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CORDIS - EU research results
CORDIS

INTEGRATED AND ADAPTIVE RESPONSES TO TOXIC EMERGENCIES FOR RAPID TRIAGE: ENGINEERING THE ROADMAP FROM CASUALTY TO PATIENT TO SURVIVOR.

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Deliverables

Cross-cultural and social factors in planning for crises management (opens in new window)

A white paper that will address the direct tension between the privacy-by-design principal and the need to establish situation awareness. Our ethics and governance panel will be tasked to oversee this activity and comment on the project’s findings on design standards, ethical guidelines, codes of practice and professional standards for emergency CBRN responses within ethnically and culturally highly heterogeneous communities. • Key Headings will include: • Processes • Communication protocols • Consented and non-consented physical and virtual interventions

Guidelines for the care and triage of vulnerable groups in crises-management operations (opens in new window)

A report with design and operational guidelines for the triage and management of casualties with: cognitive impairment, mobility impairment, sensory impairment, clinical complications (bariatric patients, cardiac, respiratory, diabetes, liver, kidney diseases, immune compromised and casualties with cancer), pregnancy, lone children, and finally casualties impaired from alcohol and recreational drug use.

Annual reports, with restricted technical annexes (opens in new window)

Six monthly activity and financial reports supported by summaries of milestones and deliverables will be produced and highlighted in our bulletin. These will be compiled, indexed and summarised for the annual reports and review. Furthermore formal and detailed presentation supported by appropriate technical specialists will be given by the co-ordinator to the annual conferences and project reviews.

Report on the Clinical trials (opens in new window)

Research Papers reporting on the findings from the clinical studies undertaken in Norway, Scotland, and Sri-Lanka on the diagnosis and identification of poisoning.

Messages for Clear and compelling communication during crises management (opens in new window)

A systematically catalogued and indexed lexicon of timely and compelling instructions, briefings and prepared messages for all types of media and stake-holders

Triage verification facility (opens in new window)

Laboratory infrastructure and SOPs for the evaluation of C-, B-, R/N triage systems challenged by pesticides, chlorine, chloropicrin, sarin, VX- nerve agents, ricin, and the N42 34 ANSI isotope list. A range of matrices including: food, water, clothing (PPE) and building materials under a range of environmental conditions will be included.

Website (opens in new window)

The public's interface to the Project

Promotional campaign trade exhibitions with press and media events (opens in new window)

A dissemination strategy and delivery timetable for three annual campaigns supporting commercial development of TOXI-triage outcomes involving press releases; social media, trade conferences, publications; research conferences; training materials and events. Scheduling and logistical planning to integrate meetings, workshops, reviews and field trials into the dissemination and marketing plan. A secondary and equally significant dissemination pathway will be the co-ordination of our activity, followed by the transfer of know-how and methodologies into CBRN research programmes undertaken by government laboratories, such as Dstl and Bundeswehr Institute of Pharmacology and Toxicology.

Data and publication repository (opens in new window)

The repository will also include all PU dissemination level deliverables from TOXI-triage. (All subject to security clearance evaluation) TOXI-triage will provide immediate, unrestricted, on-line access to published output of publically funded research; often referred to as the ‘gold’ route. Supporting data will also be lodged in the repository.

Database of biomarkers of exposure to chemical, radiological and nuclear hazards (opens in new window)

A data base will consolidate, and link to other metabolomics repositories, the outcomes of: • In-clinic metabolomic definition studies describing markers of injury, prognosis, and recovery for OP pesticides (study based at SATRC), toxic alcohol adulterants of drink (Oslo University Hospital, Norway, and Royal Infirmary of Edinburgh, UK,) and radiation injury (Edinburgh Cancer Research Centre, UK). • In-vitro studies presenting data from liver-liposomes and infused organ (animal, pig, ) challenges by live agents chemical (chlorine, chloropicrin, sarin and VX-nerve agents), biological (ricin), and radiation exposures.

Social media data for crises management operations implementation (opens in new window)

ICT tools for distributed knowledge extraction, dynamic semantic modelling and embedded reasoning recovered from social network data streams. This deliverable will use proven techniques that have resulted in the highly effective Natural Language Processing E-mail Knowledge Extraction (EKE) system.

Business plans and commercialisation outcomes (opens in new window)

A high-level strategy and manifesto for the realisation of: • An effective dissemination strategy. • Integration with CBRN networks established through previous initiatives • Compliance with current standards. • Realise opportunities for commercial exploitation in other sectors, with special emphasis on emergency medicine, environmental protection and fire and rescue. • an approach to the European Medicines Agency to propose registration of the methodologies and any biomarkers of CBRN injury.

Prototype diagnostic system for toxicity injury and exposure (opens in new window)

Presentation of optimized prototypes ( sampling, analytics, data-flows, and patient stratification) by studying patients with exposure to OP pesticides, toxic alcohol adulterants, and radiation, as well as exposure to unknown chemicals.

Prototype sampling system for reproducible non-invasive Clinical sampling. (opens in new window)

Devices, systems and SOPs for the non-invasive sampling from suspected casualties with breath, skin and saliva variants.

Publications

A rapid and non-invasive method to determine toxic levels of alcohols and γ -hydroxybutyric acid in saliva samples by gas chromatography–differential mobility spectrometry (opens in new window)

Author(s): L Criado-García, D M Ruszkiewicz, G A Eiceman, C L P Thomas
Published in: Journal of Breath Research, Issue 10/1, 2016, Page(s) 017101, ISSN 1752-7163
Publisher: IOP Publishing Ltd
DOI: 10.1088/1752-7155/10/1/017101

Systems mapping for technology development in CBRN response (opens in new window)

Author(s): Graham Hancox, Sue Hignett, Hilary Pillin, Spyros Kintzios, Jyri Silmäri, C.L. Paul Thomas
Published in: International Journal of Emergency Services, Issue 7/2, 2018, Page(s) 111-119, ISSN 2047-0894
Publisher: Emera;ld
DOI: 10.1108/ijes-08-2017-0044

Application of comprehensive NMR-based analysis strategy in annotation, isolation and structure elucidation of low molecular weight metabolites of Ricinus communis seeds (opens in new window)

Author(s): Ivan Vučković, Marja-Leena Rapinoja, Matti Vaismaa, Paula Vanninen, Harri Koskela
Published in: Phytochemical Analysis, Issue 27/1, 2016, Page(s) 64-72, ISSN 0958-0344
Publisher: John Wiley & Sons Inc.
DOI: 10.1002/pca.2600

Real-time monitoring of exhaled volatiles using atmospheric pressure chemical ionization on a compact mass spectrometer (opens in new window)

Author(s): Liam M Heaney, Dorota M Ruszkiewicz, Kayleigh L Arthur, Andria Hadjithekli, Clive Aldcroft, Martin R Lindley, CL Paul Thomas, Matthew A Turner, James C Reynolds
Published in: Bioanalysis, Issue 8/13, 2016, Page(s) 1325-1336, ISSN 1757-6180
Publisher: Future Science
DOI: 10.4155/bio-2016-0045

Comparison of in vitro metabolism and cytotoxicity of capsaicin and dihydrocapsaicin (opens in new window)

Author(s): Mia Halme, Maija Pesonen, Heta Salo, Martin Söderström, Markku Pasanen, Kirsi Vähäkangas, Paula Vanninen
Published in: Journal of Chromatography B, Issue 1009-1010, 2016, Page(s) 17-24, ISSN 1570-0232
Publisher: Elsevier BV
DOI: 10.1016/j.jchromb.2015.11.042

How long may a breath sample be stored for at  −80 °C? A study of the stability of volatile organic compounds trapped onto a mixed Tenax:Carbograph trap adsorbent bed from exhaled breath (opens in new window)

Author(s): S Kang, C L Paul Thomas
Published in: Journal of Breath Research, Issue 10/2, 2016, Page(s) 026011, ISSN 1752-7163
Publisher: IOP Publishing Ltd
DOI: 10.1088/1752-7155/10/2/026011

Biological toxins of potential bioterrorism risk: Current status of detection and identification technology (opens in new window)

Author(s): Brigitte G. Dorner, Reinhard Zeleny, Kirsi Harju, Jacques-Antoine Hennekinne, Paula Vanninen, Heinz Schimmel, Andreas Rummel
Published in: TrAC Trends in Analytical Chemistry, Issue 85, 2016, Page(s) 89-102, ISSN 0165-9936
Publisher: Elsevier BV
DOI: 10.1016/j.trac.2016.05.024

Volatile organic compound markers of psychological stress in skin: a pilot study (opens in new window)

Author(s): H J Martin, M A Turner, S Bandelow, L Edwards, Svetlana Riazanskaia, C L P Thomas
Published in: Journal of Breath Research, Issue 10/4, 2016, Page(s) 046012, ISSN 1752-7163
Publisher: IOP Publishing Ltd
DOI: 10.1088/1752-7155/10/4/046012

A pilot clinical study of the neuromuscular blocker rocuronium to reduce the duration of ventilation after organophosphorus insecticide poisoning (opens in new window)

Author(s): Jeevan Dhanarisi, Fathima Shihana, Kirsi Harju, Fahim Mohamed, Vasundhara Verma, Seyed Shahmy, Paula Vanninen, Olli Kostiainen, Indika Gawarammana, Michael Eddleston
Published in: Clinical Toxicology, 2019, Page(s) 1-8, ISSN 1556-3650
Publisher: Taylor & Francis
DOI: 10.1080/15563650.2019.1643467

Miniaturized high-performance drift tube ion mobility spectrometer (opens in new window)

Author(s): André Ahrens, Moritz Hitzemann, Stefan Zimmermann
Published in: International Journal for Ion Mobility Spectrometry, Issue 22/2, 2019, Page(s) 77-83, ISSN 1435-6163
Publisher: Springer Verlag
DOI: 10.1007/s12127-019-00248-w

Molecularly Imprinted Polymer Materials as Selective Recognition Sorbents for Explosives: A Review (opens in new window)

Author(s): Mashaalah Zarejousheghani, Wilhelm Lorenz, Paula Vanninen, Taher Alizadeh, Malcolm Cämmerer, Helko Borsdorf
Published in: Polymers, Issue 11/5, 2019, Page(s) 888, ISSN 2073-4360
Publisher: MDPI AG Basel, Switzerland
DOI: 10.3390/polym11050888

A versatile and compact reference gas generator for calibration of ion mobility spectrometers (opens in new window)

Author(s): Thomas Mayer, Malcolm Cämmerer, Helko Borsdorf
Published in: International Journal for Ion Mobility Spectrometry, Issue June 2019, 2019, Page(s) pp 1-10, ISSN 1435-6163
Publisher: Springer Verlag
DOI: 10.1007/s12127-019-00252-0

Convolutional neural networks for automated targeted analysis of raw gas chromatography-mass spectrometry data (opens in new window)

Author(s): Angelika Skarysz, Yaser Alkhalifah, Kareen Darnley, Michael Eddleston, Yang Hu, Duncan B McLaren, William H Nailon, Dahlia Salman, Martin Sykora, C L Paul Thomas, Andrea Soltoggio
Published in: 2018 International Joint Conference on Neural Networks (IJCNN), 2018, Page(s) 1-8, ISBN 978-1-5090-6014-6
Publisher: IEEE
DOI: 10.1109/IJCNN.2018.8489539

Integrating macro and micro Hierarchical Task Analyses to embed new medical devices in complex systems

Author(s): Hignett, S., Hancox, G., Pillin, H., Silmäri, J., O’Leary, A., Brodrick, E.
Published in: HEPS 2019, 2019, Page(s) p 49-53
Publisher: Healthcare Ergonomics & Patient Safety (HEPS) International Conference

Methode zur Risikoidentifizierung in Prozessen der Gefahrenabwehr (opens in new window)

Author(s): Amelunxen, C., Rupp, N. & Sander, J. I.,
Published in: Mensch und Computer 2018 - Workshop, Issue September 2018, 2018, Page(s) 634-641
Publisher: Gesellschaft für Informatik e.V
DOI: 10.18420/muc2018-ws12-0458

Mental health surveillance after the terrorist attacks in Paris (opens in new window)

Author(s): Oliver Gruebner, Martin Sykora, Sarah R Lowe, Ketan Shankardass, Ludovic Trinquart, Tom Jackson, S V Subramanian, Sandro Galea
Published in: The Lancet, Issue 387/10034, 2016, Page(s) 2195-2196, ISSN 0140-6736
Publisher: The Lancet Publishing Group
DOI: 10.1016/S0140-6736(16)30602-X

Chemical, biological, radiological, nuclear and explosive (CBRNe) events (opens in new window)

Author(s): Sue Hignett, Graham Hancox, Mary Edmunds Otter
Published in: International Journal of Emergency Services, Issue August 2019, 2019, Page(s) pp. 175-190, ISSN 2047-0894
Publisher: Emerald Publishing Limited
DOI: 10.1108/ijes-05-2018-0030

The hyperspectral and smartphone technology in CBRNE countermeasures and defence

Author(s): Kuula, Jaana
Published in: 2016, ISBN 978-951-39-6889-5
Publisher: University of Jyväskylä

Intellectual Property Rights

T4i DOVER

Application/Publication number: UK 00003167285
Date: 2016-05-31
Applicant(s): T4I ENGINEERING LTD

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