Understanding the mechanisms of human acute myeloid leukaemia (AML) evolution

Project Information

MAMLE

Grant agreement ID: 714731

DOI 10.3030/714731

Project closed

EC signature date 31 January 2017

Start date 1 February 2017

End date 31 January 2022

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost € 1 750 000,00

EU contribution € 1 750 000,00

Coordinated by

WEIZMANN INSTITUTE OF SCIENCE
Israel

Publications

Peer reviewed articles (5)

Pseudo-mutant P53 is a unique phenotype ofDNMT3A-mutated pre-leukemia

Author(s): Amos Tuval, Yardena Brilon, Hadas Azogy, Yoni Moskovitz, Dena Leshkowitz, Tomer M. Salame, Mark D. Minden, Perry Tal, Varda Rotter, Moshe Oren, Nathali Kaushansky, and Liran I. Shlush
Published in: Haematologica, 2022, ISSN 0390-6078
Publisher: Ferrata Storti Foundation
DOI: 10.3324/haematol.2021.280329.

Male predominance in AML is associated with specific preleukemic mutations

Author(s): Aviv De-Morgan, Manja Meggendorfer, Claudia Haferlach & Liran Shlush
Published in: Leukemia, Issue 08876924, 2021, ISSN 0887-6924
Publisher: Nature Publishing Group
DOI: 10.1038/s41375-020-0935-5

Prediction of acute myeloid leukaemia risk in healthy individuals

Author(s): Sagi Abelson, Grace Collord, Stanley W. K. Ng, Omer Weissbrod, Netta Mendelson Cohen, Elisabeth Niemeyer, Noam Barda, Philip C. Zuzarte, Lawrence Heisler, Yogi Sundaravadanam, Robert Luben, Shabina Hayat, Ting Ting Wang, Zhen Zhao, Iulia Cirlan, Trevor J. Pugh, David Soave, Karen Ng, Calli Latimer, Claire Hardy, Keiran Raine, David Jones, Diana Hoult, Abigail Britten, John D. McPherson, Mattias Jo
Published in: Nature, Issue 559/7714, 2018, Page(s) 400-404, ISSN 0028-0836
Publisher: Nature Publishing Group
DOI: 10.1038/s41586-018-0317-6

Recurrent deletions in clonal hematopoiesis are driven by microhomology-mediated end joining

Author(s): Tzah Feldman, Akhiad Bercovich, Yoni Moskovitz, Noa Chapal-Ilani, Amanda Mitchell, Jessie J. F. Medeiros, Tamir Biezuner, Nathali Kaushansky, Mark D. Minden, Vikas Gupta, Michael Milyavsky, Zvi Livneh, Amos Tanay & Liran I. Shlush
Published in: Nature Communications, 2021, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-021-22803-y

Dasatinib response in acute myeloid leukemia is correlated with FLT3/ITD, PTPN11 mutations and a unique gene expression signature

Author(s): Sigal Tavor, Tali Shalit,Noa Chapal Ilani, Yoni Moskovitz, Nir Livnat, Yoram Groner, Haim Barr Mark D. Minden, Alexander Plotnikov, Michael W. Deininger, Nathali Kaushansky Liran I. Shlush
Published in: Haematologica, 2020, ISSN 0390-6078
Publisher: Ferrata Storti Foundation
DOI: 10.3324/haematol.2019.240705