Understanding the mechanisms of human acute myeloid leukaemia (AML) evolution

Informazioni relative al progetto

MAMLE

ID dell’accordo di sovvenzione: 714731

DOI 10.3030/714731

Progetto chiuso

Data della firma CE 31 Gennaio 2017

Data di avvio 1 Febbraio 2017

Data di completamento 31 Gennaio 2022

Finanziato da

• EXCELLENT SCIENCE - European Research Council (ERC)

Costo totale € 1 750 000,00

Contributo UE € 1 750 000,00

Coordinato da

WEIZMANN INSTITUTE OF SCIENCE
Israel

Pubblicazioni

Peer reviewed articles (5)

Pseudo-mutant P53 is a unique phenotype ofDNMT3A-mutated pre-leukemia

Autori: Amos Tuval, Yardena Brilon, Hadas Azogy, Yoni Moskovitz, Dena Leshkowitz, Tomer M. Salame, Mark D. Minden, Perry Tal, Varda Rotter, Moshe Oren, Nathali Kaushansky, and Liran I. Shlush
Pubblicato in: Haematologica, 2022, ISSN 0390-6078
Editore: Ferrata Storti Foundation
DOI: 10.3324/haematol.2021.280329.

Male predominance in AML is associated with specific preleukemic mutations

Autori: Aviv De-Morgan, Manja Meggendorfer, Claudia Haferlach & Liran Shlush
Pubblicato in: Leukemia, Numero 08876924, 2021, ISSN 0887-6924
Editore: Nature Publishing Group
DOI: 10.1038/s41375-020-0935-5

Prediction of acute myeloid leukaemia risk in healthy individuals

Autori: Sagi Abelson, Grace Collord, Stanley W. K. Ng, Omer Weissbrod, Netta Mendelson Cohen, Elisabeth Niemeyer, Noam Barda, Philip C. Zuzarte, Lawrence Heisler, Yogi Sundaravadanam, Robert Luben, Shabina Hayat, Ting Ting Wang, Zhen Zhao, Iulia Cirlan, Trevor J. Pugh, David Soave, Karen Ng, Calli Latimer, Claire Hardy, Keiran Raine, David Jones, Diana Hoult, Abigail Britten, John D. McPherson, Mattias Jo
Pubblicato in: Nature, Numero 559/7714, 2018, Pagina/e 400-404, ISSN 0028-0836
Editore: Nature Publishing Group
DOI: 10.1038/s41586-018-0317-6

Recurrent deletions in clonal hematopoiesis are driven by microhomology-mediated end joining

Autori: Tzah Feldman, Akhiad Bercovich, Yoni Moskovitz, Noa Chapal-Ilani, Amanda Mitchell, Jessie J. F. Medeiros, Tamir Biezuner, Nathali Kaushansky, Mark D. Minden, Vikas Gupta, Michael Milyavsky, Zvi Livneh, Amos Tanay & Liran I. Shlush
Pubblicato in: Nature Communications, 2021, ISSN 2041-1723
Editore: Nature Publishing Group
DOI: 10.1038/s41467-021-22803-y

Dasatinib response in acute myeloid leukemia is correlated with FLT3/ITD, PTPN11 mutations and a unique gene expression signature

Autori: Sigal Tavor, Tali Shalit,Noa Chapal Ilani, Yoni Moskovitz, Nir Livnat, Yoram Groner, Haim Barr Mark D. Minden, Alexander Plotnikov, Michael W. Deininger, Nathali Kaushansky Liran I. Shlush
Pubblicato in: Haematologica, 2020, ISSN 0390-6078
Editore: Ferrata Storti Foundation
DOI: 10.3324/haematol.2019.240705