Chemical Tools for Unravelling Sirtuin Function

Project Information

SIRFUNCT

Grant agreement ID: 725172

DOI 10.3030/725172

Project closed

EC signature date 16 March 2017

Start date 1 April 2017

End date 31 March 2022

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost € 1 758 742,00

EU contribution € 1 758 742,00

Coordinated by

KOBENHAVNS UNIVERSITET
Denmark

Publications

Peer reviewed articles (14)

Metabolic control by sirtuins and other enzymes that sense NAD + , NADH, or their ratio.

Author(s): Anderson, Kristin A.; Madsen, Andreas S.; Olsen, Christian A.; Hirschey, Matthew D.
Published in: Biochim. Biophys. Acta Bioenergetics, Issue 2, 2017, ISSN 0005-2728
Publisher: Elsevier BV
DOI: 10.1016/j.bbabio.2017.09.005

Determination of Slow-Binding HDAC Inhibitor Potency and Subclass Selectivity

Author(s): Carlos Moreno-Yruela; Christian A. Olsen
Published in: ACS Medicinal Chemistry Letters, Issue 12, 2022, ISSN 1948-5875
Publisher: American Chemical Society
DOI: 10.1021/acsmedchemlett.1c00702

Hydroxamic acid-modified peptide microarrays for profiling isozyme-selective interactionsand inhibition of histone deacetylases

Author(s): Carlos Moreno-Yruela, Michael Bæk, Adela-Eugenie Vrsanova, Clemens Schulte, Hans M. Maric & Christian A. Olsen
Published in: Nature Communications, 2021, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-020-20250-9

Class I histone deacetylases (HDAC1–3) are histone lysine delactylases

Author(s): Carlos Moreno-Yruela, Di Zhang, Wei Wei, Michael Bæk, Jinjun Gao, Alexander L. Nielsen, Julie E. Bolding, Lu Yang, Samuel T. Jameson, Jiemin Wong, Christian A. Olsen, Yingming Zhao
Published in: Science Advances, Issue 52, 2022, ISSN 2375-2548
Publisher: American Association for the Advancement of Science
DOI: 10.1126/sciadv.abi6696

Mitochondria-Targeted Inhibitors of the Human SIRT3 Lysine Deacetylase

Author(s): Kathrin S. Troelsen; Michael Bæk; Alexander L. Nielsen; Andreas Stahl Madsen; Nima Rajabi; Christian A. Olsen
Published in: RSC Chemical Biology, Issue 6, 2021, ISSN 2633-0679
Publisher: Royal Society of Chemistry
DOI: 10.1039/d0cb00216j

Histone Deacetylase 11 is an ε-N-Myristoyllysine Hydrolase

Author(s): Madsen, Andreas; Olsen, Christian; Moreno-Yruela, Carlos; Galleano, Iacopo
Published in: Cell Chemical Biology, Issue 1, 2018, ISSN 2451-9448
Publisher: Cell Press
DOI: 10.1101/211839

Mechanism-Based Inhibitors of the Human Sirtuin 5 Deacylase: Structure-Activity Relationship, Biostructural, and Kinetic Insight

Author(s): Nima Rajabi, Marina Auth, Kathrin R. Troelsen, Martin Pannek, Dhaval P. Bhatt, Martin Fontenas, Matthew D. Hirschey, Clemens Steegborn, Andreas S. Madsen, Christian A. Olsen
Published in: Angewandte Chemie International Edition, Issue 56/47, 2017, Page(s) 14836-14841, ISSN 1433-7851
Publisher: John Wiley & Sons Ltd.
DOI: 10.1002/anie.201709050

Arylfluorosulfate-Based Electrophiles for Covalent Protein Labeling: A New Addition to the Arsenal

Author(s): Pablo Martín-Gago, Christian A. Olsen
Published in: Angewandte Chemie International Edition, Issue 58/4, 2019, Page(s) 957-966, ISSN 1433-7851
Publisher: John Wiley & Sons Ltd.
DOI: 10.1002/anie.201806037

Photo Cross‐Linking Probes Containing ϵ‐ N ‐Thioacyllysine and ϵ‐ N ‐Acyl‐(δ‐aza)lysine Residues

Author(s): Michael Bæk, Pablo Martín‐Gago, Jonas S. Laursen, Julie L. H. Madsen, Saswati Chakladar, Christian A. Olsen
Published in: Chemistry – A European Journal, Issue 26/17, 2020, Page(s) 3862-3869, ISSN 0947-6539
Publisher: John Wiley & Sons Ltd.
DOI: 10.1002/chem.201905338

Dethioacylation by Sirtuins 1–3: Considerations for Drug Design Using Mechanism-Based Sirtuin Inhibition

Author(s): Nima Rajabi, Alexander L. Nielsen, Christian A. Olsen
Published in: ACS Medicinal Chemistry Letters, 2020, ISSN 1948-5875
Publisher: American Chemical Society
DOI: 10.1021/acsmedchemlett.9b00580

Aryl Fluorosulfate Based Inhibitors that Covalently Target the SIRT5 Lysine Deacylase

Author(s): Julie Eilskov Bolding, Pablo Martin-Gago, Nima Rajabi, Luke Francis Gamon, Tobias Nørby Hansen, Christian R. O. Bartling, Kristian Strømgaard, Michael Jonathan Davies, Christian Adam Olsen
Published in: Angewandte Chemie, Issue 14337851, 2022, ISSN 1433-7851
Publisher: John Wiley & Sons Ltd.
DOI: 10.1002/anie.202204565

Investigation of Carboxylic Acid Isosteres for Inhibition of the Human SIRT5 Lysine Deacylase Enzyme

Author(s): Nima Rajabi; Alexander L. Nielsen; Tobias Nikolaj Gress Hansen; Huy T. Nguyen; Michael Bæk; Julie E. Bolding; Oskar Ørts Bahlke; Sylvester E. G. Petersen; Christian R. O. Bartling; Kristian Strømgaard; Christian A. Olsen
Published in: Angewandte Chemie International Edition, Issue 52, 2022, ISSN 1433-7851
Publisher: John Wiley & Sons Ltd.
DOI: 10.1002/anie.202115805

Chiral Posttranslational Modification to Lysine epsilon-Amino Groups

Author(s): Carlos Moreno-Yruela, Michael Bæk, Fabrizio Monda, and Christian A. Olsen
Published in: Accounts of Chemical Research, Issue 12, 2022, ISSN 0001-4842
Publisher: American Chemical Society
DOI: 10.1021/acs.accounts.2c00115

Mechanism-based inhibitors of SIRT2: structure–activity relationship, X-ray structures, target engagement, regulation of α-tubulin acetylation and inhibition of breast cancer cell migration

Author(s): Alexander L. Nielsen; Nima Rajabi; Norio Kudo; Kathrine Lundø; Carlos Moreno-Yruela; Michael Bæk; Martin Fontenas; Alessia Lucidi; Andreas S. Madsen; Minoru Yoshida; Christian A. Olsen
Published in: RSC Chemical Biology, Issue 6, 2021, ISSN 2633-0679
Publisher: Royal Society of Chemistry
DOI: 10.1039/d0cb00036a