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Small vessel diseases in a mechanistic perspective: Targets for Intervention Affected pathways and mechanistic exploitation for prevention of stroke and dementia

Risultati finali

Pubblicazioni

Relationship Between Blood Pressure and Incident Cardiovascular Disease

Autori: Malik et.al.
Pubblicato in: Hypertension, 2021, ISSN 0194-911X
Editore: Lippincott Williams & Wilkins Ltd.
DOI: 10.1161/hypertensionaha.120.16534

Effect sizes of BOLD CVR, resting-state signal fluctuations and time delay measures for the assessment of hemodynamic impairment in carotid occlusion patients

Autori: Jill B. De Vis, Alex A. Bhogal, Jeroen Hendrikse, Esben T. Petersen, Jeroen C.W. Siero
Pubblicato in: NeuroImage, Issue 179, 2018, Page(s) 530-539, ISSN 1053-8119
Editore: Academic Press
DOI: 10.1016/j.neuroimage.2018.06.017

A Review of Translational Magnetic Resonance Imaging in Human and Rodent Experimental Models of Small Vessel Disease.

Autori: Stringer MS, Lee H, Huuskonen MT, MacIntosh BJ, Brown R, Montagne A, Atwi S, Ramirez J, Jansen MA, Marshall I, Black SE, Zlokovic BV, Benveniste H, Wardlaw JM
Pubblicato in: Translational Stroke Research, 2020, ISSN 1868-4483
Editore: Springer Pub. Co.,
DOI: 10.1007/s12975-020-00843-8

Clinical management of cerebral small vessel disease: a call for a holistic approach.

Autori: Clancy U, Appleton JP, Arteaga C, Doubal FN, Bath PM, Wardlaw JM
Pubblicato in: Chinese medical journal, 2020, ISSN 0366-6999
Editore: Zhonghua Yixeuehui Zazhishe/Chinese Medical Association Publishing House
DOI: 10.1097/cm9.0000000000001177

Genetically Predicted Midlife Blood Pressure and Coronary Artery Disease Risk: Mendelian Randomization Analysis

Autori: Gill D, Georgakis MK, Zuber V, Karhunen V, Burgess S, Malik R, Dichgans M
Pubblicato in: Journal of the American Heart Association, Issue 9(14), 2020, Page(s) e016773, ISSN 2047-9980
Editore: Wiley-Blackwell
DOI: 10.1161/jaha.120.016773

Effects of cilostazol and isosorbide mononitrate on cerebral haemodynamics in the LACI-1 randomised controlled trial

Autori: Blair GW, Janssen E, Stringer MS, Thrippleton MJ, Chappell F, Shi Y, Hamilton I, Flathery K, Appleton JP, Doubal FN, Bath PM, Wardlaw JM
Pubblicato in: Stroke, 2021, ISSN 0039-2499
Editore: Lippincott Williams & Wilkins Ltd.
DOI: 10.1161/strokeaha.121.034866

Impaired Cerebral Autoregulation After Subarachnoid Hemorrhage: A Quantitative Assessment Using a Mouse Model.

Autori: Koide M, Ferris HR, Nelson MT, Wellman GC.
Pubblicato in: Front Physiol, 2021, ISSN 1664-042X
Editore: Frontiers Research Foundation
DOI: 10.3389/fphys.2021.688468

Post-stroke Cognition at 1 and 3 Years Is Influenced by the Location of White Matter Hyperintensities in Patients With Lacunar Stroke

Autori: Maria del C. Valdés Hernández,1,* Tara Grimsley-Moore,2 Francesca M. Chappell,1 Michael J. Thrippleton,1 Paul A. Armitage,3 Eleni Sakka,1 Stephen Makin,4 and Joanna M. Wardlaw1
Pubblicato in: Front Neurol., 2021, ISSN 1662-453X
Editore: Frontiers
DOI: 10.3389/fneur.2021.634460

Circulating Metabolites Differentiate Acute Ischemic Stroke from Stroke Mimics

Autori: Tiedt S, Brandmaier S, Kollmeier H, Duering M, Artati A, Adamski J, Klein M, Liebig T, Holdt LM, Teupser D, Wang-Sattler R, Schwedhelm E, Gieger C, Dichgans M
Pubblicato in: Annals of Neurology, Issue 88(4), 2020, Page(s) 736-746, ISSN 1531-8249
Editore: Wiley
DOI: 10.1002/ana.25859

Dose-response relationship between genetically proxied average blood glucose levels and incident coronary heart disease in individuals without diabetes mellitus

Autori: Burgess S, Malik R, Liu B, Mason AM, Georgakis MK, Dichgans M, Gill D
Pubblicato in: Diabetologia, Issue 64(4), 2021, Page(s) 845-849, ISSN 0012-186X
Editore: Springer Verlag
DOI: 10.1007/s00125-020-05377-0

Pharmacological depletion of microglia and perivascular macrophages prevents Vascular Cognitive Impairment in Ang II-induced hypertension.

Autori: Kerkhofs D, van Hagen BT, Milanova IV, Schell KJ, van Essen H, Wijnands E, Goossens P, Blankesteijn WM, Unger T, Prickaerts J, Biessen EA, van Oostenbrugge RJ, Foulquier S
Pubblicato in: Theranostics, 2020, ISSN 0028-3878
Editore: Lippincott Williams & Wilkins Ltd.
DOI: 10.1212/wnl.0000000000011783

Correlations in post-mortem imaging-histopathology studies of sporadic human cerebral small vessel disease: a systematic review

Autori: Catherine A Humphreys , Colin Smith , Joanna M Wardlaw
Pubblicato in: Neuropathol Appl Neurobiol, 2021, ISSN 1365-2990
Editore: John Wiley & Sons, Inc.
DOI: 10.1111/nan.12737

Strategic infarct locations for post-stroke cognitive impairment: a pooled analysis of individual patient data from 12 acute ischaemic stroke cohorts

Autori: Nick A Weaver, Hugo J Kuijf, Hugo P Aben, Jill Abrigo, Hee-Joon Bae, Mélanie Barbay, Jonathan G Best, Régis Bordet, Francesca M Chappell, J Matthijs Biesbroek, Geert Jan Biessels
Pubblicato in: Lancet Neurol, 2021, ISSN 1474-4422
Editore: The Lancet Publishing Group
DOI: 10.1016/s1474-4422(21)00060-0

Non-Invasive Assessment of Damping of Blood Flow Velocity Pulsatility in Cerebral Arteries With MRI

Autori: Tine Arts, MS,1 Laurien P. Onkenhout, MS,1 Raquel P. Amier, MS,3 Rob van der Geest, PhD,4 Thijs van Harten, MS,4 Jaap Kappelle, MD,2 Sanne Kuipers, MS,2 Matthijs J.P. van Osch, PhD,4 Ed T. van Bavel, PhD,5 Geert Jan Biessels, MD,2 and Jaco J.M. Zwanenburg
Pubblicato in: Journal of Magnetic Resonance Imaging, 2021, ISSN 1090-7807
Editore: Academic Press
DOI: 10.1002/jmri.27989

Associations between total MRI-visible small vessel disease burden and domain-specific cognitive abilities in a community-dwelling older-age cohort

Autori: Okl Hamilton , S R Cox , L Ballerini , M E Bastin , J Corley , A J Gow , S Muñoz Maniega , P Redmond , M Del C Valdés Hernández , J M Wardlaw , I J Deary
Pubblicato in: Neurobiol Aging, 2021, ISSN 0197-4580
Editore: Elsevier BV
DOI: 10.1016/j.neurobiolaging.2021.04.007

Additive Effects of Genetic Interleukin-6 Signaling Downregulation and Low-Density Lipoprotein Cholesterol Lowering on Cardiovascular Disease: A 2×2 Factorial Mendelian Randomization Analysis.

Autori: Georgakis MK, Malik R, Burgess S, Dichgans M.
Pubblicato in: J Am Heart Assoc, Issue 2022 Jan 4, 2022, Page(s) 11(1):e023277, ISSN 2047-9980
Editore: Wiley-Blackwell
DOI: 10.1161/jaha.121.023277

Associations Between White Matter Hyperintensity Burden, Cerebral Blood Flow and Transit Time in Small Vessel Disease: An Updated Meta-Analysis

Autori: Catriona R Stewart , Michael S Stringer, Yulu Shi , Michael J Thrippleton, Joanna M Wardlaw
Pubblicato in: Front Neurol, 2021, ISSN 1662-453X
Editore: Frontiers
DOI: 10.3389/fneur.2021.647848

Circadian control of brain glymphatic and lymphatic fluid flow.

Autori: Hablitz LM, Plá V, Giannetto M, Vinitsky HS, Stæger FF, Metcalfe T, Nguyen R, Benrais A, Nedergaard M
Pubblicato in: Nature communications, 2020, ISSN 2041-1723
Editore: Nature Publishing Group
DOI: 10.1038/s41467-020-18115-2

Genetically Predicted Blood Pressure Across the Lifespan: Differential Effects of Mean and Pulse Pressure on Stroke Risk

Autori: Georgakis MK, Gill D, Malik R, Protogerou AD, Webb AJS, Dichgans M
Pubblicato in: Hypertension, Issue 76(3), 2020, Page(s) 953-961, ISSN 1524-4563
Editore: American Heart Association
DOI: 10.1161/hypertensionaha.120.15136

Sources of systematic error in DCE-MRI estimation of low-level blood-brain barrier leakage

Autori: Cameron Manning,Michael Stringer,Ben Dickie,Una Clancy,Maria C. Valdés Hernandez,Stewart J. Wiseman,Daniela Jaime Garcia,Eleni Sakka,Walter H. Backes,Michael Ingrisch,Francesca Chappell,Fergus Doubal,Craig Buckley,Laura M. Parkes,Geoff J. M. Parker,Ian Marshall,Joanna M. Wardlaw,Michael J. Thrippleton
Pubblicato in: Magnetic Resonance in Medicine, 2021, ISSN 1522-2594
Editore: Wiley
DOI: 10.1002/mrm.28833

ATP- and voltage-dependent electro-metabolic signaling regulates blood flow in heart

Autori: Guiling Zhao, Humberto C. Joca, Mark T. Nelson, W. Jonathan Lederer
Pubblicato in: Proceedings of the National Academy of Sciences, Issue 117/13, 2020, Page(s) 7461-7470, ISSN 0027-8424
Editore: National Academy of Sciences
DOI: 10.1073/pnas.1922095117

Zooming in on cerebral small vessel function in small vessel diseases with 7T MRI: Rationale and design of the “ZOOM@SVDs ”study

Autori: Hilde van den Brink a , Anna Kopczak b , Tine Arts c , Laurien Onkenhout a , Jeroen C.W. Siero c , d , Jaco J.M. Zwanenburg c , Marco Duering b , e , f , Gordon W. Blair g , Fergus N.Doubal g , Michael S. Stringer g , Michael J. Thrippleton g , Hugo J. Kuijf h , Alberto de Luca a , g , Jeroen Hendrikse c , Joanna M. Wardlaw g , Martin Dichgans b , e , f , Geert Jan Biessels a , ∗ , on behalf of
Pubblicato in: Cerebral Circulation - Cognition and Behavior, 2021, ISSN 2666-2450
Editore: Elseveir
DOI: 10.1016/j.cccb.2021.100013

Evaluation of Enhanced Learning Techniques for Segmenting Ischaemic Stroke Lesions in Brain Magnetic Resonance Perfusion Images Using a Convolutional Neural Network Scheme

Autori: Carlos Uziel Pérez Malla, Maria del C. Valdés Hernández, Muhammad Febrian Rachmadi, Taku Komura
Pubblicato in: Frontiers in Neuroinformatics, Issue 13, 2019, ISSN 1662-5196
Editore: Frontiers Research Foundation
DOI: 10.3389/fninf.2019.00033

Cardiac Risk Factors for Stroke: A Comprehensive Mendelian Randomization Study

Autori: Frerich S, Malik R, Georgakis MK, Sinner MF, Kittner SJ, Mitchell BD, Dichgans M.
Pubblicato in: Stroke, 2021, ISSN 0039-2499
Editore: Lippincott Williams & Wilkins Ltd.
DOI: 10.1161/strokeaha.121.036306

Zinc drives vasorelaxation by acting on sensory nerves, endothelium and smooth muscle

Autori: Betrie AH, Brock JA, Harraz OF, Bush AI, He G-W, Nelson MT, Angus JA, Wright CE, Ayton S
Pubblicato in: Nat Commun, 2021, ISSN 2041-1723
Editore: Nature Publishing Group
DOI: 10.1038/s41467-021-23198-6

Early life predictors of late life cerebral small vessel disease in four prospective cohort studies.

Autori: Backhouse EV, Shenkin SD, McIntosh AM, Bastin ME, Whalley HC, Valdez Hernandez M, Muñoz Maniega S, Harris MA, Stolicyn A, Campbell A, Steele D, Waiter GD, Sandu AL, Waymont JMJ, Murray AD, Cox SR, de Rooij SR, Roseboom TJ, Wardlaw JM.
Pubblicato in: Brain, Issue 2021 Sep 28:awab331, 2021, ISSN 0006-8950
Editore: Oxford University Press
DOI: 10.1093/brain/awab331

Cognitive impairment in sporadic cerebral small vessel disease: A systematic review and meta-analysis.

Autori: Hamilton OKL, Backhouse EV, Janssen E, Jochems ACC, Maher C, Ritakari TE, Stevenson AJ, Xia L, Deary IJ, Wardlaw JM
Pubblicato in: Alzheimer's & dementia : the journal of the Alzheimer's Association, 2020, ISSN 1552-5279
Editore: Alzheimer’s Association
DOI: 10.1002/alz.12221

Blood-brain barrier leakage at baseline and cognitive decline in cerebral small vessel disease: a 2-year follow-up study.

Autori: Kerkhofs D, Wong SM, Zhang E, Uiterwijk R, Hoff EI, Jansen JFA, Staals J, Backes WH, van Oostenbrugge RJ
Pubblicato in: Geroscience, 2021, ISSN 2509-2715
Editore: Springer
DOI: 10.1007/s11357-021-00399-x

Cerebral small vessel disease burden and longitudinal cognitive decline from age 73 to 82: the Lothian Birth Cohort 1936.

Autori: Hamilton OKL, Cox SR, Okely JA, Conte F, Ballerini L, Bastin ME, Corley J, Taylor AM, Page D, Gow AJ, Muñoz Maniega S, Redmond P, Valdés-Hernández MDC, Wardlaw JM, Deary IJ.
Pubblicato in: Transl Psychiatry., 2021, ISSN 2158-3188
Editore: Nature Publishing Group
DOI: 10.1038/s41398-021-01495-4

Sex differences in cerebral small vessel disease: a systematic review and meta-analysis.

Autori: Jiménez-Sánchez L, Hamilton OJ, Clancy U, Backhouse E, Stewart CR, Stringer MS, Doubal FN, Wardlaw JM
Pubblicato in: Front Neurol, 2021, ISSN 1662-453X
Editore: Frontiers
DOI: 10.3389/fneur.2021.756887

PIP2 corrects cerebral blood flow deficits in small vessel disease by rescuing capillary Kir2.1 activity

Autori: Dabertrand F, Harraz OF, Koide M, Longden TA, Rosehart AC, Hill-Eubanks DC, Joutel A, Nelson MT
Pubblicato in: PNAS, 2021, ISSN 1091-6490
Editore: PNAS
DOI: 10.1073/pnas.2025998118

Improving Clinical Detection of Acute Lacunar Stroke

Autori: Arba F, Mair G, Phillips S, Sandercock P, Wardlaw JM
Pubblicato in: Stroke, 2021, ISSN 0039-2499
Editore: Lippincott Williams & Wilkins Ltd.
DOI: 10.1161/strokeaha.119.028402

Imaging NeuroVascular, Endothelial and STructural Integrity in prepAration to TrEat Small Vessel Diseases. The INVESTIGATE-SVDs study Protocol. Part of the SVDs@Target Project

Autori: Blair GW, Stringer MS, Thrippleton MJ, Chappell FM, Shuler K, Hamilton I, Garcia DJ, Doubal FN, Kopczak A, Duering M, Ingrisch M, Kerkhofs D, Staals J, van den Brink H, Arts T, Backes W,.
Pubblicato in: Cereb Circ Cogn Behav, 2021, ISSN 2666-2450
Editore: Elsevier
DOI: 10.1016/j.cccb.2021.100020

The striatum, the hippocampus, and short-term memory binding: Volumetric analysis of the subcortical grey matter's role in mild cognitive impairment

Autori: Maria C. Valdés Hernández, Rupert Clark, Szu-Han Wang, Federica Guazzo, Clara Calia, Vivek Pattan, John Starr, Sergio Della Sala, Mario Alfredo Parra
Pubblicato in: NeuroImage: Clinical, Issue 25, 2020, Page(s) 102158, ISSN 2213-1582
Editore: Elsevier BV
DOI: 10.1016/j.nicl.2019.102158

Mendelian randomization for studying the effects of perturbing drug targets

Autori: Gill. D. et. al
Pubblicato in: Wellcome Open Research, Issue 10;6:16, 2021, Page(s) 10;6:16, ISSN 2398-502X
Editore: F1000Research
DOI: 10.12688/wellcomeopenres.16544.2

Identification of plasma proteins relating to brain neurodegeneration and vascular pathology in cognitively normal individuals.

Autori: Shi L, Buchanan CR, Cox SR, Hillary RF, Marioni RE, Campbell A, Hayward C, Stolicyn A, Whalley HC, Harris MA, Waymont J, Waiter G, Backhouse E, Wardlaw JM, Steele D, Mcintosh A, Lovestone S, Buckley NJ, Nevado-Holgado AJ.
Pubblicato in: Alzheimers Dement, 2021, ISSN 1552-5279
Editore: Alzheimer’s Association
DOI: 10.1002/dad2.12240

Cerebral Vascular Dysfunctions Detected in Human Small Vessel Disease and Implications for Preclinical Studies.

Autori: Wardlaw JM, Benveniste H, Williams A.
Pubblicato in: Annu Rev Physiol, 2021, ISSN 1545-1585
Editore: Annual Reviews
DOI: 10.1146/annurev-physiol-060821-014521

Biological sex does not predict glymphatic influx in healthy young, middle aged or old mice.

Autori: Giannetto M, Xia M, Stæger FF, Metcalfe T, Vinitsky HS, Dang JAML, Xavier ALR, Kress BT, Nedergaard M, Hablitz LM
Pubblicato in: Nature, 2020, ISSN 2041-1723
Editore: Nature Publishing Group
DOI: 10.1038/s41598-020-72621-3

A Comparison of CVR Magnitude and Delay Assessed at 1.5 and 3T in Patients With Cerebral Small Vessel Disease.

Autori: Stringer MS, Blair GW, Shi Y, Hamilton I, Dickie DA, Doubal FN, Marshall IM, Thrippleton MJ, Wardlaw JM.
Pubblicato in: Front Physiol., 2021, ISSN 1664-042X
Editore: Frontiers Research Foundation
DOI: 10.3389/fphys.2021.644837

Contractile pericytes determine the direction of blood flow at capillary junctions

Autori: Gonzales AL, Klug NR, Moshkforoush A, Lee JC, Lee FK, Shui B, Tsoukias NM, Kotlikoff MI, Hill-Eubanks D, Nelson MT
Pubblicato in: PNAS, 2021, ISSN 1091-6490
Editore: PNAS
DOI: 10.1073/pnas.1922755117

Diagnosing vascular cognitive impairment: Current challenges and future perspectives

Autori: J Matthijs Biesbroek, Geert Jan Biessels
Pubblicato in: International Journal of Stroke, 2021, ISSN 0271-678X
Editore: Lippincott Williams & Wilkins Ltd.
DOI: 10.1177/17474930211073387

Midlife vascular risk factors and risk of incident dementia: Longitudinal cohort and Mendelian randomization analyses in the UK Biobank

Autori: Malik, Rainer; Georgakis, Marios K.; Neitzel, Julia; Rannikmäe, Kristiina; Ewers, Michael; Seshadri, Sudha; Sudlow, Cathie L.M.; Dichgans, Martin
Pubblicato in: Alzheimers Dement, Issue 17(9), 2021, Page(s) 1422-1431, ISSN 1552-5279
Editore: Alzheimer's Association
DOI: 10.1002/alz.12320

Arterial CO2 pressure changes during hypercapnia are associated with changes in brain parenchymal volume

Autori: Lisa A. van der Kleij, Jill B. De Vis, Jeroen de Bresser, Jeroen Hendrikse, Jeroen C. W. Siero
Pubblicato in: European Radiology Experimental, Issue 4/1, 2020, ISSN 2509-9280
Editore: Springer Nature
DOI: 10.1186/s41747-020-0144-z

Cerebral Amyloid Angiopathy: Still a Syndromal Diagnosis.

Autori: Biessels GJ
Pubblicato in: Stroke, 2020, ISSN 0039-2499
Editore: Lippincott Williams & Wilkins Ltd.
DOI: 10.1161/strokeaha.120.032703

Strain Tensor Imaging: Cardiac-induced brain tissue deformation in humans quantified with high-field MRI

Autori: Jacob-JanSloots,Geert JanBiessels,Albertode Luca, Jaco J.M.Zwanenburg
Pubblicato in: NeuroImage, 2021, ISSN 1053-8119
Editore: Academic Press
DOI: 10.1016/j.neuroimage.2021.118078

Brain network reorganisation and spatiallesion distribution in systemic lupuserythematosus

Autori: Valdés Hernández MDC, Smith K, Bastin ME, Nicole Amft E, Ralston SH, Wardlaw JM, Wiseman SJ
Pubblicato in: Lupus, 2021, ISSN 2158-2440
Editore: SAGE Publications Inc.
DOI: 10.1177/0961203320979045

Cognitive ability, education and socioeconomic status in childhood and risk of post-stroke depression in later life: A systematic review and meta-analysis

Autori: Ellen V. Backhouse, Caroline A. McHutchison, Vera Cvoro, Susan D. Shenkin, Joanna M. Wardlaw
Pubblicato in: PLOS ONE, Issue 13/7, 2018, Page(s) e0200525, ISSN 1932-6203
Editore: Public Library of Science
DOI: 10.1371/journal.pone.0200525

Prognostic Significance of Blood Pressure Variability on Beat-to-Beat Monitoring After Transient Ischemic Attack and Stroke

Autori: Alastair J.S. Webb, Sara Mazzucco, Linxin Li, Peter M. Rothwell
Pubblicato in: Stroke, Issue 49/1, 2018, Page(s) 62-67, ISSN 0039-2499
Editore: Lippincott Williams & Wilkins Ltd.
DOI: 10.1161/STROKEAHA.117.019107

Time course of blood pressure control prior to lacunar TIA and stroke

Autori: Linxin Li, Sarah J.V. Welch, Sergei A. Gutnikov, Ziyah Mehta, Peter M. Rothwell
Pubblicato in: Neurology, Issue 90/20, 2018, Page(s) e1732-e1741, ISSN 0028-3878
Editore: Lippincott Williams & Wilkins Ltd.
DOI: 10.1212/WNL.0000000000005526

Antiplatelet Treatment After Transient Ischemic Attack and Ischemic Stroke in Patients With Cerebral Microbleeds in 2 Large Cohorts and an Updated Systematic Review

Autori: Kui Kai Lau, Caroline E. Lovelock, Linxin Li, Michela Simoni, Sergei Gutnikov, Wilhelm Küker, Henry Ka Fung Mak, Peter M. Rothwell
Pubblicato in: Stroke, Issue 49/6, 2018, Page(s) 1434-1442, ISSN 0039-2499
Editore: Lippincott Williams & Wilkins Ltd.
DOI: 10.1161/STROKEAHA.117.020104

Long-Term Morphological Changes of Symptomatic Lacunar Infarcts and Surrounding White Matter on Structural Magnetic Resonance Imaging

Autori: Caroline M.J. Loos, Stephen D.J. Makin, Julie Staals, Martin S. Dennis, Robert J. van Oostenbrugge, Joanna M. Wardlaw
Pubblicato in: Stroke, Issue 49/5, 2018, Page(s) 1183-1188, ISSN 0039-2499
Editore: Lippincott Williams & Wilkins Ltd.
DOI: 10.1161/STROKEAHA.117.020495

Vascular reactivity in small cerebral perforating arteries with 7 T phase contrast MRI – A proof of concept study

Autori: Lennart J. Geurts, Alex A. Bhogal, Jeroen C.W. Siero, Peter R. Luijten, Geert Jan Biessels, Jaco J.M. Zwanenburg
Pubblicato in: NeuroImage, Issue 172, 2018, Page(s) 470-477, ISSN 1053-8119
Editore: Academic Press
DOI: 10.1016/j.neuroimage.2018.01.055

The effect of different combinations of vascular, dependency and cognitive endpoints on the sample size required to detect a treatment effect in trials of treatments to improve outcome after lacunar and non-lacunar ischaemic stroke

Autori: Stephen DJ Makin, Fergus N Doubal, Terence J Quinn, Philip MW Bath, Martin S Dennis, Joanna M Wardlaw
Pubblicato in: European Stroke Journal, Issue 3/1, 2017, Page(s) 66-73, ISSN 2396-9873
Editore: SAGE Journals
DOI: 10.1177/2396987317728854

Age-Specific Associations of Renal Impairment With Magnetic Resonance Imaging Markers of Cerebral Small Vessel Disease in Transient Ischemic Attack and Stroke

Autori: Bian Liu, Kui Kai Lau, Linxin Li, Caroline Lovelock, Ming Liu, Wilhelm Kuker, Peter M. Rothwell
Pubblicato in: Stroke, Issue 49/4, 2018, Page(s) 899-904, ISSN 0039-2499
Editore: Lippincott Williams & Wilkins Ltd.
DOI: 10.1161/STROKEAHA.117.019650

Functional, cognitive and physical outcomes 3 years after minor lacunar or cortical ischaemic stroke

Autori: Caroline A McHutchison, Vera Cvoro, Stephen Makin, Francesca M Chappell, Kirsten Shuler, Joanna M Wardlaw
Pubblicato in: Journal of Neurology, Neurosurgery & Psychiatry, Issue 436-443, 2018, Page(s) jnnp-2018-319134, ISSN 0022-3050
Editore: BMJ Publishing Group
DOI: 10.1136/jnnp-2018-319134

Small vessel disease is associated with altered cerebrovascular pulsatility but not resting cerebral blood flow

Autori: Yulu Shi, Michael J Thrippleton, Gordon W Blair, David A Dickie, Ian Marshall, Iona Hamilton, Fergus N Doubal, Francesca Chappell, Joanna M Wardlaw
Pubblicato in: Journal of Cerebral Blood Flow & Metabolism, 2018, Page(s) 0271678X1880395, ISSN 0271-678X
Editore: Lippincott Williams & Wilkins Ltd.
DOI: 10.1177/0271678x18803956

Genetic and lifestyle risk factors for MRI-defined brain infarcts in a population-based setting

Autori: Ganesh Chauhan, Hieab H.H. Adams, Claudia L. Satizabal, Joshua C. Bis, Alexander Teumer, Muralidharan Sargurupremraj, Edith Hofer, Stella Trompet, Saima Hilal, Albert Vernon Smith, Xueqiu Jian, Rainer Malik, Matthew Traylor, Sara L. Pulit, Philippe Amouyel, Bernard Mazoyer, Yi-Cheng Zhu, Sara Kaffashian, Sabrina Schilling, Gary W. Beecham, Thomas J. Montine, Gerard D. Schellenberg, Olafur Kjartans
Pubblicato in: Neurology, Issue 92/5, 2019, Page(s) e486-e503, ISSN 0028-3878
Editore: Lippincott Williams & Wilkins Ltd.
DOI: 10.1212/wnl.0000000000006851

MRI measurement of blood-brain barrier leakage: minding the gaps

Autori: Michael Jonathan Thrippleton
Pubblicato in: The Journal of Physiology, Issue 597/3, 2019, Page(s) 667-668, ISSN 0022-3751
Editore: Blackwell Publishing Inc.
DOI: 10.1113/jp277425

Intracranial pulsatility in patients with cerebral small vessel disease: a systematic review

Autori: Yulu Shi, Michael J. Thrippleton, Ian Marshall, Joanna M. Wardlaw
Pubblicato in: Clinical Science, Issue 132/1, 2018, Page(s) 157-171, ISSN 0143-5221
Editore: Portland Press, Ltd.
DOI: 10.1042/cs20171280

Cerebrovascular reactivity measurement in cerebral small vessel disease: Rationale and reproducibility of a protocol for MRI acquisition and image processing

Autori: Michael J Thrippleton, Yulu Shi, Gordon Blair, Iona Hamilton, Gordon Waiter, Christian Schwarzbauer, Cyril Pernet, Peter JD Andrews, Ian Marshall, Fergus Doubal, Joanna M Wardlaw
Pubblicato in: International Journal of Stroke, Issue 13/2, 2017, Page(s) 195-206, ISSN 1747-4930
Editore: Blackwell
DOI: 10.1177/1747493017730740

A protocol for precise comparisons of small vessel disease lesions between ex vivo magnetic resonance imaging and histopathology

Autori: Catherine A Humphreys, Maurits A Jansen, Susana Muñoz Maniega, Víctor González-Castro, Cyril Pernet, Ian J Deary, Rustam Al-Shahi Salman, Joanna M Wardlaw, Colin Smith
Pubblicato in: International Journal of Stroke, 2018, Page(s) 174749301879996, ISSN 1747-4930
Editore: Blackwell
DOI: 10.1177/1747493018799962

Age and sex-specific associations of carotid pulsatility with small vessel disease burden in transient ischemic attack and ischemic stroke

Autori: Kui Kai Lau, Petra Pego, Sara Mazzucco, Linxin Li, Dominic PJ Howard, Wilhelm Küker, Peter M Rothwell
Pubblicato in: International Journal of Stroke, Issue 13/8, 2018, Page(s) 832-839, ISSN 1747-4930
Editore: Blackwell
DOI: 10.1177/1747493018784448

Long-Term Premorbid Blood Pressure and Cerebral Small Vessel Disease Burden on Imaging in Transient Ischemic Attack and Ischemic Stroke

Autori: Kui Kai Lau, Linxin Li, Michela Simoni, Ziyah Mehta, Wilhelm Küker, Peter M. Rothwell
Pubblicato in: Stroke, Issue 49/9, 2018, Page(s) 2053-2060, ISSN 0039-2499
Editore: Lippincott Williams & Wilkins Ltd.
DOI: 10.1161/strokeaha.118.021578

MRI Relaxometry for Quantitative Analysis of USPIO Uptake in Cerebral Small Vessel Disease

Autori: Michael Thrippleton, Gordon Blair, Maria Valdes-Hernandez, Andreas Glatz, Scott Semple, Fergus Doubal, Alex Vesey, Ian Marshall, David Newby, Joanna Wardlaw
Pubblicato in: International Journal of Molecular Sciences, Issue 20/3, 2019, Page(s) 776, ISSN 1422-0067
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms20030776

Higher Pulsatility in Cerebral Perforating Arteries in Patients With Small Vessel Disease Related Stroke, a 7T MRI Study

Autori: Lennart J. Geurts, Jaco J.M. Zwanenburg, Catharina J.M. Klijn, Peter R. Luijten, Geert Jan Biessels
Pubblicato in: Stroke, Issue 50/1, 2019, Page(s) 62-68, ISSN 0039-2499
Editore: Lippincott Williams & Wilkins Ltd.
DOI: 10.1161/strokeaha.118.022516

The Glymphatic System in Central Nervous System Health and Disease: Past, Present, and Future

Autori: Benjamin A. Plog, Maiken Nedergaard
Pubblicato in: Annual Review of Pathology: Mechanisms of Disease, Issue 13/1, 2018, Page(s) 379-394, ISSN 1553-4006
Editore: Annual Reviews, Inc.
DOI: 10.1146/annurev-pathol-051217-111018

Perivascular spaces and their associations with risk factors, clinical disorders and neuroimaging features: A systematic review and meta-analysis

Autori: Farah Francis, Lucia Ballerini, Joanna M Wardlaw
Pubblicato in: International Journal of Stroke, 2019, Page(s) 174749301983032, ISSN 1747-4930
Editore: Blackwell
DOI: 10.1177/1747493019830321

Effects of dietary salt on gene and protein expression in brain tissue of a model of sporadic small vessel disease

Autori: Emma L. Bailey, Martin W. McBride, John D. McClure, Wendy Beattie, Delyth Graham, Anna F. Dominiczak, Colin Smith, Joanna M. Wardlaw
Pubblicato in: Clinical Science, Issue 132/12, 2018, Page(s) 1315-1328, ISSN 0143-5221
Editore: Portland Press, Ltd.
DOI: 10.1042/cs20171572

Flow of cerebrospinal fluid is driven by arterial pulsations and is reduced in hypertension

Autori: Humberto Mestre, Jeffrey Tithof, Ting Du, Wei Song, Weiguo Peng, Amanda M. Sweeney, Genaro Olveda, John H. Thomas, Maiken Nedergaard, Douglas H. Kelley
Pubblicato in: Nature Communications, Issue 9/1, 2018, ISSN 2041-1723
Editore: Nature Publishing Group
DOI: 10.1038/s41467-018-07318-3

Preventing cognitive decline and dementia from cerebral small vessel disease: The LACI-1 Trial. Protocol and statistical analysis plan of a phase IIa dose escalation trial testing tolerability, safety and effect on intermediary endpoints of isosorbide mononitrate and cilostazol, separately and in combination

Autori: Gordon W Blair, Jason P Appleton, Zhe Kang Law, Fergus Doubal, Katie Flaherty, Richard Dooley, Kirsten Shuler, Carla Richardson, Iona Hamilton, Yulu Shi, Michael Stringer, Julia Boyd, Michael J Thrippleton, Nikola Sprigg, Philip M Bath, Joanna M Wardlaw
Pubblicato in: International Journal of Stroke, Issue 13/5, 2017, Page(s) 530-538, ISSN 1747-4930
Editore: Blackwell
DOI: 10.1177/1747493017731947

Machine learning of neuroimaging for assisted diagnosis of cognitive impairment and dementia: A systematic review

Autori: Enrico Pellegrini, Lucia Ballerini, Maria del C. Valdes Hernandez, Francesca M. Chappell, Victor González-Castro, Devasuda Anblagan, Samuel Danso, Susana Muñoz-Maniega, Dominic Job, Cyril Pernet, Grant Mair, Tom J. MacGillivray, Emanuele Trucco, Joanna M. Wardlaw
Pubblicato in: Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring, Issue 10, 2018, Page(s) 519-535, ISSN 2352-8729
Editore: Alzheimer's & Dementia
DOI: 10.1016/j.dadm.2018.07.004

Considerations on accuracy, pattern and possible underlying factors of brain microbleed progression in older adults with absence or mild presence of vascular pathology

Autori: Alice M Harper, Lauren Clayson, Joanna M Wardlaw, Maria del C Valdés Hernández
Pubblicato in: Journal of International Medical Research, Issue 46/9, 2018, Page(s) 3518-3538, ISSN 0300-0605
Editore: Cambridge Medical Publications
DOI: 10.1177/0300060518755623

Longitudinal serum S100β and brain aging in the Lothian Birth Cohort 1936

Autori: Simon R. Cox, Mike Allerhand, Stuart J. Ritchie, Susana Muñoz Maniega, Maria Valdés Hernández, Sarah E. Harris, David Alexander Dickie, Devasuda Anblagan, Benjamin S. Aribisala, Zoe Morris, Roy Sherwood, N. Joan Abbott, John M. Starr, Mark E. Bastin, Joanna M. Wardlaw, Ian J. Deary
Pubblicato in: Neurobiology of Aging, Issue 69, 2018, Page(s) 274-282, ISSN 0197-4580
Editore: Elsevier BV
DOI: 10.1016/j.neurobiolaging.2018.05.029

PIP2 depletion promotes TRPV4 channel activity in mouse brain capillary endothelial cells

Autori: Osama F Harraz, Thomas A Longden, David Hill-Eubanks, Mark T Nelson
Pubblicato in: eLife, Issue 7, 2018, ISSN 2050-084X
Editore: eLife Sciences Publications
DOI: 10.7554/elife.38689

The relation between total cerebral small vessel disease burden and gait impairment in patients with minor stroke

Autori: Caroline MJ Loos, Caroline McHutchison, Vera Cvoro, Stephen DJ Makin, Julie Staals, Francesca Chappell, Martin S Dennis, Robert J van Oostenbrugge, Joanna M Wardlaw
Pubblicato in: International Journal of Stroke, Issue 13/5, 2017, Page(s) 518-524, ISSN 1747-4930
Editore: Blackwell
DOI: 10.1177/1747493017730780

Hypertensive organ damage predicts future cognitive performance: A 9-year follow-up study in patients with hypertension

Autori: Renske Uiterwijk, Julie Staals, Marjolein Huijts, Sander M. J. van Kuijk, Peter W. de Leeuw, Abraham A. Kroon, Robert J. van Oostenbrugge
Pubblicato in: The Journal of Clinical Hypertension, Issue 20/10, 2018, Page(s) 1458-1463, ISSN 1524-6175
Editore: Wiley-Blackwell
DOI: 10.1111/jch.13372

Genetically Determined Levels of Circulating Cytokines and Risk of Stroke

Autori: Marios K. Georgakis, Dipender Gill, Kristiina Rannikmäe, Matthew Traylor, Christopher D. Anderson, Jin-Moo Lee, Yoichiro Kamatani, Jemma C. Hopewell, Bradford B. Worrall, Jürgen Bernhagen, Cathie L. M. Sudlow, Rainer Malik, Martin Dichgans
Pubblicato in: Circulation, Issue 139/2, 2019, Page(s) 256-268, ISSN 0009-7322
Editore: Lippincott Williams & Wilkins Ltd.
DOI: 10.1161/circulationaha.118.035905

Dementia risk after transient ischaemic attack and stroke

Autori: Martin Dichgans
Pubblicato in: The Lancet Neurology, Issue 18/3, 2019, Page(s) 223-225, ISSN 1474-4422
Editore: The Lancet Publishing Group
DOI: 10.1016/s1474-4422(18)30497-6

Role of Non-Coding RNAs in Stroke

Autori: Steffen Tiedt, Martin Dichgans
Pubblicato in: Stroke, Issue 49/12, 2018, Page(s) 3098-3106, ISSN 0039-2499
Editore: Lippincott Williams & Wilkins Ltd.
DOI: 10.1161/strokeaha.118.021010

Multiancestry genome-wide association study of 520,000 subjects identifies 32 loci associated with stroke and stroke subtypes

Autori: Rainer Malik, Ganesh Chauhan, Matthew Traylor, Muralidharan Sargurupremraj, Yukinori Okada, Aniket Mishra, Loes Rutten-Jacobs, Anne-Katrin Giese, Sander W. van der Laan, Solveig Gretarsdottir, Christopher D. Anderson, Michael Chong, Hieab H. H. Adams, Tetsuro Ago, Peter Almgren, Philippe Amouyel, Hakan Ay, Traci M. Bartz, Oscar R. Benavente, Steve Bevan, Giorgio B. Boncoraglio, Robert D. Brown, Ad
Pubblicato in: Nature Genetics, Issue 50/4, 2018, Page(s) 524-537, ISSN 1061-4036
Editore: Nature Publishing Group
DOI: 10.1038/s41588-018-0058-3

CADASIL brain vessels show a HTRA1 loss-of-function profile

Autori: Andreas Zellner, Eva Scharrer, Thomas Arzberger, Chio Oka, Valérie Domenga-Denier, Anne Joutel, Stefan F. Lichtenthaler, Stephan A. Müller, Martin Dichgans, Christof Haffner
Pubblicato in: Acta Neuropathologica, Issue 136/1, 2018, Page(s) 111-125, ISSN 0001-6322
Editore: Springer Verlag
DOI: 10.1007/s00401-018-1853-8

Serum neurofilament light

Autori: Steffen Tiedt, Marco Duering, Christian Barro, Asli Gizem Kaya, Julia Boeck, Felix J. Bode, Matthias Klein, Franziska Dorn, Benno Gesierich, Lars Kellert, Birgit Ertl-Wagner, Michael W. Goertler, Gabor C. Petzold, Jens Kuhle, Frank A. Wollenweber, Nils Peters, Martin Dichgans
Pubblicato in: Neurology, Issue 91/14, 2018, Page(s) e1338-e1347, ISSN 0028-3878
Editore: Lippincott Williams & Wilkins Ltd.
DOI: 10.1212/wnl.0000000000006282

Validation of the Telephone Interview of Cognitive Status and Telephone Montreal Cognitive Assessment Against Detailed Cognitive Testing and Clinical Diagnosis of Mild Cognitive Impairment After Stroke

Autori: Vera Zietemann, Anna Kopczak, Claudia Müller, Frank Arne Wollenweber, Martin Dichgans
Pubblicato in: Stroke, Issue 48/11, 2017, Page(s) 2952-2957, ISSN 0039-2499
Editore: Lippincott Williams & Wilkins Ltd.
DOI: 10.1161/strokeaha.117.017519

Challenges and opportunities in stroke genetics

Autori: Rainer Malik, Martin Dichgans
Pubblicato in: Cardiovascular Research, Issue Vol. 114, Issue 9, 2018, Page(s) 1226-1240, ISSN 0008-6363
Editore: Elsevier BV
DOI: 10.1093/cvr/cvy068

COL4A2 is associated with lacunar ischemic stroke and deep ICH

Autori: Kristiina Rannikmäe, Vhinoth Sivakumaran, Henry Millar, Rainer Malik, Christopher D. Anderson, Mike Chong, Tushar Dave, Guido J. Falcone, Israel Fernandez-Cadenas, Jordi Jimenez-Conde, Arne Lindgren, Joan Montaner, Martin O'Donnell, Guillaume Paré, Farid Radmanesh, Natalia S. Rost, Agnieszka Slowik, Martin Söderholm, Matthew Traylor, Sara L. Pulit, Sudha Seshadri, Brad B. Worrall, Daniel Woo, H
Pubblicato in: Neurology, Issue 89/17, 2017, Page(s) 1829-1839, ISSN 0028-3878
Editore: Lippincott Williams & Wilkins Ltd.
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RNA-Seq Identifies Circulating miR-125a-5p, miR-125b-5p, and miR-143-3p as Potential Biomarkers for Acute Ischemic Stroke

Autori: Steffen Tiedt, Matthias Prestel, Rainer Malik, Nicola Schieferdecker, Marco Duering, Veronika Kautzky, Ivelina Stoycheva, Julia Böck, Bernd H. Northoff, Matthias Klein, Franziska Dorn, Knut Krohn, Daniel Teupser, Arthur Liesz, Nikolaus Plesnila, Lesca Miriam Holdt, Martin Dichgans
Pubblicato in: Circulation Research, Issue 121/8, 2017, Page(s) 970-980, ISSN 0009-7330
Editore: Lippincott Williams & Wilkins Ltd.
DOI: 10.1161/circresaha.117.311572

Smooth muscle cells of intracranial vessels: from development to disease

Autori: Juhana Frösen, Anne Joutel
Pubblicato in: Cardiovascular Research, Issue 114/4, 2018, Page(s) 501-512, ISSN 0008-6363
Editore: Elsevier BV
DOI: 10.1093/cvr/cvy002

Severity of arterial defects in the retina correlates with the burden of intracerebral haemorrhage in COL4A1-related stroke

Autori: Julien Ratelade, Nicolas Mezouar, Valérie Domenga-Denier, Ambre Rochey, Emmanuelle Plaisier, Anne Joutel
Pubblicato in: The Journal of Pathology, Issue 244/4, 2018, Page(s) 408-420, ISSN 0022-3417
Editore: John Wiley & Sons Inc.
DOI: 10.1002/path.5023

Blood–brain barrier leakage in relation to white matter hyperintensity volume and cognition in small vessel disease and normal aging

Autori: C. Eleana Zhang, Sau May Wong, Renske Uiterwijk, Walter H. Backes, Jacobus F. A. Jansen, Cécile R. L. P. N. Jeukens, Robert J. van Oostenbrugge, Julie Staals
Pubblicato in: Brain Imaging and Behavior, Issue 13/2, 2019, Page(s) 389-395, ISSN 1931-7557
Editore: Springer Pub. Co.,
DOI: 10.1007/s11682-018-9855-7

Aquaporin 1 and the Na+/K+/2Cl− cotransporter 1 are present in the leptomeningeal vasculature of the adult rodent central nervous system

Autori: Qianliang Li, Nadia N. Aalling, Benjamin Förstera, Ali Ertürk, Maiken Nedergaard, Kjeld Møllgård, Anna L. R. Xavier
Pubblicato in: Fluids and Barriers of the CNS, Issue 17/1, 2020, ISSN 2045-8118
Editore: BioMed Central
DOI: 10.1186/s12987-020-0176-z

The brain health index: Towards a combined measure of neurovascular and neurodegenerative structural brain injury

Autori: David Alexander Dickie, Maria del C Valdés Hernández, Stephen D Makin, Julie Staals, Stewart J Wiseman, Mark E Bastin, Joanna M Wardlaw
Pubblicato in: International Journal of Stroke, Issue 13/8, 2018, Page(s) 849-856, ISSN 1747-4930
Editore: Blackwell
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European Ultrahigh-Field Imaging Network for Neurodegenerative Diseases (EUFIND)

Autori: Düzel, Emrah; Acosta-Cabronero, Julio; Berron, David; Biessels, Geert Jan; Björkman-Burtscher, Isabella; Bottlaender, Michel; Bowtell, Richard; Buchem, Mark V; Cardenas-Blanco, Arturo; Boumezbeur, Fawzi; Chan, Dennis; Clare, Stuart; Costagli, Mauro; De Rochefort, Ludovic; Fillmer, Ariane; Gowland, Penny; Hansson, Oskar; Hendrikse, Jeroen; Kraff, Oliver; Ladd, Mark E; Ronen, Itamar; Petersen, Esb
Pubblicato in: "Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring, Elsevier, 2019, 11, pp.538-549. ⟨10.1016/J.DADM.2019.04.010⟩", Issue 1, 2019, Page(s) 538-549, ISSN 2352-8729
Editore: Wiley
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METACOHORTS for the study of vascular disease and its contribution to cognitive decline and neurodegeneration: An initiative of the Joint Programme for Neurodegenerative Disease Research

Autori: Martin Dichgans, Joanna Wardlaw, Eric Smith, Vera Zietemann, Sudha Seshadri, Perminder Sachdev, Geert Jan Biessels, Franz Fazekas, Oscar Benavente, Leonardo Pantoni, Frank-Erik De Leeuw, Bo Norrving, Paul Matthews, Christopher Chen, Vincent Mok, Marco Düring, Will Whiteley, Kirsten Shuler, Alvaro Alonso, Sandra E. Black, Carol Brayne, Hugues Chabriat, Charlotte Cordonnier, Fergus Doubal, Emrah Du
Pubblicato in: Alzheimer's & Dementia, Issue 12/12, 2016, Page(s) 1235-1249, ISSN 1552-5260
Editore: Elsevier BV
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MRI progression of cerebral small vessel disease and cognitive decline in patients with hypertension

Autori: Renske Uiterwijk, Julie Staals, Marjolein Huijts, Peter W. de Leeuw, Abraham A. Kroon, Robert J. van Oostenbrugge
Pubblicato in: Journal of Hypertension, Issue 35/6, 2017, Page(s) 1263-1270, ISSN 0263-6352
Editore: Lippincott Williams & Wilkins Ltd.
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Intracranial hemodynamic relationships in patients with cerebral small vessel disease

Autori: Gordon W. Blair, Michael J. Thrippleton, Yulu Shi, Iona Hamilton, Michael Stringer, Francesca Chappell, David Alexander Dickie, Peter Andrews, Ian Marshall, Fergus N. Doubal, Joanna M. Wardlaw
Pubblicato in: Neurology, Issue 94/21, 2020, Page(s) e2258-e2269, ISSN 0028-3878
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The Brain’s Glymphatic System: Current Controversies

Autori: Humberto Mestre, Yuki Mori, Maiken Nedergaard
Pubblicato in: Trends in Neurosciences, Issue TINS 1601 No. of Pages 9, 2020, ISSN 0166-2236
Editore: Elsevier BV
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Intravoxel Incoherent Motion Imaging in Small Vessel Disease

Autori: C. Eleana Zhang, Sau May Wong, Renske Uiterwijk, Julie Staals, Walter H. Backes, Erik I. Hoff, Tobien Schreuder, Cécile R.L.P.N. Jeukens, Jacobus F.A. Jansen, Robert J. van Oostenbrugge
Pubblicato in: Stroke, Issue 48/3, 2017, Page(s) 658-663, ISSN 0039-2499
Editore: Lippincott Williams & Wilkins Ltd.
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Pharmacological inhibitors of TRPV4 channels reduce cytokine production, restore endothelial function and increase survival in septic mice

Autori: Thomas Dalsgaard, Swapnil K. Sonkusare, Cory Teuscher, Matthew E. Poynter, Mark T. Nelson
Pubblicato in: Scientific Reports, Issue 6/1, 2016, ISSN 2045-2322
Editore: Nature Publishing Group
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Focal Solute Trapping and Global Glymphatic Pathway Impairment in a Murine Model of Multiple Microinfarcts

Autori: Minghuan Wang, Fengfei Ding, SaiYue Deng, Xuequn Guo, Wei Wang, Jeffrey J. Iliff, Maiken Nedergaard
Pubblicato in: The Journal of Neuroscience, Issue 37/11, 2017, Page(s) 2870-2877, ISSN 0270-6474
Editore: Society for Neuroscience
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Vascular disease and neurodegeneration: advancing together

Autori: The Lancet Neurology
Pubblicato in: The Lancet Neurology, Issue 16/5, 2017, Page(s) 333, ISSN 1474-4422
Editore: The Lancet Publishing Group
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Vascular Cognitive Impairment

Autori: Martin Dichgans, Didier Leys
Pubblicato in: Circulation Research, Issue 120/3, 2017, Page(s) 573-591, ISSN 0009-7330
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Prediction of 3-year clinical course in CADASIL

Autori: Eric Jouvent, Edouard Duchesnay, Foued Hadj-Selem, François De Guio, Jean-François Mangin, Dominique Hervé, Marco Duering, Stefan Ropele, Reinhold Schmidt, Martin Dichgans, Hugues Chabriat
Pubblicato in: Neurology, Issue 87/17, 2016, Page(s) 1787-1795, ISSN 0028-3878
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Inward rectifier potassium (Kir2.1) channels as end-stage boosters of endothelium-dependent vasodilators

Autori: Swapnil K. Sonkusare, Thomas Dalsgaard, Adrian D. Bonev, Mark T. Nelson
Pubblicato in: The Journal of Physiology, Issue 594/12, 2016, Page(s) 3271-3285, ISSN 0022-3751
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Shrinkage-mediated imaging of entire organs and organisms using uDISCO

Autori: Chenchen Pan, Ruiyao Cai, Francesca Paola Quacquarelli, Alireza Ghasemigharagoz, Athanasios Lourbopoulos, Paweł Matryba, Nikolaus Plesnila, Martin Dichgans, Farida Hellal, Ali Ertürk
Pubblicato in: Nature Methods, Issue 13/10, 2016, Page(s) 859-867, ISSN 1548-7091
Editore: Nature Publishing Group
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Capillary K+-sensing initiates retrograde hyperpolarization to increase local cerebral blood flow

Autori: Thomas A Longden, Fabrice Dabertrand, Masayo Koide, Albert L Gonzales, Nathan R Tykocki, Joseph E Brayden, David Hill-Eubanks, Mark T Nelson
Pubblicato in: Nature Neuroscience, Issue 20/5, 2017, Page(s) 717-726, ISSN 1097-6256
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Mechanistic insights into a TIMP3-sensitive pathway constitutively engaged in the regulation of cerebral hemodynamics

Autori: Carmen Capone, Fabrice Dabertrand, Celine Baron-Menguy, Athena Chalaris, Lamia Ghezali, Valérie Domenga-Denier, Stefanie Schmidt, Clément Huneau, Stefan Rose-John, Mark T Nelson, Anne Joutel
Pubblicato in: eLife, Issue 5, 2016, ISSN 2050-084X
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Purinergic regulation of vascular tone in the retrotrapezoid nucleus is specialized to support the drive to breathe

Autori: Virginia E Hawkins, Ana C Takakura, Ashley Trinh, Milene R Malheiros-Lima, Colin M Cleary, Ian C Wenker, Todd Dubreuil, Elliot M Rodriguez, Mark T Nelson, Thiago S Moreira, Daniel K Mulkey
Pubblicato in: eLife, Issue 6, 2017, ISSN 2050-084X
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Uncoupling of neurovascular communication after transient global cerebral ischemia is caused by impaired parenchymal smooth muscle K ir channel function

Autori: Gro Klitgaard Povlsen, Thomas A Longden, Adrian D Bonev, David C Hill-Eubanks, Mark T Nelson
Pubblicato in: Journal of Cerebral Blood Flow & Metabolism, Issue 36/7, 2016, Page(s) 1195-1201, ISSN 0271-678X
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Pressure-induced oxidative activation of PKG enables vasoregulation by Ca2+ sparks and BK channels

Autori: K. Khavandi, R. L. Baylie, S. A. Sugden, M. Ahmed, V. Csato, P. Eaton, D. C. Hill-Eubanks, A. D. Bonev, M. T. Nelson, A. S. Greenstein
Pubblicato in: Science Signaling, Issue 9/449, 2016, Page(s) ra100-ra100, ISSN 1937-9145
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Total Cerebral Small Vessel Disease MRI Score Is Associated with Cognitive Decline in Executive Function in Patients with Hypertension

Autori: Renske Uiterwijk, Robert J. van Oostenbrugge, Marjolein Huijts, Peter W. De Leeuw, Abraham A. Kroon, Julie Staals
Pubblicato in: Frontiers in Aging Neuroscience, Issue 8, 2016, ISSN 1663-4365
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Detection, risk factors, and functional consequences of cerebral microinfarcts

Autori: Susanne J van Veluw, Andy Y Shih, Eric E Smith, Christopher Chen, Julie A Schneider, Joanna M Wardlaw, Steven M Greenberg, Geert Jan Biessels
Pubblicato in: The Lancet Neurology, 2017, ISSN 1474-4422
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Pathogenesis of white matter changes in cerebral small vessel diseases: beyond vessel-intrinsic mechanisms

Autori: Anne Joutel, Hugues Chabriat
Pubblicato in: Clinical Science, Issue 131/8, 2017, Page(s) 635-651, ISSN 0143-5221
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Advanced Neuroimaging of Cerebral Small Vessel Disease

Autori: Gordon W. Blair, Maria Valdez Hernandez, Michael J. Thrippleton, Fergus N. Doubal, Joanna M. Wardlaw
Pubblicato in: Current Treatment Options in Cardiovascular Medicine, Issue 19/7, 2017, ISSN 1092-8464
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Education, Socioeconomic Status, and Intelligence in Childhood and Stroke Risk in Later Life

Autori: Caroline A. McHutchison, Ellen V. Backhouse, Vera Cvoro, Susan D. Shenkin, Joanna M. Wardlaw
Pubblicato in: Epidemiology, Issue 28/4, 2017, Page(s) 608-618, ISSN 1044-3983
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Early life risk factors for cerebrovascular disease

Autori: Ellen V. Backhouse, Caroline A. McHutchison, Vera Cvoro, Susan D. Shenkin, Joanna M. Wardlaw
Pubblicato in: Neurology, Issue 88/10, 2017, Page(s) 976-984, ISSN 0028-3878
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Application of Texture Analysis to Study Small Vessel Disease and Blood–Brain Barrier Integrity

Autori: Maria del C. Valdés Hernández, Victor González-Castro, Francesca M. Chappell, Eleni Sakka, Stephen Makin, Paul A. Armitage, William H. Nailon, Joanna M. Wardlaw
Pubblicato in: Frontiers in Neurology, Issue 8, 2017, ISSN 1664-2295
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Sample size considerations for trials using cerebral white matter hyperintensity progression as an intermediate outcome at 1 year after mild stroke: results of a prospective cohort study

Autori: Francesca M. Chappell, Maria del Carmen Valdés Hernández, Stephen D. Makin, Kirsten Shuler, Eleni Sakka, Martin S. Dennis, Paul A. Armitage, Susana Muñoz Maniega, Joanna M. Wardlaw
Pubblicato in: Trials, Issue 18/1, 2017, ISSN 1745-6215
Editore: BioMed Central
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Reliability of an automatic classifier for brain enlarged perivascular spaces burden and comparison with human performance

Autori: Víctor González-Castro, María del C. Valdés Hernández, Francesca M. Chappell, Paul A. Armitage, Stephen Makin, Joanna M. Wardlaw
Pubblicato in: Clinical Science, Issue 131/13, 2017, Page(s) 1465-1481, ISSN 0143-5221
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White matter hyperintensity reduction and outcomes after minor stroke

Autori: Joanna M. Wardlaw, Francesca M. Chappell, Maria del Carmen Valdés Hernández, Stephen D.J. Makin, Julie Staals, Kirsten Shuler, Michael J. Thrippleton, Paul A. Armitage, Susana Muñoz-Maniega, Anna K. Heye, Eleni Sakka, Martin S. Dennis
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Detection and characterization of small infarcts in the caudate nucleus on 7 Tesla MRI: The SMART-MR study

Autori: Rashid Ghaznawi, Jeroen de Bresser, Yolanda van der Graaf, Maarten HT Zwartbol, Theo D Witkamp, Mirjam I Geerlings, Jeroen Hendrikse
Pubblicato in: Journal of Cerebral Blood Flow & Metabolism, 2017, Page(s) 0271678X1770597, ISSN 0271-678X
Editore: Lippincott Williams & Wilkins Ltd.
DOI: 10.1177/0271678X17705974

Genetic variation at 16q24.2 is associated with small vessel stroke

Autori: Matthew Traylor, Rainer Malik, Mike A. Nalls, Ioana Cotlarciuc, Farid Radmanesh, Gudmar Thorleifsson, Ken B. Hanscombe, Carl Langefeld, Danish Saleheen, Natalia S. Rost, Idil Yet, Tim D. Spector, Jordana T. Bell, Eilis Hannon, Jonathan Mill, Ganesh Chauhan, Stephanie Debette, Joshua C. Bis, W.T. Longstreth, M. Arfan Ikram, Lenore J. Launer, Sudha Seshadri, Monica Anne Hamilton-Bruce, Jordi Jimenez
Pubblicato in: Annals of Neurology, Issue 81/3, 2017, Page(s) 383-394, ISSN 0364-5134
Editore: John Wiley & Sons Inc.
DOI: 10.1002/ana.24840

Atrial Fibrillation Genetic Risk and Ischemic Stroke Mechanisms

Autori: Steven A. Lubitz, Owen E. Parsons, Christopher D. Anderson, Emelia J. Benjamin, Rainer Malik, Lu-Chen Weng, Martin Dichgans, Cathie L. Sudlow, Peter M. Rothwell, Jonathan Rosand, Patrick T. Ellinor, Hugh S. Markus, Matthew Traylor
Pubblicato in: Stroke, Issue 48/6, 2017, Page(s) 1451-1456, ISSN 0039-2499
Editore: Lippincott Williams & Wilkins Ltd.
DOI: 10.1161/STROKEAHA.116.016198

In Vivo Imaging of Cerebrospinal Fluid Transport through the Intact Mouse Skull using Fluorescence Macroscopy

Autori: Amanda M Sweeney, Virginia Plá, Ting Du, Guojun Liu, Qian Sun, Sisi Peng, Benjamin A. Plog, Benjamin T. Kress, Xiaowei Wang, Humberto Mestre, Maiken Nedergaard
Pubblicato in: Journal of Visualized Experiments, Issue 149, 2019, Page(s) e59774, ISSN 1940-087X
Editore: MYJoVE Corporation
DOI: 10.3791/59774

Automated lesion segmentation with BIANCA: Impact of population-level features, classification algorithm and locally adaptive thresholding

Autori: Vaanathi Sundaresan, Giovanna Zamboni, Campbell Le Heron, Peter M. Rothwell, Masud Husain, Marco Battaglini, Nicola De Stefano, Mark Jenkinson, Ludovica Griffanti
Pubblicato in: NeuroImage, Issue 202, 2019, Page(s) 116056, ISSN 1053-8119
Editore: Academic Press
DOI: 10.1016/j.neuroimage.2019.116056

Spatial Gradient of Microstructural Changes in Normal-Appearing White Matter in Tracts Affected by White Matter Hyperintensities in Older Age

Autori: Susana Muñoz Maniega, Rozanna Meijboom, Francesca M. Chappell, Maria del C. Valdés Hernández, John M. Starr, Mark E. Bastin, Ian J. Deary, Joanna M. Wardlaw
Pubblicato in: Frontiers in Neurology, Issue 10, 2019, Page(s) 784, ISSN 1664-2295
Editore: Frontiers Research Foundation
DOI: 10.3389/fneur.2019.00784

“A Step and a Ceiling”: mechanical properties of Ca 2+ spark vasoregulation in resistance arteries by pressure‐induced oxidative activation of PKG

Autori: Viktoria Csato, Sharifah Z. S. A. Kadir, Kaivan Khavandi, Hayley Bennett, Sarah Sugden, Alison M. Gurney, Harry A. T. Pritchard, David Hill‐Eubanks, Philip Eaton, Mark T. Nelson, Adam S. Greenstein
Pubblicato in: Physiological Reports, Issue 7/22, 2019, Page(s) e14260, ISSN 2051-817X
Editore: Wiley
DOI: 10.14814/phy2.14260

Predictors of Lesion Cavitation After Recent Small Subcortical Stroke

Autori: Thomas Gattringer, Maria Valdes Hernandez, Anna Heye, Paul A Armitage, Stephen Makin, Francesca Chappell, Daniela Pinter, Fergus Doubal, Christian Enzinger, Franz Fazekas, Joanna M. Wardlaw
Pubblicato in: Translational Stroke Research, Issue 11/3, 2020, Page(s) 402-411, ISSN 1868-4483
Editore: Springer Pub. Co.,
DOI: 10.1007/s12975-019-00741-8

Uncoupling of Microvascular Blood Flow and Capillary Density in Vascular Cognitive Impairment

Autori: Chenxing Eleana Zhang, Julie Staals, Robert Jan van Oostenbrugge, Hans Vink
Pubblicato in: Frontiers in Neurology, Issue 10, 2019, ISSN 1664-2295
Editore: Frontiers Research Foundation
DOI: 10.3389/fneur.2019.01268

The Atherosclerosis Risk Variant rs2107595 Mediates Allele-Specific Transcriptional Regulation of HDAC9 via E2F3 and Rb1

Autori: Matthias Prestel, Caroline Prell-Schicker, Tom Webb, Rainer Malik, Barbara Lindner, Natalie Ziesch, Monika Rex-Haffner, Simone Röh, Thanatip Viturawong, Manuel Lehm, Michal Mokry, Hester den Ruijter, Saskia Haitjema, Yaw Asare, Flavia Söllner, Maryam Ghaderi Najafabadi, Rédouane Aherrahrou, Mete Civelek, Nilesh J. Samani, Matthias Mann, Christof Haffner, Martin Dichgans
Pubblicato in: Stroke, Issue 50/10, 2019, Page(s) 2651-2660, ISSN 0039-2499
Editore: Lippincott Williams & Wilkins Ltd.
DOI: 10.1161/strokeaha.119.026112

A prospective study of serum metabolites and risk of ischemic stroke

Autori: Daokun Sun, Steffen Tiedt, Bing Yu, Xueqiu Jian, Rebecca F. Gottesman, Thomas H. Mosley, Eric Boerwinkle, Martin Dichgans, Myriam Fornage
Pubblicato in: Neurology, Issue 92/16, 2019, Page(s) e1890-e1898, ISSN 0028-3878
Editore: Lippincott Williams & Wilkins Ltd.
DOI: 10.1212/wnl.0000000000007279

Prognostic value of “tissue-based” definitions of TIA and minor stroke

Autori: Robert Hurford, Linxin Li, Nicola Lovett, Magdalena Kubiak, Wilhelm Kuker, Peter M. Rothwell
Pubblicato in: Neurology, Issue 92/21, 2019, Page(s) e2455-e2461, ISSN 0028-3878
Editore: Lippincott Williams & Wilkins Ltd.
DOI: 10.1212/wnl.0000000000007531

Combining Neurovascular and Neurodegenerative Magnetic Resonance Imaging Measures in Stroke

Autori: Annick Wyss, Jesse Dawson, Francesco Arba, Joanna M. Wardlaw, David Alexander Dickie
Pubblicato in: Stroke, Issue 50/5, 2019, Page(s) 1136-1139, ISSN 0039-2499
Editore: Lippincott Williams & Wilkins Ltd.
DOI: 10.1161/STROKEAHA.118.024181

Stability of Estimated Premorbid Cognitive Ability over Time after Minor Stroke and Its Relationship with Post-Stroke Cognitive Ability

Autori: Caroline A. McHutchison, Francesca M. Chappell, Stephen Makin, Kirsten Shuler, Joanna M. Wardlaw, Vera Cvoro
Pubblicato in: Brain Sciences, Issue 9/5, 2019, Page(s) 117, ISSN 2076-3425
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/brainsci9050117

Quantifying blood-brain barrier leakage in small vessel disease: Review and consensus recommendations

Autori: Michael J. Thrippleton, Walter H. Backes, Steven Sourbron, Michael Ingrisch, Matthias J.P. van Osch, Martin Dichgans, Franz Fazekas, Stefan Ropele, Richard Frayne, Robert J. van Oostenbrugge, Eric E. Smith, Joanna M. Wardlaw
Pubblicato in: Alzheimer's & Dementia, Issue 15/6, 2019, Page(s) 840-858, ISSN 1552-5260
Editore: Elsevier BV
DOI: 10.1016/j.jalz.2019.01.013

Perivascular spaces in the centrum semiovale at the beginning of the 8th decade of life: effect on cognition and associations with mineral deposition

Autori: Maria del C. Valdés Hernández, Lucia Ballerini, Andreas Glatz, Susana Muñoz Maniega, Alan J. Gow, Mark E. Bastin, John M. Starr, Ian J. Deary, Joanna M. Wardlaw
Pubblicato in: Brain Imaging and Behavior, Issue 27-June 2019, 2019, ISSN 1931-7557
Editore: Springer Pub. Co.,
DOI: 10.1007/s11682-019-00128-1

Astrocytic connexin 43 potentiates myelin injury in ischemic white matter disease

Autori: Minghuan Wang, Chuan Qin, Xiang Luo, Jie Wang, Xuxia Wang, Minjie Xie, Jing Hu, Jie Cao, Ting Hu, Steven A. Goldman, Maiken Nedergaard, Wei Wang
Pubblicato in: Theranostics, Issue 9/15, 2019, Page(s) 4474-4493, ISSN 1838-7640
Editore: Ivyspring International Publisher
DOI: 10.7150/thno.31942

Use of Genetic Variants Related to Antihypertensive Drugs to Inform on Efficacy and Side Effects

Autori: Dipender Gill, Marios K. Georgakis, Fotios Koskeridis, Lan Jiang, Qiping Feng, Wei-Qi Wei, Evropi Theodoratou, Paul Elliott, Joshua C. Denny, Rainer Malik, Evangelos Evangelou, Abbas Dehghan, Martin Dichgans, Ioanna Tzoulaki
Pubblicato in: Circulation, Issue 140/4, 2019, Page(s) 270-279, ISSN 0009-7322
Editore: Lippincott Williams & Wilkins Ltd.
DOI: 10.1161/circulationaha.118.038814

Tolerability, safety and intermediary pharmacological effects of cilostazol and isosorbide mononitrate, alone and combined, in patients with lacunar ischaemic stroke: The LACunar Intervention-1 (LACI-1) trial, a randomised clinical trial

Autori: Gordon W. Blair, Jason P. Appleton, Katie Flaherty, Fergus Doubal, Nikola Sprigg, Richard Dooley, Carla Richardson, Iona Hamilton, Zhe Kang Law, Yulu Shi, Michael S. Stringer, Michael J. Thrippleton, Julia Boyd, Kirsten Shuler, Philip M. Bath, Joanna M. Wardlaw
Pubblicato in: EClinicalMedicine, Issue 11, 2019, Page(s) 34-43, ISSN 2589-5370
Editore: The Lancet
DOI: 10.1016/j.eclinm.2019.04.001

Effects of Isosorbide Mononitrate and/or Cilostazol on Hematological Markers, Platelet Function, and Hemodynamics in Patients With Lacunar Ischaemic Stroke: Safety Data From the Lacunar Intervention-1 (LACI-1) Trial

Autori: Jason P. Appleton, Gordon W. Blair, Katie Flaherty, Zhe Kang Law, Jane May, Lisa J. Woodhouse, Fergus Doubal, Nikola Sprigg, Philip M. Bath, Joanna M. Wardlaw
Pubblicato in: Frontiers in Neurology, Issue 10, 2019, Page(s) 723, ISSN 1664-2295
Editore: Frontiers Research Foundation
DOI: 10.3389/fneur.2019.00723

Vascular Cognitive Impairment and Dementia

Autori: Costantino Iadecola, Marco Duering, Vladimir Hachinski, Anne Joutel, Sarah T. Pendlebury, Julie A. Schneider, Martin Dichgans
Pubblicato in: Journal of the American College of Cardiology, Issue 73/25, 2019, Page(s) 3326-3344, ISSN 0735-1097
Editore: Elsevier BV
DOI: 10.1016/j.jacc.2019.04.034

Impaired Glymphatic Transport in Spontaneously Hypertensive Rats

Autori: Kristian Nygaard Mortensen, Simon Sanggaard, Humberto Mestre, Hedok Lee, Serhii Kostrikov, Anna L.R. Xavier, Albert Gjedde, Helene Benveniste, Maiken Nedergaard
Pubblicato in: The Journal of Neuroscience, Issue 39/32, 2019, Page(s) 6365-6377, ISSN 0270-6474
Editore: Society for Neuroscience
DOI: 10.1523/jneurosci.1974-18.2019

Vascular contributions to cognitive impairment and dementia: Research consortia that focus on etiology and treatable targets to lessen the burden of dementia worldwide

Autori: Jordan T. Gladman, Roderick A. Corriveau, Stephanie Debette, Martin Dichgans, Steven M. Greenberg, Perminder S. Sachdev, Joanna M. Wardlaw, Geert Jan Biessels
Pubblicato in: Alzheimer's & Dementia: Translational Research & Clinical Interventions, Issue 5/1, 2019, Page(s) 789-796, ISSN 2352-8737
Editore: Elsevier
DOI: 10.1016/j.trci.2019.09.017

Genomic risk score offers predictive performance comparable to clinical risk factors for ischaemic stroke

Autori: Gad Abraham, Rainer Malik, Ekaterina Yonova-Doing, Agus Salim, Tingting Wang, John Danesh, Adam S. Butterworth, Joanna M. M. Howson, Michael Inouye, Martin Dichgans
Pubblicato in: Nature Communications, Issue 10/1, 2019, Page(s) 1-10, ISSN 2041-1723
Editore: Nature Publishing Group
DOI: 10.1038/s41467-019-13848-1

Sleep and brain morphological changes in the eighth decade of life

Autori: Benjamin S. Aribisala, Renata L. Riha, Maria Valdes Hernandez, Susana Muñoz Maniega, Simon Cox, Ratko Radakovic, Adele Taylor, Alison Pattie, Janie Corley, Paul Redmond, Mark E. Bastin, John Starr, Ian Deary, Joanna M. Wardlaw
Pubblicato in: Sleep Medicine, Issue 65, 2020, Page(s) 152-158, ISSN 1389-9457
Editore: Elsevier BV
DOI: 10.1016/j.sleep.2019.07.015

Confounding of Cerebral Blood Flow Velocity by Blood Pressure During Breath Holding or Hyperventilation in Transient Ischemic Attack or Stroke

Autori: Alastair J.S. Webb, Matteo Paolucci, Sara Mazzucco, Linxin Li, Peter M. Rothwell
Pubblicato in: Stroke, Issue 51/2, 2020, Page(s) 468-474, ISSN 0039-2499
Editore: Lippincott Williams & Wilkins Ltd.
DOI: 10.1161/STROKEAHA.119.027829

Analysis of dynamic texture and spatial spectral descriptors of dynamic contrast-enhanced brain magnetic resonance images for studying small vessel disease

Autori: Jose Bernal, Maria del C. Valdés-Hernández, Javier Escudero, Linda Viksne, Anna K. Heye, Paul A. Armitage, Stephen Makin, Rhian M. Touyz, Joanna M. Wardlaw
Pubblicato in: Magnetic Resonance Imaging, Issue 66, 2020, Page(s) 240-247, ISSN 0730-725X
Editore: Elsevier BV
DOI: 10.1016/j.mri.2019.11.001

Reducing Hypermuscularization of the Transitional Segment Between Arterioles and Capillaries Protects Against Spontaneous Intracerebral Hemorrhage

Autori: Julien Ratelade, Nicholas R. Klug, Damiano Lombardi, Monara Kaelle Servulo Cruz Angelim, Fabrice Dabertrand, Valérie Domenga-Denier, Rustam Al-Shahi Salman, Colin Smith, Jean-Frédéric Gerbeau, Mark T. Nelson, Anne Joutel
Pubblicato in: Circulation, Issue 141/25, 2020, Page(s) 2078-2094, ISSN 0009-7322
Editore: Lippincott Williams & Wilkins Ltd.
DOI: 10.1161/CIRCULATIONAHA.119.040963

Spectral Diffusion Analysis of Intravoxel Incoherent Motion MRI in Cerebral Small Vessel Disease

Autori: Sau May Wong, Walter H. Backes, Gerhard S. Drenthen, C. Eleana Zhang, Paulien H.M. Voorter, Julie Staals, Robert J. Oostenbrugge, Jacobus F.A. Jansen
Pubblicato in: Journal of Magnetic Resonance Imaging, Issue 51/4, 2019, Page(s) 1170-1180, ISSN 1053-1807
Editore: John Wiley & Sons Inc.
DOI: 10.1002/jmri.27149

Cardiac and respiration-induced brain deformations in humans quantified with high-field MRI

Autori: Jacob Jan Sloots, Geert Jan Biessels, Jaco J.M. Zwanenburg
Pubblicato in: NeuroImage, Issue 210, 2020, Page(s) 116581, ISSN 1053-8119
Editore: Academic Press
DOI: 10.1016/j.neuroimage.2020.116581

Association between Striatal Brain Iron Deposition, Microbleeds and Cognition 1 Year After a Minor Ischaemic Stroke

Autori: Maria Valdés Hernández, Tessa Case, Francesca Chappell, Andreas Glatz, Stephen Makin, Fergus Doubal, Joanna Wardlaw
Pubblicato in: International Journal of Molecular Sciences, Issue 20/6, 2019, Page(s) 1293, ISSN 1422-0067
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms20061293

WMH and long-term outcomes in ischemic stroke

Autori: Marios K. Georgakis, Marco Duering, Joanna M. Wardlaw, Martin Dichgans
Pubblicato in: Neurology, Issue 92/12, 2019, Page(s) e1298-e1308, ISSN 0028-3878
Editore: Lippincott Williams & Wilkins Ltd.
DOI: 10.1212/wnl.0000000000007142

Computational quantification of brain perivascular space morphologies: Associations with vascular risk factors and white matter hyperintensities. A study in the Lothian Birth Cohort 1936

Autori: Lucia Ballerini, Tom Booth, Maria del C. Valdés Hernández, Stewart Wiseman, Ruggiero Lovreglio, Susana Muñoz Maniega, Zoe Morris, Alison Pattie, Janie Corley, Alan Gow, Mark E. Bastin, Ian J. Deary, Joanna Wardlaw
Pubblicato in: NeuroImage: Clinical, Issue 25, 2020, Page(s) 102120, ISSN 2213-1582
Editore: Elsevier BV
DOI: 10.1016/j.nicl.2019.102120

Imaging markers of small vessel disease and brain frailty, and outcomes in acute stroke

Autori: Jason P. Appleton, Lisa J. Woodhouse, Alessandro Adami, Jennifer L. Becker, Eivind Berge, Lesley A. Cala, Ana M. Casado, Valeria Caso, Hanne K. Christensen, Robert A. Dineen, John Gommans, Panos Koumellis, Szabolcs Szatmari, Nikola Sprigg, Philip M. Bath, Joanna M. Wardlaw
Pubblicato in: Neurology, Issue 94/5, 2020, Page(s) e439-e452, ISSN 0028-3878
Editore: Lippincott Williams & Wilkins Ltd.
DOI: 10.1212/wnl.0000000000008881

Protocol: The Lacunar Intervention Trial 2 (LACI-2). A trial of two repurposed licenced drugs to prevent progression of cerebral small vessel disease

Autori: Joanna Wardlaw, Philip M W Bath, Fergus Doubal, Anna Heye, Nikola Sprigg, Lisa J Woodhouse, Gordon Blair, Jason Appleton, Vera Cvoro, Timothy England, Ahamad Hassan, David John Werring, Alan Montgomery
Pubblicato in: European Stroke Journal, Issue April 2020, 2020, Page(s) 239698732092011, ISSN 2396-9873
Editore: SAGE Publishing
DOI: 10.1177/2396987320920110

Automatic spatial estimation of white matter hyperintensities evolution in brain MRI using disease evolution predictor deep neural networks

Autori: Muhammad Febrian Rachmadi, Maria del C. Valdés-Hernández, Stephen Makin, Joanna Wardlaw, Taku Komura
Pubblicato in: Medical Image Analysis, Issue 63, 2020, Page(s) 101712, ISSN 1361-8415
Editore: Elsevier BV
DOI: 10.1016/j.media.2020.101712

Relationship Between Venules and Perivascular Spaces in Sporadic Small Vessel Diseases

Autori: Angela C.C. Jochems, Gordon W. Blair, Michael S. Stringer, Michael J. Thrippleton, Una Clancy, Francesca M. Chappell, Rosalind Brown, Daniela Jaime Garcia, Olivia K.L. Hamilton, Alasdair G. Morgan, Ian Marshall, Kirstie Hetherington, Stewart Wiseman, Tom MacGillivray, Maria C. Valdés-Hernández, Fergus N. Doubal, Joanna M. Wardlaw
Pubblicato in: Stroke, Issue 51/5, 2020, Page(s) 1503-1506, ISSN 0039-2499
Editore: Lippincott Williams & Wilkins Ltd.
DOI: 10.1161/strokeaha.120.029163

Examining the Relationship between Semiquantitative Methods Analysing Concentration-Time and Enhancement-Time Curves from Dynamic-Contrast Enhanced Magnetic Resonance Imaging and Cerebrovascular Dysfunction in Small Vessel Disease

Autori: Jose Bernal, María Valdés-Hernández, Javier Escudero, Eleni Sakka, Paul A. Armitage, Stephen Makin, Rhian M. Touyz, Joanna M. Wardlaw
Pubblicato in: Journal of Imaging, Issue 6/6, 2020, Page(s) 43, ISSN 2313-433X
Editore: Multidisciplinary Digital Publishing Institute
DOI: 10.3390/jimaging6060043

Rationale and design of a longitudinal study of cerebral small vessel diseases, clinical and imaging outcomes in patients presenting with mild ischaemic stroke: Mild Stroke Study 3

Autori: Una Clancy, Daniela Jaime Garcia, Michael S Stringer, Michael J Thrippleton, Maria C Valdés-Hernández, Stewart Wiseman, Olivia KL Hamilton, Francesca M Chappell, Rosalind Brown, Gordon W Blair, Will Hewins, Emilie Sleight, Lucia Ballerini, Mark E Bastin, Susana Munoz Maniega, Tom MacGillivray, Kirstie Hetherington, Charlene Hamid, Carmen Arteaga, Alasdair G Morgan, Cameron Manning, Ellen Backhou
Pubblicato in: European Stroke Journal, 2020, Page(s) 239698732092961, ISSN 2396-9873
Editore: SAGE Publishing
DOI: 10.1177/2396987320929617

Genetic determinants of blood lipids and cerebral small vessel disease: role of high-density lipoprotein cholesterol

Autori: Marios K Georgakis, Rainer Malik, Christopher D Anderson, Klaus G Parhofer, Jemma C Hopewell, Martin Dichgans
Pubblicato in: Brain, Issue 143/2, 2020, Page(s) 597-610, ISSN 0006-8950
Editore: Oxford University Press
DOI: 10.1093/brain/awz413

Interleukin-6 Signaling Effects on Ischemic Stroke and Other Cardiovascular Outcomes

Autori: Marios K. Georgakis, Rainer Malik, Dipender Gill, Nora Franceschini, Cathie L. M. Sudlow, Martin Dichgans, Sara Lindstrom, Lu Wang, Erin N. Smith, William Gordon, Astrid van Hylckama Vlieg, Mariza de Andrade, Jennifer A. Brody, Jack W. Pattee, Jeffrey Haessler, Ben M. Brumpton, Daniel I. Chasman, Pierre Suchon, Ming-Huei Chen, Constance Turman, Marine Germain, Kerri L. Wiggins, James MacDonald, Si
Pubblicato in: Circulation: Genomic and Precision Medicine, Issue 13/3, 2020, Page(s) e002872, ISSN 2574-8300
Editore: American Heart Association
DOI: 10.1161/circgen.119.002872

Stroke genetics: discovery, biology, and clinical applications

Autori: Martin Dichgans, Sara L Pulit, Jonathan Rosand
Pubblicato in: The Lancet Neurology, Issue 18/6, 2019, Page(s) 587-599, ISSN 1474-4422
Editore: The Lancet Publishing Group
DOI: 10.1016/S1474-4422(19)30043-2

Prognostic relevance of cortical superficial siderosis in cerebral amyloid angiopathy

Autori: Frank Arne Wollenweber, Christian Opherk, Marialuisa Zedde, Cihan Catak, Rainer Malik, Marco Duering, Marek Janusz Konieczny, Rosario Pascarella, Raquel Samões, Manuel Correia, Joan Martí-Fàbregas, Jennifer Linn, Martin Dichgans
Pubblicato in: Neurology, Issue 92/8, 2019, Page(s) e792-e801, ISSN 0028-3878
Editore: Lippincott Williams & Wilkins Ltd.
DOI: 10.1212/wnl.0000000000006956

Preventing dementia by preventing stroke: The Berlin Manifesto

Autori: Vladimir Hachinski, Karl Einhäupl, Detlev Ganten, Suvarna Alladi, Carol Brayne, Blossom C.M. Stephan, Melanie D. Sweeney, Berislav Zlokovic, Yasser Iturria-Medina, Costantino Iadecola, Nozomi Nishimura, Chris B. Schaffer, Shawn N. Whitehead, Sandra E. Black, Leif Østergaard, Joanna Wardlaw, Steven Greenberg, Leif Friberg, Bo Norrving, Brian Rowe, Yves Joanette, Werner Hacke, Lewis Kuller, Martin
Pubblicato in: Alzheimer's & Dementia, Issue 15/7, 2019, Page(s) 961-984, ISSN 1552-5260
Editore: Elsevier BV
DOI: 10.1016/j.jalz.2019.06.001

Vessel-Associated Immune Cells in Cerebrovascular Diseases: From Perivascular Macrophages to Vessel-Associated Microglia

Autori: Takashi Koizumi, Danielle Kerkhofs, Toshiki Mizuno, Harry W. M. Steinbusch, Sébastien Foulquier
Pubblicato in: Frontiers in Neuroscience, Issue 13, 2019, Page(s) 1291, ISSN 1662-453X
Editore: Frontiers Media S.A.
DOI: 10.3389/fnins.2019.01291

Circulating Monocyte Chemoattractant Protein-1 and Risk of Stroke

Autori: Marios K. Georgakis, Rainer Malik, Harry Björkbacka, Tiberiu Alexandru Pana, Serkalem Demissie, Colby Ayers, Mohamed A. Elhadad, Myriam Fornage, Alexa S. Beiser, Emelia J. Benjamin, S. Matthijs Boekholdt, Gunnar Engström, Christian Herder, Ron C. Hoogeveen, Wolfgang Koenig, Olle Melander, Marju Orho-Melander, Alexandru Schiopu, Martin Söderholm, Nick Wareham, Christie M. Ballantyne, Annette Pet
Pubblicato in: Circulation Research, Issue 125/8, 2019, Page(s) 773-782, ISSN 0009-7330
Editore: Lippincott Williams & Wilkins Ltd.
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Genetically Downregulated Interleukin-6 Signaling Is Associated With a Favorable Cardiometabolic Profile

Autori: Georgakis MK, Malik R, Li X, Gill D, Levin MG, Vy HMT, Judy R, Ritchie M, Verma SS; Regeneron Genetics Center, Nadkarni GN, Damrauer SM, Theodoratou E, Dichgans M
Pubblicato in: Circulation, Issue 143(11), 2021, Page(s) 1177-1180, ISSN 0009-7322
Editore: Lippincott Williams & Wilkins Ltd.
DOI: 10.1161/circulationaha.120.052604

Cognitive impairment in sporadic cerebral small vessel disease: A systematic review and meta-analysis

Autori: Hamilton O KL, Blackhouse EV, Janssen E, Jochems A, Maher C, Ritakari TE, Stevenson AJ, Xia L, Deary IA, Wardlaw JM.
Pubblicato in: Alzheimers Dement, 2021, ISSN 1552-5279
Editore: Alzheimer’s Association
DOI: 10.1177/23969873211000258

Pharmacological depletion of microglia and perivascular macrophages prevents vascular Cognitive Impairment in Ang II-induced Hypertension

Autori: Danielle Kerkhofs, Britt T. van Hagen, Irina V. Milanova, Kimberly J. Schell, Helma van Essen, Erwin Wijnands, Pieter Goossens, W. Matthijs Blankesteijn, Thomas Unger, Jos Prickaerts, Erik A. Biessen, Robert J. van Oostenbrugge, Sébastien Foulquier
Pubblicato in: Theranostics, Issue 10/21, 2020, Page(s) 9512-9527, ISSN 1838-7640
Editore: Ivyspring International Publisher
DOI: 10.7150/thno.44394

PIP2: A critical regulator of vascular ion channels hiding in plain sight

Autori: Harraz OF, Hill-Eubanks D, Nelson MT
Pubblicato in: PNAS, 2021, ISSN 1091-6490
Editore: PNAS
DOI: 10.1073/pnas.2006737117

Monocyte-Chemoattractant Protein-1 Levels in Human Atherosclerotic Lesions Associate With Plaque Vulnerability

Autori: Georgakis MK, van der Laan SW, Asare Y, Mekke JM, Haitjema S, Schoneveld AH, de Jager SCA, Nurmohamed NS, Kroon J, Stroes ESG, de Kleijn DPV, de Borst GJ, Maegdefessel L, Soehnlein O, Pasterkamp G, Dichgans M
Pubblicato in: Arterioscler Thromb Vasc Biol., Issue 41(6), 2021, Page(s) 2038-2048., ISSN 1079-5642
Editore: Lippincott Williams & Wilkins Ltd.
DOI: 10.1161/atvbaha.121.316091

PIP2 Improves Cerebral Blood Flow in a Mouse Model of Alzheimer's Disease

Autori: Mughal A, Harraz OF, Gonzales AL, Hill-Eubanks D, Nelson MT
Pubblicato in: Function (Oxf), 2021, ISSN 2633-8823
Editore: American Physiological Society
DOI: 10.1093/function/zqab010

Cardiometabolic traits mediating the effect of education on osteoarthritis risk: a Mendelian randomization study.

Autori: Gill D, Karhunen V, Malik R, Dichgans M, Sofat N.
Pubblicato in: Osteoarthritis Cartilage, Issue 29(3), 2021, Page(s) 365-371, ISSN 1063-4584
Editore: W. B. Saunders Co., Ltd.
DOI: 10.1016/j.joca.2020.12.015

A Case of Sporadic Cerebral Small Vessel Disease in an Identical Twin.

Autori: van den Brink H, Weaver NA, Biessels GJ
Pubblicato in: Case reports in neurology, 2020, ISSN 1662-680X
Editore: S. Karger AG
DOI: 10.1159/000511027

Diabetes Mellitus, Glycemic Traits, and Cerebrovascular Disease: A Mendelian Randomization Study

Autori: Georgakis MK, Harshfield EL, Malik R, Franceschini N, Langenberg C, Wareham NJ, Markus HS, Dichgans M
Pubblicato in: Neurology, Issue 96(13), 2021, Page(s) e1732-e1742, ISSN 1526-632X
Editore: American Academy of Neurology
DOI: 10.1212/wnl.0000000000011555

Tracer kinetic assessment of blood-brain barrier leakage and blood volume in cerebral small vessel disease: associations with disease burden and vascular risk factors

Autori: Stringer MS, Heye AK, Armitage PA, Chappell F, del C. Valdés Hernándeza M, Mankin SDJ, Sakka E, Thrippleton MJ, Wardlaw JM.
Pubblicato in: Neuroimage Clin, 2021, ISSN 2213-1582
Editore: Elsevier BV
DOI: 10.1016/j.nicl.2021.102883

Velocity and Pulsatility Measures in the Perforating Arteries of the Basal Ganglia at 3T MRI in Reference to 7T MRI

Autori: Tine Arts, Timion A. Meijs, Heynric Grotenhuis, Michiel Voskuil, Jeroen Siero,Geert Jan Biessels and Jaco Zwanenburg
Pubblicato in: Frontiers in Neurosciences, 2021, ISSN 1662-453X
Editore: Frontiers
DOI: 10.3389/fnins.2021.665480

The capillary Kir channel as sensor and amplifier of neuronal signals: Modeling insights on K + -mediated neurovascular communication

Autori: Arash Moshkforoush, Baarbod Ashenagar, Osama F. Harraz, Fabrice Dabertrand, Thomas A. Longden, Mark T. Nelson, Nikolaos M. Tsoukias
Pubblicato in: Proceedings of the National Academy of Sciences, Issue 117/28, 2020, Page(s) 16626-16637, ISSN 0027-8424
Editore: National Academy of Sciences
DOI: 10.1073/pnas.2000151117

Structural neuroimaging differentiates vulnerability from disease manifestation in colombian families with Huntington's disease

Autori: Maria del C. Valdés Hernández, Janna Abu‐Hussain, Xinyi Qiu, Josef Priller, Mario Parra Rodríguez, Mariana Pino, Sandra Báez, Agustín Ibáñez
Pubblicato in: Brain and Behavior, Issue 9/8, 2019, Page(s) e01343, ISSN 2162-3279
Editore: Wiley
DOI: 10.1002/brb3.1343

Cilostazol for secondary prevention of stroke and cognitive decline: Systematic review and meta-analysis

Autori: McHutchison C, Blair GW, Appleton JP, Chappell FM, Doubal F, Bath PM, Wardlaw JM.
Pubblicato in: Stroke, 2021, ISSN 0039-2499
Editore: Lippincott Williams & Wilkins Ltd.
DOI: 10.1161/strokeaha.120.029454

Genetic risk, incident stroke, and the benefits of adhering to a healthy lifestyle: cohort study of 306 473 UK Biobank participants

Autori: Loes CA Rutten-Jacobs, Susanna C Larsson, Rainer Malik, Kristiina Rannikmäe, Cathie L Sudlow, Martin Dichgans, Hugh S Markus, Matthew Traylor
Pubblicato in: BMJ, Issue 363, 2018, Page(s) k4168, ISSN 0959-8138
Editore: British Medical Association
DOI: 10.1136/bmj.k4168

Cortical cerebral microinfarcts on 7T MRI: Risk factors, neuroimaging correlates and cognitive functioning - The Medea-7T study.

Autori: Zwartbol MH, Rissanen I, Ghaznawi R, de Bresser J, Kuijf HJ, Blom K, Witkamp TD, Koek HL, Biessels GJ, Hendrikse J, Geerlings MI.
Pubblicato in: J Cereb Blood Flow Metab, 2021, ISSN 0271-678X
Editore: Lippincott Williams & Wilkins Ltd.
DOI: 10.1177/0271678x211025447

Differential restoration of functional hyperemia by antihypertensive drug classes in hypertension-related cerebral small vessel diseases

Autori: Koide M, Harraz OF, Dabertrand F, Longden TA, Ferris HR, Wellman GC, Hill-Eubanks DC, Greenstein AS, Nelson M.
Pubblicato in: J Clin Invest, 2021, ISSN 0021-9738
Editore: American Society for Clinical Investigation
DOI: 10.1172/jci149029

Genetically determined blood pressure, antihypertensive drug classes, and risk of stroke subtypes

Autori: Georgakis MK, Gill D, Webb AJS, Evangelou E, Elliott P, Sudlow CLM, Dehghan A, Malik R, Tzoulaki I, Dichgans M
Pubblicato in: Neurology, Issue 95(4), 2020, Page(s) e353-e361, ISSN 0028-3878
Editore: Lippincott Williams & Wilkins Ltd.
DOI: 10.1212/wnl.0000000000009814

Circulating biomarkers of immunity and inflammation, risk of Alzheimer's disease, and hippocampal volume: a Mendelian randomization study

Autori: Fani L, Georgakis MK, Ikram MA, Ikram MK, Malik R, Dichgans M. 
Pubblicato in: Transl Psychiatry, 2021, ISSN 2158-3188
Editore: Nature Publishing Group
DOI: 10.1038/s41398-021-01400-z

Modifiable Lifestyle Factors and Risk of Stroke

Autori: Harshfield EL, Georgakis MK, Malik R, Dichgans M, Markus HS.
Pubblicato in: Stroke, Issue 52(3), 2021, Page(s) 931-936., ISSN 0039-2499
Editore: Lippincott Williams & Wilkins Ltd.
DOI: 10.1161/strokeaha.120.031710

Automated Assessment of Cerebral Arterial Perforator Function on 7T MRI

Autori: Tine Arts, MS,1* Jeroen C.W. Siero, PhD,1,2 Geert Jan Biessels, MD,3 and Jaco J.M. Zwanenburg,
Pubblicato in: Journal of Magnetic Resonance Imaging, 2021, ISSN 1090-7807
Editore: Academic Press
DOI: 10.1002/jmri.27304

The contribution of acute infarcts to cerebral small vessel disease progression

Autori: Annemieke Telgte, Kim Wiegertjes, Benno Gesierich, José P. Marques, Mathias Huebner, Jabke J. Klerk, Floris H. B. M. Schreuder, Miguel A. Araque Caballero, Hugo J. Kuijf, David G. Norris, Catharina J. M. Klijn, Martin Dichgans, Anil M. Tuladhar, Marco Duering, Frank‐Erik Leeuw
Pubblicato in: Annals of Neurology, Issue 86/4, 2019, Page(s) 582-592, ISSN 0364-5134
Editore: John Wiley & Sons Inc.
DOI: 10.1002/ana.25556

Traumatic Brain Injury Impairs Systemic Vascular Function Through Disruption of Inward-Rectifier Potassium Channels

Autori: Sackheim AM, Villalba N, Sancho M, Harraz OF, Bonev AD, D'Alessandro A, Nemkov T, Nelson MT, Freeman K
Pubblicato in: Function (Oxf), 2021, ISSN 2633-8823
Editore: American Physiological Society
DOI: 10.1093/function/zqab018

Genome-wide association study of intracranial aneurysms identifies 17 risk loci and genetic overlap with clinical risk factors

Autori: Bakker MK, van der Spek RAA, van Rheenen W, Morel S, Bourcier R, Hostettler IC, Alg VS, van Eijk KR, Koido M, Akiyama M, Terao C, Matsuda K, Walters RG, Lin K, Li L, Millwood IY, Chen Z, Rouleau GA, Zhou S, Rannikmäe K, Sudlow CLM, Houlden H, van den Berg LH, Dina C, Naggara O, Gentric JC, Shotar E, Eugène F, Desal H, Winsvold BS, Børte S, Johnsen MB, Brumpton BM, Sandvei MS, Willer CJ, Hveem K
Pubblicato in: Nature Genetics, Issue 52(12), 2021, Page(s) 1303-1313, ISSN 1061-4036
Editore: Nature Publishing Group
DOI: 10.1038/s41588-020-00725-7

Cerebrovascular Reactivity Measurement Using Magnetic Resonance Imaging: A Systematic Review

Autori: Emilie Sleight 1 2, Michael S Stringer 1 2, Ian Marshall 1 2, Joanna M Wardlaw 1 2, Michael J Thrippleton 1 2
Pubblicato in: Front Neurol., 2021, ISSN 1662-453X
Editore: Frontiers
DOI: 10.3389/fphys.2021.643468

Impaired capillary-to-arteriolar electrical signaling after traumatic brain injury

Autori: Mughal A, Sackheim AM, Sancho M, Longden TA, Russell S, Lockette W, Nelson MT, Freeman K
Pubblicato in: J Cereb Blood Flow Metab, 2021, ISSN 0271-678X
Editore: Lippincott Williams & Wilkins Ltd.
DOI: 10.1177/0271678x20962594

Direct Measurement of Cerebrospinal Fluid Production in Mice

Autori: Liu G, Mestre H, Sweeney AM, Sun Q, Weikop P, Du T, Nedergaard M
Pubblicato in: Cell reports, 2020, ISSN 2211-1247
Editore: Cell Press
DOI: 10.1016/j.celrep.2020.108524

Local IP3 receptor-mediated Ca2+ signals compound to direct blood flow in brain capillaries

Autori: Longden TA, Mughal A, Hennig GW, Harraz OF, Shui B, Lee FK, Lee JC, Reining S, Kotlikoff MI, Kong GM, Kostenis E, Hill-Eubanks D, Nelson MT
Pubblicato in: Sci Adv, 2021, ISSN 2375-2548
Editore: American Association for the Advancement of Science
DOI: 10.1126/sciadv.abh0101

A four-dimensional computational model of dynamic contrast-enhanced magnetic resonance imaging measurement of subtle blood-brain barrier leakage.

Autori: Bernal J, Valdés-Hernández MD, Escudero J, Heye A, Sakka E, Armitage PA, Makin S, Touyz RM, Wardlaw JM. Thrippleton MJ
Pubblicato in: Neuroimage, 2021, ISSN 1053-8119
Editore: Academic Press
DOI: 10.1016/j.neuroimage.2021.117786

Topological relationships between perivascular spaces and progression of white matter hyperintensities: a pilot study in a sample of the Lothian Birth Cohort 1936

Autori: Barnes A, Ballerini L, Valdés Hernández M, Chappell FM, Muñoz Maniega S, Meijboom R, Backhouse EV, Stringer MS, Coello RD, Brown R, Bastin ME, Cox SR, Deary IJ, Wardlaw JM.
Pubblicato in: medrix, 2021
Editore: medrix
DOI: 10.1101/2021.09.18.21263770

Sex differences in cerebral small vessel disease: a systematic review and meta-analysis

Autori: Jimenez Sanchez L, Hamilton OK, Backhouse EV, Clancy U, Stewart C, Wardlaw JM
Pubblicato in: medrix, 2021
Editore: medrix
DOI: 10.1101/2021.03.04.21252853

Diabetes mellitus, glycemic traits, and cerebrovascular disease: a Mendelian randomization study

Autori: Marios K Georgakis; Eric Harshfield; Rainer Malik; Nora Franceschini; Claudia Langenberg; Nick Wareham; Hugh S Markus; Martin Dichgans
Pubblicato in: Issue 9, 2019
Editore: medRxiv
DOI: 10.1101/2019.12.27.19015834

Letter, Small Vessel Disease and Social Cognition.

Autori: Hamilton OK, Wardlaw JM. Response to Schroeter ML
Pubblicato in: Alzheimers Dement, 2021, ISSN 1552-5279
Editore: Alzheimer'S Association
DOI: 10.1002/alz.12402

Modifiable lifestyle factors and risk of stroke: a Mendelian randomization analysis

Autori: Harshfield, Eric L; Georgakis, Marios K; Malik, Rainer; Dichgans, Martin; Markus, Hugh S
Pubblicato in: Crossref, Issue 8, 2020
Editore: medRxiv
DOI: 10.1101/2020.03.17.20037549

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