Self-Organising Capacity of Stem Cells during Implantation and Early Post-implantation Development: Implications for Human Development

Publicaciones

Morphogenesis of extra-embryonic tissues directs the remodelling of the mouse embryo at implantation

Autores: Christodoulou N, Weberling A, Strathdee D, Anderson KI, Timpson P and Zernicka-Goetz M.
Publicado en: Nature Communications, 2019, ISSN 2041-1723
Editor: Nature Publishing Group
DOI: 10.1038/s41467-019-11482-5

Trophectoderm mechanics direct epiblast shape upon embryo implantation

Autores: Weberling A and Zernicka-Goetz M.
Publicado en: Cell Reports, 2021, ISSN 2211-1247
Editor: Cell Press
DOI: 10.1016/j.celrep.2020.108655

Embryo Size Regulates the Timing and Mechanism of Pluripotent Tissue Morphogenesis.

Autores: Orietti LC, Rosa VS, Antonica F, Kyprianou C, Mansfield W, Marques-Souza H, Shahbazi MN and Zernicka-Goetz M.
Publicado en: Stem Cell Reports, 2020, ISSN 2213-6711
Editor: Cell Press
DOI: 10.1016/j.stemcr.2020.09.004

Concerted cell divisions in embryonic visceral endoderm guide anterior visceral endoderm migration

Autores: Francesco Antonica; Lorenzo Carlo Orietti; Richard L. Mort; Magdalena Zernicka-Goetz
Publicado en: Developmental Biology, Edición 3, 2019, ISSN 0012-1606
Editor: Academic Press
DOI: 10.1016/j.ydbio.2019.03.016

BMP signalling is required for extra-embryonic ectoderm development during pre-to-post-implantation transition of the mouse embryo.

Autores: Sozen B, Demir N and Zernicka-Goetz M
Publicado en: Developmental Biology, 2021, ISSN 0012-1606
Editor: Academic Press
DOI: 10.1016/j.ydbio.2020.11.005

Basement membrane remodelling regulates mouse embryogenesis

Autores: Kyprianou C, Christodoulou N, Hamilton RS, Nahaboo W, Boomgaard DS, Amadei G, Migeotte I and Zernicka-Goetz M.
Publicado en: Nature, 2020, ISSN 0028-0836
Editor: Nature Publishing Group
DOI: 10.1038/s41586-020-2264-2

Reconstructing aspects of human embryogenesis with pluripotent stem cells.

Autores: Sozen B, Jorgensen V, Weatherbee BAT, Chen S, Zhu M, Zernicka-Goetz M.
Publicado en: Nature Communications, 2021, ISSN 2041-1723
Editor: Nature Publishing Group
DOI: 10.1038/s41467-021-25853-4

Autophagy-mediated apoptosis eliminates aneuploid cells in a mouse model of chromosome mosaicism

Autores: Singla S, Iwamoto-Stohl LK, Zhu M and Zernicka-Goetz M.
Publicado en: Nature Communications, 2020, ISSN 2041-1723
Editor: Nature Publishing Group
DOI: 10.1038/s41467-020-16796-3

Inducible Stem-Cell-Derived Embryos Capture Mouse Morphogenetic Events In Vitro

Autores: Amadei G, Lau KYC, De Jonghe J, Gantner CW, Sozen B, Chan C, Zhu M, Kyprianou C, Hollfelder F and Zernicka-Goetz M.
Publicado en: Developmental Cell, 2021, ISSN 1878-1551
Editor: Cell Press
DOI: 10.1016/j.devcel.2020.12.004

Integrin β1 coordinates survival and morphogenesis of the embryonic lineage upon implantation and pluripotency transition

Autores: Molè MA, Weberling A, Fässler R, Campbell A, Fishel S and Zernicka-Goetz M.
Publicado en: Cell Reports, 2021, ISSN 2211-1247
Editor: Cell Press
DOI: 10.1016/j.celrep.2021.108834

Self-Organization of Mouse Stem Cells into an Extended Potential Blastoid.

Autores: Berna Sozen; Berna Sozen; Andy Cox; Andy Cox; Joachim De Jonghe; Min Bao; Florian Hollfelder; David M. Glover; David M. Glover; Magdalena Zernicka-Goetz; Magdalena Zernicka-Goetz
Publicado en: Developmental Cell, 2019, ISSN 1878-1551
Editor: Cell Press
DOI: 10.17863/cam.47244

Deconstructing and reconstructing the mouse and human early embryo

Autores: Marta N. Shahbazi, Magdalena Zernicka-Goetz
Publicado en: Nature Cell Biology, Edición 20/8, 2018, Página(s) 878-887, ISSN 1465-7392
Editor: Nature Publishing Group
DOI: 10.1038/s41556-018-0144-x

In vitro generation of mouse polarized embryo-like structures from embryonic and trophoblast stem cells

Autores: Sarah Ellys Harrison, Berna Sozen, Magdalena Zernicka-Goetz
Publicado en: Nature Protocols, Edición 13/7, 2018, Página(s) 1586-1602, ISSN 1754-2189
Editor: Nature Publishing Group
DOI: 10.1038/s41596-018-0005-x

Self-assembly of embryonic and two extra-embryonic stem cell types into gastrulating embryo-like structures

Autores: Berna Sozen, Gianluca Amadei, Andy Cox, Ran Wang, Ellen Na, Sylwia Czukiewska, Lia Chappell, Thierry Voet, Geert Michel, Naihe Jing, David M. Glover, Magdalena Zernicka-Goetz
Publicado en: Nature Cell Biology, Edición 20/8, 2018, Página(s) 979-989, ISSN 1465-7392
Editor: Nature Publishing Group
DOI: 10.1038/s41556-018-0147-7

Pluripotent state transitions coordinate morphogenesis in mouse and human embryos

Autores: Marta N. Shahbazi, Antonio Scialdone, Natalia Skorupska, Antonia Weberling, Gaelle Recher, Meng Zhu, Agnieszka Jedrusik, Liani G. Devito, Laila Noli, Iain C. Macaulay, Christa Buecker, Yakoub Khalaf, Dusko Ilic, Thierry Voet, John C. Marioni, Magdalena Zernicka-Goetz
Publicado en: Nature, 2017, ISSN 0028-0836
Editor: Nature Publishing Group
DOI: 10.1038/nature24675

Assembly of embryonic and extraembryonic stem cells to mimic embryogenesis in vitro

Autores: Sarah Ellys Harrison, Berna Sozen, Neophytos Christodoulou, Christos Kyprianou, Magdalena Zernicka-Goetz
Publicado en: Science, Edición 356/6334, 2017, Página(s) eaal1810, ISSN 0036-8075
Editor: American Association for the Advancement of Science
DOI: 10.1126/science.aal1810

Synthetic embryos complete gastrulation to neurulation and organogenesis.

Autores: Amadei G, Handford CE, Qiu C, De Jonghe J, Greenfeld H, Tran M, Martin BK, Chen DY, Aguilera-Castrejon A, Hanna JH, Elowitz M, Hollfelder F, Shendure J, Glover DM, Zernicka-Goetz M.
Publicado en: Nature, 2022, ISSN 1476-4687
Editor: Nature Publishing Group
DOI: 10.1038/s41586-022-05246-3

An in vitro stem cell model of human epiblast and yolk sac interaction

Autores: Mackinlay K, Weatherbee BAT, Rosa VS, Handford CE, Hudson G, Coorens T, Pereira LV, Behjati S, Vallier L, Shahbazi M and Zernicka-Goetz M.
Publicado en: eLife, 2021, ISSN 2050-084X
Editor: eLife Sciences Publications
DOI: 10.7554/elife.63930

Sequential formation and resolution of multiple rosettes drive embryo remodelling after implantation

Autores: Christodoulou N, Kyprianou C, Weberling A, Wang R, Cui G, Peng G, Jing N and Zernicka-Goetz M.
Publicado en: Nature Cell Biology, 2018, ISSN 1476-4679
Editor: Nature Publishing Group
DOI: 10.1038/s41556-018-0211-3

Derechos de propiedad intelectual

method and medium composition used to generate stem cell–derived embryos

Número de solicitud/publicación: UK 1615343.9
Fecha: 2017-05-01

method and medium composition used to generate stem cell–derived embryos

Número de solicitud/publicación: UK 1615343.9
Fecha: 2017-05-01

method and medium composition used to generate stem cell–derived embryos

Número de solicitud/publicación: UK 1615343.9
Fecha: 2017-05-01

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Publicaciones

Derechos de propiedad intelectual

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