Small vessel diseases in a mechanistic perspective: Targets for Intervention Affected pathways and mechanistic exploitation for prevention of stroke and dementia

Livrables

Individualized press release for every partner
Final dissemination and exploitation report
Initial Dissemination plan
Launch of website, Twitter and LinkedIn account
Final symposium/stakeholder meeting on project results

Final symposiumstakeholder meeting on project results

Publications

Relationship Between Blood Pressure and Incident Cardiovascular Disease

Auteurs: Malik et.al.
Publié dans: Hypertension, 2021, ISSN 0194-911X
Éditeur: Lippincott Williams & Wilkins Ltd.
DOI: 10.1161/hypertensionaha.120.16534

Effect sizes of BOLD CVR, resting-state signal fluctuations and time delay measures for the assessment of hemodynamic impairment in carotid occlusion patients

Auteurs: Jill B. De Vis, Alex A. Bhogal, Jeroen Hendrikse, Esben T. Petersen, Jeroen C.W. Siero
Publié dans: NeuroImage, Numéro 179, 2018, Page(s) 530-539, ISSN 1053-8119
Éditeur: Academic Press
DOI: 10.1016/j.neuroimage.2018.06.017

A Review of Translational Magnetic Resonance Imaging in Human and Rodent Experimental Models of Small Vessel Disease.

Auteurs: Stringer MS, Lee H, Huuskonen MT, MacIntosh BJ, Brown R, Montagne A, Atwi S, Ramirez J, Jansen MA, Marshall I, Black SE, Zlokovic BV, Benveniste H, Wardlaw JM
Publié dans: Translational Stroke Research, 2020, ISSN 1868-4483
Éditeur: Springer Pub. Co.,
DOI: 10.1007/s12975-020-00843-8

Clinical management of cerebral small vessel disease: a call for a holistic approach.

Auteurs: Clancy U, Appleton JP, Arteaga C, Doubal FN, Bath PM, Wardlaw JM
Publié dans: Chinese medical journal, 2020, ISSN 0366-6999
Éditeur: Zhonghua Yixeuehui Zazhishe/Chinese Medical Association Publishing House
DOI: 10.1097/cm9.0000000000001177

Genetically Predicted Midlife Blood Pressure and Coronary Artery Disease Risk: Mendelian Randomization Analysis

Auteurs: Gill D, Georgakis MK, Zuber V, Karhunen V, Burgess S, Malik R, Dichgans M
Publié dans: Journal of the American Heart Association, Numéro 9(14), 2020, Page(s) e016773, ISSN 2047-9980
Éditeur: Wiley-Blackwell
DOI: 10.1161/jaha.120.016773

Effects of cilostazol and isosorbide mononitrate on cerebral haemodynamics in the LACI-1 randomised controlled trial

Auteurs: Blair GW, Janssen E, Stringer MS, Thrippleton MJ, Chappell F, Shi Y, Hamilton I, Flathery K, Appleton JP, Doubal FN, Bath PM, Wardlaw JM
Publié dans: Stroke, 2021, ISSN 0039-2499
Éditeur: Lippincott Williams & Wilkins Ltd.
DOI: 10.1161/strokeaha.121.034866

Impaired Cerebral Autoregulation After Subarachnoid Hemorrhage: A Quantitative Assessment Using a Mouse Model.

Auteurs: Koide M, Ferris HR, Nelson MT, Wellman GC.
Publié dans: Front Physiol, 2021, ISSN 1664-042X
Éditeur: Frontiers Research Foundation
DOI: 10.3389/fphys.2021.688468

Post-stroke Cognition at 1 and 3 Years Is Influenced by the Location of White Matter Hyperintensities in Patients With Lacunar Stroke

Auteurs: Maria del C. Valdés Hernández,1,* Tara Grimsley-Moore,2 Francesca M. Chappell,1 Michael J. Thrippleton,1 Paul A. Armitage,3 Eleni Sakka,1 Stephen Makin,4 and Joanna M. Wardlaw1
Publié dans: Front Neurol., 2021, ISSN 1662-453X
Éditeur: Frontiers
DOI: 10.3389/fneur.2021.634460

Circulating Metabolites Differentiate Acute Ischemic Stroke from Stroke Mimics

Auteurs: Tiedt S, Brandmaier S, Kollmeier H, Duering M, Artati A, Adamski J, Klein M, Liebig T, Holdt LM, Teupser D, Wang-Sattler R, Schwedhelm E, Gieger C, Dichgans M
Publié dans: Annals of Neurology, Numéro 88(4), 2020, Page(s) 736-746, ISSN 1531-8249
Éditeur: Wiley
DOI: 10.1002/ana.25859

Dose-response relationship between genetically proxied average blood glucose levels and incident coronary heart disease in individuals without diabetes mellitus

Auteurs: Burgess S, Malik R, Liu B, Mason AM, Georgakis MK, Dichgans M, Gill D
Publié dans: Diabetologia, Numéro 64(4), 2021, Page(s) 845-849, ISSN 0012-186X
Éditeur: Springer Verlag
DOI: 10.1007/s00125-020-05377-0

Pharmacological depletion of microglia and perivascular macrophages prevents Vascular Cognitive Impairment in Ang II-induced hypertension.

Auteurs: Kerkhofs D, van Hagen BT, Milanova IV, Schell KJ, van Essen H, Wijnands E, Goossens P, Blankesteijn WM, Unger T, Prickaerts J, Biessen EA, van Oostenbrugge RJ, Foulquier S
Publié dans: Theranostics, 2020, ISSN 0028-3878
Éditeur: Lippincott Williams & Wilkins Ltd.
DOI: 10.1212/wnl.0000000000011783

Correlations in post-mortem imaging-histopathology studies of sporadic human cerebral small vessel disease: a systematic review

Auteurs: Catherine A Humphreys , Colin Smith , Joanna M Wardlaw
Publié dans: Neuropathol Appl Neurobiol, 2021, ISSN 1365-2990
Éditeur: John Wiley & Sons, Inc.
DOI: 10.1111/nan.12737

Strategic infarct locations for post-stroke cognitive impairment: a pooled analysis of individual patient data from 12 acute ischaemic stroke cohorts

Auteurs: Nick A Weaver, Hugo J Kuijf, Hugo P Aben, Jill Abrigo, Hee-Joon Bae, Mélanie Barbay, Jonathan G Best, Régis Bordet, Francesca M Chappell, J Matthijs Biesbroek, Geert Jan Biessels
Publié dans: Lancet Neurol, 2021, ISSN 1474-4422
Éditeur: The Lancet Publishing Group
DOI: 10.1016/s1474-4422(21)00060-0

Non-Invasive Assessment of Damping of Blood Flow Velocity Pulsatility in Cerebral Arteries With MRI

Auteurs: Tine Arts, MS,1 Laurien P. Onkenhout, MS,1 Raquel P. Amier, MS,3 Rob van der Geest, PhD,4 Thijs van Harten, MS,4 Jaap Kappelle, MD,2 Sanne Kuipers, MS,2 Matthijs J.P. van Osch, PhD,4 Ed T. van Bavel, PhD,5 Geert Jan Biessels, MD,2 and Jaco J.M. Zwanenburg
Publié dans: Journal of Magnetic Resonance Imaging, 2021, ISSN 1090-7807
Éditeur: Academic Press
DOI: 10.1002/jmri.27989

Associations between total MRI-visible small vessel disease burden and domain-specific cognitive abilities in a community-dwelling older-age cohort

Auteurs: Okl Hamilton , S R Cox , L Ballerini , M E Bastin , J Corley , A J Gow , S Muñoz Maniega , P Redmond , M Del C Valdés Hernández , J M Wardlaw , I J Deary
Publié dans: Neurobiol Aging, 2021, ISSN 0197-4580
Éditeur: Elsevier BV
DOI: 10.1016/j.neurobiolaging.2021.04.007

Additive Effects of Genetic Interleukin-6 Signaling Downregulation and Low-Density Lipoprotein Cholesterol Lowering on Cardiovascular Disease: A 2×2 Factorial Mendelian Randomization Analysis.

Auteurs: Georgakis MK, Malik R, Burgess S, Dichgans M.
Publié dans: J Am Heart Assoc, Numéro 2022 Jan 4, 2022, Page(s) 11(1):e023277, ISSN 2047-9980
Éditeur: Wiley-Blackwell
DOI: 10.1161/jaha.121.023277

Associations Between White Matter Hyperintensity Burden, Cerebral Blood Flow and Transit Time in Small Vessel Disease: An Updated Meta-Analysis

Auteurs: Catriona R Stewart , Michael S Stringer, Yulu Shi , Michael J Thrippleton, Joanna M Wardlaw
Publié dans: Front Neurol, 2021, ISSN 1662-453X
Éditeur: Frontiers
DOI: 10.3389/fneur.2021.647848

Circadian control of brain glymphatic and lymphatic fluid flow.

Auteurs: Hablitz LM, Plá V, Giannetto M, Vinitsky HS, Stæger FF, Metcalfe T, Nguyen R, Benrais A, Nedergaard M
Publié dans: Nature communications, 2020, ISSN 2041-1723
Éditeur: Nature Publishing Group
DOI: 10.1038/s41467-020-18115-2

Genetically Predicted Blood Pressure Across the Lifespan: Differential Effects of Mean and Pulse Pressure on Stroke Risk

Auteurs: Georgakis MK, Gill D, Malik R, Protogerou AD, Webb AJS, Dichgans M
Publié dans: Hypertension, Numéro 76(3), 2020, Page(s) 953-961, ISSN 1524-4563
Éditeur: American Heart Association
DOI: 10.1161/hypertensionaha.120.15136

Sources of systematic error in DCE-MRI estimation of low-level blood-brain barrier leakage

Auteurs: Cameron Manning,Michael Stringer,Ben Dickie,Una Clancy,Maria C. Valdés Hernandez,Stewart J. Wiseman,Daniela Jaime Garcia,Eleni Sakka,Walter H. Backes,Michael Ingrisch,Francesca Chappell,Fergus Doubal,Craig Buckley,Laura M. Parkes,Geoff J. M. Parker,Ian Marshall,Joanna M. Wardlaw,Michael J. Thrippleton
Publié dans: Magnetic Resonance in Medicine, 2021, ISSN 1522-2594
Éditeur: Wiley
DOI: 10.1002/mrm.28833

ATP- and voltage-dependent electro-metabolic signaling regulates blood flow in heart

Auteurs: Guiling Zhao, Humberto C. Joca, Mark T. Nelson, W. Jonathan Lederer
Publié dans: Proceedings of the National Academy of Sciences, Numéro 117/13, 2020, Page(s) 7461-7470, ISSN 0027-8424
Éditeur: National Academy of Sciences
DOI: 10.1073/pnas.1922095117

Zooming in on cerebral small vessel function in small vessel diseases with 7T MRI: Rationale and design of the “ZOOM@SVDs ”study

Auteurs: Hilde van den Brink a , Anna Kopczak b , Tine Arts c , Laurien Onkenhout a , Jeroen C.W. Siero c , d , Jaco J.M. Zwanenburg c , Marco Duering b , e , f , Gordon W. Blair g , Fergus N.Doubal g , Michael S. Stringer g , Michael J. Thrippleton g , Hugo J. Kuijf h , Alberto de Luca a , g , Jeroen Hendrikse c , Joanna M. Wardlaw g , Martin Dichgans b , e , f , Geert Jan Biessels a , ∗ , on behalf of
Publié dans: Cerebral Circulation - Cognition and Behavior, 2021, ISSN 2666-2450
Éditeur: Elseveir
DOI: 10.1016/j.cccb.2021.100013

Cardiac Risk Factors for Stroke: A Comprehensive Mendelian Randomization Study

Auteurs: Frerich S, Malik R, Georgakis MK, Sinner MF, Kittner SJ, Mitchell BD, Dichgans M.
Publié dans: Stroke, 2021, ISSN 0039-2499
Éditeur: Lippincott Williams & Wilkins Ltd.
DOI: 10.1161/strokeaha.121.036306

Zinc drives vasorelaxation by acting on sensory nerves, endothelium and smooth muscle

Auteurs: Betrie AH, Brock JA, Harraz OF, Bush AI, He G-W, Nelson MT, Angus JA, Wright CE, Ayton S
Publié dans: Nat Commun, 2021, ISSN 2041-1723
Éditeur: Nature Publishing Group
DOI: 10.1038/s41467-021-23198-6

Early life predictors of late life cerebral small vessel disease in four prospective cohort studies.

Auteurs: Backhouse EV, Shenkin SD, McIntosh AM, Bastin ME, Whalley HC, Valdez Hernandez M, Muñoz Maniega S, Harris MA, Stolicyn A, Campbell A, Steele D, Waiter GD, Sandu AL, Waymont JMJ, Murray AD, Cox SR, de Rooij SR, Roseboom TJ, Wardlaw JM.
Publié dans: Brain, Numéro 2021 Sep 28:awab331, 2021, ISSN 0006-8950
Éditeur: Oxford University Press
DOI: 10.1093/brain/awab331

Cognitive impairment in sporadic cerebral small vessel disease: A systematic review and meta-analysis.

Auteurs: Hamilton OKL, Backhouse EV, Janssen E, Jochems ACC, Maher C, Ritakari TE, Stevenson AJ, Xia L, Deary IJ, Wardlaw JM
Publié dans: Alzheimer's & dementia : the journal of the Alzheimer's Association, 2020, ISSN 1552-5279
Éditeur: Alzheimer’s Association
DOI: 10.1002/alz.12221

Blood-brain barrier leakage at baseline and cognitive decline in cerebral small vessel disease: a 2-year follow-up study.

Auteurs: Kerkhofs D, Wong SM, Zhang E, Uiterwijk R, Hoff EI, Jansen JFA, Staals J, Backes WH, van Oostenbrugge RJ
Publié dans: Geroscience, 2021, ISSN 2509-2715
Éditeur: Springer
DOI: 10.1007/s11357-021-00399-x

Cerebral small vessel disease burden and longitudinal cognitive decline from age 73 to 82: the Lothian Birth Cohort 1936.

Auteurs: Hamilton OKL, Cox SR, Okely JA, Conte F, Ballerini L, Bastin ME, Corley J, Taylor AM, Page D, Gow AJ, Muñoz Maniega S, Redmond P, Valdés-Hernández MDC, Wardlaw JM, Deary IJ.
Publié dans: Transl Psychiatry., 2021, ISSN 2158-3188
Éditeur: Nature Publishing Group
DOI: 10.1038/s41398-021-01495-4

Sex differences in cerebral small vessel disease: a systematic review and meta-analysis.

Auteurs: Jiménez-Sánchez L, Hamilton OJ, Clancy U, Backhouse E, Stewart CR, Stringer MS, Doubal FN, Wardlaw JM
Publié dans: Front Neurol, 2021, ISSN 1662-453X
Éditeur: Frontiers
DOI: 10.3389/fneur.2021.756887

PIP2 corrects cerebral blood flow deficits in small vessel disease by rescuing capillary Kir2.1 activity

Auteurs: Dabertrand F, Harraz OF, Koide M, Longden TA, Rosehart AC, Hill-Eubanks DC, Joutel A, Nelson MT
Publié dans: PNAS, 2021, ISSN 1091-6490
Éditeur: PNAS
DOI: 10.1073/pnas.2025998118

Improving Clinical Detection of Acute Lacunar Stroke

Auteurs: Arba F, Mair G, Phillips S, Sandercock P, Wardlaw JM
Publié dans: Stroke, 2021, ISSN 0039-2499
Éditeur: Lippincott Williams & Wilkins Ltd.
DOI: 10.1161/strokeaha.119.028402

Imaging NeuroVascular, Endothelial and STructural Integrity in prepAration to TrEat Small Vessel Diseases. The INVESTIGATE-SVDs study Protocol. Part of the SVDs@Target Project

Auteurs: Blair GW, Stringer MS, Thrippleton MJ, Chappell FM, Shuler K, Hamilton I, Garcia DJ, Doubal FN, Kopczak A, Duering M, Ingrisch M, Kerkhofs D, Staals J, van den Brink H, Arts T, Backes W,.
Publié dans: Cereb Circ Cogn Behav, 2021, ISSN 2666-2450
Éditeur: Elsevier
DOI: 10.1016/j.cccb.2021.100020

The striatum, the hippocampus, and short-term memory binding: Volumetric analysis of the subcortical grey matter's role in mild cognitive impairment

Auteurs: Maria C. Valdés Hernández, Rupert Clark, Szu-Han Wang, Federica Guazzo, Clara Calia, Vivek Pattan, John Starr, Sergio Della Sala, Mario Alfredo Parra
Publié dans: NeuroImage: Clinical, Numéro 25, 2020, Page(s) 102158, ISSN 2213-1582
Éditeur: Elsevier BV
DOI: 10.1016/j.nicl.2019.102158

Mendelian randomization for studying the effects of perturbing drug targets

Auteurs: Gill. D. et. al
Publié dans: Wellcome Open Research, Numéro 10;6:16, 2021, Page(s) 10;6:16, ISSN 2398-502X
Éditeur: F1000Research
DOI: 10.12688/wellcomeopenres.16544.2

Identification of plasma proteins relating to brain neurodegeneration and vascular pathology in cognitively normal individuals.

Auteurs: Shi L, Buchanan CR, Cox SR, Hillary RF, Marioni RE, Campbell A, Hayward C, Stolicyn A, Whalley HC, Harris MA, Waymont J, Waiter G, Backhouse E, Wardlaw JM, Steele D, Mcintosh A, Lovestone S, Buckley NJ, Nevado-Holgado AJ.
Publié dans: Alzheimers Dement, 2021, ISSN 1552-5279
Éditeur: Alzheimer’s Association
DOI: 10.1002/dad2.12240

Cerebral Vascular Dysfunctions Detected in Human Small Vessel Disease and Implications for Preclinical Studies.

Auteurs: Wardlaw JM, Benveniste H, Williams A.
Publié dans: Annu Rev Physiol, 2021, ISSN 1545-1585
Éditeur: Annual Reviews
DOI: 10.1146/annurev-physiol-060821-014521

Biological sex does not predict glymphatic influx in healthy young, middle aged or old mice.

Auteurs: Giannetto M, Xia M, Stæger FF, Metcalfe T, Vinitsky HS, Dang JAML, Xavier ALR, Kress BT, Nedergaard M, Hablitz LM
Publié dans: Nature, 2020, ISSN 2041-1723
Éditeur: Nature Publishing Group
DOI: 10.1038/s41598-020-72621-3

A Comparison of CVR Magnitude and Delay Assessed at 1.5 and 3T in Patients With Cerebral Small Vessel Disease.

Auteurs: Stringer MS, Blair GW, Shi Y, Hamilton I, Dickie DA, Doubal FN, Marshall IM, Thrippleton MJ, Wardlaw JM.
Publié dans: Front Physiol., 2021, ISSN 1664-042X
Éditeur: Frontiers Research Foundation
DOI: 10.3389/fphys.2021.644837

Contractile pericytes determine the direction of blood flow at capillary junctions

Auteurs: Gonzales AL, Klug NR, Moshkforoush A, Lee JC, Lee FK, Shui B, Tsoukias NM, Kotlikoff MI, Hill-Eubanks D, Nelson MT
Publié dans: PNAS, 2021, ISSN 1091-6490
Éditeur: PNAS
DOI: 10.1073/pnas.1922755117

Diagnosing vascular cognitive impairment: Current challenges and future perspectives

Auteurs: J Matthijs Biesbroek, Geert Jan Biessels
Publié dans: International Journal of Stroke, 2021, ISSN 0271-678X
Éditeur: Lippincott Williams & Wilkins Ltd.
DOI: 10.1177/17474930211073387

Midlife vascular risk factors and risk of incident dementia: Longitudinal cohort and Mendelian randomization analyses in the UK Biobank

Auteurs: Malik, Rainer; Georgakis, Marios K.; Neitzel, Julia; Rannikmäe, Kristiina; Ewers, Michael; Seshadri, Sudha; Sudlow, Cathie L.M.; Dichgans, Martin
Publié dans: Alzheimers Dement, Numéro 17(9), 2021, Page(s) 1422-1431, ISSN 1552-5279
Éditeur: Alzheimer's Association
DOI: 10.1002/alz.12320

Arterial CO2 pressure changes during hypercapnia are associated with changes in brain parenchymal volume

Auteurs: Lisa A. van der Kleij, Jill B. De Vis, Jeroen de Bresser, Jeroen Hendrikse, Jeroen C. W. Siero
Publié dans: European Radiology Experimental, Numéro 4/1, 2020, ISSN 2509-9280
Éditeur: Springer Nature
DOI: 10.1186/s41747-020-0144-z

Cerebral Amyloid Angiopathy: Still a Syndromal Diagnosis.

Auteurs: Biessels GJ
Publié dans: Stroke, 2020, ISSN 0039-2499
Éditeur: Lippincott Williams & Wilkins Ltd.
DOI: 10.1161/strokeaha.120.032703

Strain Tensor Imaging: Cardiac-induced brain tissue deformation in humans quantified with high-field MRI

Auteurs: Jacob-JanSloots,Geert JanBiessels,Albertode Luca, Jaco J.M.Zwanenburg
Publié dans: NeuroImage, 2021, ISSN 1053-8119
Éditeur: Academic Press
DOI: 10.1016/j.neuroimage.2021.118078

Brain network reorganisation and spatiallesion distribution in systemic lupuserythematosus

Auteurs: Valdés Hernández MDC, Smith K, Bastin ME, Nicole Amft E, Ralston SH, Wardlaw JM, Wiseman SJ
Publié dans: Lupus, 2021, ISSN 2158-2440
Éditeur: SAGE Publications Inc.
DOI: 10.1177/0961203320979045

Cognitive ability, education and socioeconomic status in childhood and risk of post-stroke depression in later life: A systematic review and meta-analysis

Auteurs: Ellen V. Backhouse, Caroline A. McHutchison, Vera Cvoro, Susan D. Shenkin, Joanna M. Wardlaw
Publié dans: PLOS ONE, Numéro 13/7, 2018, Page(s) e0200525, ISSN 1932-6203
Éditeur: Public Library of Science
DOI: 10.1371/journal.pone.0200525

Prognostic Significance of Blood Pressure Variability on Beat-to-Beat Monitoring After Transient Ischemic Attack and Stroke

Auteurs: Alastair J.S. Webb, Sara Mazzucco, Linxin Li, Peter M. Rothwell
Publié dans: Stroke, Numéro 49/1, 2018, Page(s) 62-67, ISSN 0039-2499
Éditeur: Lippincott Williams & Wilkins Ltd.
DOI: 10.1161/STROKEAHA.117.019107

Time course of blood pressure control prior to lacunar TIA and stroke

Auteurs: Linxin Li, Sarah J.V. Welch, Sergei A. Gutnikov, Ziyah Mehta, Peter M. Rothwell
Publié dans: Neurology, Numéro 90/20, 2018, Page(s) e1732-e1741, ISSN 0028-3878
Éditeur: Lippincott Williams & Wilkins Ltd.
DOI: 10.1212/WNL.0000000000005526

Antiplatelet Treatment After Transient Ischemic Attack and Ischemic Stroke in Patients With Cerebral Microbleeds in 2 Large Cohorts and an Updated Systematic Review

Auteurs: Kui Kai Lau, Caroline E. Lovelock, Linxin Li, Michela Simoni, Sergei Gutnikov, Wilhelm Küker, Henry Ka Fung Mak, Peter M. Rothwell
Publié dans: Stroke, Numéro 49/6, 2018, Page(s) 1434-1442, ISSN 0039-2499
Éditeur: Lippincott Williams & Wilkins Ltd.
DOI: 10.1161/STROKEAHA.117.020104

Long-Term Morphological Changes of Symptomatic Lacunar Infarcts and Surrounding White Matter on Structural Magnetic Resonance Imaging

Auteurs: Caroline M.J. Loos, Stephen D.J. Makin, Julie Staals, Martin S. Dennis, Robert J. van Oostenbrugge, Joanna M. Wardlaw
Publié dans: Stroke, Numéro 49/5, 2018, Page(s) 1183-1188, ISSN 0039-2499
Éditeur: Lippincott Williams & Wilkins Ltd.
DOI: 10.1161/STROKEAHA.117.020495

Vascular reactivity in small cerebral perforating arteries with 7 T phase contrast MRI – A proof of concept study

Auteurs: Lennart J. Geurts, Alex A. Bhogal, Jeroen C.W. Siero, Peter R. Luijten, Geert Jan Biessels, Jaco J.M. Zwanenburg
Publié dans: NeuroImage, Numéro 172, 2018, Page(s) 470-477, ISSN 1053-8119
Éditeur: Academic Press
DOI: 10.1016/j.neuroimage.2018.01.055

The effect of different combinations of vascular, dependency and cognitive endpoints on the sample size required to detect a treatment effect in trials of treatments to improve outcome after lacunar and non-lacunar ischaemic stroke

Auteurs: Stephen DJ Makin, Fergus N Doubal, Terence J Quinn, Philip MW Bath, Martin S Dennis, Joanna M Wardlaw
Publié dans: European Stroke Journal, Numéro 3/1, 2017, Page(s) 66-73, ISSN 2396-9873
Éditeur: SAGE Journals
DOI: 10.1177/2396987317728854

Age-Specific Associations of Renal Impairment With Magnetic Resonance Imaging Markers of Cerebral Small Vessel Disease in Transient Ischemic Attack and Stroke

Auteurs: Bian Liu, Kui Kai Lau, Linxin Li, Caroline Lovelock, Ming Liu, Wilhelm Kuker, Peter M. Rothwell
Publié dans: Stroke, Numéro 49/4, 2018, Page(s) 899-904, ISSN 0039-2499
Éditeur: Lippincott Williams & Wilkins Ltd.
DOI: 10.1161/STROKEAHA.117.019650

Functional, cognitive and physical outcomes 3 years after minor lacunar or cortical ischaemic stroke

Auteurs: Caroline A McHutchison, Vera Cvoro, Stephen Makin, Francesca M Chappell, Kirsten Shuler, Joanna M Wardlaw
Publié dans: Journal of Neurology, Neurosurgery & Psychiatry, Numéro 436-443, 2018, Page(s) jnnp-2018-319134, ISSN 0022-3050
Éditeur: BMJ Publishing Group
DOI: 10.1136/jnnp-2018-319134

Small vessel disease is associated with altered cerebrovascular pulsatility but not resting cerebral blood flow

Auteurs: Yulu Shi, Michael J Thrippleton, Gordon W Blair, David A Dickie, Ian Marshall, Iona Hamilton, Fergus N Doubal, Francesca Chappell, Joanna M Wardlaw
Publié dans: Journal of Cerebral Blood Flow & Metabolism, 2018, Page(s) 0271678X1880395, ISSN 0271-678X
Éditeur: Lippincott Williams & Wilkins Ltd.
DOI: 10.1177/0271678x18803956

Genetic and lifestyle risk factors for MRI-defined brain infarcts in a population-based setting

Auteurs: Ganesh Chauhan, Hieab H.H. Adams, Claudia L. Satizabal, Joshua C. Bis, Alexander Teumer, Muralidharan Sargurupremraj, Edith Hofer, Stella Trompet, Saima Hilal, Albert Vernon Smith, Xueqiu Jian, Rainer Malik, Matthew Traylor, Sara L. Pulit, Philippe Amouyel, Bernard Mazoyer, Yi-Cheng Zhu, Sara Kaffashian, Sabrina Schilling, Gary W. Beecham, Thomas J. Montine, Gerard D. Schellenberg, Olafur Kjartans
Publié dans: Neurology, Numéro 92/5, 2019, Page(s) e486-e503, ISSN 0028-3878
Éditeur: Lippincott Williams & Wilkins Ltd.
DOI: 10.1212/wnl.0000000000006851

MRI measurement of blood-brain barrier leakage: minding the gaps

Auteurs: Michael Jonathan Thrippleton
Publié dans: The Journal of Physiology, Numéro 597/3, 2019, Page(s) 667-668, ISSN 0022-3751
Éditeur: Blackwell Publishing Inc.
DOI: 10.1113/jp277425

Intracranial pulsatility in patients with cerebral small vessel disease: a systematic review

Auteurs: Yulu Shi, Michael J. Thrippleton, Ian Marshall, Joanna M. Wardlaw
Publié dans: Clinical Science, Numéro 132/1, 2018, Page(s) 157-171, ISSN 0143-5221
Éditeur: Portland Press, Ltd.
DOI: 10.1042/cs20171280

Cerebrovascular reactivity measurement in cerebral small vessel disease: Rationale and reproducibility of a protocol for MRI acquisition and image processing

Auteurs: Michael J Thrippleton, Yulu Shi, Gordon Blair, Iona Hamilton, Gordon Waiter, Christian Schwarzbauer, Cyril Pernet, Peter JD Andrews, Ian Marshall, Fergus Doubal, Joanna M Wardlaw
Publié dans: International Journal of Stroke, Numéro 13/2, 2017, Page(s) 195-206, ISSN 1747-4930
Éditeur: Blackwell
DOI: 10.1177/1747493017730740

A protocol for precise comparisons of small vessel disease lesions between ex vivo magnetic resonance imaging and histopathology

Auteurs: Catherine A Humphreys, Maurits A Jansen, Susana Muñoz Maniega, Víctor González-Castro, Cyril Pernet, Ian J Deary, Rustam Al-Shahi Salman, Joanna M Wardlaw, Colin Smith
Publié dans: International Journal of Stroke, 2018, Page(s) 174749301879996, ISSN 1747-4930
Éditeur: Blackwell
DOI: 10.1177/1747493018799962

Age and sex-specific associations of carotid pulsatility with small vessel disease burden in transient ischemic attack and ischemic stroke

Auteurs: Kui Kai Lau, Petra Pego, Sara Mazzucco, Linxin Li, Dominic PJ Howard, Wilhelm Küker, Peter M Rothwell
Publié dans: International Journal of Stroke, Numéro 13/8, 2018, Page(s) 832-839, ISSN 1747-4930
Éditeur: Blackwell
DOI: 10.1177/1747493018784448

Long-Term Premorbid Blood Pressure and Cerebral Small Vessel Disease Burden on Imaging in Transient Ischemic Attack and Ischemic Stroke

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MRI Relaxometry for Quantitative Analysis of USPIO Uptake in Cerebral Small Vessel Disease

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Higher Pulsatility in Cerebral Perforating Arteries in Patients With Small Vessel Disease Related Stroke, a 7T MRI Study

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The Glymphatic System in Central Nervous System Health and Disease: Past, Present, and Future

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Perivascular spaces and their associations with risk factors, clinical disorders and neuroimaging features: A systematic review and meta-analysis

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Preventing cognitive decline and dementia from cerebral small vessel disease: The LACI-1 Trial. Protocol and statistical analysis plan of a phase IIa dose escalation trial testing tolerability, safety and effect on intermediary endpoints of isosorbide mononitrate and cilostazol, separately and in combination

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Machine learning of neuroimaging for assisted diagnosis of cognitive impairment and dementia: A systematic review

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Considerations on accuracy, pattern and possible underlying factors of brain microbleed progression in older adults with absence or mild presence of vascular pathology

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PIP2 depletion promotes TRPV4 channel activity in mouse brain capillary endothelial cells

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The relation between total cerebral small vessel disease burden and gait impairment in patients with minor stroke

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Hypertensive organ damage predicts future cognitive performance: A 9-year follow-up study in patients with hypertension

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Genetically Determined Levels of Circulating Cytokines and Risk of Stroke

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Dementia risk after transient ischaemic attack and stroke

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Role of Non-Coding RNAs in Stroke

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Multiancestry genome-wide association study of 520,000 subjects identifies 32 loci associated with stroke and stroke subtypes

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CADASIL brain vessels show a HTRA1 loss-of-function profile

Auteurs: Andreas Zellner, Eva Scharrer, Thomas Arzberger, Chio Oka, Valérie Domenga-Denier, Anne Joutel, Stefan F. Lichtenthaler, Stephan A. Müller, Martin Dichgans, Christof Haffner
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Serum neurofilament light

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Validation of the Telephone Interview of Cognitive Status and Telephone Montreal Cognitive Assessment Against Detailed Cognitive Testing and Clinical Diagnosis of Mild Cognitive Impairment After Stroke

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Challenges and opportunities in stroke genetics

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COL4A2 is associated with lacunar ischemic stroke and deep ICH

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RNA-Seq Identifies Circulating miR-125a-5p, miR-125b-5p, and miR-143-3p as Potential Biomarkers for Acute Ischemic Stroke

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Smooth muscle cells of intracranial vessels: from development to disease

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Severity of arterial defects in the retina correlates with the burden of intracerebral haemorrhage in COL4A1-related stroke

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Blood–brain barrier leakage in relation to white matter hyperintensity volume and cognition in small vessel disease and normal aging

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Aquaporin 1 and the Na+/K+/2Cl− cotransporter 1 are present in the leptomeningeal vasculature of the adult rodent central nervous system

Auteurs: Qianliang Li, Nadia N. Aalling, Benjamin Förstera, Ali Ertürk, Maiken Nedergaard, Kjeld Møllgård, Anna L. R. Xavier
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The brain health index: Towards a combined measure of neurovascular and neurodegenerative structural brain injury

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European Ultrahigh-Field Imaging Network for Neurodegenerative Diseases (EUFIND)

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METACOHORTS for the study of vascular disease and its contribution to cognitive decline and neurodegeneration: An initiative of the Joint Programme for Neurodegenerative Disease Research

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MRI progression of cerebral small vessel disease and cognitive decline in patients with hypertension

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Intracranial hemodynamic relationships in patients with cerebral small vessel disease

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The Brain’s Glymphatic System: Current Controversies

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Intravoxel Incoherent Motion Imaging in Small Vessel Disease

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Pharmacological inhibitors of TRPV4 channels reduce cytokine production, restore endothelial function and increase survival in septic mice

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Focal Solute Trapping and Global Glymphatic Pathway Impairment in a Murine Model of Multiple Microinfarcts

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Vascular disease and neurodegeneration: advancing together

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Vascular Cognitive Impairment

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Capillary K+-sensing initiates retrograde hyperpolarization to increase local cerebral blood flow

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Mechanistic insights into a TIMP3-sensitive pathway constitutively engaged in the regulation of cerebral hemodynamics

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Total Cerebral Small Vessel Disease MRI Score Is Associated with Cognitive Decline in Executive Function in Patients with Hypertension

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White matter hyperintensity reduction and outcomes after minor stroke

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Detection and characterization of small infarcts in the caudate nucleus on 7 Tesla MRI: The SMART-MR study

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Genetic variation at 16q24.2 is associated with small vessel stroke

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Atrial Fibrillation Genetic Risk and Ischemic Stroke Mechanisms

Auteurs: Steven A. Lubitz, Owen E. Parsons, Christopher D. Anderson, Emelia J. Benjamin, Rainer Malik, Lu-Chen Weng, Martin Dichgans, Cathie L. Sudlow, Peter M. Rothwell, Jonathan Rosand, Patrick T. Ellinor, Hugh S. Markus, Matthew Traylor
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In Vivo Imaging of Cerebrospinal Fluid Transport through the Intact Mouse Skull using Fluorescence Macroscopy

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Automated lesion segmentation with BIANCA: Impact of population-level features, classification algorithm and locally adaptive thresholding

Auteurs: Vaanathi Sundaresan, Giovanna Zamboni, Campbell Le Heron, Peter M. Rothwell, Masud Husain, Marco Battaglini, Nicola De Stefano, Mark Jenkinson, Ludovica Griffanti
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Spatial Gradient of Microstructural Changes in Normal-Appearing White Matter in Tracts Affected by White Matter Hyperintensities in Older Age

Auteurs: Susana Muñoz Maniega, Rozanna Meijboom, Francesca M. Chappell, Maria del C. Valdés Hernández, John M. Starr, Mark E. Bastin, Ian J. Deary, Joanna M. Wardlaw
Publié dans: Frontiers in Neurology, Numéro 10, 2019, Page(s) 784, ISSN 1664-2295
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“A Step and a Ceiling”: mechanical properties of Ca 2+ spark vasoregulation in resistance arteries by pressure‐induced oxidative activation of PKG

Auteurs: Viktoria Csato, Sharifah Z. S. A. Kadir, Kaivan Khavandi, Hayley Bennett, Sarah Sugden, Alison M. Gurney, Harry A. T. Pritchard, David Hill‐Eubanks, Philip Eaton, Mark T. Nelson, Adam S. Greenstein
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Predictors of Lesion Cavitation After Recent Small Subcortical Stroke

Auteurs: Thomas Gattringer, Maria Valdes Hernandez, Anna Heye, Paul A Armitage, Stephen Makin, Francesca Chappell, Daniela Pinter, Fergus Doubal, Christian Enzinger, Franz Fazekas, Joanna M. Wardlaw
Publié dans: Translational Stroke Research, Numéro 11/3, 2020, Page(s) 402-411, ISSN 1868-4483
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Uncoupling of Microvascular Blood Flow and Capillary Density in Vascular Cognitive Impairment

Auteurs: Chenxing Eleana Zhang, Julie Staals, Robert Jan van Oostenbrugge, Hans Vink
Publié dans: Frontiers in Neurology, Numéro 10, 2019, ISSN 1664-2295
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The Atherosclerosis Risk Variant rs2107595 Mediates Allele-Specific Transcriptional Regulation of HDAC9 via E2F3 and Rb1

Auteurs: Matthias Prestel, Caroline Prell-Schicker, Tom Webb, Rainer Malik, Barbara Lindner, Natalie Ziesch, Monika Rex-Haffner, Simone Röh, Thanatip Viturawong, Manuel Lehm, Michal Mokry, Hester den Ruijter, Saskia Haitjema, Yaw Asare, Flavia Söllner, Maryam Ghaderi Najafabadi, Rédouane Aherrahrou, Mete Civelek, Nilesh J. Samani, Matthias Mann, Christof Haffner, Martin Dichgans
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A prospective study of serum metabolites and risk of ischemic stroke

Auteurs: Daokun Sun, Steffen Tiedt, Bing Yu, Xueqiu Jian, Rebecca F. Gottesman, Thomas H. Mosley, Eric Boerwinkle, Martin Dichgans, Myriam Fornage
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Prognostic value of “tissue-based” definitions of TIA and minor stroke

Auteurs: Robert Hurford, Linxin Li, Nicola Lovett, Magdalena Kubiak, Wilhelm Kuker, Peter M. Rothwell
Publié dans: Neurology, Numéro 92/21, 2019, Page(s) e2455-e2461, ISSN 0028-3878
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Combining Neurovascular and Neurodegenerative Magnetic Resonance Imaging Measures in Stroke

Auteurs: Annick Wyss, Jesse Dawson, Francesco Arba, Joanna M. Wardlaw, David Alexander Dickie
Publié dans: Stroke, Numéro 50/5, 2019, Page(s) 1136-1139, ISSN 0039-2499
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Stability of Estimated Premorbid Cognitive Ability over Time after Minor Stroke and Its Relationship with Post-Stroke Cognitive Ability

Auteurs: Caroline A. McHutchison, Francesca M. Chappell, Stephen Makin, Kirsten Shuler, Joanna M. Wardlaw, Vera Cvoro
Publié dans: Brain Sciences, Numéro 9/5, 2019, Page(s) 117, ISSN 2076-3425
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Quantifying blood-brain barrier leakage in small vessel disease: Review and consensus recommendations

Auteurs: Michael J. Thrippleton, Walter H. Backes, Steven Sourbron, Michael Ingrisch, Matthias J.P. van Osch, Martin Dichgans, Franz Fazekas, Stefan Ropele, Richard Frayne, Robert J. van Oostenbrugge, Eric E. Smith, Joanna M. Wardlaw
Publié dans: Alzheimer's & Dementia, Numéro 15/6, 2019, Page(s) 840-858, ISSN 1552-5260
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Perivascular spaces in the centrum semiovale at the beginning of the 8th decade of life: effect on cognition and associations with mineral deposition

Auteurs: Maria del C. Valdés Hernández, Lucia Ballerini, Andreas Glatz, Susana Muñoz Maniega, Alan J. Gow, Mark E. Bastin, John M. Starr, Ian J. Deary, Joanna M. Wardlaw
Publié dans: Brain Imaging and Behavior, Numéro 27-June 2019, 2019, ISSN 1931-7557
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Astrocytic connexin 43 potentiates myelin injury in ischemic white matter disease

Auteurs: Minghuan Wang, Chuan Qin, Xiang Luo, Jie Wang, Xuxia Wang, Minjie Xie, Jing Hu, Jie Cao, Ting Hu, Steven A. Goldman, Maiken Nedergaard, Wei Wang
Publié dans: Theranostics, Numéro 9/15, 2019, Page(s) 4474-4493, ISSN 1838-7640
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Use of Genetic Variants Related to Antihypertensive Drugs to Inform on Efficacy and Side Effects

Auteurs: Dipender Gill, Marios K. Georgakis, Fotios Koskeridis, Lan Jiang, Qiping Feng, Wei-Qi Wei, Evropi Theodoratou, Paul Elliott, Joshua C. Denny, Rainer Malik, Evangelos Evangelou, Abbas Dehghan, Martin Dichgans, Ioanna Tzoulaki
Publié dans: Circulation, Numéro 140/4, 2019, Page(s) 270-279, ISSN 0009-7322
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Tolerability, safety and intermediary pharmacological effects of cilostazol and isosorbide mononitrate, alone and combined, in patients with lacunar ischaemic stroke: The LACunar Intervention-1 (LACI-1) trial, a randomised clinical trial

Auteurs: Gordon W. Blair, Jason P. Appleton, Katie Flaherty, Fergus Doubal, Nikola Sprigg, Richard Dooley, Carla Richardson, Iona Hamilton, Zhe Kang Law, Yulu Shi, Michael S. Stringer, Michael J. Thrippleton, Julia Boyd, Kirsten Shuler, Philip M. Bath, Joanna M. Wardlaw
Publié dans: EClinicalMedicine, Numéro 11, 2019, Page(s) 34-43, ISSN 2589-5370
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Effects of Isosorbide Mononitrate and/or Cilostazol on Hematological Markers, Platelet Function, and Hemodynamics in Patients With Lacunar Ischaemic Stroke: Safety Data From the Lacunar Intervention-1 (LACI-1) Trial

Auteurs: Jason P. Appleton, Gordon W. Blair, Katie Flaherty, Zhe Kang Law, Jane May, Lisa J. Woodhouse, Fergus Doubal, Nikola Sprigg, Philip M. Bath, Joanna M. Wardlaw
Publié dans: Frontiers in Neurology, Numéro 10, 2019, Page(s) 723, ISSN 1664-2295
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Vascular Cognitive Impairment and Dementia

Auteurs: Costantino Iadecola, Marco Duering, Vladimir Hachinski, Anne Joutel, Sarah T. Pendlebury, Julie A. Schneider, Martin Dichgans
Publié dans: Journal of the American College of Cardiology, Numéro 73/25, 2019, Page(s) 3326-3344, ISSN 0735-1097
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Impaired Glymphatic Transport in Spontaneously Hypertensive Rats

Auteurs: Kristian Nygaard Mortensen, Simon Sanggaard, Humberto Mestre, Hedok Lee, Serhii Kostrikov, Anna L.R. Xavier, Albert Gjedde, Helene Benveniste, Maiken Nedergaard
Publié dans: The Journal of Neuroscience, Numéro 39/32, 2019, Page(s) 6365-6377, ISSN 0270-6474
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Vascular contributions to cognitive impairment and dementia: Research consortia that focus on etiology and treatable targets to lessen the burden of dementia worldwide

Auteurs: Jordan T. Gladman, Roderick A. Corriveau, Stephanie Debette, Martin Dichgans, Steven M. Greenberg, Perminder S. Sachdev, Joanna M. Wardlaw, Geert Jan Biessels
Publié dans: Alzheimer's & Dementia: Translational Research & Clinical Interventions, Numéro 5/1, 2019, Page(s) 789-796, ISSN 2352-8737
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Genomic risk score offers predictive performance comparable to clinical risk factors for ischaemic stroke

Auteurs: Gad Abraham, Rainer Malik, Ekaterina Yonova-Doing, Agus Salim, Tingting Wang, John Danesh, Adam S. Butterworth, Joanna M. M. Howson, Michael Inouye, Martin Dichgans
Publié dans: Nature Communications, Numéro 10/1, 2019, Page(s) 1-10, ISSN 2041-1723
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Sleep and brain morphological changes in the eighth decade of life

Auteurs: Benjamin S. Aribisala, Renata L. Riha, Maria Valdes Hernandez, Susana Muñoz Maniega, Simon Cox, Ratko Radakovic, Adele Taylor, Alison Pattie, Janie Corley, Paul Redmond, Mark E. Bastin, John Starr, Ian Deary, Joanna M. Wardlaw
Publié dans: Sleep Medicine, Numéro 65, 2020, Page(s) 152-158, ISSN 1389-9457
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Confounding of Cerebral Blood Flow Velocity by Blood Pressure During Breath Holding or Hyperventilation in Transient Ischemic Attack or Stroke

Auteurs: Alastair J.S. Webb, Matteo Paolucci, Sara Mazzucco, Linxin Li, Peter M. Rothwell
Publié dans: Stroke, Numéro 51/2, 2020, Page(s) 468-474, ISSN 0039-2499
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Analysis of dynamic texture and spatial spectral descriptors of dynamic contrast-enhanced brain magnetic resonance images for studying small vessel disease

Auteurs: Jose Bernal, Maria del C. Valdés-Hernández, Javier Escudero, Linda Viksne, Anna K. Heye, Paul A. Armitage, Stephen Makin, Rhian M. Touyz, Joanna M. Wardlaw
Publié dans: Magnetic Resonance Imaging, Numéro 66, 2020, Page(s) 240-247, ISSN 0730-725X
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Reducing Hypermuscularization of the Transitional Segment Between Arterioles and Capillaries Protects Against Spontaneous Intracerebral Hemorrhage

Auteurs: Julien Ratelade, Nicholas R. Klug, Damiano Lombardi, Monara Kaelle Servulo Cruz Angelim, Fabrice Dabertrand, Valérie Domenga-Denier, Rustam Al-Shahi Salman, Colin Smith, Jean-Frédéric Gerbeau, Mark T. Nelson, Anne Joutel
Publié dans: Circulation, Numéro 141/25, 2020, Page(s) 2078-2094, ISSN 0009-7322
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Spectral Diffusion Analysis of Intravoxel Incoherent Motion MRI in Cerebral Small Vessel Disease

Auteurs: Sau May Wong, Walter H. Backes, Gerhard S. Drenthen, C. Eleana Zhang, Paulien H.M. Voorter, Julie Staals, Robert J. Oostenbrugge, Jacobus F.A. Jansen
Publié dans: Journal of Magnetic Resonance Imaging, Numéro 51/4, 2019, Page(s) 1170-1180, ISSN 1053-1807
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Cardiac and respiration-induced brain deformations in humans quantified with high-field MRI

Auteurs: Jacob Jan Sloots, Geert Jan Biessels, Jaco J.M. Zwanenburg
Publié dans: NeuroImage, Numéro 210, 2020, Page(s) 116581, ISSN 1053-8119
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Association between Striatal Brain Iron Deposition, Microbleeds and Cognition 1 Year After a Minor Ischaemic Stroke

Auteurs: Maria Valdés Hernández, Tessa Case, Francesca Chappell, Andreas Glatz, Stephen Makin, Fergus Doubal, Joanna Wardlaw
Publié dans: International Journal of Molecular Sciences, Numéro 20/6, 2019, Page(s) 1293, ISSN 1422-0067
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WMH and long-term outcomes in ischemic stroke

Auteurs: Marios K. Georgakis, Marco Duering, Joanna M. Wardlaw, Martin Dichgans
Publié dans: Neurology, Numéro 92/12, 2019, Page(s) e1298-e1308, ISSN 0028-3878
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Computational quantification of brain perivascular space morphologies: Associations with vascular risk factors and white matter hyperintensities. A study in the Lothian Birth Cohort 1936

Auteurs: Lucia Ballerini, Tom Booth, Maria del C. Valdés Hernández, Stewart Wiseman, Ruggiero Lovreglio, Susana Muñoz Maniega, Zoe Morris, Alison Pattie, Janie Corley, Alan Gow, Mark E. Bastin, Ian J. Deary, Joanna Wardlaw
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Imaging markers of small vessel disease and brain frailty, and outcomes in acute stroke

Auteurs: Jason P. Appleton, Lisa J. Woodhouse, Alessandro Adami, Jennifer L. Becker, Eivind Berge, Lesley A. Cala, Ana M. Casado, Valeria Caso, Hanne K. Christensen, Robert A. Dineen, John Gommans, Panos Koumellis, Szabolcs Szatmari, Nikola Sprigg, Philip M. Bath, Joanna M. Wardlaw
Publié dans: Neurology, Numéro 94/5, 2020, Page(s) e439-e452, ISSN 0028-3878
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Protocol: The Lacunar Intervention Trial 2 (LACI-2). A trial of two repurposed licenced drugs to prevent progression of cerebral small vessel disease

Auteurs: Joanna Wardlaw, Philip M W Bath, Fergus Doubal, Anna Heye, Nikola Sprigg, Lisa J Woodhouse, Gordon Blair, Jason Appleton, Vera Cvoro, Timothy England, Ahamad Hassan, David John Werring, Alan Montgomery
Publié dans: European Stroke Journal, Numéro April 2020, 2020, Page(s) 239698732092011, ISSN 2396-9873
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Automatic spatial estimation of white matter hyperintensities evolution in brain MRI using disease evolution predictor deep neural networks

Auteurs: Muhammad Febrian Rachmadi, Maria del C. Valdés-Hernández, Stephen Makin, Joanna Wardlaw, Taku Komura
Publié dans: Medical Image Analysis, Numéro 63, 2020, Page(s) 101712, ISSN 1361-8415
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Relationship Between Venules and Perivascular Spaces in Sporadic Small Vessel Diseases

Auteurs: Angela C.C. Jochems, Gordon W. Blair, Michael S. Stringer, Michael J. Thrippleton, Una Clancy, Francesca M. Chappell, Rosalind Brown, Daniela Jaime Garcia, Olivia K.L. Hamilton, Alasdair G. Morgan, Ian Marshall, Kirstie Hetherington, Stewart Wiseman, Tom MacGillivray, Maria C. Valdés-Hernández, Fergus N. Doubal, Joanna M. Wardlaw
Publié dans: Stroke, Numéro 51/5, 2020, Page(s) 1503-1506, ISSN 0039-2499
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Examining the Relationship between Semiquantitative Methods Analysing Concentration-Time and Enhancement-Time Curves from Dynamic-Contrast Enhanced Magnetic Resonance Imaging and Cerebrovascular Dysfunction in Small Vessel Disease

Auteurs: Jose Bernal, María Valdés-Hernández, Javier Escudero, Eleni Sakka, Paul A. Armitage, Stephen Makin, Rhian M. Touyz, Joanna M. Wardlaw
Publié dans: Journal of Imaging, Numéro 6/6, 2020, Page(s) 43, ISSN 2313-433X
Éditeur: Multidisciplinary Digital Publishing Institute
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Rationale and design of a longitudinal study of cerebral small vessel diseases, clinical and imaging outcomes in patients presenting with mild ischaemic stroke: Mild Stroke Study 3

Auteurs: Una Clancy, Daniela Jaime Garcia, Michael S Stringer, Michael J Thrippleton, Maria C Valdés-Hernández, Stewart Wiseman, Olivia KL Hamilton, Francesca M Chappell, Rosalind Brown, Gordon W Blair, Will Hewins, Emilie Sleight, Lucia Ballerini, Mark E Bastin, Susana Munoz Maniega, Tom MacGillivray, Kirstie Hetherington, Charlene Hamid, Carmen Arteaga, Alasdair G Morgan, Cameron Manning, Ellen Backhou
Publié dans: European Stroke Journal, 2020, Page(s) 239698732092961, ISSN 2396-9873
Éditeur: SAGE Publishing
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Genetic determinants of blood lipids and cerebral small vessel disease: role of high-density lipoprotein cholesterol

Auteurs: Marios K Georgakis, Rainer Malik, Christopher D Anderson, Klaus G Parhofer, Jemma C Hopewell, Martin Dichgans
Publié dans: Brain, Numéro 143/2, 2020, Page(s) 597-610, ISSN 0006-8950
Éditeur: Oxford University Press
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Interleukin-6 Signaling Effects on Ischemic Stroke and Other Cardiovascular Outcomes

Auteurs: Marios K. Georgakis, Rainer Malik, Dipender Gill, Nora Franceschini, Cathie L. M. Sudlow, Martin Dichgans, Sara Lindstrom, Lu Wang, Erin N. Smith, William Gordon, Astrid van Hylckama Vlieg, Mariza de Andrade, Jennifer A. Brody, Jack W. Pattee, Jeffrey Haessler, Ben M. Brumpton, Daniel I. Chasman, Pierre Suchon, Ming-Huei Chen, Constance Turman, Marine Germain, Kerri L. Wiggins, James MacDonald, Si
Publié dans: Circulation: Genomic and Precision Medicine, Numéro 13/3, 2020, Page(s) e002872, ISSN 2574-8300
Éditeur: American Heart Association
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Stroke genetics: discovery, biology, and clinical applications

Auteurs: Martin Dichgans, Sara L Pulit, Jonathan Rosand
Publié dans: The Lancet Neurology, Numéro 18/6, 2019, Page(s) 587-599, ISSN 1474-4422
Éditeur: The Lancet Publishing Group
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Prognostic relevance of cortical superficial siderosis in cerebral amyloid angiopathy

Auteurs: Frank Arne Wollenweber, Christian Opherk, Marialuisa Zedde, Cihan Catak, Rainer Malik, Marco Duering, Marek Janusz Konieczny, Rosario Pascarella, Raquel Samões, Manuel Correia, Joan Martí-Fàbregas, Jennifer Linn, Martin Dichgans
Publié dans: Neurology, Numéro 92/8, 2019, Page(s) e792-e801, ISSN 0028-3878
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Preventing dementia by preventing stroke: The Berlin Manifesto

Auteurs: Vladimir Hachinski, Karl Einhäupl, Detlev Ganten, Suvarna Alladi, Carol Brayne, Blossom C.M. Stephan, Melanie D. Sweeney, Berislav Zlokovic, Yasser Iturria-Medina, Costantino Iadecola, Nozomi Nishimura, Chris B. Schaffer, Shawn N. Whitehead, Sandra E. Black, Leif Østergaard, Joanna Wardlaw, Steven Greenberg, Leif Friberg, Bo Norrving, Brian Rowe, Yves Joanette, Werner Hacke, Lewis Kuller, Martin
Publié dans: Alzheimer's & Dementia, Numéro 15/7, 2019, Page(s) 961-984, ISSN 1552-5260
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Vessel-Associated Immune Cells in Cerebrovascular Diseases: From Perivascular Macrophages to Vessel-Associated Microglia

Auteurs: Takashi Koizumi, Danielle Kerkhofs, Toshiki Mizuno, Harry W. M. Steinbusch, Sébastien Foulquier
Publié dans: Frontiers in Neuroscience, Numéro 13, 2019, Page(s) 1291, ISSN 1662-453X
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Circulating Monocyte Chemoattractant Protein-1 and Risk of Stroke

Auteurs: Marios K. Georgakis, Rainer Malik, Harry Björkbacka, Tiberiu Alexandru Pana, Serkalem Demissie, Colby Ayers, Mohamed A. Elhadad, Myriam Fornage, Alexa S. Beiser, Emelia J. Benjamin, S. Matthijs Boekholdt, Gunnar Engström, Christian Herder, Ron C. Hoogeveen, Wolfgang Koenig, Olle Melander, Marju Orho-Melander, Alexandru Schiopu, Martin Söderholm, Nick Wareham, Christie M. Ballantyne, Annette Pet
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Genetically Downregulated Interleukin-6 Signaling Is Associated With a Favorable Cardiometabolic Profile

Auteurs: Georgakis MK, Malik R, Li X, Gill D, Levin MG, Vy HMT, Judy R, Ritchie M, Verma SS; Regeneron Genetics Center, Nadkarni GN, Damrauer SM, Theodoratou E, Dichgans M
Publié dans: Circulation, Numéro 143(11), 2021, Page(s) 1177-1180, ISSN 0009-7322
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Cognitive impairment in sporadic cerebral small vessel disease: A systematic review and meta-analysis

Auteurs: Hamilton O KL, Blackhouse EV, Janssen E, Jochems A, Maher C, Ritakari TE, Stevenson AJ, Xia L, Deary IA, Wardlaw JM.
Publié dans: Alzheimers Dement, 2021, ISSN 1552-5279
Éditeur: Alzheimer’s Association
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Pharmacological depletion of microglia and perivascular macrophages prevents vascular Cognitive Impairment in Ang II-induced Hypertension

Auteurs: Danielle Kerkhofs, Britt T. van Hagen, Irina V. Milanova, Kimberly J. Schell, Helma van Essen, Erwin Wijnands, Pieter Goossens, W. Matthijs Blankesteijn, Thomas Unger, Jos Prickaerts, Erik A. Biessen, Robert J. van Oostenbrugge, Sébastien Foulquier
Publié dans: Theranostics, Numéro 10/21, 2020, Page(s) 9512-9527, ISSN 1838-7640
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PIP2: A critical regulator of vascular ion channels hiding in plain sight

Auteurs: Harraz OF, Hill-Eubanks D, Nelson MT
Publié dans: PNAS, 2021, ISSN 1091-6490
Éditeur: PNAS
DOI: 10.1073/pnas.2006737117

Monocyte-Chemoattractant Protein-1 Levels in Human Atherosclerotic Lesions Associate With Plaque Vulnerability

Auteurs: Georgakis MK, van der Laan SW, Asare Y, Mekke JM, Haitjema S, Schoneveld AH, de Jager SCA, Nurmohamed NS, Kroon J, Stroes ESG, de Kleijn DPV, de Borst GJ, Maegdefessel L, Soehnlein O, Pasterkamp G, Dichgans M
Publié dans: Arterioscler Thromb Vasc Biol., Numéro 41(6), 2021, Page(s) 2038-2048., ISSN 1079-5642
Éditeur: Lippincott Williams & Wilkins Ltd.
DOI: 10.1161/atvbaha.121.316091

PIP2 Improves Cerebral Blood Flow in a Mouse Model of Alzheimer's Disease

Auteurs: Mughal A, Harraz OF, Gonzales AL, Hill-Eubanks D, Nelson MT
Publié dans: Function (Oxf), 2021, ISSN 2633-8823
Éditeur: American Physiological Society
DOI: 10.1093/function/zqab010

Cardiometabolic traits mediating the effect of education on osteoarthritis risk: a Mendelian randomization study.

Auteurs: Gill D, Karhunen V, Malik R, Dichgans M, Sofat N.
Publié dans: Osteoarthritis Cartilage, Numéro 29(3), 2021, Page(s) 365-371, ISSN 1063-4584
Éditeur: W. B. Saunders Co., Ltd.
DOI: 10.1016/j.joca.2020.12.015

A Case of Sporadic Cerebral Small Vessel Disease in an Identical Twin.

Auteurs: van den Brink H, Weaver NA, Biessels GJ
Publié dans: Case reports in neurology, 2020, ISSN 1662-680X
Éditeur: S. Karger AG
DOI: 10.1159/000511027

Diabetes Mellitus, Glycemic Traits, and Cerebrovascular Disease: A Mendelian Randomization Study

Auteurs: Georgakis MK, Harshfield EL, Malik R, Franceschini N, Langenberg C, Wareham NJ, Markus HS, Dichgans M
Publié dans: Neurology, Numéro 96(13), 2021, Page(s) e1732-e1742, ISSN 1526-632X
Éditeur: American Academy of Neurology
DOI: 10.1212/wnl.0000000000011555

Tracer kinetic assessment of blood-brain barrier leakage and blood volume in cerebral small vessel disease: associations with disease burden and vascular risk factors

Auteurs: Stringer MS, Heye AK, Armitage PA, Chappell F, del C. Valdés Hernándeza M, Mankin SDJ, Sakka E, Thrippleton MJ, Wardlaw JM.
Publié dans: Neuroimage Clin, 2021, ISSN 2213-1582
Éditeur: Elsevier BV
DOI: 10.1016/j.nicl.2021.102883

Velocity and Pulsatility Measures in the Perforating Arteries of the Basal Ganglia at 3T MRI in Reference to 7T MRI

Auteurs: Tine Arts, Timion A. Meijs, Heynric Grotenhuis, Michiel Voskuil, Jeroen Siero,Geert Jan Biessels and Jaco Zwanenburg
Publié dans: Frontiers in Neurosciences, 2021, ISSN 1662-453X
Éditeur: Frontiers
DOI: 10.3389/fnins.2021.665480

The capillary Kir channel as sensor and amplifier of neuronal signals: Modeling insights on K + -mediated neurovascular communication

Auteurs: Arash Moshkforoush, Baarbod Ashenagar, Osama F. Harraz, Fabrice Dabertrand, Thomas A. Longden, Mark T. Nelson, Nikolaos M. Tsoukias
Publié dans: Proceedings of the National Academy of Sciences, Numéro 117/28, 2020, Page(s) 16626-16637, ISSN 0027-8424
Éditeur: National Academy of Sciences
DOI: 10.1073/pnas.2000151117

Cilostazol for secondary prevention of stroke and cognitive decline: Systematic review and meta-analysis

Auteurs: McHutchison C, Blair GW, Appleton JP, Chappell FM, Doubal F, Bath PM, Wardlaw JM.
Publié dans: Stroke, 2021, ISSN 0039-2499
Éditeur: Lippincott Williams & Wilkins Ltd.
DOI: 10.1161/strokeaha.120.029454

Genetic risk, incident stroke, and the benefits of adhering to a healthy lifestyle: cohort study of 306 473 UK Biobank participants

Auteurs: Loes CA Rutten-Jacobs, Susanna C Larsson, Rainer Malik, Kristiina Rannikmäe, Cathie L Sudlow, Martin Dichgans, Hugh S Markus, Matthew Traylor
Publié dans: BMJ, Numéro 363, 2018, Page(s) k4168, ISSN 0959-8138
Éditeur: British Medical Association
DOI: 10.1136/bmj.k4168

Cortical cerebral microinfarcts on 7T MRI: Risk factors, neuroimaging correlates and cognitive functioning - The Medea-7T study.

Auteurs: Zwartbol MH, Rissanen I, Ghaznawi R, de Bresser J, Kuijf HJ, Blom K, Witkamp TD, Koek HL, Biessels GJ, Hendrikse J, Geerlings MI.
Publié dans: J Cereb Blood Flow Metab, 2021, ISSN 0271-678X
Éditeur: Lippincott Williams & Wilkins Ltd.
DOI: 10.1177/0271678x211025447

Differential restoration of functional hyperemia by antihypertensive drug classes in hypertension-related cerebral small vessel diseases

Auteurs: Koide M, Harraz OF, Dabertrand F, Longden TA, Ferris HR, Wellman GC, Hill-Eubanks DC, Greenstein AS, Nelson M.
Publié dans: J Clin Invest, 2021, ISSN 0021-9738
Éditeur: American Society for Clinical Investigation
DOI: 10.1172/jci149029

Genetically determined blood pressure, antihypertensive drug classes, and risk of stroke subtypes

Auteurs: Georgakis MK, Gill D, Webb AJS, Evangelou E, Elliott P, Sudlow CLM, Dehghan A, Malik R, Tzoulaki I, Dichgans M
Publié dans: Neurology, Numéro 95(4), 2020, Page(s) e353-e361, ISSN 0028-3878
Éditeur: Lippincott Williams & Wilkins Ltd.
DOI: 10.1212/wnl.0000000000009814

Circulating biomarkers of immunity and inflammation, risk of Alzheimer's disease, and hippocampal volume: a Mendelian randomization study

Auteurs: Fani L, Georgakis MK, Ikram MA, Ikram MK, Malik R, Dichgans M.
Publié dans: Transl Psychiatry, 2021, ISSN 2158-3188
Éditeur: Nature Publishing Group
DOI: 10.1038/s41398-021-01400-z

Modifiable Lifestyle Factors and Risk of Stroke

Auteurs: Harshfield EL, Georgakis MK, Malik R, Dichgans M, Markus HS.
Publié dans: Stroke, Numéro 52(3), 2021, Page(s) 931-936., ISSN 0039-2499
Éditeur: Lippincott Williams & Wilkins Ltd.
DOI: 10.1161/strokeaha.120.031710

Automated Assessment of Cerebral Arterial Perforator Function on 7T MRI

Auteurs: Tine Arts, MS,1* Jeroen C.W. Siero, PhD,1,2 Geert Jan Biessels, MD,3 and Jaco J.M. Zwanenburg,
Publié dans: Journal of Magnetic Resonance Imaging, 2021, ISSN 1090-7807
Éditeur: Academic Press
DOI: 10.1002/jmri.27304

The contribution of acute infarcts to cerebral small vessel disease progression

Auteurs: Annemieke Telgte, Kim Wiegertjes, Benno Gesierich, José P. Marques, Mathias Huebner, Jabke J. Klerk, Floris H. B. M. Schreuder, Miguel A. Araque Caballero, Hugo J. Kuijf, David G. Norris, Catharina J. M. Klijn, Martin Dichgans, Anil M. Tuladhar, Marco Duering, Frank‐Erik Leeuw
Publié dans: Annals of Neurology, Numéro 86/4, 2019, Page(s) 582-592, ISSN 0364-5134
Éditeur: John Wiley & Sons Inc.
DOI: 10.1002/ana.25556

Traumatic Brain Injury Impairs Systemic Vascular Function Through Disruption of Inward-Rectifier Potassium Channels

Auteurs: Sackheim AM, Villalba N, Sancho M, Harraz OF, Bonev AD, D'Alessandro A, Nemkov T, Nelson MT, Freeman K
Publié dans: Function (Oxf), 2021, ISSN 2633-8823
Éditeur: American Physiological Society
DOI: 10.1093/function/zqab018

Genome-wide association study of intracranial aneurysms identifies 17 risk loci and genetic overlap with clinical risk factors

Auteurs: Bakker MK, van der Spek RAA, van Rheenen W, Morel S, Bourcier R, Hostettler IC, Alg VS, van Eijk KR, Koido M, Akiyama M, Terao C, Matsuda K, Walters RG, Lin K, Li L, Millwood IY, Chen Z, Rouleau GA, Zhou S, Rannikmäe K, Sudlow CLM, Houlden H, van den Berg LH, Dina C, Naggara O, Gentric JC, Shotar E, Eugène F, Desal H, Winsvold BS, Børte S, Johnsen MB, Brumpton BM, Sandvei MS, Willer CJ, Hveem K
Publié dans: Nature Genetics, Numéro 52(12), 2021, Page(s) 1303-1313, ISSN 1061-4036
Éditeur: Nature Publishing Group
DOI: 10.1038/s41588-020-00725-7

Cerebrovascular Reactivity Measurement Using Magnetic Resonance Imaging: A Systematic Review

Auteurs: Emilie Sleight 1 2, Michael S Stringer 1 2, Ian Marshall 1 2, Joanna M Wardlaw 1 2, Michael J Thrippleton 1 2
Publié dans: Front Neurol., 2021, ISSN 1662-453X
Éditeur: Frontiers
DOI: 10.3389/fphys.2021.643468

Impaired capillary-to-arteriolar electrical signaling after traumatic brain injury

Auteurs: Mughal A, Sackheim AM, Sancho M, Longden TA, Russell S, Lockette W, Nelson MT, Freeman K
Publié dans: J Cereb Blood Flow Metab, 2021, ISSN 0271-678X
Éditeur: Lippincott Williams & Wilkins Ltd.
DOI: 10.1177/0271678x20962594

Direct Measurement of Cerebrospinal Fluid Production in Mice

Auteurs: Liu G, Mestre H, Sweeney AM, Sun Q, Weikop P, Du T, Nedergaard M
Publié dans: Cell reports, 2020, ISSN 2211-1247
Éditeur: Cell Press
DOI: 10.1016/j.celrep.2020.108524

Local IP3 receptor-mediated Ca2+ signals compound to direct blood flow in brain capillaries

Auteurs: Longden TA, Mughal A, Hennig GW, Harraz OF, Shui B, Lee FK, Lee JC, Reining S, Kotlikoff MI, Kong GM, Kostenis E, Hill-Eubanks D, Nelson MT
Publié dans: Sci Adv, 2021, ISSN 2375-2548
Éditeur: American Association for the Advancement of Science
DOI: 10.1126/sciadv.abh0101

A four-dimensional computational model of dynamic contrast-enhanced magnetic resonance imaging measurement of subtle blood-brain barrier leakage.

Auteurs: Bernal J, Valdés-Hernández MD, Escudero J, Heye A, Sakka E, Armitage PA, Makin S, Touyz RM, Wardlaw JM. Thrippleton MJ
Publié dans: Neuroimage, 2021, ISSN 1053-8119
Éditeur: Academic Press
DOI: 10.1016/j.neuroimage.2021.117786

Topological relationships between perivascular spaces and progression of white matter hyperintensities: a pilot study in a sample of the Lothian Birth Cohort 1936

Auteurs: Barnes A, Ballerini L, Valdés Hernández M, Chappell FM, Muñoz Maniega S, Meijboom R, Backhouse EV, Stringer MS, Coello RD, Brown R, Bastin ME, Cox SR, Deary IJ, Wardlaw JM.
Publié dans: medrix, 2021
Éditeur: medrix
DOI: 10.1101/2021.09.18.21263770

Sex differences in cerebral small vessel disease: a systematic review and meta-analysis

Auteurs: Jimenez Sanchez L, Hamilton OK, Backhouse EV, Clancy U, Stewart C, Wardlaw JM
Publié dans: medrix, 2021
Éditeur: medrix
DOI: 10.1101/2021.03.04.21252853

Diabetes mellitus, glycemic traits, and cerebrovascular disease: a Mendelian randomization study

Auteurs: Marios K Georgakis; Eric Harshfield; Rainer Malik; Nora Franceschini; Claudia Langenberg; Nick Wareham; Hugh S Markus; Martin Dichgans
Publié dans: Numéro 9, 2019
Éditeur: medRxiv
DOI: 10.1101/2019.12.27.19015834

Letter, Small Vessel Disease and Social Cognition.

Auteurs: Hamilton OK, Wardlaw JM. Response to Schroeter ML
Publié dans: Alzheimers Dement, 2021, ISSN 1552-5279
Éditeur: Alzheimer'S Association
DOI: 10.1002/alz.12402

Modifiable lifestyle factors and risk of stroke: a Mendelian randomization analysis

Auteurs: Harshfield, Eric L; Georgakis, Marios K; Malik, Rainer; Dichgans, Martin; Markus, Hugh S
Publié dans: Crossref, Numéro 8, 2020
Éditeur: medRxiv
DOI: 10.1101/2020.03.17.20037549

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