Development of functional genomic screens to identify conserved host cell processes targeted by fungal effector proteins

Projektinformationen

EffectorTargets

ID Finanzhilfevereinbarung: 656945

DOI 10.3030/656945

Projekt abgeschlossen

EK-Unterschriftsdatum 25 März 2015

Startdatum 9 September 2015

Enddatum 8 September 2017

Finanziert unter

• EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions

Gesamtkosten € 183 454,80

EU-Beitrag € 183 454,80

Koordiniert durch

IMPERIAL COLLEGE OF SCIENCE TECHNOLOGY AND MEDICINE
United Kingdom

Ziel

In nature, fungi live in close contact with many different hosts: plants, other fungi, insects and even vertebrates including humans. They do so because the host often supplies key nutrients, which enables the fungus to grow and successfully reproduce. In many cases though, a fungus can act as a parasite and infects the host. As a result, the host mounts an immune reaction to combat the fungal infection. The fungus, in turn, has evolved ways to circumvent the immune reaction. This “arms race” between fungus and host has given rise to a plethora of secreted proteins that the fungus uses to suppress the host immune responses and circumvent host defence reactions. These secreted proteins from fungi that function in this arms race are commonly known as “effectors”. A very important plant pathogenic fungus that is predicted to encode close to 500 of such effector proteins is the barley powdery mildew fungus Blumeria graminis f. sp. hordei. Unravelling the functions of these effector proteins will provide important insights into fungal pathogenicity and host immunity. To date, the roles of the vast majority of the effector proteins are unknown. One way to elucidate the functions of these numerous effector proteins is to express each separately in model eukaryotic organisms like yeast, Saccharomyces cerevisiae, or algae, Chlamydomonas reinhardtii and identify conserved cellular targets of these effector proteins. This approach has proven to be very successful in identifying targets of bacterial effector proteins. In the project described here, this yeast- and algae-based system will be applied for the first time for fungal effector proteins.
Effectors are, besides being used by fungi to infect plants and other organisms, also a potential new source to rewire cells. When interesting conserved targets of these effectors are found, it opens up ways to use them in biotechnology and for medical purposes.

Wissenschaftliches Gebiet

• natural sciences › biological sciences › microbiology › phycology
• medical and health sciences › health sciences › infectious diseases
• natural sciences › biological sciences › biochemistry › biomolecules › proteins
• natural sciences › biological sciences › microbiology › mycology
• natural sciences › biological sciences › zoology › entomology

Programm/Programme

• H2020-EU.1.3. - EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions Main Programme
• H2020-EU.1.3.2. - Nurturing excellence by means of cross-border and cross-sector mobility

Thema/Themen

• MSCA-IF-2014-EF - Marie Skłodowska-Curie Individual Fellowships (IF-EF)

Aufforderung zur Vorschlagseinreichung

H2020-MSCA-IF-2014

Finanzierungsplan

MSCA-IF-EF-RI - RI – Reintegration panel

Koordinator

IMPERIAL COLLEGE OF SCIENCE TECHNOLOGY AND MEDICINE

• Netto-EU-Beitrag: € 183 454,80
• Adresse: SOUTH KENSINGTON CAMPUS EXHIBITION ROAD ; SW7 2AZ LONDON ; Vereinigtes Königreich
• Region: London › Inner London — West › Westminster
• Aktivitätstyp: Higher or Secondary Education Establishments
• Gesamtkosten: € 183 454,80