Memory Engram Maintenance and Expression

Project Information

MEME

Grant agreement ID: 715968

DOI

10.3030/715968

Project closed

EC signature date 31 January 2017

Start date 1 February 2017

End date 31 January 2023

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost

€ 1 500 000,00

EU contribution

€ 1 500 000,00

Coordinated by

THE PROVOST, FELLOWS, FOUNDATION SCHOLARS & THE OTHER MEMBERS OF BOARD, OF THE COLLEGE OF THE HOLY & UNDIVIDED TRINITY OF QUEEN ELIZABETH NEAR DUBLIN
Ireland

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Publications

Peer reviewed articles (11)

Engram cell connectivity: an evolving substrate for information storage

Author(s): Tomás J Ryan, Clara Ortega-de San Luis, Maurizio Pezzoli, Siddhartha Sen
Published in: Current Opinion in Neurobiology, Issue Volume 67, April 2021, 2021, Page(s) Pages 215-225, ISSN 0959-4388
Publisher: Elsevier BV
DOI: 10.1016/j.conb.2021.01.006

Understanding the physical basis of memory: Molecular mechanisms of the engram

Author(s): Clara Ortega-de San Luis, Tomás J. Ryan
Published in: Journal of Biological Chemistry, Issue Volume 298, ISSUE 5, 2022, Page(s) 101866, May 2022, ISSN 0021-9258
Publisher: American Society for Biochemistry and Molecular Biology Inc.
DOI: 10.1016/j.jbc.2022.101866

Immune activation state modulates infant engram expression across development

Author(s): Sarah D. Power, Erika Stewart, Louisa G. Zielke, Eric Patrick Byrne, Clara Ortega-de San Luis, Lydia Lynch, Tomás J. Ryan
Published in: Science Advances, Issue In press, 2023, Page(s) In press, ISSN 2375-2548
Publisher: AAAS
DOI: 10.1101/2022.04.24.488172

Forgetting as a form of adaptive engram cell plasticity

Author(s): Tomás J. Ryan, Paul W. Frankland
Published in: Nature Reviews Neuroscience, Issue Volume 23 (2022), 2022, Page(s) pages 173–186 (2022), ISSN 1471-003X
Publisher: Nature Publishing Group
DOI: 10.1038/s41583-021-00548-3

The role of higher-order thalamus during learning and correct performance in goal-directed behavior

Author(s): Danilo La Terra, Ann-Sofie Bjerre, Marius Rosier, Rei Masuda, Tomás J Ryan, Lucy M Palmer
Published in: eLife, 2022, ISSN 2050-084X
Publisher: eLife Sciences Publications
DOI: 10.7554/elife.77177

Natural forgetting reversibly modulates engram expression

Author(s): James D. O’Leary, Rasmus Bruckner, Livia Autore, Tomás J. Ryan
Published in: eLife, Issue In press, 2023, Page(s) In press, ISSN 2050-084X
Publisher: eLife Sciences Publications
DOI: 10.1101/2023.04.15.537013

United states of amnesia: rescuing memory loss from diverse conditions

Author(s): Clara Ortega-de San Luis, Tomás J. Ryan
Published in: Disease Models & Mechanisms, Issue 11/5, 2018, Page(s) dmm035055, ISSN 1754-8403
Publisher: The Company of Biologists Ltd.
DOI: 10.1242/dmm.035055

Engram Cell Excitability State Determines the Efficacy of Memory Retrieval

Author(s): Michele Pignatelli, Tomás J. Ryan, Dheeraj S. Roy, Chanel Lovett, Lillian M. Smith, Shruti Muralidhar, Susumu Tonegawa
Published in: Neuron, Issue 101/2, 2019, Page(s) 274-284.e5, ISSN 0896-6273
Publisher: Cell Press
DOI: 10.1016/j.neuron.2018.11.029

Adaptive Expression of Engrams by Retroactive Interference

Author(s): Livia Autore, James D. O’Leary, Clara Ortega-de San Luis, Tomás J. Ryan
Published in: Cell Reports, Issue Volume 42, ISSUE 8, 2023, Page(s) 112999, August 29, 2023, ISSN 2211-1247
Publisher: Cell Press
DOI: 10.1016/j.celrep.2023.112999

The memory toolbox: how genetic manipulations and cellular imaging are transforming our understanding of learned information

Author(s): Antoine Harel, Tomás J. Ryan
Published in: Current Opinion in Behavioral Sciences, Issue Volume 32, April 2020, 2020, Page(s) Pages 136-147, ISSN 2352-1546
Publisher: Elsevier Limited
DOI: 10.1016/j.cobeha.2020.02.016

On the research of time past: the hunt for the substrate of memory

Author(s): Bridget N. Queenan, Tomás J. Ryan, Michael S. Gazzaniga, Charles R. Gallistel
Published in: Annals of the New York Academy of Sciences, Issue Volume1396, Issue1, 2017, Page(s) Pages 108-125, ISSN 1749-6632
Publisher: Wiley-Blackwell
DOI: 10.1111/nyas.13348

Book chapters (2)

If engrams are the answer, what is the question?

Author(s): Fionn M. O'Sullivan, Tomás J. Ryan
Published in: Engram Biology, edited by S. Ramirez & J. Gräff , 2023, Springer Nature, reproduced with permission of Springer Nature, Issue In press, 2023/24, 2023, Page(s) In press
Publisher: Springer Nature
DOI: 10.31234/osf.io/f6amv

Memory and Instinct as a Continuum of Information Storage

Author(s): Tomás J. Ryan
Published in: The Cognitive Neurosciences (Sixth Edition) Edited by David Poeppel, George R. Mangun, Michael S. Gazzaniga, 2020, Page(s) Chapter 18
Publisher: MIT Press
DOI: 10.7551/mitpress/11442.003.0026

Other (5)

A Topological Study of a Surface Signaling Network with Relevance to Brain Function

Author(s): Siddhartha Sen, Tomás J. Ryan, David Muldowney, Maurizio Pezzoli
Published in: bioRxiv, 2022
Publisher: bioRxiv
DOI: 10.1101/2022.08.01.502331

Memory: It’s Not a Lie if You Believe It

Author(s): Livia Autore, Tomás J. Ryan
Published in: Current Biology, Issue Volume 30, ISSUE 12, 2020, Page(s) PR717-R720, June 22, 2020
Publisher: Cell Press
DOI: 10.1016/j.cub.2020.04.076

Framing the future of neuroscience in a time of great upheaval: Introducing a series of essays by the scholars of the FENS-Kavli network

Author(s): Flavio Donato, Tomás J. Ryan
Published in: European Journal of Neuroscience, 2022
Publisher: Wiley
DOI: 10.1111/ejn.15763

Engram cell connectivity as a mechanism for information encoding and memory function

Author(s): Clara Ortega-de San Luis, Maurizio Pezzoli, Esteban Urrieta, Tomás J. Ryan
Published in: bioRxiv, 2023
Publisher: CSHL
DOI: 10.1101/2023.09.21.558774

FENS-Kavli Network of Excellence: Science needs strong European cohesion

Author(s): Timothy O'Leary, Tobias U. Hauser, Tomás J. Ryan, Carolina Rezaval
Published in: European Journal of Neuroscience, 2022
Publisher: Wiley
DOI: 10.1111/ejn.15814