Image-Guided Surgery (IGS) and Personalised Postoperative Immunotherapy To Improving Cancer Outcome

Risultati finali

Training by research and network-wide training completed
Dissemination plan (M7) and Project publications including review articles written by ESRs (M48)
Public engagement activities completed
Conference M30 (Gantt Chart)
Progress reports and periodic reports to EC

Progress reports and periodic reports to EC (months 1-48)

Rotations and SECs completed

Project website live

Pubblicazioni

Optimization of the Extraction from Spent Coffee Grounds Using the Desirability Approach

Autori: Maria Rosa Gigliobianco, Barbara Campisi, Dolores Vargas Peregrina, Roberta Censi, Gulzhan Khamitova, Simone Angeloni, Giovanni Caprioli, Marco Zannotti, Stefano Ferraro, Rita Giovannetti, Cristina Angeloni, Giulio Lupidi, Letizia Pruccoli, Andrea Tarozzi, Dario Voinovich, Piera Di Martino
Pubblicato in: Antioxidants, Numero 9/5, 2020, Pagina/e 370, ISSN 2076-3921
Editore: x
DOI: 10.3390/antiox9050370

Evaluating Brightness and Spectral Properties of Click Beetle and Firefly Luciferases Using Luciferin Analogues: Identification of Preferred Pairings of Luciferase and Substrate for In Vivo Bioluminescence Imaging

Autori: Giorgia Zambito, Natasa Gaspar, Yanto Ridwan, Mary P. Hall, Ce Shi, Thomas A. Kirkland, Lance P. Encell, Clemens Löwik, Laura Mezzanotte
Pubblicato in: Molecular Imaging and Biology, 2020, ISSN 1536-1632
Editore: Elsevier BV
DOI: 10.1007/s11307-020-01523-7

The Effects of Crosslinking on the Rheology and Cellular Behavior of Polymer-Based 3D-Multilayered Scaffolds for Restoring Articular Cartilage

Autori: Yaima Campos, Francisco J. Sola, Gastón Fuentes, Luis Quintanilla, Amisel Almirall, Luis J. Cruz, José C. Rodríguez-Cabello, Yasuhiko Tabata
Pubblicato in: Polymers, Numero 13/6, 2021, Pagina/e 907, ISSN 2073-4360
Editore: MDPI
DOI: 10.3390/polym13060907

Apoptosis in human liver carcinoma caused by gold nanoparticles in combination with carvedilol is mediated via modulation of MAPK/Akt/mTOR pathway and EGFR/FAAD proteins

Autori: Raimundo De Araï¿½jo Jr, Jonas Pessoa, Luis Cruz, Alan Chan, Emï¿½lio De Castro Miguel, Rï¿½mulo Cavalcante, Gerly Anne Brito, Heloiza Fernada Silva, Luiz Gasparotto, Paulo Guedes, Aurigena Araï¿½jo
Pubblicato in: International Journal of Oncology, 2017, ISSN 1019-6439
Editore: Demetrios A. Spandidos Ed. & Pub.
DOI: 10.3892/ijo.2017.4179

Spherical neutral Gold nanoparticles improve anti-inflammatory response, oxidative stress and fibrosis in alcohol-methamphetamine-induced liver injury in rats

Autori: Thaís Gomes de Carvalho, Vinícius Barreto Garcia, Aurigena Antunes de Araújo, Luiz Henrique da Silva Gasparotto, Heloiza Silva, Gerlane Coelho Bernardo Guerra, Emilio de Castro Miguel, Renata Ferreira de Carvalho Leitão, Deiziane Viana da Silva Costa, Luis J Cruz, Alan B. Chan, Raimundo Fernandes de Araújo Júnior
Pubblicato in: International Journal of Pharmaceutics, 2018, ISSN 0378-5173
Editore: Elsevier BV
DOI: 10.1016/j.ijpharm.2018.06.008

Molecular Adjuvants Based on Plasmids Encoding Protein Aggregation Domains Affect Bone Marrow Niche Homeostasis

Autori: Maria Giovanna Sabbieti, Giovanna Lacava, Andrea Amaroli, Luigi Marchetti, Roberta Censi, Piera Di Martino, Dimitrios Agas
Pubblicato in: Current Gene Therapy, Numero 17/5, 2018, ISSN 1566-5232
Editore: Bentham Science Publishers
DOI: 10.2174/1566523218666180105122626

Diverse Functions of Macrophages in Different Tumor Microenvironments

Autori: Ming Yang, Daniel McKay, Jeffrey W. Pollard, Claire E. Lewis
Pubblicato in: Cancer Research, Numero 78/19, 2018, Pagina/e 5492-5503, ISSN 0008-5472
Editore: American Association for Cancer Research
DOI: 10.1158/0008-5472.CAN-18-1367

Combinatory therapy adopting nanoparticle-based cancer vaccination with immune checkpoint blockade for treatment of post-surgical tumor recurrences

Autori: Chih Kit Chung, C.G. Da Silva, Dana Kralisch, Alan Chan, Ferry Ossendorp, Luis J. Cruz
Pubblicato in: Journal of Controlled Release, Numero 285, 2018, Pagina/e 56-66, ISSN 0168-3659
Editore: Elsevier BV
DOI: 10.1016/j.jconrel.2018.07.011

Memory CD4+ T cells are generated in the human fetal intestine

Autori: Na Li, Vincent van Unen, Tamim Abdelaal, Nannan Guo, Sofya A. Kasatskaya, Kristin Ladell, James E. McLaren, Evgeny S. Egorov, Mark Izraelson, Susana M. Chuva de Sousa Lopes, Thomas Höllt, Olga V Britanova, Jeroen Eggermont, Noel F. C. C. de Miranda, Dmitriy M. Chudakov, David A. Price, Boudewijn P. F. Lelieveldt, Frits Koning
Pubblicato in: Nature Immunology, 2019, ISSN 1529-2908
Editore: Nature Publishing Group
DOI: 10.1038/s41590-018-0294-9

Opportunities of bacterial cellulose to treat epithelial tissues

Autori: Irene Anton-Sales, Uwe Beekmann, Anna Laromaine, Anna Roig, Dana Kralisch
Pubblicato in: Current Drug Targets, Numero 20, 2018, Pagina/e 808-822, ISSN 1389-4501
Editore: Bentham Science Publishers
DOI: 10.2174/1389450120666181129092144

Quantification of phenolic compounds in different types of crafts beers, worts, starting and spent ingredients by liquid chromatography-tandem mass spectrometry

Autori: Manuela Cortese, Maria Rosa Gigliobianco, Dolores Vargas Peregrina, Gianni Sagratini, Roberta Censi, Piera Di Martino
Pubblicato in: Journal of Chromatography A, 2019, Pagina/e 460622, ISSN 0021-9673
Editore: Elsevier BV
DOI: 10.1016/j.chroma.2019.460622

Environmentally compatible bioconjugated gold nanoparticles as efficient contrast agents for inflammation-induced cancer imaging

Autori: Vinícius Barreto Garcia, Thaís Gomes de Carvalho, Luiz Henrique da Silva Gasparotto, Heloiza Fernanda Oliveira da Silva, Aurigena Antunes de Araújo, Gerlane Coelho Bernardo Guerra, Timo Schomann, Luis J. Cruz, Alan B. Chan, Raimundo Fernandes de Araújo Júnior
Pubblicato in: Nanoscale Research Letters, Numero 14/1, 2019, ISSN 1931-7573
Editore: Springer Verlag
DOI: 10.1186/s11671-019-2986-y

Tissue classification by rapid evaporative ionization mass spectrometry (REIMS): comparison between a diathermic knife and CO2 laser sampling on classification performance

Autori: Michele Genangeli, Ron M. A. Heeren, Tiffany Porta Siegel
Pubblicato in: Analytical and Bioanalytical Chemistry, 2019, ISSN 1618-2642
Editore: Springer Verlag
DOI: 10.1007/s00216-019-02148-8

MALDI-Mass Spectrometry Imaging to Investigate Lipid and Bile Acid Modifications Caused by Lentil Extract Used as a Potential Hypocholesterolemic Treatment

Autori: Michele Genangeli, Annemarie M. M. Heijens, Alice Rustichelli, Noortje Dien Schuit, Maria Vittoria Micioni Di Bonaventura, Carlo Cifani, Sauro Vittori, Tiffany Porta Siegel, Ron M.A. Heeren
Pubblicato in: Journal of The American Society for Mass Spectrometry, Numero 30/10, 2019, Pagina/e 2041-2050, ISSN 1044-0305
Editore: Elsevier BV
DOI: 10.1007/s13361-019-02265-9

PD-L1 blockade engages tumor-infiltrating lymphocytes to co-express targetable activating and inhibitory receptors

Autori: Guillaume Beyrend, Esmé van der Gracht, Ayse Yilmaz, Suzanne van Duikeren, Marcel Camps, Thomas Höllt, Anna Vilanova, Vincent van Unen, Frits Koning, Noel F. C. C. de Miranda, Ramon Arens, Ferry Ossendorp
Pubblicato in: Journal for ImmunoTherapy of Cancer, Numero 7/1, 2019, ISSN 2051-1426
Editore: J Immunother Cancer
DOI: 10.1186/s40425-019-0700-3

Cytofast: A workflow for visual and quantitative analysis of flow and mass cytometry data to discover immune signatures and correlations

Autori: Guillaume Beyrend, Koen Stam, Thomas Höllt, Ferry Ossendorp, Ramon Arens
Pubblicato in: Computational and Structural Biotechnology Journal, Numero 16, 2018, Pagina/e 435-442, ISSN 2001-0370
Editore: Comput Struct Biotechnol J
DOI: 10.1016/j.csbj.2018.10.004

A comparison of automatic cell identification methods for single-cell RNA sequencing data

Autori: Tamim Abdelaal, Lieke Michielsen, Davy Cats, Dylan Hoogduin, Hailiang Mei, Marcel J. T. Reinders, Ahmed Mahfouz
Pubblicato in: Genome Biology, Numero 20/1, 2019, ISSN 1474-760X
Editore: Genome Biol
DOI: 10.1186/s13059-019-1795-z

Early-Life Compartmentalization of Immune Cells in Human Fetal Tissues Revealed by High-Dimensional Mass Cytometry

Autori: Na Li, Vincent van Unen, Nannan Guo, Tamim Abdelaal, Antonios Somarakis, Jeroen Eggermont, Ahmed Mahfouz, Susana M. Chuva de Sousa Lopes, Boudewijn P. F. Lelieveldt, Frits Koning
Pubblicato in: Frontiers in Immunology, Numero 10, 2019, ISSN 1664-3224
Editore: Front Immunol
DOI: 10.3389/fimmu.2019.01932

Cytomegalovirus infection and progressive differentiation of effector-memory T cells

Autori: Iris N. Pardieck, Guillaume Beyrend, Anke Redeker, Ramon Arens
Pubblicato in: F1000Research, Numero 7, 2018, Pagina/e 1554, ISSN 2046-1402
Editore: F1000 Research Ltd.
DOI: 10.12688/f1000research.15753.1

High-dimensional cytometric analysis of colorectal cancer reveals novel mediators of antitumour immunity

Autori: Natasja L de Vries, Vincent van Unen, Marieke E Ijsselsteijn, Tamim Abdelaal, Ruud van der Breggen, Arantza Farina Sarasqueta, Ahmed Mahfouz, Koen C M J Peeters, Thomas Höllt, Boudewijn P F Lelieveldt, Frits Koning, Noel F C C de Miranda
Pubblicato in: Gut, 2019, Pagina/e gutjnl-2019-318672, ISSN 0017-5749
Editore: BMJ Publishing Group
DOI: 10.1136/gutjnl-2019-318672

Thermosensitive hybrid hydrogels for the controlled release of bioactive vancomycin in the treatment of orthopaedic implant infections

Autori: Roberta Censi, Cristina Casadidio, Alessandra Dubbini, Manuela Cortese, Stefania Scuri, Iolanda Grappasonni, Samuel Golob, Dario Vojnovic, Maria Giovanna Sabbieti, Dimitrios Agas, Piera Di Martino
Pubblicato in: European Journal of Pharmaceutics and Biopharmaceutics, Numero 142, 2019, Pagina/e 322-333, ISSN 0939-6411
Editore: Elsevier BV
DOI: 10.1016/j.ejpb.2019.07.006

Precisely Tailoring Upconversion Dynamics via Energy Migration in Core-Shell Nanostructures

Autori: Jing Zuo, Dapeng Sun, Langping Tu, Yanni Wu, Yinghui Cao, Bin Xue, Youlin Zhang, Yulei Chang, Xiaomin Liu, Xianggui Kong, Wybren Jan Buma, Evert Jan Meijer, Hong Zhang
Pubblicato in: Angewandte Chemie International Edition, Numero 57/12, 2018, Pagina/e 3054-3058, ISSN 1433-7851
Editore: John Wiley & Sons Ltd.
DOI: 10.1002/anie.201711606

Nanocrystals of Poorly Soluble Drugs: Drug Bioavailability and Physicochemical Stability

Autori: Di Martino, Piera; Gigliobianco, Maria; Casadidio, Cristina; Censi, Roberta
Pubblicato in: Pharmaceutics, Vol 10, Iss 3, p 134 (2018), Numero 4, 2018, ISSN 1999-4923
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.20944/PREPRINTS201807.0233.V1

Cosmetic Formulation Based on an Açai Extract

Autori: Roberta Censi, Dolores Vargas Peregrina, Giovanna Lacava, Dimitrios Agas, Giulio Lupidi, Maria Sabbieti, Piera Di Martino
Pubblicato in: Cosmetics, Numero 5/3, 2018, Pagina/e 48, ISSN 2079-9284
Editore: Cosmetics 2018
DOI: 10.3390/cosmetics5030048

Detecting tumour-positive resection margins after oral cancer surgery by spraying a fluorescent tracer activated by gamma-glutamyltranspeptidase

Autori: Maxime D. Slooter, Henricus J.M. Handgraaf, Martin C. Boonstra, Lily-Ann van der Velden, Shadhvi S. Bhairosingh, Ivo Que, Lorraine M. de Haan, Stijn Keereweer, Pieter B.A.A. van Driel, Alan Chan, Hisataka Kobayashi, Alexander L. Vahrmeijer, Clemens W.G.M. Löwik
Pubblicato in: Oral Oncology, Numero 78, 2018, Pagina/e 1-7, ISSN 1368-8375
Editore: Pergamon Press Ltd.
DOI: 10.1016/j.oraloncology.2017.12.006

Click beetle luciferase mutant and near infrared naphthyl-luciferins for improved bioluminescence imaging

Autori: Mary P. Hall, Carolyn C. Woodroofe, Monika G. Wood, Ivo Que, Moniek van’t Root, Yanto Ridwan, Ce Shi, Thomas A. Kirkland, Lance P. Encell, Keith V. Wood, Clemens Löwik, Laura Mezzanotte
Pubblicato in: Nature Communications, Numero 9/1, 2018, ISSN 2041-1723
Editore: Nature Publishing Group
DOI: 10.1038/s41467-017-02542-9

Chitin and Chitosans: Characteristics, Eco-Friendly Processes, and Applications in Cosmetic Science

Autori: Cristina Casadidio, Dolores Vargas Peregrina, Maria Rosa Gigliobianco, Siyuan Deng, Roberta Censi, Piera Di Martino
Pubblicato in: Marine Drugs, Numero 17/6, 2019, Pagina/e 369, ISSN 1660-3397
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/md17060369

A Dual-Color Bioluminescence Reporter Mouse for Simultaneous in vivo Imaging of T Cell Localization and Function

Autori: Jan Willem Kleinovink, Laura Mezzanotte, Giorgia Zambito, Marieke F. Fransen, Luis J. Cruz, J. Sjef Verbeek, Alan Chan, Ferry Ossendorp, Clemens Löwik
Pubblicato in: Frontiers in Immunology, Numero 9, 2019, ISSN 1664-3224
Editore: Front. Immunol
DOI: 10.3389/fimmu.2018.03097

CyTOFmerge: integrating mass cytometry data across multiple panels

Autori: Tamim Abdelaal, Thomas Höllt, Vincent van Unen, Boudewijn P F Lelieveldt, Frits Koning, Marcel J T Reinders, Ahmed Mahfouz
Pubblicato in: Bioinformatics, Numero 35/20, 2019, Pagina/e 4063-4071, ISSN 1367-4803
Editore: Oxford University Press
DOI: 10.1093/bioinformatics/btz180

Predicting Cell Populations in Single Cell Mass Cytometry Data

Autori: Tamim Abdelaal, Vincent van Unen, Thomas Höllt, Frits Koning, Marcel J.T. Reinders, Ahmed Mahfouz
Pubblicato in: Cytometry Part A, Numero 95/7, 2019, Pagina/e 769-781, ISSN 1552-4922
Editore: John Wiley & Sons Ltd.
DOI: 10.1002/cyto.a.23738

Effective chemoimmunotherapy by co-delivery of doxorubicin and immune adjuvants in biodegradable nanoparticles

Autori: Candido G. Da Silva, Marcel G.M. Camps, Tracy M.W.Y. Li, Luana Zerrillo, Clemens W. Löwik, Ferry Ossendorp, Luis J. Cruz
Pubblicato in: Theranostics, Numero 9/22, 2019, Pagina/e 6485-6500, ISSN 1838-7640
Editore: Ivyspring International Publisher
DOI: 10.7150/thno.34429

Polymeric Nanocapsules as Nanotechnological Alternative for Drug Delivery System: Current Status, Challenges and Opportunities

Autori: Siyuan Deng, Maria Rosa Gigliobianco, Roberta Censi, Piera Di Martino
Pubblicato in: Nanomaterials, Numero 10/5, 2020, Pagina/e 847, ISSN 2079-4991
Editore: MDPI
DOI: 10.3390/nano10050847

Doxorubicin Loaded Poloxamer Thermosensitive Hydrogels: Chemical, Pharmacological and Biological Evaluation

Autori: Chih Kit Chung, Jomarien García-Couce, Yaima Campos, Dana Kralisch, Katja Bierau, Alan Chan, Ferry Ossendorp, Luis Javier Cruz
Pubblicato in: Molecules, Numero 25/9, 2020, Pagina/e 2219, ISSN 1420-3049
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/molecules25092219

Recent Advances in Rare-Earth-Doped Nanoparticles for NIR-II Imaging and Cancer Theranostics

Autori: Zhenfeng Yu, Christina Eich, Luis J. Cruz
Pubblicato in: Frontiers in Chemistry, Numero 8, 2020, ISSN 2296-2646
Editore: Frontiers in Chemistry
DOI: 10.3389/fchem.2020.00496

Precise Photodynamic Therapy of Cancer via Subcellular Dynamic Tracing of Dual-loaded Upconversion Nanophotosensitizers

Autori: Yulei Chang, Xiaodan Li, Li Zhang, Lu Xia, Xiaomin Liu, Cuixia Li, Youlin Zhang, Langping Tu, Bin Xue, Huiying Zhao, Hong Zhang, Xianggui Kong
Pubblicato in: Scientific Reports, Numero 7, 2017, Pagina/e 45633, ISSN 2045-2322
Editore: Nature Publishing Group
DOI: 10.1038/srep45633

One-step in situ solid-substrate-based whole blood immunoassay based on FRET between upconversion and gold nanoparticles

Autori: Cuixia Li, Jing Zuo, Qiqing Li, Yulei Chang, Youlin Zhang, Langping Tu, Xiaomin Liu, Bin Xue, Huiying Zhao, Hong Zhang, Xianggui Kong
Pubblicato in: Biosensors and Bioelectronics, Numero 92, 2017, Pagina/e 335-341, ISSN 0956-5663
Editore: Pergamon Press Ltd.
DOI: 10.1016/j.bios.2016.11.003

Accurate Quantitative Sensing of Intracellular pH based on Self-ratiometric Upconversion Luminescent Nanoprobe

Autori: Cuixia Li, Jing Zuo, Li Zhang, Yulei Chang, Youlin Zhang, Langping Tu, Xiaomin Liu, Bin Xue, Qiqing Li, Huiying Zhao, Hong Zhang, Xianggui Kong
Pubblicato in: Scientific Reports, Numero 6/1, 2016, ISSN 2045-2322
Editore: Nature Publishing Group
DOI: 10.1038/srep38617

In Vivo Molecular Bioluminescence Imaging: New Tools and Applications

Autori: Laura Mezzanotte, Moniek van ‘t Root, Hacer Karatas, Elena A. Goun, Clemens W.G.M. Löwik
Pubblicato in: Trends in Biotechnology, Numero 35/7, 2017, Pagina/e 640-652, ISSN 0167-7799
Editore: Elsevier BV
DOI: 10.1016/j.tibtech.2017.03.012

SpaGE: Spatial Gene Enhancement using scRNA-seq

Autori: Tamim Abdelaal, Soufiane Mourragui, Ahmed Mahfouz, Marcel J T Reinders
Pubblicato in: Nucleic Acids Research, Numero 48/18, 2020, Pagina/e e107-e107, ISSN 0305-1048
Editore: Oxford University Press
DOI: 10.1093/nar/gkaa740

Po-260 deep phenotyping of colorectal cancers by high-dimensional mass cytometry reveals tumor-specific immune landscapes

Autori: N De Vries, V Van Unen, T Abdelaal, M Van Herk, R Van der Breggen, A Farina Sarasqueta, T Höllt, B Lelieveldt, F Koning, N De Miranda
Pubblicato in: Tumour Microenvironment, 2018, Pagina/e A328.2-A329
Editore: BMJ Publishing Group Ltd
DOI: 10.1136/esmoopen-2018-EACR25.775

Perivascular macrophages in health and disease

Autori: Antonio Lapenna, Michele De Palma, Claire E. Lewis
Pubblicato in: Nature Reviews Immunology, 2018, ISSN 1474-1733
Editore: Nature Publishing Group
DOI: 10.1038/s41577-018-0056-9

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