Image-Guided Surgery (IGS) and Personalised Postoperative Immunotherapy To Improving Cancer Outcome

Resultado final

Training by research and network-wide training completed
Dissemination plan (M7) and Project publications including review articles written by ESRs (M48)
Public engagement activities completed
Conference M30 (Gantt Chart)
Progress reports and periodic reports to EC

Progress reports and periodic reports to EC (months 1-48)

Rotations and SECs completed

Project website live

Publicaciones

Optimization of the Extraction from Spent Coffee Grounds Using the Desirability Approach

Autores: Maria Rosa Gigliobianco, Barbara Campisi, Dolores Vargas Peregrina, Roberta Censi, Gulzhan Khamitova, Simone Angeloni, Giovanni Caprioli, Marco Zannotti, Stefano Ferraro, Rita Giovannetti, Cristina Angeloni, Giulio Lupidi, Letizia Pruccoli, Andrea Tarozzi, Dario Voinovich, Piera Di Martino
Publicado en: Antioxidants, Edición 9/5, 2020, Página(s) 370, ISSN 2076-3921
Editor: x
DOI: 10.3390/antiox9050370

Evaluating Brightness and Spectral Properties of Click Beetle and Firefly Luciferases Using Luciferin Analogues: Identification of Preferred Pairings of Luciferase and Substrate for In Vivo Bioluminescence Imaging

Autores: Giorgia Zambito, Natasa Gaspar, Yanto Ridwan, Mary P. Hall, Ce Shi, Thomas A. Kirkland, Lance P. Encell, Clemens Löwik, Laura Mezzanotte
Publicado en: Molecular Imaging and Biology, 2020, ISSN 1536-1632
Editor: Elsevier BV
DOI: 10.1007/s11307-020-01523-7

The Effects of Crosslinking on the Rheology and Cellular Behavior of Polymer-Based 3D-Multilayered Scaffolds for Restoring Articular Cartilage

Autores: Yaima Campos, Francisco J. Sola, Gastón Fuentes, Luis Quintanilla, Amisel Almirall, Luis J. Cruz, José C. Rodríguez-Cabello, Yasuhiko Tabata
Publicado en: Polymers, Edición 13/6, 2021, Página(s) 907, ISSN 2073-4360
Editor: MDPI
DOI: 10.3390/polym13060907

Apoptosis in human liver carcinoma caused by gold nanoparticles in combination with carvedilol is mediated via modulation of MAPK/Akt/mTOR pathway and EGFR/FAAD proteins

Autores: Raimundo De Araï¿½jo Jr, Jonas Pessoa, Luis Cruz, Alan Chan, Emï¿½lio De Castro Miguel, Rï¿½mulo Cavalcante, Gerly Anne Brito, Heloiza Fernada Silva, Luiz Gasparotto, Paulo Guedes, Aurigena Araï¿½jo
Publicado en: International Journal of Oncology, 2017, ISSN 1019-6439
Editor: Demetrios A. Spandidos Ed. & Pub.
DOI: 10.3892/ijo.2017.4179

Spherical neutral Gold nanoparticles improve anti-inflammatory response, oxidative stress and fibrosis in alcohol-methamphetamine-induced liver injury in rats

Autores: Thaís Gomes de Carvalho, Vinícius Barreto Garcia, Aurigena Antunes de Araújo, Luiz Henrique da Silva Gasparotto, Heloiza Silva, Gerlane Coelho Bernardo Guerra, Emilio de Castro Miguel, Renata Ferreira de Carvalho Leitão, Deiziane Viana da Silva Costa, Luis J Cruz, Alan B. Chan, Raimundo Fernandes de Araújo Júnior
Publicado en: International Journal of Pharmaceutics, 2018, ISSN 0378-5173
Editor: Elsevier BV
DOI: 10.1016/j.ijpharm.2018.06.008

Molecular Adjuvants Based on Plasmids Encoding Protein Aggregation Domains Affect Bone Marrow Niche Homeostasis

Autores: Maria Giovanna Sabbieti, Giovanna Lacava, Andrea Amaroli, Luigi Marchetti, Roberta Censi, Piera Di Martino, Dimitrios Agas
Publicado en: Current Gene Therapy, Edición 17/5, 2018, ISSN 1566-5232
Editor: Bentham Science Publishers
DOI: 10.2174/1566523218666180105122626

Diverse Functions of Macrophages in Different Tumor Microenvironments

Autores: Ming Yang, Daniel McKay, Jeffrey W. Pollard, Claire E. Lewis
Publicado en: Cancer Research, Edición 78/19, 2018, Página(s) 5492-5503, ISSN 0008-5472
Editor: American Association for Cancer Research
DOI: 10.1158/0008-5472.CAN-18-1367

Combinatory therapy adopting nanoparticle-based cancer vaccination with immune checkpoint blockade for treatment of post-surgical tumor recurrences

Autores: Chih Kit Chung, C.G. Da Silva, Dana Kralisch, Alan Chan, Ferry Ossendorp, Luis J. Cruz
Publicado en: Journal of Controlled Release, Edición 285, 2018, Página(s) 56-66, ISSN 0168-3659
Editor: Elsevier BV
DOI: 10.1016/j.jconrel.2018.07.011

Memory CD4+ T cells are generated in the human fetal intestine

Autores: Na Li, Vincent van Unen, Tamim Abdelaal, Nannan Guo, Sofya A. Kasatskaya, Kristin Ladell, James E. McLaren, Evgeny S. Egorov, Mark Izraelson, Susana M. Chuva de Sousa Lopes, Thomas Höllt, Olga V Britanova, Jeroen Eggermont, Noel F. C. C. de Miranda, Dmitriy M. Chudakov, David A. Price, Boudewijn P. F. Lelieveldt, Frits Koning
Publicado en: Nature Immunology, 2019, ISSN 1529-2908
Editor: Nature Publishing Group
DOI: 10.1038/s41590-018-0294-9

Opportunities of bacterial cellulose to treat epithelial tissues

Autores: Irene Anton-Sales, Uwe Beekmann, Anna Laromaine, Anna Roig, Dana Kralisch
Publicado en: Current Drug Targets, Edición 20, 2018, Página(s) 808-822, ISSN 1389-4501
Editor: Bentham Science Publishers
DOI: 10.2174/1389450120666181129092144

Quantification of phenolic compounds in different types of crafts beers, worts, starting and spent ingredients by liquid chromatography-tandem mass spectrometry

Autores: Manuela Cortese, Maria Rosa Gigliobianco, Dolores Vargas Peregrina, Gianni Sagratini, Roberta Censi, Piera Di Martino
Publicado en: Journal of Chromatography A, 2019, Página(s) 460622, ISSN 0021-9673
Editor: Elsevier BV
DOI: 10.1016/j.chroma.2019.460622

Environmentally compatible bioconjugated gold nanoparticles as efficient contrast agents for inflammation-induced cancer imaging

Autores: Vinícius Barreto Garcia, Thaís Gomes de Carvalho, Luiz Henrique da Silva Gasparotto, Heloiza Fernanda Oliveira da Silva, Aurigena Antunes de Araújo, Gerlane Coelho Bernardo Guerra, Timo Schomann, Luis J. Cruz, Alan B. Chan, Raimundo Fernandes de Araújo Júnior
Publicado en: Nanoscale Research Letters, Edición 14/1, 2019, ISSN 1931-7573
Editor: Springer Verlag
DOI: 10.1186/s11671-019-2986-y

Tissue classification by rapid evaporative ionization mass spectrometry (REIMS): comparison between a diathermic knife and CO2 laser sampling on classification performance

Autores: Michele Genangeli, Ron M. A. Heeren, Tiffany Porta Siegel
Publicado en: Analytical and Bioanalytical Chemistry, 2019, ISSN 1618-2642
Editor: Springer Verlag
DOI: 10.1007/s00216-019-02148-8

MALDI-Mass Spectrometry Imaging to Investigate Lipid and Bile Acid Modifications Caused by Lentil Extract Used as a Potential Hypocholesterolemic Treatment

Autores: Michele Genangeli, Annemarie M. M. Heijens, Alice Rustichelli, Noortje Dien Schuit, Maria Vittoria Micioni Di Bonaventura, Carlo Cifani, Sauro Vittori, Tiffany Porta Siegel, Ron M.A. Heeren
Publicado en: Journal of The American Society for Mass Spectrometry, Edición 30/10, 2019, Página(s) 2041-2050, ISSN 1044-0305
Editor: Elsevier BV
DOI: 10.1007/s13361-019-02265-9

PD-L1 blockade engages tumor-infiltrating lymphocytes to co-express targetable activating and inhibitory receptors

Autores: Guillaume Beyrend, Esmé van der Gracht, Ayse Yilmaz, Suzanne van Duikeren, Marcel Camps, Thomas Höllt, Anna Vilanova, Vincent van Unen, Frits Koning, Noel F. C. C. de Miranda, Ramon Arens, Ferry Ossendorp
Publicado en: Journal for ImmunoTherapy of Cancer, Edición 7/1, 2019, ISSN 2051-1426
Editor: J Immunother Cancer
DOI: 10.1186/s40425-019-0700-3

Cytofast: A workflow for visual and quantitative analysis of flow and mass cytometry data to discover immune signatures and correlations

Autores: Guillaume Beyrend, Koen Stam, Thomas Höllt, Ferry Ossendorp, Ramon Arens
Publicado en: Computational and Structural Biotechnology Journal, Edición 16, 2018, Página(s) 435-442, ISSN 2001-0370
Editor: Comput Struct Biotechnol J
DOI: 10.1016/j.csbj.2018.10.004

A comparison of automatic cell identification methods for single-cell RNA sequencing data

Autores: Tamim Abdelaal, Lieke Michielsen, Davy Cats, Dylan Hoogduin, Hailiang Mei, Marcel J. T. Reinders, Ahmed Mahfouz
Publicado en: Genome Biology, Edición 20/1, 2019, ISSN 1474-760X
Editor: Genome Biol
DOI: 10.1186/s13059-019-1795-z

Early-Life Compartmentalization of Immune Cells in Human Fetal Tissues Revealed by High-Dimensional Mass Cytometry

Autores: Na Li, Vincent van Unen, Nannan Guo, Tamim Abdelaal, Antonios Somarakis, Jeroen Eggermont, Ahmed Mahfouz, Susana M. Chuva de Sousa Lopes, Boudewijn P. F. Lelieveldt, Frits Koning
Publicado en: Frontiers in Immunology, Edición 10, 2019, ISSN 1664-3224
Editor: Front Immunol
DOI: 10.3389/fimmu.2019.01932

Cytomegalovirus infection and progressive differentiation of effector-memory T cells

Autores: Iris N. Pardieck, Guillaume Beyrend, Anke Redeker, Ramon Arens
Publicado en: F1000Research, Edición 7, 2018, Página(s) 1554, ISSN 2046-1402
Editor: F1000 Research Ltd.
DOI: 10.12688/f1000research.15753.1

High-dimensional cytometric analysis of colorectal cancer reveals novel mediators of antitumour immunity

Autores: Natasja L de Vries, Vincent van Unen, Marieke E Ijsselsteijn, Tamim Abdelaal, Ruud van der Breggen, Arantza Farina Sarasqueta, Ahmed Mahfouz, Koen C M J Peeters, Thomas Höllt, Boudewijn P F Lelieveldt, Frits Koning, Noel F C C de Miranda
Publicado en: Gut, 2019, Página(s) gutjnl-2019-318672, ISSN 0017-5749
Editor: BMJ Publishing Group
DOI: 10.1136/gutjnl-2019-318672

Thermosensitive hybrid hydrogels for the controlled release of bioactive vancomycin in the treatment of orthopaedic implant infections

Autores: Roberta Censi, Cristina Casadidio, Alessandra Dubbini, Manuela Cortese, Stefania Scuri, Iolanda Grappasonni, Samuel Golob, Dario Vojnovic, Maria Giovanna Sabbieti, Dimitrios Agas, Piera Di Martino
Publicado en: European Journal of Pharmaceutics and Biopharmaceutics, Edición 142, 2019, Página(s) 322-333, ISSN 0939-6411
Editor: Elsevier BV
DOI: 10.1016/j.ejpb.2019.07.006

Precisely Tailoring Upconversion Dynamics via Energy Migration in Core-Shell Nanostructures

Autores: Jing Zuo, Dapeng Sun, Langping Tu, Yanni Wu, Yinghui Cao, Bin Xue, Youlin Zhang, Yulei Chang, Xiaomin Liu, Xianggui Kong, Wybren Jan Buma, Evert Jan Meijer, Hong Zhang
Publicado en: Angewandte Chemie International Edition, Edición 57/12, 2018, Página(s) 3054-3058, ISSN 1433-7851
Editor: John Wiley & Sons Ltd.
DOI: 10.1002/anie.201711606

Nanocrystals of Poorly Soluble Drugs: Drug Bioavailability and Physicochemical Stability

Autores: Di Martino, Piera; Gigliobianco, Maria; Casadidio, Cristina; Censi, Roberta
Publicado en: Pharmaceutics, Vol 10, Iss 3, p 134 (2018), Edición 4, 2018, ISSN 1999-4923
Editor: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.20944/PREPRINTS201807.0233.V1

Cosmetic Formulation Based on an Açai Extract

Autores: Roberta Censi, Dolores Vargas Peregrina, Giovanna Lacava, Dimitrios Agas, Giulio Lupidi, Maria Sabbieti, Piera Di Martino
Publicado en: Cosmetics, Edición 5/3, 2018, Página(s) 48, ISSN 2079-9284
Editor: Cosmetics 2018
DOI: 10.3390/cosmetics5030048

Detecting tumour-positive resection margins after oral cancer surgery by spraying a fluorescent tracer activated by gamma-glutamyltranspeptidase

Autores: Maxime D. Slooter, Henricus J.M. Handgraaf, Martin C. Boonstra, Lily-Ann van der Velden, Shadhvi S. Bhairosingh, Ivo Que, Lorraine M. de Haan, Stijn Keereweer, Pieter B.A.A. van Driel, Alan Chan, Hisataka Kobayashi, Alexander L. Vahrmeijer, Clemens W.G.M. Löwik
Publicado en: Oral Oncology, Edición 78, 2018, Página(s) 1-7, ISSN 1368-8375
Editor: Pergamon Press Ltd.
DOI: 10.1016/j.oraloncology.2017.12.006

Click beetle luciferase mutant and near infrared naphthyl-luciferins for improved bioluminescence imaging

Autores: Mary P. Hall, Carolyn C. Woodroofe, Monika G. Wood, Ivo Que, Moniek van’t Root, Yanto Ridwan, Ce Shi, Thomas A. Kirkland, Lance P. Encell, Keith V. Wood, Clemens Löwik, Laura Mezzanotte
Publicado en: Nature Communications, Edición 9/1, 2018, ISSN 2041-1723
Editor: Nature Publishing Group
DOI: 10.1038/s41467-017-02542-9

Chitin and Chitosans: Characteristics, Eco-Friendly Processes, and Applications in Cosmetic Science

Autores: Cristina Casadidio, Dolores Vargas Peregrina, Maria Rosa Gigliobianco, Siyuan Deng, Roberta Censi, Piera Di Martino
Publicado en: Marine Drugs, Edición 17/6, 2019, Página(s) 369, ISSN 1660-3397
Editor: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/md17060369

A Dual-Color Bioluminescence Reporter Mouse for Simultaneous in vivo Imaging of T Cell Localization and Function

Autores: Jan Willem Kleinovink, Laura Mezzanotte, Giorgia Zambito, Marieke F. Fransen, Luis J. Cruz, J. Sjef Verbeek, Alan Chan, Ferry Ossendorp, Clemens Löwik
Publicado en: Frontiers in Immunology, Edición 9, 2019, ISSN 1664-3224
Editor: Front. Immunol
DOI: 10.3389/fimmu.2018.03097

CyTOFmerge: integrating mass cytometry data across multiple panels

Autores: Tamim Abdelaal, Thomas Höllt, Vincent van Unen, Boudewijn P F Lelieveldt, Frits Koning, Marcel J T Reinders, Ahmed Mahfouz
Publicado en: Bioinformatics, Edición 35/20, 2019, Página(s) 4063-4071, ISSN 1367-4803
Editor: Oxford University Press
DOI: 10.1093/bioinformatics/btz180

Predicting Cell Populations in Single Cell Mass Cytometry Data

Autores: Tamim Abdelaal, Vincent van Unen, Thomas Höllt, Frits Koning, Marcel J.T. Reinders, Ahmed Mahfouz
Publicado en: Cytometry Part A, Edición 95/7, 2019, Página(s) 769-781, ISSN 1552-4922
Editor: John Wiley & Sons Ltd.
DOI: 10.1002/cyto.a.23738

Effective chemoimmunotherapy by co-delivery of doxorubicin and immune adjuvants in biodegradable nanoparticles

Autores: Candido G. Da Silva, Marcel G.M. Camps, Tracy M.W.Y. Li, Luana Zerrillo, Clemens W. Löwik, Ferry Ossendorp, Luis J. Cruz
Publicado en: Theranostics, Edición 9/22, 2019, Página(s) 6485-6500, ISSN 1838-7640
Editor: Ivyspring International Publisher
DOI: 10.7150/thno.34429

Polymeric Nanocapsules as Nanotechnological Alternative for Drug Delivery System: Current Status, Challenges and Opportunities

Autores: Siyuan Deng, Maria Rosa Gigliobianco, Roberta Censi, Piera Di Martino
Publicado en: Nanomaterials, Edición 10/5, 2020, Página(s) 847, ISSN 2079-4991
Editor: MDPI
DOI: 10.3390/nano10050847

Doxorubicin Loaded Poloxamer Thermosensitive Hydrogels: Chemical, Pharmacological and Biological Evaluation

Autores: Chih Kit Chung, Jomarien García-Couce, Yaima Campos, Dana Kralisch, Katja Bierau, Alan Chan, Ferry Ossendorp, Luis Javier Cruz
Publicado en: Molecules, Edición 25/9, 2020, Página(s) 2219, ISSN 1420-3049
Editor: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/molecules25092219

Recent Advances in Rare-Earth-Doped Nanoparticles for NIR-II Imaging and Cancer Theranostics

Autores: Zhenfeng Yu, Christina Eich, Luis J. Cruz
Publicado en: Frontiers in Chemistry, Edición 8, 2020, ISSN 2296-2646
Editor: Frontiers in Chemistry
DOI: 10.3389/fchem.2020.00496

Precise Photodynamic Therapy of Cancer via Subcellular Dynamic Tracing of Dual-loaded Upconversion Nanophotosensitizers

Autores: Yulei Chang, Xiaodan Li, Li Zhang, Lu Xia, Xiaomin Liu, Cuixia Li, Youlin Zhang, Langping Tu, Bin Xue, Huiying Zhao, Hong Zhang, Xianggui Kong
Publicado en: Scientific Reports, Edición 7, 2017, Página(s) 45633, ISSN 2045-2322
Editor: Nature Publishing Group
DOI: 10.1038/srep45633

One-step in situ solid-substrate-based whole blood immunoassay based on FRET between upconversion and gold nanoparticles

Autores: Cuixia Li, Jing Zuo, Qiqing Li, Yulei Chang, Youlin Zhang, Langping Tu, Xiaomin Liu, Bin Xue, Huiying Zhao, Hong Zhang, Xianggui Kong
Publicado en: Biosensors and Bioelectronics, Edición 92, 2017, Página(s) 335-341, ISSN 0956-5663
Editor: Pergamon Press Ltd.
DOI: 10.1016/j.bios.2016.11.003

Accurate Quantitative Sensing of Intracellular pH based on Self-ratiometric Upconversion Luminescent Nanoprobe

Autores: Cuixia Li, Jing Zuo, Li Zhang, Yulei Chang, Youlin Zhang, Langping Tu, Xiaomin Liu, Bin Xue, Qiqing Li, Huiying Zhao, Hong Zhang, Xianggui Kong
Publicado en: Scientific Reports, Edición 6/1, 2016, ISSN 2045-2322
Editor: Nature Publishing Group
DOI: 10.1038/srep38617

In Vivo Molecular Bioluminescence Imaging: New Tools and Applications

Autores: Laura Mezzanotte, Moniek van ‘t Root, Hacer Karatas, Elena A. Goun, Clemens W.G.M. Löwik
Publicado en: Trends in Biotechnology, Edición 35/7, 2017, Página(s) 640-652, ISSN 0167-7799
Editor: Elsevier BV
DOI: 10.1016/j.tibtech.2017.03.012

SpaGE: Spatial Gene Enhancement using scRNA-seq

Autores: Tamim Abdelaal, Soufiane Mourragui, Ahmed Mahfouz, Marcel J T Reinders
Publicado en: Nucleic Acids Research, Edición 48/18, 2020, Página(s) e107-e107, ISSN 0305-1048
Editor: Oxford University Press
DOI: 10.1093/nar/gkaa740

Po-260 deep phenotyping of colorectal cancers by high-dimensional mass cytometry reveals tumor-specific immune landscapes

Autores: N De Vries, V Van Unen, T Abdelaal, M Van Herk, R Van der Breggen, A Farina Sarasqueta, T Höllt, B Lelieveldt, F Koning, N De Miranda
Publicado en: Tumour Microenvironment, 2018, Página(s) A328.2-A329
Editor: BMJ Publishing Group Ltd
DOI: 10.1136/esmoopen-2018-EACR25.775

Perivascular macrophages in health and disease

Autores: Antonio Lapenna, Michele De Palma, Claire E. Lewis
Publicado en: Nature Reviews Immunology, 2018, ISSN 1474-1733
Editor: Nature Publishing Group
DOI: 10.1038/s41577-018-0056-9

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