Matrix during cancer progression

Project Information

MATRICAN

Grant agreement ID: 682881

DOI 10.3030/682881

Project closed

EC signature date 8 August 2016

Start date 1 September 2016

End date 31 August 2021

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost € 1 997 500,00

EU contribution € 1 997 500,00

Coordinated by

KOBENHAVNS UNIVERSITET
Denmark

Publications

Peer reviewed articles (7)

Deciphering the temporal heterogeneity of cancer-associated fibroblast subpopulations in breast cancer

Author(s): Freja Albjerg Venning, Kamilla Westarp Zornhagen, Lena Wullkopf, Jonas Sjölund, Carmen Rodriguez-Cupello, Pontus Kjellman, Mikkel Morsing, Morteza Chalabi Hajkarim, Kyoung Jae Won, Janine Terra Erler, Chris Denis Madsen
Published in: Journal of Experimental & Clinical Cancer Research, Issue 40/1, 2021, ISSN 1756-9966
Publisher: Springer Nature
DOI: 10.1186/s13046-021-01944-4

Organ-Specific, Fibroblast-Derived Matrix as a Tool for Studying Breast Cancer Metastasis

Author(s): Adina R. D. Jensen, Edward R. Horton, Lene H. Blicher, Elin J. Pietras, Cornelia Steinhauer, Raphael Reuten, Erwin M. Schoof, Janine T. Erler
Published in: Cancers, Issue 13/13, 2021, Page(s) 3331, ISSN 2072-6694
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/cancers13133331

Basement membrane stiffness determines metastases formation

Author(s): Raphael Reuten, Sina Zendehroud, Monica Nicolau, Lutz Fleischhauer, Anu Laitala, Stefanie Kiderlen, Denise Nikodemus, Lena Wullkopf, Sebastian Rune Nielsen, Sarah McNeilly, Carina Prein, Maria Rafaeva, Erwin M. Schoof, Benjamin Furtwängler, Bo T. Porse, Hyobin Kim, Kyoung Jae Won, Stefanie Sudhop, Kamilla Westarp Zornhagen, Frank Suhr, Eleni Maniati, Oliver M. T. Pearce, Manuel Koch, Lene Broeng
Published in: Nature Materials, 2021, ISSN 1476-1122
Publisher: Nature Publishing Group
DOI: 10.1038/s41563-020-00894-0

Suppression of tumor-associated neutrophils by lorlatinib attenuates pancreatic cancer growth and improves treatment with immune checkpoint blockade

Author(s): Sebastian R. Nielsen, Jan E. Strøbech, Edward R. Horton, Rene Jackstadt, Anu Laitala, Marina C. Bravo, Giorgia Maltese, Adina R. D. Jensen, Raphael Reuten, Maria Rafaeva, Saadia A. Karim, Chang-Il Hwang, Luis Arnes, David A. Tuveson, Owen J. Sansom, Jennifer P. Morton, Janine T. Erler
Published in: Nature Communications, Issue 12/1, 2021, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-021-23731-7

ISDoT: in situ decellularization of tissues for high-resolution imaging and proteomic analysis of native extracellular matrix

Author(s): Alejandro E Mayorca-Guiliani, Chris D Madsen, Thomas R Cox, Edward R Horton, Freja A Venning, Janine T Erler
Published in: Nature Medicine, Issue 23/7, 2017, Page(s) 890-898, ISSN 1078-8956
Publisher: Nature Publishing Group
DOI: 10.1038/nm.4352

Mesenchymal stromal cell activation by breast cancer secretomes in bioengineered 3D microenvironments

Author(s): Ulrich Blache, Edward R Horton, Tian Xia, Erwin M Schoof, Lene H Blicher, Angelina Schönenberger, Jess G Snedeker, Ivan Martin, Janine T Erler, Martin Ehrbar
Published in: Life Science Alliance, Issue 2/3, 2019, Page(s) e201900304, ISSN 2575-1077
Publisher: Life Science Alliance
DOI: 10.26508/lsa.201900304

Decellularization and antibody staining of mouse tissues to map native extracellular matrix structures in 3D

Author(s): Alejandro E Mayorca-Guiliani, Oliver Willacy, Chris D. Madsen, Maria Rafaeva, Stefanie Elisabeth Heumüller, Felix Bock, Gerhard Sengle, Manuel Koch, Thomas Imhof, Frank Zaucke, Raimund Wagener, Takako Sasaki, Janine T. Erler, Raphael Reuten
Published in: Nature Protocols, 2019, ISSN 1754-2189
Publisher: Nature Publishing Group
DOI: 10.1038/s41596-019-0225-8