Development of Biomaterial-based Delivery Systems for Parkinson’s disease - an Integrated Pan-European Approach

Projektinformationen

BrainMatTrain

ID Finanzhilfevereinbarung: 676408

DOI 10.3030/676408

Projekt abgeschlossen

EK-Unterschriftsdatum 27 Juli 2015

Startdatum 1 Januar 2016

Enddatum 31 Dezember 2019

Finanziert unter

• EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions

Gesamtkosten € 3 995 083,44

EU-Beitrag € 3 995 083,44

Koordiniert durch

UNIVERSITY OF GALWAY
Ireland

Leistungen

Documents, reports (18)

A multi-modal scaffold functionalised with anti-inflammatory moieties that protects dopaminergic neurons in an in vivo model of PD.

A multi-modal scaffold functionalised with anti-inflammatory moieties that protects dopaminergic neurons in an in vivo model of PD.

Progress Report

progress report

Mid Term Review Meeting
A multi-modal scaffold functionalised with both anti-inflammatory and neuroprotective moieties that protect dopaminergic neurons in an in vivo model of PD.
Draft Periodic Report

Draft Report

Multi-modal delivery system targeting neuroinflammation and neuroprotection optimised.
An optimised neurotropic factor functionalised collagen reservoir system fabricated

An optimised neurotropic factor functionalised collagen reservoir system.

A multi-modal scaffold functionalised with neuroprotective moieties that protects dopaminergic neurons in an in vivo model of PD

A multi-modal scaffold functionalised with neuroprotective moieties that protects dopaminergic neurons in an in vivo model of PD

Efficacy of BrainMatTrain scaffolds to protect nigrostriatal dopaminergic neurons optimised in an organotypic slice culture model of PD

Efficacy of BrainMatTrain scaffolds to protect nigrostriatal dopaminergic neurons optimised in an organotypic slice culture model of PD.

Data Management Plan

The Data Management Plan describes the data management life cycle for all data sets that will be collected, processed or generated by the action. It is a document describing what data will be collected, processed or generated and following what methodology and standards, whether and how this data will be shared and/or made open, and how it will be curated and preserved.

Efficacy of BrainMatTrain scaffolds to protect nigrostriatal dopaminergic neurons optimised in an adult stem cell derived dopaminergic neuronal in vitro model of PD

Efficacy of BrainMatTrain scaffolds to protect nigrostriatal dopaminergic neurons optimised in an adult stem cell derived dopaminergic neuronal in vitro model of PD.

Efficacy of BrainMatTrain scaffolds to protect nigrostriatal dopaminergic neurons optimised in a lab-on-a-chip model of PD.
Multi-modal delivery system targeting neuroinflammation and neuroprotection developed.
Injectable matrix for ex vivo neurotrophin gene therapy optimised
Multi-modal delivery system targeting neuroinflammation and neuroprotection validated

Multi-modal delivery system targeting neuroinflammation and neuroprotection validated.

Supervisory Board of the Network

supervisory board of the Network

Ethics

documents to be submitted

Proteomic response of multi-modal collagen scaffolds following implantation in an in vivo model of PD investigated

Proteomic response of multi-modal collagen scaffolds following implantation in an in vivo model of PD investigated.

Veröffentlichungen

Peer reviewed articles (13)

Direct Reprogramming of Resident NG2 Glia into Neurons with Properties of Fast-Spiking Parvalbumin-Containing Interneurons

Autoren: Maria Pereira, Marcella Birtele, Shelby Shrigley, Julio Aguila Benitez, Eva Hedlund, Malin Parmar, Daniella Rylander Ottosson
Veröffentlicht in: Stem Cell Reports, Ausgabe 9/3, 2017, Seite(n) 742-751, ISSN 2213-6711
Herausgeber: Cell Press
DOI: 10.1016/j.stemcr.2017.07.023

Nerve growth factor released from collagen scaffolds protects axotomized cholinergic neurons of the basal nucleus of Meynert in organotypic brain slices

Autoren: Bettina M. Foidl, Buket Ucar, Alina Schwarz, Ana L. Rebelo, Abhay Pandit, Christian Humpel
Veröffentlicht in: Journal of Neuroscience Methods, Ausgabe 295, 2018, Seite(n) 77-86, ISSN 0165-0270
Herausgeber: Elsevier BV
DOI: 10.1016/j.jneumeth.2017.12.003

Collagen for brain repair: therapeutic perspectives

Autoren: Christian Humpel, Buket Ucar
Veröffentlicht in: Neural Regeneration Research, Ausgabe 13/4, 2018, Seite(n) 595, ISSN 1673-5374
Herausgeber: Neural Regeneration Research
DOI: 10.4103/1673-5374.230273

Simple Generation of a High Yield Culture of Induced Neurons from Human Adult Skin Fibroblasts

Autoren: Shelby Shrigley, Karolina Pircs, Roger A. Barker, Malin Parmar, Janelle Drouin-Ouellet
Veröffentlicht in: Journal of Visualized Experiments, Ausgabe 132, 2018, ISSN 1940-087X
Herausgeber: MYJoVE Corporation
DOI: 10.3791/56904

Encapsulation of young donor age dopaminergic grafts in a GDNF-loaded collagen hydrogel further increases their survival, reinnervation, and functional efficacy after intrastriatal transplantation in hemi-Parkinsonian rats

Autoren: Niamh Moriarty, Sílvia Cabré, Verónica Alamilla, Abhay Pandit, Eilís Dowd
Veröffentlicht in: European Journal of Neuroscience, 2018, ISSN 0953-816X
Herausgeber: Blackwell Publishing Inc.
DOI: 10.1111/ejn.14090

Mitral cells and the glucagon-like peptide 1 receptor: The sweet smell of success?

Autoren: Enrico Bagnoli, Una FitzGerald
Veröffentlicht in: European Journal of Neuroscience, 2018, ISSN 0953-816X
Herausgeber: Blackwell Publishing Inc.
DOI: 10.1111/ejn.14115

The unlikely partnership between LRRK2 and α-synuclein in Parkinson's disease

Autoren: Noémie Cresto, Camille Gardier, Francesco Gubinelli, Marie-Claude Gaillard, Géraldine Liot, Andrew B. West, Emmanuel Brouillet
Veröffentlicht in: European Journal of Neuroscience, 2018, ISSN 0953-816X
Herausgeber: Blackwell Publishing Inc.
DOI: 10.1111/ejn.14182

A window into the brain: Tools to assess preclinical efficacy of biomaterials-based therapies on central nervous system disorders

Autoren: Juhi Samal, Ana Lucia Rebelo, Abhay Pandit
Veröffentlicht in: Advanced Drug Delivery Reviews, Ausgabe S0169-409X(19)3001516, 2019, ISSN 0169-409X
Herausgeber: Elsevier BV
DOI: 10.1016/j.addr.2019.01.012

Therapeutic efficacy of glial cell-derived neurotrophic factor loaded collagen scaffolds in ex vivo organotypic brain slice Parkinson’s disease models

Autoren: Buket Ucar, Christian Humpel
Veröffentlicht in: Brain Research Bulletin, Ausgabe 149, 2019, Seite(n) 86-95, ISSN 0361-9230
Herausgeber: Elsevier BV
DOI: 10.1016/j.brainresbull.2019.04.012

Organotypic brain slice cultures: A review

Autoren: C. Humpel
Veröffentlicht in: Neuroscience, Ausgabe 305, 2015, Seite(n) 86-98, ISSN 0306-4522
Herausgeber: Elsevier BV
DOI: 10.1016/j.neuroscience.2015.07.086

Viral mimetic priming enhances α-synuclein-induced degeneration: Implications for Parkinson’s disease

Autoren: Laura K. Olsen, Andrew G. Cairns, Jörgen Ådén, Niamh Moriarty, Silvia Cabre, Veronica R. Alamilla, Fredrik Almqvist, Eilís Dowd, Declan P. McKernan
Veröffentlicht in: Brain, Behavior, and Immunity, Ausgabe 80, 2019, Seite(n) 525-535, ISSN 0889-1591
Herausgeber: Academic Press
DOI: 10.1016/j.bbi.2019.04.036

Direct reprogramming into interneurons: potential for brain repair

Autoren: Maria Pereira, Marcella Birtele, Daniella Rylander Ottosson
Veröffentlicht in: Cellular and Molecular Life Sciences, Ausgabe 76/20, 2019, Seite(n) 3953-3967, ISSN 1420-682X
Herausgeber: Birkhauser Verlag
DOI: 10.1007/s00018-019-03193-3

The C-terminal domain of LRRK2 with the G2019S mutation is sufficient to produce neurodegeneration of dopaminergic neurons in vivo

Autoren: Noémie Cresto, Marie-Claude Gaillard, Camille Gardier, Francesco Gubinelli, Elsa Diguet, Déborah Bellet, Laurine Legroux, Julien Mitja, Gwenaëlle Auregan, Martine Guillermier, Charlène Josephine, Caroline Jan, Noëlle Dufour, Alain Joliot, Philippe Hantraye, Gilles Bonvento, Nicole Déglon, Alexis-Pierre Bemelmans, Karine Cambon, Géraldine Liot, Emmanuel Brouillet
Veröffentlicht in: Neurobiology of Disease, Ausgabe 134, 2020, Seite(n) 104614, ISSN 0969-9961
Herausgeber: Academic Press
DOI: 10.1016/j.nbd.2019.104614

Conference proceedings (45)

Flow simulation of a collagen solution in syringes with different geometries

Autoren: Syntouka, Ioanna Marina; Riches, Phil; Busby, Grahame; Kazakidi, Asimina
Veröffentlicht in: BioMedEng18 Proceedings, Ausgabe 1, 2018
Herausgeber: Zenodo
DOI: 10.5281/zenodo.1470591

Characterisation of two genetic rat models of Parkinson Disease through two presynaptic PET tracers; [18F]-LBT999 and 6-[18F]fluoro-L-m-tyrosine

Autoren: Roost, Pauline; Gaudin, Mylène; Guillermier, Martine; Gubinelli, Francesco; Cresto, Noémie; Eymin, Leopold; Josephine, Charlène; Gaillard, Marie-Claude; Bemelmans, Alexis; Bramoullé; Brouillet, Emmanuel; Hantraye, Philippe; Van Camp, Nadja
Veröffentlicht in: Physiopathology of Parkinson's disease (HOPE2018), Lille, France, April 2018, 2018
Herausgeber: Physiopathology of Parkinson's disease (HOPE2018)
DOI: 10.5281/zenodo.2417096

Mapping alteration of dopaminergic neurons in a rat model of Parkinson Disease through the comparison of the presynaptic PET tracers, [18F]-LBT999 and 6-[18F]fluoro-L-m-tyrosine

Autoren: Roost, Pauline; Gaudin, Mylène; Guillermier, Martine; Gubinelli, Francesco; Cresto, Noémie; Eymin, Leopold; Josephine, Charlène; Gaillard, Marie-Claude; Bemelmans, Alexis; Bramoullé, Yann; Brouillet, Emmanuel; Hantraye, Philippe; Van Camp, Nadja
Veröffentlicht in: European Molecular Imaging Meeting (EMIM2018), San Sebastián, Spain, March 2018, 2018
Herausgeber: European Molecular Imaging Meeting (EMIM2018)
DOI: 10.5281/zenodo.2416040

PET imaging of dopaminergic changes in the rodent brain after AAV-mediated overexpression of human α-synuclein

Autoren: Roost, Pauline; Gaudin, Mylène; Guillermier, Martine; Gubinelli, Francesco; Cresto, Noémie; Eymin, Leopold; Josephine, Charlène; Gaillard, Marie-Claude; Bemelmans, Alexis; Bramoullé, Yann; Brouillet, Emmanuel; Hantraye, Philippe; Van Camp, Nadja
Veröffentlicht in: Young Researchers in Life Sciences Conference (YRLS2018), Paris, France, 02-04 May 2018, 2018
Herausgeber: Young Researchers in Life Sciences Conference (YRLS2018), Paris, France, May 2018
DOI: 10.5281/zenodo.2419882

Mapping alteration of dopaminergic neurons in a rat model of Parkinson Disease through the comparison of the presynaptic PET tracers

Autoren: Roost, Pauline; Gubinelli, Francesco; Gaudin, Mylène; Guillermier, Martine; Cresto, Noémie; Eymin, Leopold; Josephine, Charlène; Gaillard, Marie-Claude; Bemelmans, Alexis; Bramoullé, Yann; Brouillet, Emmanuel; Hantraye, Philippe; Van Camp, Nadja
Veröffentlicht in: Network for European CNS Transplantation and Restoration Meeting (NECTAR2018), Paris, France, December 2018, 2018
Herausgeber: Network for European CNS Transplantation and Restoration Meeting (NECTAR2018)
DOI: 10.5281/zenodo.2417607

An injectable Collagen Hydrogel as a delivery system for Parkinson's disease

Autoren: Francesco Gubinelli; Sílvia Cabré Giménez; Veronica Alamilla Marroquin; Marie-Claude Gaillard; Eilis Dowd; Emmanuel Brouillet; Julien Flament
Veröffentlicht in: PHysiopathology Of Parkinson's DisEaSe (HOPE 2018), Lille, April 2018, 2018
Herausgeber: PHysiopathology Of Parkinson's DisEaSe (HOPE 2018)
DOI: 10.5281/zenodo.2537684

In vivo characterisation of an IL-10 rich collagen hydrogel scaffold for Parkinson's disease

Autoren: Cabre, Silvia; Alamilla, Veronica; Moriarty, Niamh; Pandit, Abhay; Dowd, Eilis
Veröffentlicht in: 11th FENS Forum of Neuroscience (FENS), Berlin, Germany, July 2018, 2018
Herausgeber: 11th FENS Forum of Neuroscience (FENS)
DOI: 10.5281/zenodo.2540458

Potential of an injectable IL-10 rich collagen hydrogel for cell transplantation in Parkinson's Disease

Autoren: Cabre, Silvia; Alamilla, Veronica; Moriarty, Niamh; Pandit, Abhay; Dowd, Eilis
Veröffentlicht in: Network for European CNS Transplantation and Restoration (NECTAR) Conference, 2018
Herausgeber: NECTAR Conference (NECTAR 2018), Paris, France
DOI: 10.5281/zenodo.2540533

Proteomic profiling of striatal tissue of a rat model of Parkinson's disease after implantation of collagen-encapsulated mesenchymal stem cells

Autoren: Santaella, Anna; Verbeek, Marcel; Wessels, Hans; Gloerich, Jolein; .Kuiperij, Bea; Bloem, Bas; van Gool, Alain; Cabré, Silvia; Alamilla, Veronica; Dowd, Eilís
Veröffentlicht in: Network for European CNS Transplantation and Restoration (NECTAR) Conference, 2018
Herausgeber: NECTAR 2018
DOI: 10.5281/zenodo.2381435

Reprogramming of Adult Human Fibroblasts to Dopaminergic Neurons

Autoren: Shelby Shrigley; Janelle Drouin-Ouellet; Marcella Birtele; Roger A Barker; Malin Parmar
Veröffentlicht in: Network for European CNS Transplantation and Restoration (NECTAR) Conference, 2018
Herausgeber: NECTAR Conference
DOI: 10.5281/zenodo.2542102

Direct Reprogramming of Adult Human Fibroblasts to Dopaminergic Neurons

Autoren: Shelby Shrigley; Janelle Drouin-Ouellet; Maria Pereira; Roger A Barker; Malin Parmar
Veröffentlicht in: Lund University, 2018
Herausgeber: Lund University, Neuroscience
DOI: 10.5281/zenodo.2542081

REPROGRAMMING OF ADULT HUMAN FIBROBLASTS FROM HEALTHY INDIVIDUALS AND PARKINSON´S DISEASE PATIENTS

Autoren: Shelby Shrigley; Maria Pereira; Roger A Barker; Janelle Drouin-Ouellet; Malin Parmar
Veröffentlicht in: Intern. Society for Stem Cell Research ISSCR Conference, 2018
Herausgeber: ISSCR Conference
DOI: 10.5281/zenodo.2542094

DOPAL and the Olfactory Bulb: a novel platform to mimic prodromal Parkinson's disease

Autoren: Bagnoli, Enrico; Trotier, Alexandre; McMahon, Jill; Biggs, Manus; FitzGerald, Una
Veröffentlicht in: Nectar Conference, 2018
Herausgeber: Nectar Conference
DOI: 10.5281/zenodo.2537933

The effect of DOPAL on the bioenergetic performances of primary olfactory bulb mixed cultures

Autoren: Bagnoli, Enrico; FitzGerald, Una
Veröffentlicht in: Galway Neuroscience Centre (GNC), 2018
Herausgeber: Galway Neuroscience Centre (GNC)
DOI: 10.5281/zenodo.2537925

DOPAL-Treated Olfactory Bulb Organotypic Slices as a Model of Prodromal Parkinson's Disease

Autoren: Bagnoli, Enrico; FitzGerald, Una
Veröffentlicht in: GRC Conference, 2018
Herausgeber: GRC Conference
DOI: 10.5281/zenodo.2537943

Therapeutic efficacy of GDNF loaded collagen scaffolds in organotypic brain slices with rotenone-induced Parkinson´s disease

Autoren: Ucar, Buket; Schwarz, Alina; Humpel, Christian
Veröffentlicht in: Live Science Meeting Innsbruck, 2018
Herausgeber: University Innsbruck, Austria
DOI: 10.5281/zenodo.2531572

Therapeutic Efficacy of GDNF Loaded Collagen Scaffolds in ex vivo organotypic brain slice Parkinson`s Disease Models

Autoren: Ucar, Buket; Humpel, Christian
Veröffentlicht in: Network for European CNS Transplantation and Restoration (NECTAR) Conference, 2018
Herausgeber: Network for European CNS Transplantation and Restoration (NECTAR)
DOI: 10.5281/zenodo.2547572

Carbohydrate-functionalised collagen hydrogels for cell delivery in a neural environment

Autoren: Rebelo, Ana Lucia; Russo, Laura; Dowd, Eilis; Pandit, Abhay
Veröffentlicht in: Matrix Biology Ireland, 2018
Herausgeber: MBI
DOI: 10.5281/zenodo.2547649

Optimisation of a Collagen-based System for Cell Delivery to the Brain

Autoren: Rebelo, Ana Lucia; Dowd, Eilis; Pandit, Abhay
Veröffentlicht in: Network for European CNS Transplantation and Restoration (NECTAR) Conference, 2017
Herausgeber: NECTAR
DOI: 10.5281/zenodo.2547677

A Method for the Characterisation of N-Glycome from Human Brain Glycoproteins

Autoren: Rebelo, Ana Lucia; Pandit, Abhay; Saldova, Radka
Veröffentlicht in: Network for European CNS Transplantation and Restoration (NECTAR) Conference, 2018
Herausgeber: Network for European CNS Transplantation and Restoration (NECTAR)
DOI: 10.5281/zenodo.2547659

Optimisation of a Carbohydrate-Functionalised Collagen Gel for Ventral Mesencephalic Cell Delivery

Autoren: Rebelo, AL; Russo, L; Dowd, E; Pandit, A
Veröffentlicht in: International Carbohydrate Symposium (ICS) Conference, 2018
Herausgeber: ICS Proceedings
DOI: 10.5281/zenodo.2547642

Inflammation biomarker discovery in Parkinson's disease and

Autoren: Santaella, Anna; Kuiperij, Bea; Verbeek, Marcel; Bloem, Bas; Esselink, Rianne; van Rumund, Anouke; van Gool, Alain
Veröffentlicht in: CSF Society Conference, 2018
Herausgeber: CSF Society
DOI: 10.5281/zenodo.2384831

Flow Simulation of a Natural Polymer in a Syringe Needle Delivery Device

Autoren: Syntouka, Ioanna Marina; Riches, Philip; Busby, Grahame; Kazakidi, Asimina
Veröffentlicht in: ECCM Conference Glasgow, Ausgabe 1, 2019
Herausgeber: ECCM Conference Glasgow
DOI: 10.5281/zenodo.2660401

3D printing of stem cells in liquid-like solids for neural tissue fabrication

Autoren: Janko Kajtez
Veröffentlicht in: ISSCR 2018 Annual Meeting, 2018
Herausgeber: ISSCR 2018 Annual Meeting
DOI: 10.5281/zenodo.3217895

Delivery of an Injectable Biomaterial to the Striatum- a Computational Analysis

Autoren: Syntouka, Ioanna Marina; Riches, Philip; McDonald, Alexis; Kazakidi, Asimina
Veröffentlicht in: Ausgabe 2, 2019
Herausgeber: NER 2019
DOI: 10.5281/zenodo.3067128

Towards an effective, needle-based delivery device for Parkinson's disease: a simulation study on the impact of needle diameter

Autoren: Syntouka, Ioanna Marina; Riches, Philip; Busby, Grahame; Kazakidi, Asimina
Veröffentlicht in: World Conference of Biomechanics, Ausgabe 2, 2018
Herausgeber: World Conference of Biomechanics
DOI: 10.5281/zenodo.3067551

Computational Analysis of Intrastriatal Delivery of Collagen

Autoren: Syntouka, Ioanna Marina; Riches, Philip; McDonald, Alexis; Kazakidi, Asimina
Veröffentlicht in: Ausgabe 2, 2019
Herausgeber: TERMIS EU 2019
DOI: 10.5281/zenodo.3067803

Computational analysis of collagen delivery to the striatum

Autoren: Syntouka, Ioanna Marina; Busby, Grahame; Kazakidi, Asimina
Veröffentlicht in: Ausgabe 2, 2018
Herausgeber: NECTAR Conference 2018
DOI: 10.5281/zenodo.3066996

Flow simulation of a collagen solution in syringes with different geometries

Autoren: Syntouka, Ioanna Marina; Riches, Philip; Busby, Grahame; Kazakidi, Asimina
Veröffentlicht in: Ausgabe 2, 2018
Herausgeber: BioMedEng 2018
DOI: 10.5281/zenodo.3066863

Kinase domain of LRRK2G2019S is sufficient to trigger neurodegeneration of dopaminergic neurons and increases alpha-synuclein toxicity in vivo

Autoren: Francesco Gubinelli; Noémie Cresto; Marie-Claude Gaillard; Gwenaëlle Auregan; Martine Guillermier; Camille Gardier; Charlène Josephine; Fanny Petit; Caroline Jan; Pauline Gipchtein; Noëlle Dufour; Philippe Hantraye; Géraldine Liot; Alexis Pierre Bemelmans; Emmanuel Brouillet
Veröffentlicht in: Ausgabe 3, 2017
Herausgeber: NECTAR
DOI: 10.5281/zenodo.3233730

α-syn and LRRK2: a synergistic relationship?

Autoren: Noémie Cresto; Francesco Gubinelli; Pauline Roost; Marie-Claude Gaillard; Camille Gardier; Charlène Josephine; Philippe Hantraye; Géraldine Liot; Alexis Pierre Bemelmans; Nadja van Camp; Emmanuel Brouillet
Veröffentlicht in: Ausgabe 2, 2018
Herausgeber: NECTAR
DOI: 10.5281/zenodo.3233726

Human fetal ventral midbrain in standard culture versus organoids

Autoren: Marcella Birtele; Alessandro Fiorenzano; Jenny Nelander; Malin Parmar
Veröffentlicht in: Ausgabe 2, 2019
Herausgeber: International Society for Stem Cell Research
DOI: 10.5281/zenodo.3358629

Functional analysis and single cell characterization of human fetal ventral midbrain in 2D and 3D cultures

Autoren: Marcella Birtele; Alessandro Fiorenzano; Yogita Sharma; Jenny Nelander; Malin Parmar
Veröffentlicht in: Ausgabe 2, 2019
Herausgeber: World Parkinson Congress
DOI: 10.5281/zenodo.3358637

Assessment of the impact of GDF-5-loaded collagen hydrogels on ventral mesencephalic grafts in a rat model of Parkinson's disease

Autoren: Alamilla, Veronica; Cabré, Silvia; Moriarty, Niamh; Kelly, Rachel; Pandit, Abhay; Dowd, Eilís
Veröffentlicht in: Ausgabe 1, 2019
Herausgeber: British Neuroscience Association
DOI: 10.5281/zenodo.3233943

Complete Characterisation of the Human Brain N-glycome and How it Changes upon Parkinson’s Disease

Autoren: Ana Lucia Rebelo
Veröffentlicht in: MBI, Dublin, Ireland, 2018
Herausgeber: MBI, Dublin, Ireland
DOI: 10.5281/zenodo.3570670

Collagen Microgels for Regenerative Medicine

Autoren: Jose Rey; Abhay Pandit; Grahame Busby; Manuel Salmeron-Sanchez; Cristina Gonzalez-Garcia
Veröffentlicht in: European Society of Biomaterials, Ausgabe 1, 2019
Herausgeber: European Society of Biomaterials
DOI: 10.5281/zenodo.2560488

Transplantation of human pluripotent cell derived dopaminergic neurons into a novel accelerated a-synuclein rat model of Parkinson's disease

Autoren: Shelby Shrigley; Deirdre B Hoban; Bengt Mattsson; Jenny Nelander-Wahlestedt; Anders Björklund; Malin Parmar
Veröffentlicht in: NYSCF, Ausgabe 1, 2019
Herausgeber: NYSCF
DOI: 10.5281/zenodo.3456984

The Sweet Side of the Brain: Complete Characterisation of the N-glycome of Human Brain tissue and its Alteration upon Parkinson’s Disease

Autoren: Ana Lucia Rebelo
Veröffentlicht in: TERMIS EU, 2019
Herausgeber: TERMIS,
DOI: 10.5281/zenodo.3570975

Electrophysiological properties of long term cultured human induced neurons

Autoren: Birtele Marcella; Drouin-Ouellet Janella; Rylander-Ottosson Daniella; Barker Roger; Parmar Malin
Veröffentlicht in: ISSCR Conference, Melbourne,, 2018
Herausgeber: ISSCR Conference, Melbourne
DOI: 10.5281/zenodo.2538581

Promoting functional maturation of induced human adult neurons.

Autoren: Marcella Birtele
Veröffentlicht in: NECTAR, 2018
Herausgeber: NECTAR
DOI: 10.5281/zenodo.2538583

Impact of cell intrinsic properties on transplantation in rodent models of Parkinson's disease

Autoren: Impact of cell intrinsic properties on transplantation in rodent models of Parkinson's disease Shelby Shrigley
Veröffentlicht in: NECTAR, 2019
Herausgeber: NECTAR
DOI: 10.5281/zenodo.3463178

Effects of GDF-5-loaded collagen hydrogels after intrastriatal transplantation of ventral mesencephalic cells in a rat model of Parkinson’s disease.

Autoren: Verónica Alamilla
Veröffentlicht in: NECTAR, 2018
Herausgeber: NECTAR
DOI: 10.5281/zenodo.2549691

Utility of ventral mesencephalic tissue explants for assessment of neurotrophin-functionalised biomaterial hydrogels in the context of Parkinson’s disease therapeutics

Autoren: Verónica Alamilla
Veröffentlicht in: FENS, 2018
Herausgeber: FENS
DOI: 10.5281/zenodo.2549588

Therapeutic Efficacy of Glial Cell Line-Derived Neurotrophic Factor Loaded Collagen Scaffolds in ex vivo organotypic brain slice Parkinson`s Disease Models

Autoren: Ucar, Buket; Humpel, Christian
Veröffentlicht in: Ausgabe 1, 2019
Herausgeber: Life Science Meeting Innsbruck
DOI: 10.5281/zenodo.3631098

Glial cell-derived neurotrophic factor loaded collagen scaffolds provide neuroprotection in ex vivo organotypic brain slice Parkinson's disease models

Autoren: Ucar, Buket; Humpel, Christian
Veröffentlicht in: Ausgabe 1, 2019
Herausgeber: Austrian Neuroscience Association
DOI: 10.5281/zenodo.3631080

Non-peer reviewed articles (6)

Abstract book of the 5th World Parkinson Congress, Kyoto, Japan, June 4–7, 2019

Autoren: Shelby Shrigley; Fredrik Nilsson; Janelle Drouin-Ouellet; Marcella Birtele; Roger A Barker; Malin Parmar
Veröffentlicht in: Journal of Parkinson's Disease, Ausgabe 9/s1, 2019, Seite(n) 1-278, ISSN 1877-7171
Herausgeber: IOS Press
DOI: 10.3233/JPD-199900

Glyco25, XXV International Symposium on Glycoconjugates

Autoren: Ana Lucia Rebelo
Veröffentlicht in: Glycoconjugate Journal, Ausgabe 36/4, 2019, Seite(n) 267-397, ISSN 0282-0080
Herausgeber: Kluwer Academic Publishers
DOI: 10.1007/s10719-019-09880-4

BNA Festival of Neuroscience 2019

Autoren: Enrico Bagnoli
Veröffentlicht in: Brain and Neuroscience Advances, Ausgabe 3, 2019, Seite(n) 239821281985549, ISSN 2398-2128
Herausgeber: BNA
DOI: 10.1177/2398212819855490

GLIA Porto 2019: Abstracts Oral Presentations, Posters, Indexes

Autoren: Enrico Bagnoli
Veröffentlicht in: Glia, Ausgabe 67/S1, 2019, ISSN 0894-1491
Herausgeber: John Wiley & Sons Inc.
DOI: 10.1002/glia.23674

In Vivo Direct Reprogramming of Resident Glial Cells into Interneurons by Intracerebral Injection of Viral Vectors

Autoren: Maria Pereira, Marcella Birtele, Daniella Rylander Ottosson
Veröffentlicht in: Journal of Visualized Experiments, Ausgabe 148, 2019, ISSN 1940-087X
Herausgeber: MYJoVE Corporation
DOI: 10.3791/59465

Leaky Optoelectrical Fiber for Optogenetic Stimulation and Electrochemical Detection of Dopamine Exocytosis from Human Dopaminergic Neurons

Autoren: Shashank Vasudevan, Janko Kajtez, Ada‐Ioana Bunea, Ana Gonzalez‐Ramos, Tania Ramos‐Moreno, Arto Heiskanen, Merab Kokaia, Niels B. Larsen, Alberto Martínez‐Serrano, Stephan S. Keller, Jenny Emnéus
Veröffentlicht in: Advanced Science, Ausgabe 6/24, 2019, Seite(n) 1902011, ISSN 2198-3844
Herausgeber: Advanced Science
DOI: 10.1002/advs.201902011