Mensch und Computer 2018 - Workshop, Issue September 2018, 2018, Page(s) 634-641
Publisher:
Gesellschaft für Informatik e.V
DOI:
10.18420/muc2018-ws12-0458
Author(s):
Oliver Gruebner, Martin Sykora, Sarah R Lowe, Ketan Shankardass, Ludovic Trinquart, Tom Jackson, S V Subramanian, Sandro Galea
Published in:
The Lancet, Issue 387/10034, 2016, Page(s) 2195-2196, ISSN 0140-6736
Publisher:
The Lancet Publishing Group
DOI:
10.1016/S0140-6736(16)30602-X
Author(s):
Sue Hignett, Graham Hancox, Mary Edmunds Otter
Published in:
International Journal of Emergency Services, Issue August 2019, 2019, Page(s) pp. 175-190, ISSN 2047-0894
Publisher:
Emerald Publishing Limited
DOI:
10.1108/ijes-05-2018-0030
Author(s):
Kuula, Jaana
Published in:
2016, ISBN 978-951-39-6889-5
Publisher:
University of Jyväskylä
Intellectual Property Rights
Application/Publication number:
UK
00003167285
Date:
2016-05-31
Applicant(s):
T4I ENGINEERING LTD
Application/Publication number:
UK
00003167285
Date:
2016-05-31
Applicant(s):
T4I ENGINEERING LTD
Application/Publication number:
UK
00003167285
Date:
2016-05-31
Applicant(s):
T4I ENGINEERING LTD
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