Development of Biomaterial-based Delivery Systems for Parkinson’s disease - an Integrated Pan-European Approach

Informations projet

BrainMatTrain

N° de convention de subvention: 676408

DOI 10.3030/676408

Projet clôturé

Date de signature de la CE 27 Juillet 2015

Date de début 1 Janvier 2016

Date de fin 31 Decembre 2019

Financé au titre de

• EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions

Coût total € 3 995 083,44

Contribution de l’UE € 3 995 083,44

Coordonné par

UNIVERSITY OF GALWAY
Ireland

Livrables

Documents, reports (18)

A multi-modal scaffold functionalised with anti-inflammatory moieties that protects dopaminergic neurons in an in vivo model of PD.

A multi-modal scaffold functionalised with anti-inflammatory moieties that protects dopaminergic neurons in an in vivo model of PD.

Progress Report

progress report

Mid Term Review Meeting
A multi-modal scaffold functionalised with both anti-inflammatory and neuroprotective moieties that protect dopaminergic neurons in an in vivo model of PD.
Draft Periodic Report

Draft Report

Multi-modal delivery system targeting neuroinflammation and neuroprotection optimised.
An optimised neurotropic factor functionalised collagen reservoir system fabricated

An optimised neurotropic factor functionalised collagen reservoir system.

A multi-modal scaffold functionalised with neuroprotective moieties that protects dopaminergic neurons in an in vivo model of PD

A multi-modal scaffold functionalised with neuroprotective moieties that protects dopaminergic neurons in an in vivo model of PD

Efficacy of BrainMatTrain scaffolds to protect nigrostriatal dopaminergic neurons optimised in an organotypic slice culture model of PD

Efficacy of BrainMatTrain scaffolds to protect nigrostriatal dopaminergic neurons optimised in an organotypic slice culture model of PD.

Data Management Plan

The Data Management Plan describes the data management life cycle for all data sets that will be collected, processed or generated by the action. It is a document describing what data will be collected, processed or generated and following what methodology and standards, whether and how this data will be shared and/or made open, and how it will be curated and preserved.

Efficacy of BrainMatTrain scaffolds to protect nigrostriatal dopaminergic neurons optimised in an adult stem cell derived dopaminergic neuronal in vitro model of PD

Efficacy of BrainMatTrain scaffolds to protect nigrostriatal dopaminergic neurons optimised in an adult stem cell derived dopaminergic neuronal in vitro model of PD.

Efficacy of BrainMatTrain scaffolds to protect nigrostriatal dopaminergic neurons optimised in a lab-on-a-chip model of PD.
Multi-modal delivery system targeting neuroinflammation and neuroprotection developed.
Injectable matrix for ex vivo neurotrophin gene therapy optimised
Multi-modal delivery system targeting neuroinflammation and neuroprotection validated

Multi-modal delivery system targeting neuroinflammation and neuroprotection validated.

Supervisory Board of the Network

supervisory board of the Network

Ethics

documents to be submitted

Proteomic response of multi-modal collagen scaffolds following implantation in an in vivo model of PD investigated

Proteomic response of multi-modal collagen scaffolds following implantation in an in vivo model of PD investigated.

Publications

Peer reviewed articles (13)

Direct Reprogramming of Resident NG2 Glia into Neurons with Properties of Fast-Spiking Parvalbumin-Containing Interneurons

Auteurs: Maria Pereira, Marcella Birtele, Shelby Shrigley, Julio Aguila Benitez, Eva Hedlund, Malin Parmar, Daniella Rylander Ottosson
Publié dans: Stem Cell Reports, Numéro 9/3, 2017, Page(s) 742-751, ISSN 2213-6711
Éditeur: Cell Press
DOI: 10.1016/j.stemcr.2017.07.023

Nerve growth factor released from collagen scaffolds protects axotomized cholinergic neurons of the basal nucleus of Meynert in organotypic brain slices

Auteurs: Bettina M. Foidl, Buket Ucar, Alina Schwarz, Ana L. Rebelo, Abhay Pandit, Christian Humpel
Publié dans: Journal of Neuroscience Methods, Numéro 295, 2018, Page(s) 77-86, ISSN 0165-0270
Éditeur: Elsevier BV
DOI: 10.1016/j.jneumeth.2017.12.003

Collagen for brain repair: therapeutic perspectives

Auteurs: Christian Humpel, Buket Ucar
Publié dans: Neural Regeneration Research, Numéro 13/4, 2018, Page(s) 595, ISSN 1673-5374
Éditeur: Neural Regeneration Research
DOI: 10.4103/1673-5374.230273

Simple Generation of a High Yield Culture of Induced Neurons from Human Adult Skin Fibroblasts

Auteurs: Shelby Shrigley, Karolina Pircs, Roger A. Barker, Malin Parmar, Janelle Drouin-Ouellet
Publié dans: Journal of Visualized Experiments, Numéro 132, 2018, ISSN 1940-087X
Éditeur: MYJoVE Corporation
DOI: 10.3791/56904

Encapsulation of young donor age dopaminergic grafts in a GDNF-loaded collagen hydrogel further increases their survival, reinnervation, and functional efficacy after intrastriatal transplantation in hemi-Parkinsonian rats

Auteurs: Niamh Moriarty, Sílvia Cabré, Verónica Alamilla, Abhay Pandit, Eilís Dowd
Publié dans: European Journal of Neuroscience, 2018, ISSN 0953-816X
Éditeur: Blackwell Publishing Inc.
DOI: 10.1111/ejn.14090

Mitral cells and the glucagon-like peptide 1 receptor: The sweet smell of success?

Auteurs: Enrico Bagnoli, Una FitzGerald
Publié dans: European Journal of Neuroscience, 2018, ISSN 0953-816X
Éditeur: Blackwell Publishing Inc.
DOI: 10.1111/ejn.14115

The unlikely partnership between LRRK2 and α-synuclein in Parkinson's disease

Auteurs: Noémie Cresto, Camille Gardier, Francesco Gubinelli, Marie-Claude Gaillard, Géraldine Liot, Andrew B. West, Emmanuel Brouillet
Publié dans: European Journal of Neuroscience, 2018, ISSN 0953-816X
Éditeur: Blackwell Publishing Inc.
DOI: 10.1111/ejn.14182

A window into the brain: Tools to assess preclinical efficacy of biomaterials-based therapies on central nervous system disorders

Auteurs: Juhi Samal, Ana Lucia Rebelo, Abhay Pandit
Publié dans: Advanced Drug Delivery Reviews, Numéro S0169-409X(19)3001516, 2019, ISSN 0169-409X
Éditeur: Elsevier BV
DOI: 10.1016/j.addr.2019.01.012

Therapeutic efficacy of glial cell-derived neurotrophic factor loaded collagen scaffolds in ex vivo organotypic brain slice Parkinson’s disease models

Auteurs: Buket Ucar, Christian Humpel
Publié dans: Brain Research Bulletin, Numéro 149, 2019, Page(s) 86-95, ISSN 0361-9230
Éditeur: Elsevier BV
DOI: 10.1016/j.brainresbull.2019.04.012

Organotypic brain slice cultures: A review

Auteurs: C. Humpel
Publié dans: Neuroscience, Numéro 305, 2015, Page(s) 86-98, ISSN 0306-4522
Éditeur: Elsevier BV
DOI: 10.1016/j.neuroscience.2015.07.086

Viral mimetic priming enhances α-synuclein-induced degeneration: Implications for Parkinson’s disease

Auteurs: Laura K. Olsen, Andrew G. Cairns, Jörgen Ådén, Niamh Moriarty, Silvia Cabre, Veronica R. Alamilla, Fredrik Almqvist, Eilís Dowd, Declan P. McKernan
Publié dans: Brain, Behavior, and Immunity, Numéro 80, 2019, Page(s) 525-535, ISSN 0889-1591
Éditeur: Academic Press
DOI: 10.1016/j.bbi.2019.04.036

Direct reprogramming into interneurons: potential for brain repair

Auteurs: Maria Pereira, Marcella Birtele, Daniella Rylander Ottosson
Publié dans: Cellular and Molecular Life Sciences, Numéro 76/20, 2019, Page(s) 3953-3967, ISSN 1420-682X
Éditeur: Birkhauser Verlag
DOI: 10.1007/s00018-019-03193-3

The C-terminal domain of LRRK2 with the G2019S mutation is sufficient to produce neurodegeneration of dopaminergic neurons in vivo

Auteurs: Noémie Cresto, Marie-Claude Gaillard, Camille Gardier, Francesco Gubinelli, Elsa Diguet, Déborah Bellet, Laurine Legroux, Julien Mitja, Gwenaëlle Auregan, Martine Guillermier, Charlène Josephine, Caroline Jan, Noëlle Dufour, Alain Joliot, Philippe Hantraye, Gilles Bonvento, Nicole Déglon, Alexis-Pierre Bemelmans, Karine Cambon, Géraldine Liot, Emmanuel Brouillet
Publié dans: Neurobiology of Disease, Numéro 134, 2020, Page(s) 104614, ISSN 0969-9961
Éditeur: Academic Press
DOI: 10.1016/j.nbd.2019.104614

Conference proceedings (45)

Flow simulation of a collagen solution in syringes with different geometries

Auteurs: Syntouka, Ioanna Marina; Riches, Phil; Busby, Grahame; Kazakidi, Asimina
Publié dans: BioMedEng18 Proceedings, Numéro 1, 2018
Éditeur: Zenodo
DOI: 10.5281/zenodo.1470591

Characterisation of two genetic rat models of Parkinson Disease through two presynaptic PET tracers; [18F]-LBT999 and 6-[18F]fluoro-L-m-tyrosine

Auteurs: Roost, Pauline; Gaudin, Mylène; Guillermier, Martine; Gubinelli, Francesco; Cresto, Noémie; Eymin, Leopold; Josephine, Charlène; Gaillard, Marie-Claude; Bemelmans, Alexis; Bramoullé; Brouillet, Emmanuel; Hantraye, Philippe; Van Camp, Nadja
Publié dans: Physiopathology of Parkinson's disease (HOPE2018), Lille, France, April 2018, 2018
Éditeur: Physiopathology of Parkinson's disease (HOPE2018)
DOI: 10.5281/zenodo.2417096

Mapping alteration of dopaminergic neurons in a rat model of Parkinson Disease through the comparison of the presynaptic PET tracers, [18F]-LBT999 and 6-[18F]fluoro-L-m-tyrosine

Auteurs: Roost, Pauline; Gaudin, Mylène; Guillermier, Martine; Gubinelli, Francesco; Cresto, Noémie; Eymin, Leopold; Josephine, Charlène; Gaillard, Marie-Claude; Bemelmans, Alexis; Bramoullé, Yann; Brouillet, Emmanuel; Hantraye, Philippe; Van Camp, Nadja
Publié dans: European Molecular Imaging Meeting (EMIM2018), San Sebastián, Spain, March 2018, 2018
Éditeur: European Molecular Imaging Meeting (EMIM2018)
DOI: 10.5281/zenodo.2416040

PET imaging of dopaminergic changes in the rodent brain after AAV-mediated overexpression of human α-synuclein

Auteurs: Roost, Pauline; Gaudin, Mylène; Guillermier, Martine; Gubinelli, Francesco; Cresto, Noémie; Eymin, Leopold; Josephine, Charlène; Gaillard, Marie-Claude; Bemelmans, Alexis; Bramoullé, Yann; Brouillet, Emmanuel; Hantraye, Philippe; Van Camp, Nadja
Publié dans: Young Researchers in Life Sciences Conference (YRLS2018), Paris, France, 02-04 May 2018, 2018
Éditeur: Young Researchers in Life Sciences Conference (YRLS2018), Paris, France, May 2018
DOI: 10.5281/zenodo.2419882

Mapping alteration of dopaminergic neurons in a rat model of Parkinson Disease through the comparison of the presynaptic PET tracers

Auteurs: Roost, Pauline; Gubinelli, Francesco; Gaudin, Mylène; Guillermier, Martine; Cresto, Noémie; Eymin, Leopold; Josephine, Charlène; Gaillard, Marie-Claude; Bemelmans, Alexis; Bramoullé, Yann; Brouillet, Emmanuel; Hantraye, Philippe; Van Camp, Nadja
Publié dans: Network for European CNS Transplantation and Restoration Meeting (NECTAR2018), Paris, France, December 2018, 2018
Éditeur: Network for European CNS Transplantation and Restoration Meeting (NECTAR2018)
DOI: 10.5281/zenodo.2417607

An injectable Collagen Hydrogel as a delivery system for Parkinson's disease

Auteurs: Francesco Gubinelli; Sílvia Cabré Giménez; Veronica Alamilla Marroquin; Marie-Claude Gaillard; Eilis Dowd; Emmanuel Brouillet; Julien Flament
Publié dans: PHysiopathology Of Parkinson's DisEaSe (HOPE 2018), Lille, April 2018, 2018
Éditeur: PHysiopathology Of Parkinson's DisEaSe (HOPE 2018)
DOI: 10.5281/zenodo.2537684

In vivo characterisation of an IL-10 rich collagen hydrogel scaffold for Parkinson's disease

Auteurs: Cabre, Silvia; Alamilla, Veronica; Moriarty, Niamh; Pandit, Abhay; Dowd, Eilis
Publié dans: 11th FENS Forum of Neuroscience (FENS), Berlin, Germany, July 2018, 2018
Éditeur: 11th FENS Forum of Neuroscience (FENS)
DOI: 10.5281/zenodo.2540458

Potential of an injectable IL-10 rich collagen hydrogel for cell transplantation in Parkinson's Disease

Auteurs: Cabre, Silvia; Alamilla, Veronica; Moriarty, Niamh; Pandit, Abhay; Dowd, Eilis
Publié dans: Network for European CNS Transplantation and Restoration (NECTAR) Conference, 2018
Éditeur: NECTAR Conference (NECTAR 2018), Paris, France
DOI: 10.5281/zenodo.2540533

Proteomic profiling of striatal tissue of a rat model of Parkinson's disease after implantation of collagen-encapsulated mesenchymal stem cells

Auteurs: Santaella, Anna; Verbeek, Marcel; Wessels, Hans; Gloerich, Jolein; .Kuiperij, Bea; Bloem, Bas; van Gool, Alain; Cabré, Silvia; Alamilla, Veronica; Dowd, Eilís
Publié dans: Network for European CNS Transplantation and Restoration (NECTAR) Conference, 2018
Éditeur: NECTAR 2018
DOI: 10.5281/zenodo.2381435

Reprogramming of Adult Human Fibroblasts to Dopaminergic Neurons

Auteurs: Shelby Shrigley; Janelle Drouin-Ouellet; Marcella Birtele; Roger A Barker; Malin Parmar
Publié dans: Network for European CNS Transplantation and Restoration (NECTAR) Conference, 2018
Éditeur: NECTAR Conference
DOI: 10.5281/zenodo.2542102

Direct Reprogramming of Adult Human Fibroblasts to Dopaminergic Neurons

Auteurs: Shelby Shrigley; Janelle Drouin-Ouellet; Maria Pereira; Roger A Barker; Malin Parmar
Publié dans: Lund University, 2018
Éditeur: Lund University, Neuroscience
DOI: 10.5281/zenodo.2542081

REPROGRAMMING OF ADULT HUMAN FIBROBLASTS FROM HEALTHY INDIVIDUALS AND PARKINSON´S DISEASE PATIENTS

Auteurs: Shelby Shrigley; Maria Pereira; Roger A Barker; Janelle Drouin-Ouellet; Malin Parmar
Publié dans: Intern. Society for Stem Cell Research ISSCR Conference, 2018
Éditeur: ISSCR Conference
DOI: 10.5281/zenodo.2542094

DOPAL and the Olfactory Bulb: a novel platform to mimic prodromal Parkinson's disease

Auteurs: Bagnoli, Enrico; Trotier, Alexandre; McMahon, Jill; Biggs, Manus; FitzGerald, Una
Publié dans: Nectar Conference, 2018
Éditeur: Nectar Conference
DOI: 10.5281/zenodo.2537933

The effect of DOPAL on the bioenergetic performances of primary olfactory bulb mixed cultures

Auteurs: Bagnoli, Enrico; FitzGerald, Una
Publié dans: Galway Neuroscience Centre (GNC), 2018
Éditeur: Galway Neuroscience Centre (GNC)
DOI: 10.5281/zenodo.2537925

DOPAL-Treated Olfactory Bulb Organotypic Slices as a Model of Prodromal Parkinson's Disease

Auteurs: Bagnoli, Enrico; FitzGerald, Una
Publié dans: GRC Conference, 2018
Éditeur: GRC Conference
DOI: 10.5281/zenodo.2537943

Therapeutic efficacy of GDNF loaded collagen scaffolds in organotypic brain slices with rotenone-induced Parkinson´s disease

Auteurs: Ucar, Buket; Schwarz, Alina; Humpel, Christian
Publié dans: Live Science Meeting Innsbruck, 2018
Éditeur: University Innsbruck, Austria
DOI: 10.5281/zenodo.2531572

Therapeutic Efficacy of GDNF Loaded Collagen Scaffolds in ex vivo organotypic brain slice Parkinson`s Disease Models

Auteurs: Ucar, Buket; Humpel, Christian
Publié dans: Network for European CNS Transplantation and Restoration (NECTAR) Conference, 2018
Éditeur: Network for European CNS Transplantation and Restoration (NECTAR)
DOI: 10.5281/zenodo.2547572

Carbohydrate-functionalised collagen hydrogels for cell delivery in a neural environment

Auteurs: Rebelo, Ana Lucia; Russo, Laura; Dowd, Eilis; Pandit, Abhay
Publié dans: Matrix Biology Ireland, 2018
Éditeur: MBI
DOI: 10.5281/zenodo.2547649

Optimisation of a Collagen-based System for Cell Delivery to the Brain

Auteurs: Rebelo, Ana Lucia; Dowd, Eilis; Pandit, Abhay
Publié dans: Network for European CNS Transplantation and Restoration (NECTAR) Conference, 2017
Éditeur: NECTAR
DOI: 10.5281/zenodo.2547677

A Method for the Characterisation of N-Glycome from Human Brain Glycoproteins

Auteurs: Rebelo, Ana Lucia; Pandit, Abhay; Saldova, Radka
Publié dans: Network for European CNS Transplantation and Restoration (NECTAR) Conference, 2018
Éditeur: Network for European CNS Transplantation and Restoration (NECTAR)
DOI: 10.5281/zenodo.2547659

Optimisation of a Carbohydrate-Functionalised Collagen Gel for Ventral Mesencephalic Cell Delivery

Auteurs: Rebelo, AL; Russo, L; Dowd, E; Pandit, A
Publié dans: International Carbohydrate Symposium (ICS) Conference, 2018
Éditeur: ICS Proceedings
DOI: 10.5281/zenodo.2547642

Inflammation biomarker discovery in Parkinson's disease and

Auteurs: Santaella, Anna; Kuiperij, Bea; Verbeek, Marcel; Bloem, Bas; Esselink, Rianne; van Rumund, Anouke; van Gool, Alain
Publié dans: CSF Society Conference, 2018
Éditeur: CSF Society
DOI: 10.5281/zenodo.2384831

Flow Simulation of a Natural Polymer in a Syringe Needle Delivery Device

Auteurs: Syntouka, Ioanna Marina; Riches, Philip; Busby, Grahame; Kazakidi, Asimina
Publié dans: ECCM Conference Glasgow, Numéro 1, 2019
Éditeur: ECCM Conference Glasgow
DOI: 10.5281/zenodo.2660401

3D printing of stem cells in liquid-like solids for neural tissue fabrication

Auteurs: Janko Kajtez
Publié dans: ISSCR 2018 Annual Meeting, 2018
Éditeur: ISSCR 2018 Annual Meeting
DOI: 10.5281/zenodo.3217895

Delivery of an Injectable Biomaterial to the Striatum- a Computational Analysis

Auteurs: Syntouka, Ioanna Marina; Riches, Philip; McDonald, Alexis; Kazakidi, Asimina
Publié dans: Numéro 2, 2019
Éditeur: NER 2019
DOI: 10.5281/zenodo.3067128

Towards an effective, needle-based delivery device for Parkinson's disease: a simulation study on the impact of needle diameter

Auteurs: Syntouka, Ioanna Marina; Riches, Philip; Busby, Grahame; Kazakidi, Asimina
Publié dans: World Conference of Biomechanics, Numéro 2, 2018
Éditeur: World Conference of Biomechanics
DOI: 10.5281/zenodo.3067551

Computational Analysis of Intrastriatal Delivery of Collagen

Auteurs: Syntouka, Ioanna Marina; Riches, Philip; McDonald, Alexis; Kazakidi, Asimina
Publié dans: Numéro 2, 2019
Éditeur: TERMIS EU 2019
DOI: 10.5281/zenodo.3067803

Computational analysis of collagen delivery to the striatum

Auteurs: Syntouka, Ioanna Marina; Busby, Grahame; Kazakidi, Asimina
Publié dans: Numéro 2, 2018
Éditeur: NECTAR Conference 2018
DOI: 10.5281/zenodo.3066996

Flow simulation of a collagen solution in syringes with different geometries

Auteurs: Syntouka, Ioanna Marina; Riches, Philip; Busby, Grahame; Kazakidi, Asimina
Publié dans: Numéro 2, 2018
Éditeur: BioMedEng 2018
DOI: 10.5281/zenodo.3066863

Kinase domain of LRRK2G2019S is sufficient to trigger neurodegeneration of dopaminergic neurons and increases alpha-synuclein toxicity in vivo

Auteurs: Francesco Gubinelli; Noémie Cresto; Marie-Claude Gaillard; Gwenaëlle Auregan; Martine Guillermier; Camille Gardier; Charlène Josephine; Fanny Petit; Caroline Jan; Pauline Gipchtein; Noëlle Dufour; Philippe Hantraye; Géraldine Liot; Alexis Pierre Bemelmans; Emmanuel Brouillet
Publié dans: Numéro 3, 2017
Éditeur: NECTAR
DOI: 10.5281/zenodo.3233730

α-syn and LRRK2: a synergistic relationship?

Auteurs: Noémie Cresto; Francesco Gubinelli; Pauline Roost; Marie-Claude Gaillard; Camille Gardier; Charlène Josephine; Philippe Hantraye; Géraldine Liot; Alexis Pierre Bemelmans; Nadja van Camp; Emmanuel Brouillet
Publié dans: Numéro 2, 2018
Éditeur: NECTAR
DOI: 10.5281/zenodo.3233726

Human fetal ventral midbrain in standard culture versus organoids

Auteurs: Marcella Birtele; Alessandro Fiorenzano; Jenny Nelander; Malin Parmar
Publié dans: Numéro 2, 2019
Éditeur: International Society for Stem Cell Research
DOI: 10.5281/zenodo.3358629

Functional analysis and single cell characterization of human fetal ventral midbrain in 2D and 3D cultures

Auteurs: Marcella Birtele; Alessandro Fiorenzano; Yogita Sharma; Jenny Nelander; Malin Parmar
Publié dans: Numéro 2, 2019
Éditeur: World Parkinson Congress
DOI: 10.5281/zenodo.3358637

Assessment of the impact of GDF-5-loaded collagen hydrogels on ventral mesencephalic grafts in a rat model of Parkinson's disease

Auteurs: Alamilla, Veronica; Cabré, Silvia; Moriarty, Niamh; Kelly, Rachel; Pandit, Abhay; Dowd, Eilís
Publié dans: Numéro 1, 2019
Éditeur: British Neuroscience Association
DOI: 10.5281/zenodo.3233943

Complete Characterisation of the Human Brain N-glycome and How it Changes upon Parkinson’s Disease

Auteurs: Ana Lucia Rebelo
Publié dans: MBI, Dublin, Ireland, 2018
Éditeur: MBI, Dublin, Ireland
DOI: 10.5281/zenodo.3570670

Collagen Microgels for Regenerative Medicine

Auteurs: Jose Rey; Abhay Pandit; Grahame Busby; Manuel Salmeron-Sanchez; Cristina Gonzalez-Garcia
Publié dans: European Society of Biomaterials, Numéro 1, 2019
Éditeur: European Society of Biomaterials
DOI: 10.5281/zenodo.2560488

Transplantation of human pluripotent cell derived dopaminergic neurons into a novel accelerated a-synuclein rat model of Parkinson's disease

Auteurs: Shelby Shrigley; Deirdre B Hoban; Bengt Mattsson; Jenny Nelander-Wahlestedt; Anders Björklund; Malin Parmar
Publié dans: NYSCF, Numéro 1, 2019
Éditeur: NYSCF
DOI: 10.5281/zenodo.3456984

The Sweet Side of the Brain: Complete Characterisation of the N-glycome of Human Brain tissue and its Alteration upon Parkinson’s Disease

Auteurs: Ana Lucia Rebelo
Publié dans: TERMIS EU, 2019
Éditeur: TERMIS,
DOI: 10.5281/zenodo.3570975

Electrophysiological properties of long term cultured human induced neurons

Auteurs: Birtele Marcella; Drouin-Ouellet Janella; Rylander-Ottosson Daniella; Barker Roger; Parmar Malin
Publié dans: ISSCR Conference, Melbourne,, 2018
Éditeur: ISSCR Conference, Melbourne
DOI: 10.5281/zenodo.2538581

Promoting functional maturation of induced human adult neurons.

Auteurs: Marcella Birtele
Publié dans: NECTAR, 2018
Éditeur: NECTAR
DOI: 10.5281/zenodo.2538583

Impact of cell intrinsic properties on transplantation in rodent models of Parkinson's disease

Auteurs: Impact of cell intrinsic properties on transplantation in rodent models of Parkinson's disease Shelby Shrigley
Publié dans: NECTAR, 2019
Éditeur: NECTAR
DOI: 10.5281/zenodo.3463178

Effects of GDF-5-loaded collagen hydrogels after intrastriatal transplantation of ventral mesencephalic cells in a rat model of Parkinson’s disease.

Auteurs: Verónica Alamilla
Publié dans: NECTAR, 2018
Éditeur: NECTAR
DOI: 10.5281/zenodo.2549691

Utility of ventral mesencephalic tissue explants for assessment of neurotrophin-functionalised biomaterial hydrogels in the context of Parkinson’s disease therapeutics

Auteurs: Verónica Alamilla
Publié dans: FENS, 2018
Éditeur: FENS
DOI: 10.5281/zenodo.2549588

Therapeutic Efficacy of Glial Cell Line-Derived Neurotrophic Factor Loaded Collagen Scaffolds in ex vivo organotypic brain slice Parkinson`s Disease Models

Auteurs: Ucar, Buket; Humpel, Christian
Publié dans: Numéro 1, 2019
Éditeur: Life Science Meeting Innsbruck
DOI: 10.5281/zenodo.3631098

Glial cell-derived neurotrophic factor loaded collagen scaffolds provide neuroprotection in ex vivo organotypic brain slice Parkinson's disease models

Auteurs: Ucar, Buket; Humpel, Christian
Publié dans: Numéro 1, 2019
Éditeur: Austrian Neuroscience Association
DOI: 10.5281/zenodo.3631080

Non-peer reviewed articles (6)

Abstract book of the 5th World Parkinson Congress, Kyoto, Japan, June 4–7, 2019

Auteurs: Shelby Shrigley; Fredrik Nilsson; Janelle Drouin-Ouellet; Marcella Birtele; Roger A Barker; Malin Parmar
Publié dans: Journal of Parkinson's Disease, Numéro 9/s1, 2019, Page(s) 1-278, ISSN 1877-7171
Éditeur: IOS Press
DOI: 10.3233/JPD-199900

Glyco25, XXV International Symposium on Glycoconjugates

Auteurs: Ana Lucia Rebelo
Publié dans: Glycoconjugate Journal, Numéro 36/4, 2019, Page(s) 267-397, ISSN 0282-0080
Éditeur: Kluwer Academic Publishers
DOI: 10.1007/s10719-019-09880-4

BNA Festival of Neuroscience 2019

Auteurs: Enrico Bagnoli
Publié dans: Brain and Neuroscience Advances, Numéro 3, 2019, Page(s) 239821281985549, ISSN 2398-2128
Éditeur: BNA
DOI: 10.1177/2398212819855490

GLIA Porto 2019: Abstracts Oral Presentations, Posters, Indexes

Auteurs: Enrico Bagnoli
Publié dans: Glia, Numéro 67/S1, 2019, ISSN 0894-1491
Éditeur: John Wiley & Sons Inc.
DOI: 10.1002/glia.23674

In Vivo Direct Reprogramming of Resident Glial Cells into Interneurons by Intracerebral Injection of Viral Vectors

Auteurs: Maria Pereira, Marcella Birtele, Daniella Rylander Ottosson
Publié dans: Journal of Visualized Experiments, Numéro 148, 2019, ISSN 1940-087X
Éditeur: MYJoVE Corporation
DOI: 10.3791/59465

Leaky Optoelectrical Fiber for Optogenetic Stimulation and Electrochemical Detection of Dopamine Exocytosis from Human Dopaminergic Neurons

Auteurs: Shashank Vasudevan, Janko Kajtez, Ada‐Ioana Bunea, Ana Gonzalez‐Ramos, Tania Ramos‐Moreno, Arto Heiskanen, Merab Kokaia, Niels B. Larsen, Alberto Martínez‐Serrano, Stephan S. Keller, Jenny Emnéus
Publié dans: Advanced Science, Numéro 6/24, 2019, Page(s) 1902011, ISSN 2198-3844
Éditeur: Advanced Science
DOI: 10.1002/advs.201902011