Obiettivo We propose the development of a groundbreaking technology platform that, for the first time, integrates nuclear magnetic resonance metabolomics and micro-imaging with microfluidic perfusion tissue slice culture. This will revolutionise life science research with unprecedented local insight into life processes in intact tissues under highly controlled conditions. We focus on liver tissue slice culture, with the immediate target of elucidating the mechanism of liver damage by drug-induced cholestasis. In the long term, the new technology will find wide application in other tissues, including intestinal, pancreatic, and brain slices. It will form the foundation of a new approach in the life sciences, allowing the detailed metabolicstudy of tissues at the system level.Liver disease is a significant and growing public health problem: 29 million people currently suffer from a serious liver condition in the EU. While the causes for some liver conditions are known, the mechanism of liver damage is generally poorly understood, largely due to the difficulty of studying live liver tissue at the systemic level. The proposed comprehensive research programme leads to a new technological platform for microfluidic tissue slice culture with direct observation of tissue metabolism and transport processes through nuclear magnetic resonance.It joins the expertise and creativity of four leading academic groups and one SME representing the disciplines of micro-engineering, physical chemistry, magnetic resonance, biochemistry, toxicology, and clinical hepatology across three institutions from three EU countries. Due to its high level of interdisciplinary integration, TISuMR is uniquely able to provide emerging researchers with a career springboard.TISuMR will have a profound impact on wider society by providing alternatives to animal testing, by increasing the efficiency and specificity of drug safety testing, and by enabling new treatments in the management of liver disease. Campo scientifico natural sciencesphysical sciencesclassical mechanicsfluid mechanicsmicrofluidicsnatural sciencesphysical sciencesopticsspectroscopyabsorption spectroscopymedical and health sciencesclinical medicinehepatologynatural sciencesmathematicspure mathematicsgeometrynatural scienceschemical sciencesphysical chemistry Parole chiave Nuclear Magnetic Resonance Tissue Slice Culture Liver Pathology Programma(i) H2020-EU.1.2. - EXCELLENT SCIENCE - Future and Emerging Technologies (FET) Main Programme H2020-EU.1.2.1. - FET Open Argomento(i) FETOPEN-01-2016-2017 - FET-Open research and innovation actions Invito a presentare proposte H2020-FETOPEN-2016-2017 Vedi altri progetti per questo bando Bando secondario H2020-FETOPEN-1-2016-2017 Meccanismo di finanziamento RIA - Research and Innovation action Coordinatore UNIVERSITY OF SOUTHAMPTON Contribution nette de l'UE € 1 256 126,25 Indirizzo Highfield SO17 1BJ Southampton Regno Unito Mostra sulla mappa Regione South East (England) Hampshire and Isle of Wight Southampton Tipo di attività Higher or Secondary Education Establishments Collegamenti Contatta l’organizzazione Opens in new window Sito web Opens in new window Partecipazione a programmi di R&I dell'UE Opens in new window Rete di collaborazione HORIZON Opens in new window Costo totale € 1 256 126,25 Partecipanti (2) Classifica in ordine alfabetico Classifica per Contributo netto dell'UE Espandi tutto Riduci tutto RIJKSUNIVERSITEIT GRONINGEN Paesi Bassi Contribution nette de l'UE € 935 121,25 Indirizzo Broerstraat 5 9712CP Groningen Mostra sulla mappa Regione Noord-Nederland Groningen Overig Groningen Tipo di attività Higher or Secondary Education Establishments Collegamenti Contatta l’organizzazione Opens in new window Sito web Opens in new window Partecipazione a programmi di R&I dell'UE Opens in new window Rete di collaborazione HORIZON Opens in new window Costo totale € 935 121,25 KARLSRUHER INSTITUT FUER TECHNOLOGIE Germania Contribution nette de l'UE € 947 185,00 Indirizzo KAISERSTRASSE 12 76131 Karlsruhe Mostra sulla mappa Regione Baden-Württemberg Karlsruhe Karlsruhe, Stadtkreis Tipo di attività Higher or Secondary Education Establishments Collegamenti Contatta l’organizzazione Opens in new window Sito web Opens in new window Partecipazione a programmi di R&I dell'UE Opens in new window Rete di collaborazione HORIZON Opens in new window Costo totale € 947 185,00