Obiettivo Magnetic resonance imaging (MRI) and nuclear magnetic resonance (NMR) and are two well-established powerful and versatile tools that are extensively used in many fields of research, in clinics and in industry.Despite considerable efforts involving highly sophisticated instrumentation, these techniques suffer from low sensitivity, which keeps many of today’s most interesting problems in modern analytical sciences below the limits of MR detection. Hyperpolarization (HP) in principle provides a solution to this limitation. We have recently pioneered breakthrough approaches using dissolution dynamic nuclear polarization (d-DNP) for preparing nuclear spins in highly aligned states, and therefore boosting sensitivity in several proof-of-concept reports on model systems. The proposed project aims to leverage these new advances through a series of new concepts i) to generate the highest possible hyperpolarization that can be transported in a persistent state, and ii) to demonstrate their use in magnetic resonance experiments with > 10’000 fold sensitivity enhancements, with the potential of revolutionizing the fields of MRI and NMR.By physically separating the source of polarization from the substrate at a microscopic level, we will achieve polarized samples with lifetimes of days that can be stored and transported over long distances to MRI centers, hospitals and NMR laboratories. Notable applications in the fields of drug discovery, metabolomics and real-time metabolic imaging in living animals will be demonstrated.These goals require a leap forward with respect to today’s protocols, and we propose to achieve this through a combination of innovative sample formulations, new NMR methodology and advanced instrumentation.This project will yield to a broadly applicable method revolutionizing analytical chemistry, drug discovery and medical diagnostics, and thereby will provide a powerful tool to solve challenges at the forefront of molecular and chemical sciences today. Campo scientifico natural scienceschemical sciencesanalytical chemistrymedical and health sciencesclinical medicineradiologynuclear medicineengineering and technologymedical engineeringdiagnostic imagingmagnetic resonance imaging Parole chiave Nuclear magnetic resonance (NMR) magnetic resonance imaging (MRI) hyperpolarization dissolution dynamic nuclear polarization Programma(i) H2020-EU.1.1. - EXCELLENT SCIENCE - European Research Council (ERC) Main Programme Argomento(i) ERC-2016-STG - ERC Starting Grant Invito a presentare proposte ERC-2016-STG Vedi altri progetti per questo bando Meccanismo di finanziamento ERC-STG - Starting Grant Istituzione ospitante UNIVERSITE LYON 1 CLAUDE BERNARD Contribution nette de l'UE € 1 816 250,00 Indirizzo BOULEVARD DU 11 NOVEMBRE 1918 NUM43 69622 Villeurbanne Cedex Francia Mostra sulla mappa Regione Auvergne-Rhône-Alpes Rhône-Alpes Rhône Tipo di attività Higher or Secondary Education Establishments Collegamenti Contatta l’organizzazione Opens in new window Sito web Opens in new window Partecipazione a programmi di R&I dell'UE Opens in new window Rete di collaborazione HORIZON Opens in new window Costo totale € 1 995 000,00 Beneficiari (2) Classifica in ordine alfabetico Classifica per Contributo netto dell'UE Espandi tutto Riduci tutto UNIVERSITE LYON 1 CLAUDE BERNARD Francia Contribution nette de l'UE € 1 816 250,00 Indirizzo BOULEVARD DU 11 NOVEMBRE 1918 NUM43 69622 Villeurbanne Cedex Mostra sulla mappa Regione Auvergne-Rhône-Alpes Rhône-Alpes Rhône Tipo di attività Higher or Secondary Education Establishments Collegamenti Contatta l’organizzazione Opens in new window Sito web Opens in new window Partecipazione a programmi di R&I dell'UE Opens in new window Rete di collaborazione HORIZON Opens in new window Costo totale € 1 995 000,00 Terza parte Soggetto giuridico diverso da un subappaltatore che è affiliato o legalmente collegato a un partecipante. Il soggetto svolge le attività secondo le condizioni stabilite nell’accordo di sovvenzione, fornisce beni o servizi per l’azione, ma non ha sottoscritto l’accordo di sovvenzione. Una terza parte rispetta le regole applicabili al suo partecipante correlato ai sensi dell’accordo di sovvenzione per quanto riguarda l’ammissibilità dei costi e il controllo delle spese. CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS Francia Contribution nette de l'UE € 178 750,00 Indirizzo RUE MICHEL ANGE 3 75794 Paris Mostra sulla mappa Regione Ile-de-France Ile-de-France Paris Tipo di attività Research Organisations Collegamenti Contatta l’organizzazione Opens in new window Sito web Opens in new window Partecipazione a programmi di R&I dell'UE Opens in new window Rete di collaborazione HORIZON Opens in new window Costo totale € 178 750,00