CDK6 in transcription - turning a foe in a friend

Project Information

CDK6-DrugOpp

Grant agreement ID: 694354

DOI 10.3030/694354

Project closed

EC signature date 1 August 2016

Start date 1 September 2016

End date 31 August 2022

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost € 2 497 520,00

EU contribution € 2 497 520,00

Coordinated by

VETERINAERMEDIZINISCHE UNIVERSITAET WIEN
Austria

Publications

Peer reviewed articles (15)

The role of CDK6 in cancer

Author(s): Sofie Nebenfuehr, Karoline Kollmann, Veronika Sexl
Published in: International Journal of Cancer, Issue 147/11, 2020, Page(s) 2988-2995, ISSN 0020-7136
Publisher: John Wiley & Sons Inc.
DOI: 10.1002/ijc.33054

CDK6 Degradation Is Counteracted by p16INK4A and p18INK4C in AML

Author(s): Belinda S. Schmalzbauer; Teresemary Thondanpallil; Gerwin Heller; Alessia Schirripa; Clio-Melina Sperl; Isabella M. Mayer; Vanessa M. Knab; Sofie Nebenfuehr; Markus Zojer; André C. Mueller; Frédéric Fontaine; Thorsten Klampfl; Veronika Sexl; Karoline Kollmann
Published in: Cancers (Basel), Issue 20726694, 2022, ISSN 2072-6694
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/cancers14061554

Isolation, Maintenance and Expansion of Adult Hematopoietic Stem/Progenitor Cells and Leukemic Stem Cells

Author(s): Isabella Maria Mayer; Andrea Hoelbl-Kovacic; Veronika Sexl; Eszter Doma
Published in: Cancers (Basel), Issue 20726694, 2022, ISSN 2072-6694
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/cancers14071723

A robust approach for the generation of functional hematopoietic progenitor cell lines to model leukemic transformation

Author(s): Eszter Doma, Isabella Maria Mayer, Tania Brandstoetter, Barbara Maurer, Reinhard Grausenburger, Ingeborg Menzl, Markus Zojer, Andrea Hoelbl-Kovacic, Leif Carlsson, Gerwin Heller, Karoline Kollmann, Veronika Sexl
Published in: Blood Advances, Issue 5/1, 2021, Page(s) 39-53, ISSN 2473-9529
Publisher: American Society of Hematology
DOI: 10.1182/bloodadvances.2020003022

The interplay of CDK4 and CDK6 in melanoma

Author(s): Karoline Kollmann, Coralie Briand, Florian Bellutti, Nikolaus Schicher, Stefan Blunder, Markus Zojer, Christoph Hoeller
Published in: Oncotarget, Issue 10/14, 2019, Page(s) 1346-1359, ISSN 1949-2553
Publisher: Impact Journals
DOI: 10.18632/oncotarget.26515

Inducible deletion of CDK4 and CDK6 - deciphering CDK4/6 inhibitor effects in the hematopoietic system

Author(s): Barbara Maurer, Tania Brandstoetter, Sebastian Kollmann, Veronika Sexl, Michaela Prchal-Murphy
Published in: Haematologica, 2020, Page(s) haematol.2020.256313, ISSN 0390-6078
Publisher: Ferrata Storti Foundation
DOI: 10.3324/haematol.2020.256313

CDK4/6 and MAPK—Crosstalk as Opportunity for Cancer Treatment

Author(s): Lisa Scheiblecker, Karoline Kollmann, Veronika Sexl
Published in: Pharmaceuticals, Issue 13/12, 2020, Page(s) 418, ISSN 1424-8247
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ph13120418

CDK6 Inhibition: A Novel Approach in AML Management

Author(s): Iris Z. Uras, Veronika Sexl, Karoline Kollmann
Published in: International Journal of Molecular Sciences, Issue 21/7, 2020, Page(s) 2528, ISSN 1422-0067
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms21072528

Cdk6 contributes to cytoskeletal stability in erythroid cells

Author(s): Iris Z. Uras, Ruth M. Scheicher, Karoline Kollmann, Martin Glösmann, Michaela Prchal-Murphy, Anca S. Tigan, Daniela A. Fux, Sandro Altamura, Joana Neves, Martina U. Muckenthaler, Keiryn L. Bennett, Stefan Kubicek, Philip W. Hinds, Marieke von Lindern, Veronika Sexl
Published in: Haematologica, Issue 102/6, 2017, Page(s) 995-1005, ISSN 0390-6078
Publisher: Ferrata Storti Foundation
DOI: 10.3324/haematol.2016.159947

p27 in FLT3-driven acute myeloid leukemia: many roads lead to ruin

Author(s): Iris Z Uras, Florian Bellutti, Veronika Sexl
Published in: Haematologica, Issue 102/8, 2017, Page(s) 1299-1301, ISSN 0390-6078
Publisher: Ferrata Storti Foundation
DOI: 10.3324/haematol.2017.171819

Cdk6: At the interface of Rb and p53

Author(s): Sofie Nebenfuehr, Florian Bellutti, Veronika Sexl
Published in: Molecular & Cellular Oncology, Issue 5/5, 2018, Page(s) e1511206, ISSN 2372-3556
Publisher: Taylor & Francis
DOI: 10.1080/23723556.2018.1511206

CDK6 Antagonizes p53-Induced Responses during Tumorigenesis

Author(s): Florian Bellutti, Anca-Sarmiza Tigan, Sofie Nebenfuehr, Marlies Dolezal, Markus Zojer, Reinhard Grausenburger, Svenja Hartenberger, Sebastian Kollmann, Eszter Doma, Michaela Prchal-Murphy, Iris Z. Uras, Alexander Höllein, Donna S. Neuberg, Benjamin L. Ebert, Anna Ringler, Andre C. Mueller, Joanna I. Loizou, Philip W. Hinds, Claus Vogl, Gerwin Heller, Stefan Kubicek, Johannes Zuber, Marcos Malumbr
Published in: Cancer Discovery, Issue 8/7, 2018, Page(s) 884-897, ISSN 2159-8274
Publisher: American Association for Cancer Research Inc.
DOI: 10.1158/2159-8290.CD-17-0912

CDK6 coordinates JAK2 V617F mutant MPN via NF-κB and apoptotic networks

Author(s): Iris Z. Uras, Barbara Maurer, Harini Nivarthi, Philipp Jodl, Karoline Kollmann, Michaela Prchal-Murphy, Jelena D. Milosevic Feenstra, Markus Zojer, Sabine Lagger, Reinhard Grausenburger, Beatrice Grabner, Raimund Holly, Anoop Kavirayani, Christoph Bock, Heinz Gisslinger, Peter Valent, Robert Kralovics, Veronika Sexl
Published in: Blood, Issue 133/15, 2019, Page(s) 1677-1690, ISSN 0006-4971
Publisher: American Society of Hematology
DOI: 10.1182/blood-2018-08-872648

Therapeutic Vulnerabilities in FLT3-Mutant AML Unmasked by Palbociclib

Author(s): Iris Uras, Barbara Maurer, Sofie Nebenfuehr, Markus Zojer, Peter Valent, Veronika Sexl
Published in: International Journal of Molecular Sciences, Issue 19/12, 2018, Page(s) 3987, ISSN 1422-0067
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms19123987

The Effect of CDK6 Expression on DNA Methylation and DNMT3B Regulation

Author(s): Gerwin Heller, Sofie Nebenfuehr, Florian Bellutti, Huriye Ünal, Markus Zojer, Lisa Scheiblecker, Veronika Sexl, Karoline Kollmann
Published in: iScience, Issue 23/10, 2020, Page(s) 101602, ISSN 2589-0042
Publisher: Cell Press
DOI: 10.1016/j.isci.2020.101602