An Integrated Heart Model for the simulation of the cardiac function

Publications

A Multiscale Poromechanics Model Integrating Myocardial Perfusion and the Epicardial Coronary Vessels

Author(s): Nicolás Alejandro Barnafi Wittwer; Simone Di Gregorio; Luca Dede'; Paolo Zunino; Christian Vergara; Alfio Quarteroni
Published in: SIAM Journal on Applied Mathematics, Issue Vol. 82, Iss. 4 (2022), 2022, ISSN 0036-1399
Publisher: Society for Industrial and Applied Mathematics
DOI: 10.1137/21m1424482

Iterative splitting schemes for a soft material poromechanics model

Author(s): Jakub Wiktor Both; Nicolas A. Barnafi; Nicolas A. Barnafi; Florin Adrian Radu; Paolo Zunino; Alfio Quarteroni
Published in: Computer Methods in Applied Mechanics and Engineering, Issue 1, 2022, ISSN 0045-7825
Publisher: Elsevier BV
DOI: 10.1016/j.cma.2021.114183

An oscillation-free fully staggered algorithm for velocity-dependent active models of cardiac mechanics

Author(s): F. Regazzoni, A. Quarteroni
Published in: Computer Methods in Applied Mechanics and Engineering, Issue Volume 373, 1 January 2021, 113506, 2021, ISSN 0045-7825
Publisher: Elsevier BV
DOI: 10.1016/j.cma.2020.113506

Integration of activation maps of epicardial veins in computational cardiac electrophysiology

Author(s): Simone Stella; Christian Vergara; Massimiliano Maines; Domenico Catanzariti; Pasquale Claudio Africa; Cristina Dematte; Maurizio Centonze; Fabio Nobile; Maurizio Del Greco; Alfio Quarteroni; Alfio Quarteroni
Published in: Computers in Biology and Medicine, Issue Volume 127, December 2020, 104047, 2020, ISSN 0010-4825
Publisher: Pergamon Press Ltd.
DOI: 10.1016/j.compbiomed.2020.104047

3D–0D closed-loop model for the simulation of cardiac biventricular electromechanics

Author(s): Roberto Piersanti; Francesco Regazzoni; Matteo Salvador; Antonio F. Corno; Luca Dede’; Christian Vergara; Alfio Quarteroni
Published in: Computer Methods in Applied Mechanics and Engineering, 2022, ISSN 0045-7825
Publisher: Elsevier BV
DOI: 10.1016/j.cma.2022.114607

A physics-informed multi-fidelity approach for the estimation of differential equations parameters in low-data or large-noise regimes

Author(s): Regazzoni, Francesco; Pagani, Stefano; Cosenza, Alessandro; Lombardi, Alessandro; Quarteroni, Alfio
Published in: Rendiconti Lincei. Matematica e Applicazioni, Issue Atti Accad. Naz. Lincei Cl. Sci. Fis. Mat. Natur. 32 (2021), no. 3, 2021, Page(s) 437–470, ISSN 1120-6330
Publisher: Accademia Nazionale dei Lincei
DOI: 10.4171/rlm/943

Electromechanical modeling of human ventricles with ischemic cardiomyopathy: numerical simulations in sinus rhythm and under arrhythmia

Author(s): Matteo Salvador; Marco Fedele; Pasquale Claudio Africa; Eric Sung; Luca Dedè; Adityo Prakosa; Jonathan Chrispin; Natalia A. Trayanova; Alfio Quarteroni
Published in: Computers in Biology and Medicine, Issue 4, 2021, ISSN 0010-4825
Publisher: Pergamon Press Ltd.
DOI: 10.1016/j.compbiomed.2021.104674

Computational electrophysiology of the coronary sinus branches based on electro-anatomical mapping for the prediction of the latest activated region

Author(s): Vergara C., Stella S., Maines M., Africa P.C., Catanzariti D., Dematte' C., Centonze M., Nobile F., Quarteroni A., Del Greco M.,
Published in: Medical & Biological Engineering & Computing, Issue 60, 2022, Page(s) 2307-2319, ISSN 0140-0118
Publisher: Institute of Electrical Engineers
DOI: 10.1007/s11517-022-02610-3

Mathematical analysis and numerical approximation of a general linearized poro-hyperelastic model

Author(s): Nicolás Barnafi, Paolo Zunino, Luca Dedè, Alfio Quarteroni
Published in: Computers & Mathematics with Applications, 2020, Page(s) 1-27, ISSN 0898-1221
Publisher: Pergamon Press Ltd.
DOI: 10.1016/j.camwa.2020.07.025

Projection-based reduced order models for parameterized nonlinear time-dependent problems arising in cardiac mechanics

Author(s): Cicci, Ludovica; Fresca, Stefania; Pagani, Stefano; Manzoni, Andrea; Quarteroni, Alfio
Published in: Mathematics in Engineering, Issue 2023, Volume 5, Issue 2, 2023, Page(s) 1-38, ISSN 2640-3501
Publisher: AIMS press
DOI: 10.3934/mine.2023026

Image-Based Computational Hemodynamics Analysis of Systolic Obstruction in Hypertrophic Cardiomyopathy

Author(s): Ivan Fumagalli; Piermario Vitullo; Christian Vergara; Marco Fedele; Antonio F. Corno; Sonia Ippolito; Roberto Scrofani; Alfio Quarteroni; Alfio Quarteroni
Published in: Frontiers in Physiology, 2022, ISSN 1664-042X
Publisher: Frontiers Research Foundation
DOI: 10.3389/fphys.2021.787082

Data integration for the numerical simulation of cardiac electrophysiology.

Author(s): Stefano Pagani; Luca Dedè; Andrea Manzoni; Alfio Quarteroni; Alfio Quarteroni
Published in: Pacing and Clinical Electrophysiology, Issue 5, 2021, ISSN 0147-8389
Publisher: Blackwell Publishing Inc.
DOI: 10.1111/pace.14198

A comprehensive and biophysically detailed computational model of the whole human heart electromechanics

Author(s): Fedele, Marco; Piersanti, Roberto; Regazzoni, Francesco; Salvador, Matteo; Africa, Pasquale; Bucelli, Michele; Zingaro, Alberto; Dede', Luca; Quarteroni, Alfio
Published in: Computer Methods in Applied Mechanics and Engineering, Issue Volume 410, 15 May 2023, 2023, ISSN 0045-7825
Publisher: Elsevier BV
DOI: 10.1016/j.cma.2023.115983

Hemodynamics of the heart's left atrium based on a Variational Multiscale-LES numerical method

Author(s): Alberto Zingaro; Luca Dede'; F. Menghini; Alfio Quarteroni; Alfio Quarteroni
Published in: European Journal of Mechanics - B/Fluids, Issue Volume 89, September–October 2021, 2021, Page(s) 380-400, ISSN 0997-7546
Publisher: Elsevier BV
DOI: 10.1016/j.euromechflu.2021.06.014

A Computational Study of the Electrophysiological Substrate in Patients Suffering From Atrial Fibrillation

Author(s): Pagani, S.; Dede', L.; Frontera, A.; Salvador, M.; Limite, L. R.; Manzoni, A.; Lipartiti, F.; Tsitsinakis, G.; Hadjis, A.; Della Bella, P.; Quarteroni, A.
Published in: Frontiers in Physiology, Issue vol. 10, 2021, ISSN 1664-042X
Publisher: Frontiers Research Foundation
DOI: 10.3389/fphys.2021.673612

Active Force Generation in Cardiac Muscle Cells: Mathematical Modeling and Numerical Simulation of the Actin-Myosin Interaction

Author(s): Francesco Regazzoni, Luca Dedè, Alfio Quarteroni
Published in: Vietnam Journal of Mathematics, 2020, ISSN 2305-221X
Publisher: Springer Science + Business Media
DOI: 10.1007/s10013-020-00433-z

POD-Enhanced Deep Learning-Based Reduced Order Models for the Real-Time Simulation of Cardiac Electrophysiology in the Left Atrium.

Author(s): Stefania Fresca; Andrea Manzoni; Luca Dedè; Alfio Quarteroni; Alfio Quarteroni
Published in: Frontiers in Physiology, Issue 6, 2021, ISSN 1664-042X
Publisher: Frontiers Research Foundation
DOI: 10.3389/fphys.2021.679076

Multipatch Isogeometric Analysis for electrophysiology: Simulation in a human heart

Author(s): Michele Bucelli, Matteo Salvador, Luca Dedè, Alfio Quarteroni
Published in: Computer Methods in Applied Mechanics and Engineering, Issue Volume 376, 1 April 2021, 2021, Page(s) 113666, ISSN 0045-7825
Publisher: Elsevier BV
DOI: 10.1016/j.cma.2021.113666

Polygonal surface processing and mesh generation tools for the numerical simulation of the cardiac function

Author(s): Marco Fedele, Alfio Quarteroni
Published in: International Journal for Numerical Methods in Biomedical Engineering, 2021, ISSN 2040-7947
Publisher: John Wiley & Sons Ltd
DOI: 10.1002/cnm.3435

Enabling forward uncertainty quantification and sensitivity analysis in cardiac electrophysiology by reduced order modeling and machine learning.

Author(s): Stefano Pagani; Andrea Manzoni
Published in: International Journal for Numerical Methods in Biomedical Engineering, 2021, ISSN 2040-7947
Publisher: John Wiley & Sons Ltd
DOI: 10.1002/cnm.3450

Deep learning-based reduced order models in cardiac electrophysiology

Author(s): Fresca, S.; Manzoni, A.; Dedè, L.; Quarteroni, A.
Published in: PLOS One, Issue 15, 10, 2020, ISSN 1932-6203
Publisher: Public Library of Science
DOI: 10.1371/journal.pone.0239416

A computational model applied to myocardial perfusion in the human heart: From large coronaries to microvasculature

Author(s): Di Gregorio Simone, Fedele Marco, Pontone Gianluca, Corno,Antonio, Zunino Paolo, Vergara Christian, Quarteroni Alfio
Published in: JOURNAL OF COMPUTATIONAL PHYSICS, Issue 424, 2021, Page(s) 109836-109859, ISSN 0021-9991
Publisher: Academic Press
DOI: 10.1016/j.jcp.2020.109836

PDE-Aware Deep Learning for Inverse Problems in Cardiac Electrophysiology

Author(s): Riccardo Tenderini; Stefano Pagani; Alfio Quarteroni; Simone Deparis
Published in: SIAM Journal on Scientific Computing, Issue Vol. 44, Iss. 3 (2022), 2022, ISSN 1064-8275
Publisher: Society for Industrial and Applied Mathematics
DOI: 10.1137/21m1438529

Fluid-structure interaction analysis of transcatheter aortic valve implantation

Author(s): Fumagalli, Ivan; Polidori, Rebecca; Renzi, Francesca; Fusini, Laura; Quarteroni, Alfio; Pontone, Gianluca; Vergara, Christian
Published in: International Journal for Numerical Methods in Biomedical Engineering, Issue e3704, 2023, ISSN 2040-7947
Publisher: Wiley
DOI: 10.1002/cnm.3704

An image-based computational hemodynamics study of the Systolic Anterior Motion of the mitral valve

Author(s): Ivan Fumagalli, Marco Fedele, Christian Vergara, Luca Dedè, Sonia Ippolito, Francesca Nicolò, Carlo Antona, Roberto Scrofani, Alfio Quarteroni
Published in: Computers in Biology and Medicine, Issue Volume 123, August 2020, 103922, 2020, ISSN 0010-4825
Publisher: Pergamon Press Ltd.
DOI: 10.1016/j.compbiomed.2020.103922

lifex: A flexible, high performance library for the numerical solution of complex finite element problems

Author(s): Pasquale Claudio Africa
Published in: SoftwareX, Issue vol. 23 (2023), 2023, ISSN 2352-7110
Publisher: Elsevier
DOI: 10.1016/j.softx.2022.101252

A machine learning method for real-time numerical simulations of cardiac electromechanics

Author(s): F. Regazzoni; M. Salvador; L. Dede’; A. Quarteroni
Published in: COMPUTER METHODS IN APPLIED MECHANICS AND ENGINEERING, 2022, ISSN 0045-7825
Publisher: Elsevier BV
DOI: 10.1016/j.cma.2022.114825

The role of mechano-electric feedbacks and hemodynamic coupling in scar-related ventricular tachycardia

Author(s): Matteo Salvador; Francesco Regazzoni; Stefano Pagani; Luca Dede'; Natalia Trayanova; Alfio Quarteroni
Published in: Computers in Biology and Medicine, Issue 6, 2022, ISSN 0010-4825
Publisher: Pergamon Press Ltd.
DOI: 10.1016/j.compbiomed.2021.105203

Partitioned and monolithic algorithms for the numerical solution of cardiac fluid-structure interaction

Author(s): Michele Bucelli, Luca Dede', Alfio Quarteroni, Christian Vergara
Published in: Communications in Computational Physics, Issue 32 (2022), 2022, Page(s) 1217-1256, ISSN 1815-2406
Publisher: Global Science Press
DOI: 10.4208/cicp.oa-2021-0243

lifex-fiber: an open tool for myofibers generation in cardiac computational models

Author(s): Pasquale Claudio Africa, Roberto Piersanti, Marco Fedele, Luca Dede’ , Alfio Quarteroni
Published in: BMC Bioinformatics, Issue 24 (1):143, 2023, ISSN 1471-2105
Publisher: BioMed Central
DOI: 10.1186/s12859-023-05260-w

A mathematical model that integrates cardiac electrophysiology, mechanics and fluid dynamics: application to the human left heart

Author(s): Michele Bucelli; Alberto Zingaro; Pasquale Claudio Africa; Ivan Fumagalli; Luca Dede'; Alfio Quarteroni
Published in: International Journal for Numerical Methods in Biomedical Engineering, Issue 1, 2023, Page(s) Volume39, Issue3, March 2023, e3678, ISSN 2040-7947
Publisher: Wiley
DOI: 10.1002/cnm.3678

The Impact of Left Atrium Appendage Morphology on Stroke Risk Assessment in Atrial Fibrillation: A Computational Fluid Dynamics Study

Author(s): Alessandro Masci, Lorenzo Barone, Luca Dedè, Marco Fedele, Corrado Tomasi, Alfio Quarteroni, Cristiana Corsi
Published in: Frontiers in Physiology, Issue 9, 2019, ISSN 1664-042X
Publisher: Frontiers Research Foundation
DOI: 10.3389/fphys.2018.01938

Isogeometric Analysis of the electrophysiology in the human heart: Numerical simulation of the bidomain equations on the atria

Author(s): Luca Pegolotti, Luca Dedè, Alfio Quarteroni
Published in: Computer Methods in Applied Mechanics and Engineering, Issue 343, 2019, Page(s) 52-73, ISSN 0045-7825
Publisher: Elsevier BV
DOI: 10.1016/j.cma.2018.08.032

A transmurally heterogeneous orthotropic activation model for ventricular contraction and its numerical validation

Author(s): Luca Barbarotta, Simone Rossi, Luca Dedè, Alfio Quarteroni
Published in: International Journal for Numerical Methods in Biomedical Engineering, Issue 34/12, 2018, Page(s) e3137, ISSN 2040-7939
Publisher: John Wiley & Sons Ltd.
DOI: 10.1002/cnm.3137

A monolithic algorithm for the simulation of cardiac electromechanics in the human left ventricle

Author(s): Antonello Gerbi, Luca Dede’, Alfio Quarteroni
Published in: Mathematics in Engineering, Issue 1/1, 2018, Page(s) 1-37, ISSN 2640-3501
Publisher: AIMS Press
DOI: 10.3934/mine.2018.1.1

Numerical approximation of parametrized problems in cardiac electrophysiology by a local reduced basis method

Author(s): Stefano Pagani, Andrea Manzoni, Alfio Quarteroni
Published in: Computer Methods in Applied Mechanics and Engineering, Issue 340, 2018, Page(s) 530-558, ISSN 0045-7825
Publisher: Elsevier BV
DOI: 10.1016/j.cma.2018.06.003

Biophysically detailed mathematical models of multiscale cardiac active mechanics

Author(s): Francesco Regazzoni, Luca Dedè, Alfio Quarteroni
Published in: PLOS Computational Biology, 2020, ISSN 1553-734X
Publisher: Public Library of Science

Computational fluid dynamics of blood flow in an idealized left human heart

Author(s): Luca Dedè, Filippo Menghini, Alfio Quarteroni
Published in: International Journal for Numerical Methods in Biomedical Engineering, 2019, ISSN 2040-7939
Publisher: John Wiley & Sons Ltd.
DOI: 10.1002/cnm.3287

An intergrid transfer operator using radial basis functions with application to cardiac electromechanics

Author(s): Matteo Salvador, Luca Dede', Alfio Quarteroni
Published in: Computational Mechanics, Issue Volume 66, Issue 1, July 2020, 2020, ISSN 0178-7675
Publisher: Springer Verlag

Machine learning of multiscale active force generation models for the efficient simulation of cardiac electromechanics

Author(s): F. Regazzoni, L. Dedè, A. Quarteroni
Published in: Computer Methods in Applied Mechanics and Engineering, Issue 370, 2020, Page(s) 113268, ISSN 0045-7825
Publisher: Elsevier BV
DOI: 10.1016/j.cma.2020.113268

Mathematical and numerical models for the cardiac electromechanical function

Author(s): Luca Dedè; Alfio Quarteroni; Francesco Regazzoni
Published in: Atti Accademia Nazionale dei Lincei, Issue Classe Scienze Fisiche Matematiche Naturali 32 (2021), no. 2, 2021, Page(s) 233-272, ISSN 1120-6330
Publisher: Accademia Nazionale dei Lincei
DOI: 10.4171/rlm/935

Modeling the cardiac electromechanical function: A mathematical journey

Author(s): Alfio Quarteroni; Luca Dedè; Francesco Regazzoni
Published in: Bulletin of the American Mathematical Society, Issue 59 (2022), 2022, Page(s) 371-403, ISSN 0273-0979
Publisher: American Mathematical Society
DOI: 10.1090/bull/1738

A stable loosely-coupled scheme for cardiac electro-fluid-structure interaction

Author(s): Michele Bucelli , Martin Geraint Gabriel , Alfio Quarteroni , Giacomo Gigante , Christian Vergara
Published in: Journal of Computational Physics, Issue Volume 490, 1 October 2023, 112326, 2023, ISSN 0021-9991
Publisher: Academic Press
DOI: 10.1016/j.jcp.2023.112326

Deep-HyROMnet: A Deep Learning-Based Operator Approximation for Hyper-Reduction of Nonlinear Parametrized PDEs

Author(s): Cicci, Ludovica; Fresca, Stefania; Manzoni, Andrea
Published in: Journal of Scientific Computing, Issue 93, Article number: 57 (2022), 2022, ISSN 0885-7474
Publisher: Kluwer Academic/Plenum Publishers
DOI: 10.1007/s10915-022-02001-8

Efficient and certified solution of parametrized one-way coupled problems through DEIM-based data projection across non-conforming interfaces

Author(s): Elena Zappon, Andrea Manzoni, Alfio Quarteroni
Published in: Advances in Computational Mathematics, Issue 49, 21, 2023, ISSN 1019-7168
Publisher: Kluwer Academic Publishers
DOI: 10.48550/arxiv.2203.09226

A cardiac electromechanical model coupled with a lumped-parameter model for closed-loop blood circulation

Author(s): F. Regazzoni; M. Salvador; P.C. Africa; M. Fedele; L. Dedè; A. Quarteroni
Published in: Journal of Computational Physics, Issue 4, 2022, ISSN 0021-9991
Publisher: Academic Press
DOI: 10.1016/j.jcp.2022.111083

Modeling cardiac muscle fibers in ventricular and atrial electrophysiology simulations

Author(s): Roberto Piersanti, Pasquale C. Africa, Marco Fedele, Christian Vergara, Luca Dedè, Antonio F. Corno, Alfio Quarteroni
Published in: Computer Methods in Applied Mechanics and Engineering, Issue 373, 2021, Page(s) 113468, ISSN 0045-7825
Publisher: Elsevier BV
DOI: 10.1016/j.cma.2020.113468

A geometric multiscale model for the numerical simulation of blood flow in the human left heart

Author(s): Alberto Zingaro; Ivan Fumagalli; Luca Dede; Marco Fedele; Pasquale C. Africa; Antonio F. Corno; Alfio Quarteroni
Published in: Discrete and Continuous Dynamical Systems - Series S, Issue 5, 2022, ISSN 1937-1632
Publisher: American Institute of Mathematical Sciences
DOI: 10.3934/dcdss.2022052

Segregated algorithms for the numerical simulation of cardiac electromechanics in the left human ventricle

Author(s): L. Dede', A. Gerbi, A. Quarteroni
Published in: The Mathematics of Mechanobiology, 2020, Page(s) 81--116, ISBN 978-3-030-45196-7
Publisher: Springer Verlag
DOI: 10.1007/978-3-030-45197-4_3

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