Optimal Decision Making under Uncertainty in Biomanufacturing Operations

Informazioni relative al progetto

OPTBIOMAN

ID dell’accordo di sovvenzione: 709073

DOI 10.3030/709073

Progetto chiuso

Data della firma CE 25 Febbraio 2016

Data di avvio 1 Marzo 2016

Data di completamento 28 Febbraio 2018

Finanziato da

• EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions

Costo totale € 177 598,80

Contributo UE € 177 598,80

Coordinato da

TECHNISCHE UNIVERSITEIT EINDHOVEN
Netherlands

Obiettivo

An inter-disciplinary modelling and optimization framework will be developed to economically optimize biomanufacturing decision under high process variability, failure risks, and expensive operating costs. New stochastic models will be developed to link the underlying biological and chemical dynamics of the biomanufacturing processes (cell-level dynamics) with the financial trade-offs in terms of yield, quality, operating costs, and failure risks (manufacturing system-level dynamics). In particular, the research project will model and analyze the economics of the upstream fermentation and downstream purification operations. Novel approximations and heuristics will be developed based on the unique features of the problem setting in order to solve large size problems encountered in industry practices. Optimal (near-optimal) operating policies will be theoretically and numerically analyzed for both upstream fermentation and downstream chromatography operating decisions. The framework will provide timely and effective tools and models to economically optimize biomanufacturing decisions. A solid inter-disciplinary research foundation will be built combining the knowledge from the biological and chemical engineering, stochastic control, reliability theory, and manufacturing systems engineering. This research project will expand and strengthen the industry network of the OPAC group at Eindhoven University of Technology towards the emerging biomanufacturing industry in the Europe. The tools and models developed in this project will be relevant to the European industry practices, and will benefit the European society by making these therapeutic drugs more accessible in the future.

Campo scientifico

• engineering and technology › environmental biotechnology › bioremediation › bioreactors
• engineering and technology › chemical engineering
• natural sciences › computer and information sciences › artificial intelligence › heuristic programming
• engineering and technology › industrial biotechnology › bioprocessing technologies › fermentation
• natural sciences › mathematics › applied mathematics › mathematical model

Programma(i)

• H2020-EU.1.3. - EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions Main Programme
• H2020-EU.1.3.2. - Nurturing excellence by means of cross-border and cross-sector mobility

Argomento(i)

• MSCA-IF-2015-EF - Marie Skłodowska-Curie Individual Fellowships (IF-EF)

Invito a presentare proposte

H2020-MSCA-IF-2015

Meccanismo di finanziamento

MSCA-IF-EF-RI - RI – Reintegration panel

Coordinatore

TECHNISCHE UNIVERSITEIT EINDHOVEN

• Contribution nette de l'UE: € 177 598,80
• Indirizzo: GROENE LOPER 3 ; 5612 AE Eindhoven ; Paesi Bassi
• Regione: Zuid-Nederland › Noord-Brabant › Zuidoost-Noord-Brabant
• Tipo di attività: Higher or Secondary Education Establishments
• Costo totale: € 177 598,80