PROTECTion against Endocrine Disruptors; Detection, mixtures, health effects, risk assessment and communication.

Informazioni relative al progetto

PROTECTED

ID dell’accordo di sovvenzione: 722634

DOI 10.3030/722634

Progetto chiuso

Data della firma CE 31 Agosto 2016

Data di avvio 1 Gennaio 2017

Data di completamento 30 Giugno 2021

Finanziato da

• EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions

Costo totale € 3 974 594,76

Contributo UE € 3 974 594,76

Coordinato da

THE QUEEN'S UNIVERSITY OF BELFAST
United Kingdom

Risultati finali

Documents, reports (8)

Final WP6 report

Final WP6 report.

Completion of network-wide events

Completion of network-wide events.

End of Project Meeting/Final Report

End of Project Meeting/Final Report.

Final WP2 report

Final WP2 report.

Final WP5 report

Final WP5 report.

Final WP7 report

Final WP7 report.

Final WP3 report

Final WP3 report.

Final WP4 report

Final WP4 report.

Other (2)

Completion of Dissemination and Outreach activities as outlined in section 2.3 and listed in Table 2.3a.
Award Doctoral Degree (where appropriate)

Award Doctoral Degrees (where appropriate).

Websites, patent fillings, videos etc. (2)

Web-site/intranet

Web-site/intranet.

Wikipedia entry

Wikipedia entry.

Pubblicazioni

Peer reviewed articles (32)

Targeting the aryl hydrocarbon receptor with a novel set of triarylmethanes.

Autori: Elizabeth Goya-Jorge; Céline Rampal; Rafael Gozalbes; Maité Sylla-Iyarreta Veitía; Clotilde Ferroud; Nicolas Loones; Laureano E. Carpio; Rosa M. Giner; Stephen J. Barigye
Pubblicato in: European Journal of Medicinal Chemistry, 2020, ISSN 0223-5234
Editore: Elsevier BV
DOI: 10.1016/j.ejmech.2020.112777

Public Awareness and Risk Perceptions of Endocrine Disrupting Chemicals: A Qualitative Study

Autori: Melissa Kelly, Lisa Connolly, Moira Dean
Pubblicato in: International Journal of Environmental Research and Public Health, Numero 17/21, 2020, Pagina/e 7778, ISSN 1660-4601
Editore: MDPI
DOI: 10.3390/ijerph17217778

Discovery of 2-aryl and 2-pyridinylbenzothiazoles endowed with antimicrobial and aryl hydrocarbon receptor agonistic activities

Autori: Elizabeth Goya-Jorge, Fatma Abdmouleh, Laureano E. Carpio, Rosa M. Giner, Maité Sylla-Iyarreta Veitía
Pubblicato in: European Journal of Pharmaceutical Sciences, Numero 151, 2020, Pagina/e 105386, ISSN 0928-0987
Editore: Elsevier BV
DOI: 10.1016/j.ejps.2020.105386

Plant Occurring Flavonoids as Modulators of the Aryl Hydrocarbon Receptor

Autori: Elizabeth Goya-Jorge, María Elisa Jorge Rodríguez, Maité Sylla-Iyarreta Veitía, Rosa M. Giner
Pubblicato in: Molecules, Numero 26/8, 2021, Pagina/e 2315, ISSN 1420-3049
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/molecules26082315

PROTECTion against Endocrine Disruption through Quantitative Structure-Activity Relationship modelling [“Revisión de los modelos computacionales que relacionan la estructura química con la disrupción del sistema endocrino”]

Autori: Elizabeth Goya-Jorge Jesús V. de Julián-Ortiz Rafael Gozalbes
Pubblicato in: Revista de Toxicología, Numero June 2020, 2020, Pagina/e 55-68, ISSN 0212-7113
Editore: Asociacion Espanola de Toxicologia

Human-Based Exposure Levels of Perfluoroalkyl Acids May Induce Harmful Effects to Health by Disrupting Major Components of Androgen Receptor Signalling In Vitro

Autori: J. McComb, I. G. Mills, Hanne Friis Berntsen, E. Ropstad, S. Verhaegen, L. Connolly
Pubblicato in: Exposure and Health, Numero 12/3, 2020, Pagina/e 527-538, ISSN 2451-9766
Editore: Springer
DOI: 10.1007/s12403-019-00318-8

Induction of AhR transactivation by PBDD/Fs and PCDD/Fs using a novel human-relevant, high-throughput DRhuman CALUX reporter gene assay

Autori: Clémence Budin, Harrie Besselink, Barbara M.A. van Vugt-Lussenburg, Hai-Yen Man, Bart van der Burg, Abraham Brouwer
Pubblicato in: Chemosphere, Numero 263, 2021, Pagina/e 128086, ISSN 0045-6535
Editore: Pergamon Press Ltd.
DOI: 10.1016/j.chemosphere.2020.128086

A human relevant mixture of persistent organic pollutants (POPs) and perfluorooctane sulfonic acid (PFOS) enhance nerve growth factor (NGF)-induced neurite outgrowth in PC12 cells

Autori: Ajay Yadav, Mazia Amber, Denis Zosen, Nils Anders Labba, Eva Henriette Willemijn Huiberts, Johanna Samulin Erdem, Fred Haugen, Hanne Friis Berntsen, Shanbeh Zienolddiny, Ragnhild Elisabeth Paulsen, Erik Ropstad, Lisa Connolly, Steven Verhaegen
Pubblicato in: Toxicology Letters, Numero 338, 2021, Pagina/e 85-96, ISSN 0378-4274
Editore: Elsevier BV
DOI: 10.1016/j.toxlet.2020.12.007

Investigation of In Vitro Endocrine Activities of Microcystis and Planktothrix Cyanobacterial Strains

Autori: Vittoria Mallia, Lada Ivanova, Gunnar S. Eriksen, Emma Harper, Lisa Connolly, Silvio Uhlig
Pubblicato in: Toxins, Numero 12/4, 2020, Pagina/e 228, ISSN 2072-6651
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/toxins12040228

Effects of Defined Mixtures of Persistent Organic Pollutants (POPs) on Pre-lethal Cytotoxicity in the Human A-498 Kidney Cell Line In Vitro

Autori: Mazia Amber, Yuling Xie, Hanne Friis Berntsen, Karin Elizabeth Zimmer, Erik Ropstad, Steven Verhaegen, Lisa Connolly
Pubblicato in: Exposure and Health, 2021, ISSN 2451-9766
Editore: Springer nature
DOI: 10.1007/s12403-021-00396-7

In vitro profiling of the potential endocrine disrupting activities affecting steroid and aryl hydrocarbon receptors of compounds and mixtures prevalent in human drinking water resources

Autori: Doan TQ, Connolly L, Igout A, Nott K, Muller M, Scippo ML
Pubblicato in: Chemosphere, Numero 258, 2020, Pagina/e 127332, ISSN 0045-6535
Editore: Pergamon Press Ltd.
DOI: 10.1016/j.chemosphere.2020.127332

Predictive modeling of aryl hydrocarbon receptor (AhR) agonism

Autori: Elizabeth Goya-Jorge, Rosa M. Giner, Maité Sylla-Iyarreta Veitía, Rafael Gozalbes, Stephen J. Barigye
Pubblicato in: Chemosphere, Numero 256, 2020, Pagina/e 127068, ISSN 0045-6535
Editore: Pergamon Press Ltd.
DOI: 10.1016/j.chemosphere.2020.127068

Assessing the chemical-induced estrogenicity using in silico and in vitro methods

Autori: Elizabeth Goya-Jorge, Mazia Amber, Rafael Gozalbes, Lisa Connolly, Stephen J. Barigye
Pubblicato in: Environmental Toxicology and Pharmacology, 2021, Pagina/e 103688, ISSN 1382-6689
Editore: Elsevier BV
DOI: 10.1016/j.etap.2021.103688

Versicolorin A enhances the genotoxicity of aflatoxin B1 in human liver cells by inducing the transactivation of the Ah-receptor

Autori: Clémence Budin, Hai-Yen Man, Carine Al-Ayoubi, Sylvie Puel, Barbara M.A. van Vugt-Lussenburg, Abraham Brouwer, Isabelle P. Oswald, Bart van der Burg, Laura Soler
Pubblicato in: Food and Chemical Toxicology, Numero 153, 2021, Pagina/e 112258, ISSN 0278-6915
Editore: Elsevier BV
DOI: 10.1016/j.fct.2021.112258

The insulin-like growth factor system: A target for endocrine disruptors?

Autori: Chiara Talia, Lisa Connolly, Paul A. Fowler
Pubblicato in: Environment International, Numero 147, 2021, Pagina/e 106311, ISSN 0160-4120
Editore: Pergamon Press Ltd.
DOI: 10.1016/j.envint.2020.106311

Testing the twin testosterone transfer hypothesis—intergenerational analysis of 317 dizygotic twins born in Aberdeen, Scotland

Autori: Chiara Talia, Edwin-Amalraj Raja, Sohinee Bhattacharya, Paul A Fowler
Pubblicato in: Human Reproduction, Numero 35/7, 2020, Pagina/e 1702-1711, ISSN 0268-1161
Editore: Oxford University Press
DOI: 10.1093/humrep/deaa091

Microcystins and Microcystis aeruginosa PCC7806 extracts modulate steroidogenesis differentially in the human H295R adrenal model

Autori: Vittoria Mallia, Steven Verhaegen, Bjarne Styrishave, Gunnar Sundstøl Eriksen, Malene Louise Johannsen, Erik Ropstad, Silvio Uhlig
Pubblicato in: PLOS ONE, Numero 15/12, 2020, Pagina/e e0244000, ISSN 1932-6203
Editore: Public Library of Science
DOI: 10.1371/journal.pone.0244000

A mixture of persistent organic pollutants relevant for human exposure inhibits the transactivation activity of the aryl hydrocarbon receptor in vitro

Autori: T.Q. Doan, H.F. Berntsen, S. Verhaegen, E. Ropstad, L. Connolly, A. Igout, M. Muller, M.L. Scippo
Pubblicato in: Environmental Pollution, Numero 254, 2019, Pagina/e 113098, ISSN 0269-7491
Editore: Pergamon Press Ltd.
DOI: 10.1016/j.envpol.2019.113098

Elucidating the aryl hydrocarbon receptor antagonism from a chemical-structural perspective

Autori: E. Goya-Jorge, T.Q. Doan, M.L. Scippo, M. Muller, R.M. Giner, S.J. Barigye, R. Gozalbes
Pubblicato in: SAR and QSAR in Environmental Research, Numero 31/3, 2020, Pagina/e 209-226, ISSN 1062-936X
Editore: Taylor & Francis
DOI: 10.1080/1062936x.2019.1708460

Detection of high PBDD/Fs levels and dioxin-like activity in toys using a combination of GC-HRMS, rat-based and human-based DR CALUX® reporter gene assays

Autori: Clémence Budin, Jindrich Petrlik, Jitka Strakova, Stephan Hamm, Bjorn Beeler, Peter Behnisch, Harrie Besselink, Bart van der Burg, Abraham Brouwer
Pubblicato in: Chemosphere, Numero 251, 2020, Pagina/e 126579, ISSN 0045-6535
Editore: Pergamon Press Ltd.
DOI: 10.1016/j.chemosphere.2020.126579

Potential adverse effects on animal health and performance caused by the addition of mineral adsorbents to feeds to reduce mycotoxin exposure

Autori: Christopher T. Elliott, Lisa Connolly, Oluwatobi Kolawole
Pubblicato in: Mycotoxin Research, Numero 36/1, 2020, Pagina/e 115-126, ISSN 0178-7888
Editore: Hans W. Schmidt
DOI: 10.1007/s12550-019-00375-7

Comparative In Vitro Assessment of a Range of Commercial Feed Additives with Multiple Mycotoxin Binding Claims

Autori: Kolawole, Meneely, Greer, Chevallier, Jones, Connolly, Elliott
Pubblicato in: Toxins, Numero 11/11, 2019, Pagina/e 659, ISSN 2072-6651
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/toxins11110659

Human blood-based exposure levels of persistent organic pollutant (POP) mixtures antagonise androgen receptor transactivation and translocation

Autori: J. McComb, I.G. Mills, M. Muller, H.F. Berntsen, K.E. Zimmer, E. Ropstad, S. Verhaegen, L. Connolly
Pubblicato in: Environment International, Numero 132, 2019, Pagina/e 105083, ISSN 0160-4120
Editore: Pergamon Press Ltd.
DOI: 10.1016/j.envint.2019.105083

DMSO effects larval zebrafish (Danio rerio) behavior, with additive and interaction effects when combined with positive controls

Autori: Maria Christou, Arturas Kavaliauskis, Erik Ropstad, Thomas William Kenneth Fraser
Pubblicato in: Science of The Total Environment, Numero 709, 2020, Pagina/e 134490, ISSN 0048-9697
Editore: Elsevier BV
DOI: 10.1016/j.scitotenv.2019.134490

Antagonistic activity towards the androgen receptor independent from natural sex hormones in human milk samples from the Norwegian HUMIS cohort

Autori: Bérénice Collet, Barbara M.A. van Vugt-Lussenburg, Kees Swart, Rick Helmus, Matthijs Naderman, Eva de Rijke, Merete Eggesbø, Abraham Brouwer, Bart van der Burg
Pubblicato in: Environment International, Numero 143, 2020, Pagina/e 105948, ISSN 0160-4120
Editore: Pergamon Press Ltd.
DOI: 10.1016/j.envint.2020.105948

Calcium signaling as a possible mechanism behind increased locomotor response in zebrafish larvae exposed to a human relevant persistent organic pollutant mixture or PFOS

Autori: Maria Christou, Thomas W.K. Fraser, Vidar Berg, Erik Ropstad, Jorke H. Kamstra
Pubblicato in: Environmental Research, Numero 187, 2020, Pagina/e 109702, ISSN 0013-9351
Editore: Academic Press
DOI: 10.1016/j.envres.2020.109702

Acute Exposure to Zearalenone Disturbs Intestinal Homeostasis by Modulating the Wnt/β-Catenin Signaling Pathway

Autori: Tarek Lahjouji, Aurora Bertaccini, Manon Neves, Sylvie Puel, Isabelle P. Oswald, Laura Soler
Pubblicato in: Toxins, Numero 12/2, 2020, Pagina/e 113, ISSN 2072-6651
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/toxins12020113

Novel Microcystins from Planktothrix prolifica NIVA-CYA 544 Identified by LC-MS/MS, Functional Group Derivatization and 15N-labeling

Autori: Vittoria Mallia, Silvio Uhlig, Cheryl Rafuse, Juris Meija, Christopher O. Miles
Pubblicato in: Marine Drugs, Numero 17/11, 2019, Pagina/e 643, ISSN 1660-3397
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/md17110643

A human relevant mixture of persistent organic pollutants (POPs) and perfluorooctane sulfonic acid (PFOS) differentially affect glutamate induced excitotoxic responses in chicken cerebellum granule neurons (CGNs) in vitro

Autori: Ajay Yadav, Steven Verhaegen, Evelien Verbruggen, Marie Kerhoas, Eva Henriëtte Willemijn Huiberts, Mussie Ghezu Hadera, Hanne Friis Berntsen, Karin Elisabeth Zimmer, Erik Ropstad, Ragnhild Elisabeth Paulsen
Pubblicato in: Reproductive Toxicology, Numero 100, 2021, Pagina/e 109-119, ISSN 0890-6238
Editore: Elsevier BV
DOI: 10.1016/j.reprotox.2021.01.008

Developmental exposure to a POPs mixture or PFOS increased body weight and reduced swimming ability but had no effect on reproduction or behavior in zebrafish adults

Autori: Maria Christou, Erik Ropstad, Stephen Brown, Jorke H. Kamstra, Thomas W.K. Fraser
Pubblicato in: Aquatic Toxicology, Numero 237, 2021, Pagina/e 105882, ISSN 0166-445X
Editore: Elsevier BV
DOI: 10.1016/j.aquatox.2021.105882

Low Doses of Mycotoxin Mixtures below EU Regulatory Limits Can Negatively Affect the Performance of Broiler Chickens: A Longitudinal Study

Autori: Oluwatobi Kolawole, Abigail Graham, Caroline Donaldson, Bronagh Owens, Wilfred A. Abia, Julie Meneely, Michael J. Alcorn, Lisa Connolly, Christopher T. Elliott
Pubblicato in: Toxins, Numero 12/7, 2020, Pagina/e 433, ISSN 2072-6651
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/toxins12070433

In vitro differential responses of rat and human aryl hydrocarbon receptor to two distinct ligands and to different polyphenols.

Autori: Marc Muller; Ahmed Igout; Thi-Que Doan; Lisa Connolly; Marie-Louise Scippo
Pubblicato in: Environmental Pollution, Numero 6, 2020, ISSN 0269-7491
Editore: Pergamon Press Ltd.
DOI: 10.1016/j.envpol.2020.114966