Decoding dynamic chromatin signaling by single-molecule multiplex detection

BAF restricts cGAS on nuclear DNA to prevent innate immune activation

Autores: Guey B, Wischnewski M, Decout A, Makasheva K, Kaynak M, Sakar MS, Fierz B, Ablasser A
Publicado en: Science, 2020, ISSN 0036-8075
Editor: American Association for the Advancement of Science
DOI: 10.1126/science.aaw6421

Structural mechanism of cGAS inhibition by the nucleosome

Autores: Pathare GR, Decout A, Glück S, Cavadini S, Makasheva K, Hovius R, Kempf G, Weiss J, Kozicka Z, Guey B, Melenec P, Fierz B, Thomä NH, Ablasser A.
Publicado en: Nature, 2020, ISSN 0028-0836
Editor: Nature Publishing Group
DOI: 10.1038/s41586-020-2750-6

PR-DUB preserves Polycomb repression by preventing excessive accumulation of H2Aub1, an antagonist of chromatin compaction

Autores: Jacques Bonnet, Iuliia Boichenko, Richard Kalb, Matilde Le Jeune, Svetlana Maltseva, Mattia Pieropan, Katja Finkl, Beat Fierz, Jürg Müller
Publicado en: Genes & Development, 2022, ISSN 0890-9369
Editor: Cold Spring Harbor Laboratory Press
DOI: 10.1101/gad.350014.122

Single-molecule FRET reveals multiscale chromatin dynamics modulated by HP1α

Autores: Sinan Kilic, Suren Felekyan, Olga Doroshenko, Iuliia Boichenko, Mykola Dimura, Hayk Vardanyan, Louise C. Bryan, Gaurav Arya, Claus A. M. Seidel, Beat Fierz
Publicado en: Nature Communications, Edición 9/1, 2018, ISSN 2041-1723
Editor: Nature Publishing Group
DOI: 10.1038/s41467-017-02619-5

A bi-terminal protein ligation strategy to probe chromatin structure during DNA damage

Autores: Sinan Kilic, Iuliia Boichenko, Carolin C. Lechner, Beat Fierz
Publicado en: Chemical Science, Edición 9/15, 2018, Página(s) 3704-3709, ISSN 2041-6520
Editor: Royal Society of Chemistry
DOI: 10.1039/c8sc00681d

Chromatin Fiber Invasion and Nucleosome Displacement by the Rap1 Transcription Factor

Autores: Maxime Mivelaz, Anne-Marinette Cao, Slawomir Kubik, Sevil Zencir, Ruud Hovius, Iuliia Boichenko, Anna Maria Stachowicz, Christoph F. Kurat, David Shore, Beat Fierz
Publicado en: Molecular Cell, 2019, ISSN 1097-2765
Editor: Cell Press
DOI: 10.1016/j.molcel.2019.10.025

Multiplexed Single-Molecule Experiments Reveal Nucleosome Invasion Dynamics of the Cas9 Genome Editor

Autores: Makasheva K, Bryan LC, Anders C, Panikulam S, Jinek M, Fierz B
Publicado en: JACS, 2021, ISSN 0002-7863
Editor: American Chemical Society
DOI: 10.1021/jacs.1c06195

Nucleosome Binding by the Lysine Specific Demethylase 1 (LSD1) Enzyme Enables Histone H3 Demethylation.

Autores: Abhinav Dhall; Patrick M. M. Shelton; Aurore Marie-France Delachat; Calvin Jon Antolin Leonen; Beat Fierz; Champak Chatterjee
Publicado en: Biochemistry, Edición 1, 2020, Página(s) Vol 59, 2479-2483
Editor: American Chemical Society
DOI: 10.1021/acs.biochem.0c00412

Chemical and biophysical methods to explore dynamic mechanisms of chromatin silencing

Autores: Iuliia Boichenko, Beat Fierz
Publicado en: Current Opinion in Chemical Biology, Edición 51, 2019, Página(s) 1-10, ISSN 1367-5931
Editor: Elsevier BV
DOI: 10.1016/j.cbpa.2019.01.022

Re-evaluating the role of nucleosomal bivalency in early development

Autores: Rohan N. Shah, Adrian T. Grzybowski, Jimmy Elias, Zhonglei Chen, Takamitsu Hattori, Carolin C. Lechner, Peter W. Lewis, Shohei Koide, Beat Fierz, Alexander J. Ruthenburg
Publicado en: BioRxiv, 2021
Editor: CSH
DOI: 10.1101/2021.09.09.458948

CENP-A and CENP-B collaborate to create an open centromeric chromatin state

Autores: Harsh Nagpal, Beat Fierz
Publicado en: BioRxiv, 2022, ISSN 2692-8205
Editor: CSH
DOI: 10.1101/2022.07.08.499316

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