Nanobody-targeted photodynamic therapy to kill cancer

Project Information

KILLCANCER

Grant agreement ID: 677582

DOI 10.3030/677582

Project closed

EC signature date 27 April 2016

Start date 1 July 2016

End date 31 December 2021

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost € 1 500 000,00

EU contribution € 1 500 000,00

Coordinated by

UNIVERSITEIT UTRECHT
Netherlands

Publications

Peer reviewed articles (12)

Dual Targeting of Endothelial and Cancer Cells Potentiates In Vitro Nanobody-Targeted Photodynamic Therapy

Author(s): Vida Mashayekhi, Katerina T. Xenaki, Paul M.P. van Bergen en Henegouwen, Sabrina Oliveira
Published in: Cancers, Issue 12/10, 2020, Page(s) 2732, ISSN 2072-6694
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/cancers12102732

Nanobody-targeted photodynamic therapy for the treatment of feline oral carcinoma: a step towards translation to the veterinary clinic

Author(s): Irati Beltrán Hernández, Guillaume C.M. Grinwis, Alessia Di Maggio, Paul M.P. van Bergen en Henegouwen, Wim E. Hennink, Erik Teske, Jan W. Hesselink, Sebastiaan A. van Nimwegen, Jan A. Mol and Sabrina Oliveira
Published in: Nanophotonics, 2021, ISSN 2192-8614
Publisher: De Gruyter
DOI: 10.1515/nanoph-2021-0195

Oncologic Photodynamic Therapy: Basic Principles, Current Clinical Status and Future Directions

Author(s): Demian van Straten, Vida Mashayekhi, Henriette de Bruijn, Sabrina Oliveira, Dominic Robinson
Published in: Cancers, Issue 9/12, 2017, Page(s) 19, ISSN 2072-6694
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/cancers9020019

Nanobody-Targeted Photodynamic Therapy Selectively Kills Viral GPCR-Expressing Glioblastoma Cells

Author(s): Timo W. M. De Groof, Vida Mashayekhi, Tian Shu Fan, Nick D. Bergkamp, Javier Sastre Toraño, Jeffrey R. van Senten, Raimond Heukers, Martine J. Smit, Sabrina Oliveira
Published in: Molecular Pharmaceutics, Issue 16/7, 2019, Page(s) 3145-3156, ISSN 1543-8384
Publisher: American Chemical Society
DOI: 10.1021/acs.molpharmaceut.9b00360

VHH-Photosensitizer Conjugates for Targeted Photodynamic Therapy of Met-Overexpressing Tumor Cells

Author(s): Raimond Heukers, Vida Mashayekhi, Mercedes Ramirez-Escudero, Hans de Haard, Theo Verrips, Paul. van Bergen en Henegouwen, Sabrina Oliveira
Published in: Antibodies, Issue 8/2, 2019, Page(s) 26, ISSN 2073-4468
Publisher: MDPI
DOI: 10.3390/antib8020026

Patient-Derived Head and Neck Cancer Organoids Recapitulate EGFR Expression Levels of Respective Tissues and Are Responsive to EGFR-Targeted Photodynamic Therapy

Author(s): Else Driehuis, Sacha Spelier, Irati Beltrán Hernández, Remco de Bree, Stefan M. Willems, Hans Clevers, Sabrina Oliveira
Published in: Journal of Clinical Medicine, Issue 8/11, 2019, Page(s) 1880, ISSN 2077-0383
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/jcm8111880

Preclinical and Clinical Evidence of Immune Responses Triggered in Oncologic Photodynamic Therapy: Clinical Recommendations

Author(s): Beltrán Hernández, Yu, Ossendorp, Korbelik, Oliveira
Published in: Journal of Clinical Medicine, Issue 9/2, 2020, Page(s) 333, ISSN 2077-0383
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/jcm9020333

Nanobody-targeted photodynamic therapy induces significant tumor regression of trastuzumab-resistant HER2-positive breast cancer, after a single treatment session

Author(s): Marion M. Deken, Marta M. Kijanka, Irati Beltrán Hernández, Maxime D. Slooter, Henriette S. de Bruijn, Paul J. van Diest, Paul M.P. van Bergen en Henegouwen, Clemens W.G.M. Lowik, Dominic J. Robinson, Alexander L. Vahrmeijer, Sabrina Oliveira
Published in: Journal of Controlled Release, Issue 323, 2020, Page(s) 269-281, ISSN 0168-3659
Publisher: Elsevier BV
DOI: 10.1016/j.jconrel.2020.04.030

Acute cellular and vascular responses to photodynamic therapy using EGFR-targeted nanobody-photosensitizer conjugates studied with intravital optical imaging and magnetic resonance imaging

Author(s): Henriette S. de Bruijn, Vida Mashayekhi, Tom J.L. Schreurs, Pieter B.A.A. van Driel, Gustav J. Strijkers, Paul J. van Diest, Clemens W.G.M. Lowik, Ann L.B. Seynhaeve, Timo L.M. ten Hagen, Jeanine J. Prompers, Paul M.P. van Bergen en Henegouwen, Dominic J. Robinson, Sabrina Oliveira
Published in: Theranostics, Issue 10/5, 2020, Page(s) 2436-2452, ISSN 1838-7640
Publisher: Ivyspring International Publisher
DOI: 10.7150/thno.37949

The Potential of Nanobody-Targeted Photodynamic Therapy to Trigger Immune Responses

Author(s): Irati Beltrán Hernández, Mathieu L. Angelier, Tommaso Del Buono D’Ondes, Alessia Di Maggio, Yingxin Yu, Sabrina Oliveira
Published in: Cancers, Issue 12/4, 2020, Page(s) 978, ISSN 2072-6694
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/cancers12040978

Vascular targeted photodynamic therapy: A review of the efforts towards molecular targeting of tumor vasculature

Author(s): Vida Mashayekhi, Charlotte Op 't Hoog, Sabrina Oliveira
Published in: Journal of Porphyrins and Phthalocyanines, Issue 23/11n12, 2019, Page(s) 1229-1240, ISSN 1088-4246
Publisher: Society of Porphyrins and Phthalocyanines
DOI: 10.1142/s1088424619300180

Molecular targets for anticancer therapies in companion animals and humans: what can we learn from each other?

Author(s): Irati Beltrán Hernández, Jannes Z. Kromhout, Erik Teske, Wim E. Hennink, Sebastiaan A. van Nimwegen, Sabrina Oliveira
Published in: Theranostics, 2021, ISSN 1838-7640
Publisher: Ivyspring International Publisher
DOI: 10.7150/thno.55760