Chemical Tools for Unravelling Sirtuin Function

Project Information

SIRFUNCT

Grant agreement ID: 725172

DOI

10.3030/725172

Project closed

EC signature date 16 March 2017

Start date 1 April 2017

End date 31 March 2022

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost

€ 1 758 742,00

EU contribution

€ 1 758 742,00

Coordinated by

KOBENHAVNS UNIVERSITET
Denmark

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Publications

Peer reviewed articles (14)

Metabolic control by sirtuins and other enzymes that sense NAD + , NADH, or their ratio.

Author(s): Anderson, Kristin A.; Madsen, Andreas S.; Olsen, Christian A.; Hirschey, Matthew D.
Published in: Biochim. Biophys. Acta Bioenergetics, Issue 2, 2017, ISSN 0005-2728
Publisher: Elsevier BV
DOI: 10.1016/j.bbabio.2017.09.005

Determination of Slow-Binding HDAC Inhibitor Potency and Subclass Selectivity

Author(s): Carlos Moreno-Yruela; Christian A. Olsen
Published in: ACS Medicinal Chemistry Letters, Issue 12, 2022, ISSN 1948-5875
Publisher: American Chemical Society
DOI: 10.1021/acsmedchemlett.1c00702

Hydroxamic acid-modified peptide microarrays for profiling isozyme-selective interactionsand inhibition of histone deacetylases

Author(s): Carlos Moreno-Yruela, Michael Bæk, Adela-Eugenie Vrsanova, Clemens Schulte, Hans M. Maric & Christian A. Olsen
Published in: Nature Communications, Issue 52, 2021, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-020-20250-9

Class I histone deacetylases (HDAC1–3) are histone lysine delactylases

Author(s): Carlos Moreno-Yruela, Di Zhang, Wei Wei, Michael Bæk, Jinjun Gao, Alexander L. Nielsen, Julie E. Bolding, Lu Yang, Samuel T. Jameson, Jiemin Wong, Christian A. Olsen, Yingming Zhao
Published in: Science Advances, Issue 52, 2022, ISSN 2375-2548
Publisher: American Association for the Advancement of Science
DOI: 10.1126/sciadv.abi6696

Mitochondria-Targeted Inhibitors of the Human SIRT3 Lysine Deacetylase

Author(s): Kathrin S. Troelsen; Michael Bæk; Alexander L. Nielsen; Andreas Stahl Madsen; Nima Rajabi; Christian A. Olsen
Published in: RSC Chemical Biology, Issue 6, 2021, ISSN 2633-0679
Publisher: Royal Society of Chemistry
DOI: 10.1039/d0cb00216j

Histone Deacetylase 11 is an ε-N-Myristoyllysine Hydrolase

Author(s): Madsen, Andreas; Olsen, Christian; Moreno-Yruela, Carlos; Galleano, Iacopo
Published in: Cell Chemical Biology, Issue 1, 2018, ISSN 2451-9448
Publisher: Cell Press
DOI: 10.1101/211839

Mechanism-Based Inhibitors of the Human Sirtuin 5 Deacylase: Structure-Activity Relationship, Biostructural, and Kinetic Insight

Author(s): Nima Rajabi, Marina Auth, Kathrin R. Troelsen, Martin Pannek, Dhaval P. Bhatt, Martin Fontenas, Matthew D. Hirschey, Clemens Steegborn, Andreas S. Madsen, Christian A. Olsen
Published in: Angewandte Chemie International Edition, Issue 56/47, 2017, Page(s) 14836-14841, ISSN 1433-7851
Publisher: John Wiley & Sons Ltd.
DOI: 10.1002/anie.201709050

Arylfluorosulfate-Based Electrophiles for Covalent Protein Labeling: A New Addition to the Arsenal

Author(s): Pablo Martín-Gago, Christian A. Olsen
Published in: Angewandte Chemie International Edition, Issue 58/4, 2019, Page(s) 957-966, ISSN 1433-7851
Publisher: John Wiley & Sons Ltd.
DOI: 10.1002/anie.201806037

Photo Cross‐Linking Probes Containing ϵ‐ N ‐Thioacyllysine and ϵ‐ N ‐Acyl‐(δ‐aza)lysine Residues

Author(s): Michael Bæk, Pablo Martín‐Gago, Jonas S. Laursen, Julie L. H. Madsen, Saswati Chakladar, Christian A. Olsen
Published in: Chemistry – A European Journal, Issue 26/17, 2020, Page(s) 3862-3869, ISSN 0947-6539
Publisher: John Wiley & Sons Ltd.
DOI: 10.1002/chem.201905338

Dethioacylation by Sirtuins 1–3: Considerations for Drug Design Using Mechanism-Based Sirtuin Inhibition

Author(s): Nima Rajabi, Alexander L. Nielsen, Christian A. Olsen
Published in: ACS Medicinal Chemistry Letters, Issue 12, 2020, ISSN 1948-5875
Publisher: American Chemical Society
DOI: 10.1021/acsmedchemlett.9b00580

Aryl Fluorosulfate Based Inhibitors that Covalently Target the SIRT5 Lysine Deacylase

Author(s): Julie Eilskov Bolding, Pablo Martin-Gago, Nima Rajabi, Luke Francis Gamon, Tobias Nørby Hansen, Christian R. O. Bartling, Kristian Strømgaard, Michael Jonathan Davies, Christian Adam Olsen
Published in: Angewandte Chemie, 2022, ISSN 1433-7851
Publisher: John Wiley & Sons Ltd.
DOI: 10.1002/anie.202204565

Investigation of Carboxylic Acid Isosteres for Inhibition of the Human SIRT5 Lysine Deacylase Enzyme

Author(s): Nima Rajabi; Alexander L. Nielsen; Tobias Nikolaj Gress Hansen; Huy T. Nguyen; Michael Bæk; Julie E. Bolding; Oskar Ørts Bahlke; Sylvester E. G. Petersen; Christian R. O. Bartling; Kristian Strømgaard; Christian A. Olsen
Published in: Angewandte Chemie International Edition, Issue 52, 2022, ISSN 1433-7851
Publisher: John Wiley & Sons Ltd.
DOI: 10.1002/anie.202115805

Chiral Posttranslational Modification to Lysine epsilon-Amino Groups

Author(s): Carlos Moreno-Yruela, Michael Bæk, Fabrizio Monda, and Christian A. Olsen
Published in: Accounts of Chemical Research, Issue 12, 2022, ISSN 0001-4842
Publisher: American Chemical Society
DOI: 10.1021/acs.accounts.2c00115

Mechanism-based inhibitors of SIRT2: structure–activity relationship, X-ray structures, target engagement, regulation of α-tubulin acetylation and inhibition of breast cancer cell migration

Author(s): Alexander L. Nielsen; Nima Rajabi; Norio Kudo; Kathrine Lundø; Carlos Moreno-Yruela; Michael Bæk; Martin Fontenas; Alessia Lucidi; Andreas S. Madsen; Minoru Yoshida; Christian A. Olsen
Published in: RSC Chemical Biology, Issue 6, 2021, ISSN 2633-0679
Publisher: Royal Society of Chemistry
DOI: 10.1039/d0cb00036a