Mediation of stem cell identity and aging by proteostasis

Publikacje

The intrinsic chaperone network of Arabidopsis stem cells confers protection against proteotoxic stress

Autorzy: Ernesto Llamas, Salvador Torres‐Montilla, Hyun Ju Lee, María Victoria Barja, Elena Schlimgen, Nick Dunken, Prerana Wagle, Wolfgang Werr, Alga Zuccaro, Manuel Rodríguez‐Concepción, David Vilchez
Opublikowane w: Aging Cell, Numer 20/8, 2021, ISSN 1474-9718
Wydawca: Blackwell Publishing Inc.
DOI: 10.1111/acel.13446

Systemic regulation of mitochondria by germline proteostasis prevents protein aggregation in the soma of C. elegans

Autorzy: Giuseppe Calculli, Hyun Ju Lee, Koning Shen, Uyen Pham, Marija Herholz, Aleksandra Trifunovic, Andrew Dillin, David Vilchez
Opublikowane w: Science Advances, Numer 7/26, 2021, Strona(/y) eabg3012, ISSN 2375-2548
Wydawca: American Association for the Advancement of Science (AAAS)
DOI: 10.1126/sciadv.abg3012

The ubiquitin-conjugating enzyme UBE2K determines neurogenic potential through histone H3 in human embryonic stem cells

Autorzy: Azra Fatima, Dilber Irmak, Alireza Noormohammadi, Markus M. Rinschen, Aniruddha Das, Orsolya Leidecker, Christina Schindler, Víctor Sánchez-Gaya, Prerana Wagle, Wojciech Pokrzywa, Thorsten Hoppe, Alvaro Rada-Iglesias, David Vilchez
Opublikowane w: Communications Biology, Numer 3/1, 2020, ISSN 2399-3642
Wydawca: Springer Nature
DOI: 10.1038/s42003-020-0984-3

Rewiring of the ubiquitinated proteome determines ageing in C. elegans

Autorzy: Seda Koyuncu, Rute Loureiro, Hyun Ju Lee, Prerana Wagle, Marcus Krueger, David Vilchez
Opublikowane w: Nature, Numer 596/7871, 2021, Strona(/y) 285-290, ISSN 0028-0836
Wydawca: Nature Publishing Group
DOI: 10.1038/s41586-021-03781-z

A post-transcriptional program coordinated by CSDE1 prevents intrinsic neural differentiation of human embryonic stem cells

Autorzy: Hyun Ju Lee, Deniz Bartsch, Cally Xiao, Santiago Guerrero, Gaurav Ahuja, Christina Schindler, James J. Moresco, John R. Yates, Fátima Gebauer, Hisham Bazzi, Christoph Dieterich, Leo Kurian, David Vilchez
Opublikowane w: Nature Communications, Numer 8/1, 2017, ISSN 2041-1723
Wydawca: Nature Publishing Group
DOI: 10.1038/s41467-017-01744-5

Somatic increase of CCT8 mimics proteostasis of human pluripotent stem cells and extends C. elegans lifespan

Autorzy: Alireza Noormohammadi, Amirabbas Khodakarami, Ricardo Gutierrez-Garcia, Hyun Ju Lee, Seda Koyuncu, Tim König, Christina Schindler, Isabel Saez, Azra Fatima, Christoph Dieterich, David Vilchez
Opublikowane w: Nature Communications, Numer 7, 2016, Strona(/y) 13649, ISSN 2041-1723
Wydawca: Nature Publishing Group
DOI: 10.1038/ncomms13649

The ubiquitin ligase UBR5 suppresses proteostasis collapse in pluripotent stem cells from Huntington’s disease patients

Autorzy: Seda Koyuncu, Isabel Saez, Hyun Ju Lee, Ricardo Gutierrez-Garcia, Wojciech Pokrzywa, Azra Fatima, Thorsten Hoppe, David Vilchez
Opublikowane w: Nature Communications, Numer 9/1, 2018, ISSN 2041-1723
Wydawca: Nature Publishing Group
DOI: 10.1038/s41467-018-05320-3

Insights into the ubiquitin-proteasome system of human embryonic stem cells

Autorzy: Isabel Saez, Seda Koyuncu, Ricardo Gutierrez-Garcia, Christoph Dieterich, David Vilchez
Opublikowane w: Scientific Reports, Numer 8/1, 2018, ISSN 2045-2322
Wydawca: Nature Publishing Group
DOI: 10.1038/s41598-018-22384-9

Prostaglandin signals from adult germline stem cells delay somatic ageing of Caenorhabditis elegans

Autorzy: Hyun Ju Lee, Alireza Noormohammadi, Seda Koyuncu, Giuseppe Calculli, Milos S. Simic, Marija Herholz, Aleksandra Trifunovic, David Vilchez
Opublikowane w: Nature Metabolism, Numer 1/8, 2019, Strona(/y) 790-810, ISSN 2522-5812
Wydawca: Springer Nature
DOI: 10.1038/s42255-019-0097-9

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