Memory Engram Maintenance and Expression

Project Information

MEME

Grant agreement ID: 715968

DOI 10.3030/715968

Project closed

EC signature date 31 January 2017

Start date 1 February 2017

End date 31 January 2023

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost € 1 500 000,00

EU contribution € 1 500 000,00

Coordinated by

THE PROVOST, FELLOWS, FOUNDATION SCHOLARS & THE OTHER MEMBERS OF BOARD, OF THE COLLEGE OF THE HOLY & UNDIVIDED TRINITY OF QUEEN ELIZABETH NEAR DUBLIN
Ireland

Publications

Peer reviewed articles (11)

Engram cell connectivity: an evolving substrate for information storage

Author(s): Tomás J Ryan, Clara Ortega-de San Luis, Maurizio Pezzoli, Siddhartha Sen
Published in: Current Opinion in Neurobiology, Issue Volume 67, April 2021, 2021, Page(s) Pages 215-225, ISSN 0959-4388
Publisher: Elsevier BV
DOI: 10.1016/j.conb.2021.01.006

Understanding the physical basis of memory: Molecular mechanisms of the engram

Author(s): Clara Ortega-de San Luis, Tomás J. Ryan
Published in: Journal of Biological Chemistry, Issue Volume 298, ISSUE 5, 2022, Page(s) 101866, May 2022, ISSN 0021-9258
Publisher: American Society for Biochemistry and Molecular Biology Inc.
DOI: 10.1016/j.jbc.2022.101866

Immune activation state modulates infant engram expression across development

Author(s): Sarah D. Power, Erika Stewart, Louisa G. Zielke, Eric Patrick Byrne, Clara Ortega-de San Luis, Lydia Lynch, Tomás J. Ryan
Published in: Science Advances, Issue In press, 2023, Page(s) In press, ISSN 2375-2548
Publisher: AAAS
DOI: 10.1101/2022.04.24.488172

Forgetting as a form of adaptive engram cell plasticity

Author(s): Tomás J. Ryan, Paul W. Frankland
Published in: Nature Reviews Neuroscience, Issue Volume 23 (2022), 2022, Page(s) pages 173–186 (2022), ISSN 1471-003X
Publisher: Nature Publishing Group
DOI: 10.1038/s41583-021-00548-3

The role of higher-order thalamus during learning and correct performance in goal-directed behavior

Author(s): Danilo La Terra, Ann-Sofie Bjerre, Marius Rosier, Rei Masuda, Tomás J Ryan, Lucy M Palmer
Published in: eLife, 2022, ISSN 2050-084X
Publisher: eLife Sciences Publications
DOI: 10.7554/elife.77177

Natural forgetting reversibly modulates engram expression

Author(s): James D. O’Leary, Rasmus Bruckner, Livia Autore, Tomás J. Ryan
Published in: eLife, Issue In press, 2023, Page(s) In press, ISSN 2050-084X
Publisher: eLife Sciences Publications
DOI: 10.1101/2023.04.15.537013

United states of amnesia: rescuing memory loss from diverse conditions

Author(s): Clara Ortega-de San Luis, Tomás J. Ryan
Published in: Disease Models & Mechanisms, Issue 11/5, 2018, Page(s) dmm035055, ISSN 1754-8403
Publisher: The Company of Biologists Ltd.
DOI: 10.1242/dmm.035055

Engram Cell Excitability State Determines the Efficacy of Memory Retrieval

Author(s): Michele Pignatelli, Tomás J. Ryan, Dheeraj S. Roy, Chanel Lovett, Lillian M. Smith, Shruti Muralidhar, Susumu Tonegawa
Published in: Neuron, Issue 101/2, 2019, Page(s) 274-284.e5, ISSN 0896-6273
Publisher: Cell Press
DOI: 10.1016/j.neuron.2018.11.029

Adaptive Expression of Engrams by Retroactive Interference

Author(s): Livia Autore, James D. O’Leary, Clara Ortega-de San Luis, Tomás J. Ryan
Published in: Cell Reports, Issue Volume 42, ISSUE 8, 2023, Page(s) 112999, August 29, 2023, ISSN 2211-1247
Publisher: Cell Press
DOI: 10.1016/j.celrep.2023.112999

The memory toolbox: how genetic manipulations and cellular imaging are transforming our understanding of learned information

Author(s): Antoine Harel, Tomás J. Ryan
Published in: Current Opinion in Behavioral Sciences, Issue Volume 32, April 2020, 2020, Page(s) Pages 136-147, ISSN 2352-1546
Publisher: Elsevier Limited
DOI: 10.1016/j.cobeha.2020.02.016

On the research of time past: the hunt for the substrate of memory

Author(s): Bridget N. Queenan, Tomás J. Ryan, Michael S. Gazzaniga, Charles R. Gallistel
Published in: Annals of the New York Academy of Sciences, Issue Volume1396, Issue1, 2017, Page(s) Pages 108-125, ISSN 1749-6632
Publisher: Wiley-Blackwell
DOI: 10.1111/nyas.13348

Book chapters (2)

If engrams are the answer, what is the question?

Author(s): Fionn M. O'Sullivan, Tomás J. Ryan
Published in: Engram Biology, edited by S. Ramirez & J. Gräff , 2023, Springer Nature, reproduced with permission of Springer Nature, Issue In press, 2023/24, 2023, Page(s) In press
Publisher: Springer Nature
DOI: 10.31234/osf.io/f6amv

Memory and Instinct as a Continuum of Information Storage

Author(s): Tomás J. Ryan
Published in: The Cognitive Neurosciences (Sixth Edition) Edited by David Poeppel, George R. Mangun, Michael S. Gazzaniga, 2020, Page(s) Chapter 18
Publisher: MIT Press
DOI: 10.7551/mitpress/11442.003.0026

Other (5)

A Topological Study of a Surface Signaling Network with Relevance to Brain Function

Author(s): Siddhartha Sen, Tomás J. Ryan, David Muldowney, Maurizio Pezzoli
Published in: bioRxiv, 2022
Publisher: bioRxiv
DOI: 10.1101/2022.08.01.502331

Memory: It’s Not a Lie if You Believe It

Author(s): Livia Autore, Tomás J. Ryan
Published in: Current Biology, Issue Volume 30, ISSUE 12, 2020, Page(s) PR717-R720, June 22, 2020
Publisher: Cell Press
DOI: 10.1016/j.cub.2020.04.076

Framing the future of neuroscience in a time of great upheaval: Introducing a series of essays by the scholars of the FENS-Kavli network

Author(s): Flavio Donato, Tomás J. Ryan
Published in: European Journal of Neuroscience, 2022
Publisher: Wiley
DOI: 10.1111/ejn.15763

Engram cell connectivity as a mechanism for information encoding and memory function

Author(s): Clara Ortega-de San Luis, Maurizio Pezzoli, Esteban Urrieta, Tomás J. Ryan
Published in: bioRxiv, 2023
Publisher: CSHL
DOI: 10.1101/2023.09.21.558774

FENS-Kavli Network of Excellence: Science needs strong European cohesion

Author(s): Timothy O'Leary, Tobias U. Hauser, Tomás J. Ryan, Carolina Rezaval
Published in: European Journal of Neuroscience, 2022
Publisher: Wiley
DOI: 10.1111/ejn.15814