Imaging and detection of tumor-associated glycan structures on tumor cells

Informazioni relative al progetto

GlycoImaging

ID dell’accordo di sovvenzione: 721297

DOI 10.3030/721297

Progetto chiuso

Data della firma CE 6 Dicembre 2016

Data di avvio 1 Aprile 2017

Data di completamento 30 Settembre 2021

Finanziato da

• EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions

Costo totale € 2 138 720,04

Contributo UE € 2 138 720,04

Coordinato da

MALMO UNIVERSITET
Sweden

Risultati finali

Websites, patent fillings, videos etc. (3)

Produce a project poster and a presentation
Produce a minimum of 2 press releases

Produce a minimum of 2 press releases

Project website launched

Pubblicazioni

Peer reviewed articles (16)

Installation of O-glycan sulfation capacities in human HEK293 cells for display of sulfated mucins

Autori: Lingbo Sun; Andriana Konstantinidi; Zilu Ye; Rebecca Nason; Yuecheng Zhang; Christian Büll; Barbro Kahl-Knutson; Lars Hansen; Hakon Leffler; Sergey Y. Vakhrushev; Zhang Yang; Henrik Clausen; Yoshiki Narimatsu
Pubblicato in: Journal of biological chemistry, Numero Dec 24;298(2), 2021, Pagina/e 1-14, ISSN 0021-9258
Editore: American Society for Biochemistry and Molecular Biology Inc.
DOI: 10.1016/j.jbc.2021.101382

Molecularly imprinted polymers in biological applications

Autori: Zahra El-Schich, Yuecheng Zhang, Marek Feith, Sarah Beyer, Louise Sternbæk, Lars Ohlsson, Maria Stollenwerk, Anette Gjörloff Wingren
Pubblicato in: BioTechniques, Numero 69/6, 2020, Pagina/e 406-419, ISSN 0736-6205
Editore: Eaton Publishing Co.
DOI: 10.2144/btn-2020-0091

Sialic Acid as a Biomarker Studied in Breast Cancer Cell Lines In Vitro Using Fluorescent Molecularly Imprinted Polymers

Autori: Zahra El-Schich, Yuecheng Zhang, Tommy Göransson, Nishtman Dizeyi, Jenny L. Persson, Emil Johansson, Remi Caraballo, Mikael Elofsson, Sudhirkumar Shinde, Börje Sellergren, Anette Gjörloff Wingren
Pubblicato in: Applied Sciences, Numero 11/7, 2021, Pagina/e 3256, ISSN 2076-3417
Editore: MDPI
DOI: 10.3390/app11073256

Targeted inhibition of ERα signaling and PIP5K1α/Akt pathways in castration‐resistant prostate cancer

Autori: Julius Semenas, Tianyan Wang, Azharuddin Sajid Syed Khaja, AKM Firoj Mahmud, Athanasios Simoulis, Thomas Grundström, Maria Fällman, Jenny L. Persson
Pubblicato in: Molecular Oncology, Numero 15/4, 2021, Pagina/e 968-986, ISSN 1574-7891
Editore: Elsevier BV
DOI: 10.1002/1878-0261.12873

Establishment of Prostate Tumor Growth and Metastasis Is Supported by Bone Marrow Cells and Is Mediated by PIP5K1α Lipid Kinase

Autori: Richard Karlsson, Per Larsson, Regina Miftakhova, Azharuddin Sajid Syed Khaja, Martuza Sarwar, Julius Semenas, Sa Chen, Andreas Hedblom, Tianyan Wang, Kristina Ekström-Holka, Athanasios Simoulis, Anjani Kumar, Niels Ødum, Thomas Grundström, Jenny L. Persson
Pubblicato in: Cancers, Numero 12/9, 2020, Pagina/e 2719, ISSN 2072-6694
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/cancers12092719

Primary breast cancer biomarkers based on glycosylation and extracellular vesicles detected from human serum

Autori: Joonas Terävä, Alejandra Verhassel, Orsola Botti, Md. Khirul Islam, Janne Leivo, Saara Wittfooth, Pirkko Härkönen, Kim Pettersson, Kamlesh Gidwani
Pubblicato in: Cancer Reports, 2021, ISSN 2573-8348
Editore: Wiley Online Library
DOI: 10.1002/cnr2.1540

Imprinted Particles for Direct Fluorescence Detection of Sialic Acid in Polar Media and on Cancer Cells with Enhanced Control of Nonspecific Binding

Autori: Martha Kimani, Sarah Beyer, Zahra El-Schich, Kornelia Gawlitza, Anette Gjörloff-Wingren, Knut Rurack
Pubblicato in: ACS Applied Polymer Materials, Numero 3/5, 2021, Pagina/e 2363-2373, ISSN 2637-6105
Editore: ACS Publications
DOI: 10.1021/acsapm.0c01353

Quantitative characterization of O-GalNAc glycosylation

Autori: Tomislav Čaval, Noortje de Haan, Andriana Konstantinidi, Sergey Y Vakhrushev
Pubblicato in: Current Opinion in Structural Biology, Numero 68, 2021, Pagina/e 135-141, ISSN 0959-440X
Editore: Elsevier BV
DOI: 10.1016/j.sbi.2020.12.010

The GAGOme: a cell-based library of displayed glycosaminoglycans

Autori: Yen-Hsi Chen, Yoshiki Narimatsu, Thomas M. Clausen, Catarina Gomes, Richard Karlsson, Catharina Steentoft, Charlotte B. Spliid, Tobias Gustavsson, Ali Salanti, Andrea Persson, Anders Malmström, Daniel Willén, Ulf Ellervik, Eric P. Bennett, Yang Mao, Henrik Clausen, Zhang Yang
Pubblicato in: Nature Methods, Numero 15/11, 2018, Pagina/e 881-888, ISSN 1548-7091
Editore: Nature Publishing Group
DOI: 10.1038/s41592-018-0086-z

Determination of cytokine regulated glycan expression by using molecularly imprinted polymers targeting sialic acid

Autori: Yuecheng Zhang, Kushtrim Llapashtica, Sudhirkumar Shinde, Borje Sellergren, Zahra El-Schich, Anette Gjorloff Wingren
Pubblicato in: Journal of Cancer Metastasis and Treatment, Numero 2019, 2019, ISSN 2454-2857
Editore: OAE Publishing Inc.
DOI: 10.20517/2394-4722.2018.112

An Atlas of Human Glycosylation Pathways Enables Display of the Human Glycome by Gene Engineered Cells

Autori: Yoshiki Narimatsu, Hiren J. Joshi, Rebecca Nason, Julie Van Coillie, Richard Karlsson, Lingbo Sun, Zilu Ye, Yen-Hsi Chen, Katrine T. Schjoldager, Catharina Steentoft, Sanae Furukawa, Barbara A. Bensing, Paul M. Sullam, Andrew J. Thompson, James C. Paulson, Christian Büll, Gosse J. Adema, Ulla Mandel, Lars Hansen, Eric Paul Bennett, Ajit Varki, Sergey Y. Vakhrushev, Zhang Yang, Henrik Clausen
Pubblicato in: Molecular Cell, Numero 75/2, 2019, Pagina/e 394-407.e5, ISSN 1097-2765
Editore: Cell Press
DOI: 10.1016/j.molcel.2019.05.017

γ‐(S)‐Guanidinylmethyl Modified Triplex‐Forming Peptide Nucleic Acids Increase Hoogsteen‐Face Affinity for a MicroRNA and Enhance Cellular Uptake

Autori: Ville Tähtinen, Alejandra Verhassel, Johanna Tuomela, Pasi Markus Virta
Pubblicato in: ChemBioChem, 2019, ISSN 1439-4227
Editore: John Wiley & Sons Ltd.
DOI: 10.1002/cbic.201900393

Engineering mammalian cells to produce plant-specific N-glycosylation on proteins

Autori: Joachim Steen Larsen, Richard Torbjörn Gustav Karlsson, Weihua Tian, Morten Alder Schulz, Annemarie Matthes, Henrik Clausen, Bent Larsen Petersen, Zhang Yang
Pubblicato in: Glycobiology, 2020, ISSN 1460-2423
Editore: Glycobiology
DOI: 10.1093/glycob/cwaa009

The functional interlink between AR and MMP9/VEGF signaling axis is mediated through PIP5K1α/pAKT in prostate cancer

Autori: Per Larsson, Azharuddin Sajid Syed Khaja, Julius Semenas, Tianyan Wang, Martuza Sarwar, Nishtman Dizeyi, Athanasios Simoulis, Andreas Hedblom, Sun Nyunt Wai, Niels Ødum, Jenny L. Persson
Pubblicato in: International Journal of Cancer, Numero 146/6, 2019, Pagina/e 1686-1699, ISSN 0020-7136
Editore: John Wiley & Sons Inc.
DOI: 10.1002/ijc.32607

Different isolation approaches lead to diverse glycosylated extracellular vesicle populations

Autori: Daniela Freitas, Meritxell Balmaña, Juliana Poças, Diana Campos, Hugo Osório, Andriana Konstantinidi, Sergey Y. Vakhrushev, Ana Magalhães, Celso A. Reis
Pubblicato in: Journal of Extracellular Vesicles, Numero 8/1, 2019, Pagina/e 1621131, ISSN 2001-3078
Editore: Taylor & Francis
DOI: 10.1080/20013078.2019.1621131

Synthesis of an Alkyne-Modified Bleomycin Disaccharide Precursor, Conversion to a 18 F-Labeled Radiotracer, and Preliminary in vivo-PET Imaging Studies

Autori: Sajal K. Maity, Cheng-Bin Yim, Satish Jadhav, Alejandra Verhassel, Johanna Tuomela, Olof Solin, Tove J. Grönroos, Pasi Virta
Pubblicato in: European Journal of Organic Chemistry, Numero 2019/1, 2019, Pagina/e 156-163, ISSN 1434-193X
Editore: John Wiley & Sons Ltd.
DOI: 10.1002/ejoc.201801488

Thesis and dissertations (1)

Glycosylation in cancer and infection – the role of sialic acid

Autori: Yuecheng Zhang
Pubblicato in: 2021
Editore: Malmö University

Conference proceedings (1)

Digital holographic cytometry - Macrophage uptake of nanoprobes

Autori: Louise Sternbæk, Martha Wamaitha Kimani, Kornelia Gawlitza Birgit Janicke, Kersti Alm, and Anette Gjörloff Wingren
Pubblicato in: Imaging&Microscopy, Numero 1, 2019, Pagina/e 21-23
Editore: Wiley

Book chapters (1)

Dual-Fluorescent Nanoparticle Probes Consisting of a Carbon Nanodot Core and a Molecularly Imprinted Polymer Shell

Autori: Shan Jiang, Kornelia Gawlitza, Knut Rurack
Pubblicato in: Molecularly Imprinted Polymers - Methods and Protocols, Numero 2359, 2021, Pagina/e 195-208, ISBN 978-1-0716-1628-4
Editore: Springer US
DOI: 10.1007/978-1-0716-1629-1_17

Diritti di proprietà intellettuale

Patent (3)

FLUORESCENT PARTICLES WITH MOLECULARLY IMPRINTED FLUORESCENT POLYMER SHELLS FOR CELL STAINING APPLICATIONS IN CYTOMETRY AND MICROSCOPY

Numero candidatura/pubblicazione: 20 19066550
Data: 2019-06-21
Candidato/i: BUNDESANSTALT FUER MATERIALFORSCHUNG UND -PRUEFUNG

FLUORESCENT PARTICLES WITH MOLECULARLY IMPRINTED FLUORESCENT POLYMER SHELLS FOR CELL STAINING APPLICATIONS IN CYTOMETRY AND MICROSCOPY

Numero candidatura/pubblicazione: 20 19066550
Data: 2019-06-21
Candidato/i: PHASE HOLOGRAPHIC IMAGING PHI AB

FLUORESCENT PARTICLES WITH MOLECULARLY IMPRINTED FLUORESCENT POLYMER SHELLS FOR CELL STAINING APPLICATIONS IN CYTOMETRY AND MICROSCOPY

Numero candidatura/pubblicazione: 20 19066550
Data: 2019-06-21
Candidato/i: MALMO UNIVERSITET