An Integrated Heart Model for the simulation of the cardiac function

Project Information

iHEART

Grant agreement ID: 740132

DOI

10.3030/740132

Project closed

EC signature date 17 May 2017

Start date 1 December 2017

End date 31 May 2023

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost

€ 2 351 544,00

EU contribution

€ 2 351 544,00

Coordinated by

POLITECNICO DI MILANO
Italy

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Publications

Peer reviewed articles (48)

A Multiscale Poromechanics Model Integrating Myocardial Perfusion and the Epicardial Coronary Vessels

Author(s): Nicolás Alejandro Barnafi Wittwer; Simone Di Gregorio; Luca Dede'; Paolo Zunino; Christian Vergara; Alfio Quarteroni
Published in: SIAM Journal on Applied Mathematics, Issue Vol. 82, Iss. 4 (2022), 2022, ISSN 0036-1399
Publisher: Society for Industrial and Applied Mathematics
DOI: 10.1137/21m1424482

Iterative splitting schemes for a soft material poromechanics model

Author(s): Jakub Wiktor Both; Nicolas A. Barnafi; Nicolas A. Barnafi; Florin Adrian Radu; Paolo Zunino; Alfio Quarteroni
Published in: Computer Methods in Applied Mechanics and Engineering, Issue 1, 2022, ISSN 0045-7825
Publisher: Elsevier BV
DOI: 10.1016/j.cma.2021.114183

An oscillation-free fully staggered algorithm for velocity-dependent active models of cardiac mechanics

Author(s): F. Regazzoni, A. Quarteroni
Published in: Computer Methods in Applied Mechanics and Engineering, Issue Volume 373, 1 January 2021, 113506, 2021, ISSN 0045-7825
Publisher: Elsevier BV
DOI: 10.1016/j.cma.2020.113506

Integration of activation maps of epicardial veins in computational cardiac electrophysiology

Author(s): Simone Stella; Christian Vergara; Massimiliano Maines; Domenico Catanzariti; Pasquale Claudio Africa; Cristina Dematte; Maurizio Centonze; Fabio Nobile; Maurizio Del Greco; Alfio Quarteroni; Alfio Quarteroni
Published in: Computers in Biology and Medicine, Issue Volume 127, December 2020, 104047, 2020, ISSN 0010-4825
Publisher: Pergamon Press Ltd.
DOI: 10.1016/j.compbiomed.2020.104047

3D–0D closed-loop model for the simulation of cardiac biventricular electromechanics

Author(s): Roberto Piersanti; Francesco Regazzoni; Matteo Salvador; Antonio F. Corno; Luca Dede’; Christian Vergara; Alfio Quarteroni
Published in: Computer Methods in Applied Mechanics and Engineering, 2022, ISSN 0045-7825
Publisher: Elsevier BV
DOI: 10.1016/j.cma.2022.114607

A physics-informed multi-fidelity approach for the estimation of differential equations parameters in low-data or large-noise regimes

Author(s): Regazzoni, Francesco; Pagani, Stefano; Cosenza, Alessandro; Lombardi, Alessandro; Quarteroni, Alfio
Published in: Rendiconti Lincei. Matematica e Applicazioni, Issue Atti Accad. Naz. Lincei Cl. Sci. Fis. Mat. Natur. 32 (2021), no. 3, 2021, Page(s) 437–470, ISSN 1120-6330
Publisher: Accademia Nazionale dei Lincei
DOI: 10.4171/rlm/943

Electromechanical modeling of human ventricles with ischemic cardiomyopathy: numerical simulations in sinus rhythm and under arrhythmia

Author(s): Matteo Salvador; Marco Fedele; Pasquale Claudio Africa; Eric Sung; Luca Dedè; Adityo Prakosa; Jonathan Chrispin; Natalia A. Trayanova; Alfio Quarteroni
Published in: Computers in Biology and Medicine, Issue 4, 2021, ISSN 0010-4825
Publisher: Pergamon Press Ltd.
DOI: 10.1016/j.compbiomed.2021.104674

Computational electrophysiology of the coronary sinus branches based on electro-anatomical mapping for the prediction of the latest activated region

Author(s): Vergara C., Stella S., Maines M., Africa P.C., Catanzariti D., Dematte' C., Centonze M., Nobile F., Quarteroni A., Del Greco M.,
Published in: Medical & Biological Engineering & Computing, Issue 60, 2022, Page(s) 2307-2319, ISSN 0140-0118
Publisher: Institute of Electrical Engineers
DOI: 10.1007/s11517-022-02610-3

Mathematical analysis and numerical approximation of a general linearized poro-hyperelastic model

Author(s): Nicolás Barnafi, Paolo Zunino, Luca Dedè, Alfio Quarteroni
Published in: Computers & Mathematics with Applications, 2020, Page(s) 1-27, ISSN 0898-1221
Publisher: Pergamon Press Ltd.
DOI: 10.1016/j.camwa.2020.07.025

Projection-based reduced order models for parameterized nonlinear time-dependent problems arising in cardiac mechanics

Author(s): Cicci, Ludovica; Fresca, Stefania; Pagani, Stefano; Manzoni, Andrea; Quarteroni, Alfio
Published in: Mathematics in Engineering, Issue 2023, Volume 5, Issue 2, 2023, Page(s) 1-38, ISSN 2640-3501
Publisher: AIMS press
DOI: 10.3934/mine.2023026

Image-Based Computational Hemodynamics Analysis of Systolic Obstruction in Hypertrophic Cardiomyopathy

Author(s): Ivan Fumagalli; Piermario Vitullo; Christian Vergara; Marco Fedele; Antonio F. Corno; Sonia Ippolito; Roberto Scrofani; Alfio Quarteroni; Alfio Quarteroni
Published in: Frontiers in Physiology, 2022, ISSN 1664-042X
Publisher: Frontiers Research Foundation
DOI: 10.3389/fphys.2021.787082

Data integration for the numerical simulation of cardiac electrophysiology.

Author(s): Stefano Pagani; Luca Dedè; Andrea Manzoni; Alfio Quarteroni; Alfio Quarteroni
Published in: Pacing and Clinical Electrophysiology, Issue 5, 2021, ISSN 0147-8389
Publisher: Blackwell Publishing Inc.
DOI: 10.1111/pace.14198

A comprehensive and biophysically detailed computational model of the whole human heart electromechanics

Author(s): Fedele, Marco; Piersanti, Roberto; Regazzoni, Francesco; Salvador, Matteo; Africa, Pasquale; Bucelli, Michele; Zingaro, Alberto; Dede', Luca; Quarteroni, Alfio
Published in: Computer Methods in Applied Mechanics and Engineering, Issue Volume 410, 15 May 2023, 2023, ISSN 0045-7825
Publisher: Elsevier BV
DOI: 10.1016/j.cma.2023.115983

Hemodynamics of the heart's left atrium based on a Variational Multiscale-LES numerical method

Author(s): Alberto Zingaro; Luca Dede'; F. Menghini; Alfio Quarteroni; Alfio Quarteroni
Published in: European Journal of Mechanics - B/Fluids, Issue Volume 89, September–October 2021, 2021, Page(s) 380-400, ISSN 0997-7546
Publisher: Elsevier BV
DOI: 10.1016/j.euromechflu.2021.06.014

A Computational Study of the Electrophysiological Substrate in Patients Suffering From Atrial Fibrillation

Author(s): Pagani, S.; Dede', L.; Frontera, A.; Salvador, M.; Limite, L. R.; Manzoni, A.; Lipartiti, F.; Tsitsinakis, G.; Hadjis, A.; Della Bella, P.; Quarteroni, A.
Published in: Frontiers in Physiology, Issue vol. 10, 2021, ISSN 1664-042X
Publisher: Frontiers Research Foundation
DOI: 10.3389/fphys.2021.673612

Active Force Generation in Cardiac Muscle Cells: Mathematical Modeling and Numerical Simulation of the Actin-Myosin Interaction

Author(s): Francesco Regazzoni, Luca Dedè, Alfio Quarteroni
Published in: Vietnam Journal of Mathematics, 2020, ISSN 2305-221X
Publisher: Springer Science + Business Media
DOI: 10.1007/s10013-020-00433-z

POD-Enhanced Deep Learning-Based Reduced Order Models for the Real-Time Simulation of Cardiac Electrophysiology in the Left Atrium.

Author(s): Stefania Fresca; Andrea Manzoni; Luca Dedè; Alfio Quarteroni; Alfio Quarteroni
Published in: Frontiers in Physiology, Issue 6, 2021, ISSN 1664-042X
Publisher: Frontiers Research Foundation
DOI: 10.3389/fphys.2021.679076

Multipatch Isogeometric Analysis for electrophysiology: Simulation in a human heart

Author(s): Michele Bucelli, Matteo Salvador, Luca Dedè, Alfio Quarteroni
Published in: Computer Methods in Applied Mechanics and Engineering, Issue Volume 376, 1 April 2021, 2021, Page(s) 113666, ISSN 0045-7825
Publisher: Elsevier BV
DOI: 10.1016/j.cma.2021.113666

Polygonal surface processing and mesh generation tools for the numerical simulation of the cardiac function

Author(s): Marco Fedele, Alfio Quarteroni
Published in: International Journal for Numerical Methods in Biomedical Engineering, 2021, ISSN 2040-7947
Publisher: John Wiley & Sons Ltd
DOI: 10.1002/cnm.3435

Enabling forward uncertainty quantification and sensitivity analysis in cardiac electrophysiology by reduced order modeling and machine learning.

Author(s): Stefano Pagani; Andrea Manzoni
Published in: International Journal for Numerical Methods in Biomedical Engineering, 2021, ISSN 2040-7947
Publisher: John Wiley & Sons Ltd
DOI: 10.1002/cnm.3450

Deep learning-based reduced order models in cardiac electrophysiology

Author(s): Fresca, S.; Manzoni, A.; Dedè, L.; Quarteroni, A.
Published in: PLOS One, Issue 15, 10, 2020, ISSN 1932-6203
Publisher: Public Library of Science
DOI: 10.1371/journal.pone.0239416

A computational model applied to myocardial perfusion in the human heart: From large coronaries to microvasculature

Author(s): Di Gregorio Simone, Fedele Marco, Pontone Gianluca, Corno,Antonio, Zunino Paolo, Vergara Christian, Quarteroni Alfio
Published in: JOURNAL OF COMPUTATIONAL PHYSICS, Issue 424, 2021, Page(s) 109836-109859, ISSN 0021-9991
Publisher: Academic Press
DOI: 10.1016/j.jcp.2020.109836

PDE-Aware Deep Learning for Inverse Problems in Cardiac Electrophysiology

Author(s): Riccardo Tenderini; Stefano Pagani; Alfio Quarteroni; Simone Deparis
Published in: SIAM Journal on Scientific Computing, Issue Vol. 44, Iss. 3 (2022), 2022, ISSN 1064-8275
Publisher: Society for Industrial and Applied Mathematics
DOI: 10.1137/21m1438529

Fluid-structure interaction analysis of transcatheter aortic valve implantation

Author(s): Fumagalli, Ivan; Polidori, Rebecca; Renzi, Francesca; Fusini, Laura; Quarteroni, Alfio; Pontone, Gianluca; Vergara, Christian
Published in: International Journal for Numerical Methods in Biomedical Engineering, Issue e3704, 2023, ISSN 2040-7947
Publisher: Wiley
DOI: 10.1002/cnm.3704

An image-based computational hemodynamics study of the Systolic Anterior Motion of the mitral valve

Author(s): Ivan Fumagalli, Marco Fedele, Christian Vergara, Luca Dedè, Sonia Ippolito, Francesca Nicolò, Carlo Antona, Roberto Scrofani, Alfio Quarteroni
Published in: Computers in Biology and Medicine, Issue Volume 123, August 2020, 103922, 2020, ISSN 0010-4825
Publisher: Pergamon Press Ltd.
DOI: 10.1016/j.compbiomed.2020.103922

lifex: A flexible, high performance library for the numerical solution of complex finite element problems

Author(s): Pasquale Claudio Africa
Published in: SoftwareX, Issue vol. 23 (2023), 2023, ISSN 2352-7110
Publisher: Elsevier
DOI: 10.1016/j.softx.2022.101252

A machine learning method for real-time numerical simulations of cardiac electromechanics

Author(s): F. Regazzoni; M. Salvador; L. Dede’; A. Quarteroni
Published in: COMPUTER METHODS IN APPLIED MECHANICS AND ENGINEERING, 2022, ISSN 0045-7825
Publisher: Elsevier BV
DOI: 10.1016/j.cma.2022.114825

The role of mechano-electric feedbacks and hemodynamic coupling in scar-related ventricular tachycardia

Author(s): Matteo Salvador; Francesco Regazzoni; Stefano Pagani; Luca Dede'; Natalia Trayanova; Alfio Quarteroni
Published in: Computers in Biology and Medicine, Issue 6, 2022, ISSN 0010-4825
Publisher: Pergamon Press Ltd.
DOI: 10.1016/j.compbiomed.2021.105203

Partitioned and monolithic algorithms for the numerical solution of cardiac fluid-structure interaction

Author(s): Michele Bucelli, Luca Dede', Alfio Quarteroni, Christian Vergara
Published in: Communications in Computational Physics, Issue 32 (2022), 2022, Page(s) 1217-1256, ISSN 1815-2406
Publisher: Global Science Press
DOI: 10.4208/cicp.oa-2021-0243

lifex-fiber: an open tool for myofibers generation in cardiac computational models

Author(s): Pasquale Claudio Africa, Roberto Piersanti, Marco Fedele, Luca Dede’ , Alfio Quarteroni
Published in: BMC Bioinformatics, Issue 24 (1):143, 2023, ISSN 1471-2105
Publisher: BioMed Central
DOI: 10.1186/s12859-023-05260-w

A mathematical model that integrates cardiac electrophysiology, mechanics and fluid dynamics: application to the human left heart

Author(s): Michele Bucelli; Alberto Zingaro; Pasquale Claudio Africa; Ivan Fumagalli; Luca Dede'; Alfio Quarteroni
Published in: International Journal for Numerical Methods in Biomedical Engineering, Issue 1, 2023, Page(s) Volume39, Issue3, March 2023, e3678, ISSN 2040-7947
Publisher: Wiley
DOI: 10.1002/cnm.3678

The Impact of Left Atrium Appendage Morphology on Stroke Risk Assessment in Atrial Fibrillation: A Computational Fluid Dynamics Study

Author(s): Alessandro Masci, Lorenzo Barone, Luca Dedè, Marco Fedele, Corrado Tomasi, Alfio Quarteroni, Cristiana Corsi
Published in: Frontiers in Physiology, Issue 9, 2019, ISSN 1664-042X
Publisher: Frontiers Research Foundation
DOI: 10.3389/fphys.2018.01938

Isogeometric Analysis of the electrophysiology in the human heart: Numerical simulation of the bidomain equations on the atria

Author(s): Luca Pegolotti, Luca Dedè, Alfio Quarteroni
Published in: Computer Methods in Applied Mechanics and Engineering, Issue 343, 2019, Page(s) 52-73, ISSN 0045-7825
Publisher: Elsevier BV
DOI: 10.1016/j.cma.2018.08.032

A transmurally heterogeneous orthotropic activation model for ventricular contraction and its numerical validation

Author(s): Luca Barbarotta, Simone Rossi, Luca Dedè, Alfio Quarteroni
Published in: International Journal for Numerical Methods in Biomedical Engineering, Issue 34/12, 2018, Page(s) e3137, ISSN 2040-7939
Publisher: John Wiley & Sons Ltd.
DOI: 10.1002/cnm.3137

A monolithic algorithm for the simulation of cardiac electromechanics in the human left ventricle

Author(s): Antonello Gerbi, Luca Dede’, Alfio Quarteroni
Published in: Mathematics in Engineering, Issue 1/1, 2018, Page(s) 1-37, ISSN 2640-3501
Publisher: AIMS Press
DOI: 10.3934/mine.2018.1.1

Numerical approximation of parametrized problems in cardiac electrophysiology by a local reduced basis method

Author(s): Stefano Pagani, Andrea Manzoni, Alfio Quarteroni
Published in: Computer Methods in Applied Mechanics and Engineering, Issue 340, 2018, Page(s) 530-558, ISSN 0045-7825
Publisher: Elsevier BV
DOI: 10.1016/j.cma.2018.06.003

Biophysically detailed mathematical models of multiscale cardiac active mechanics

Author(s): Francesco Regazzoni, Luca Dedè, Alfio Quarteroni
Published in: PLOS Computational Biology, Issue 16/10, 2020, Page(s) e1008294, ISSN 1553-734X
Publisher: Public Library of Science
DOI: 10.1371/journal.pcbi.1008294

Computational fluid dynamics of blood flow in an idealized left human heart

Author(s): Luca Dedè, Filippo Menghini, Alfio Quarteroni
Published in: International Journal for Numerical Methods in Biomedical Engineering, 2019, ISSN 2040-7939
Publisher: John Wiley & Sons Ltd.
DOI: 10.1002/cnm.3287

An intergrid transfer operator using radial basis functions with application to cardiac electromechanics

Author(s): Matteo Salvador, Luca Dede', Alfio Quarteroni
Published in: Computational Mechanics, Issue Volume 66, Issue 1, July 2020, 2020, ISSN 0178-7675
Publisher: Springer Verlag

Machine learning of multiscale active force generation models for the efficient simulation of cardiac electromechanics

Author(s): F. Regazzoni, L. Dedè, A. Quarteroni
Published in: Computer Methods in Applied Mechanics and Engineering, Issue 370, 2020, Page(s) 113268, ISSN 0045-7825
Publisher: Elsevier BV
DOI: 10.1016/j.cma.2020.113268

Mathematical and numerical models for the cardiac electromechanical function

Author(s): Luca Dedè; Alfio Quarteroni; Francesco Regazzoni
Published in: Atti Accademia Nazionale dei Lincei, Issue Classe Scienze Fisiche Matematiche Naturali 32 (2021), no. 2, 2021, Page(s) 233-272, ISSN 1120-6330
Publisher: Accademia Nazionale dei Lincei
DOI: 10.4171/rlm/935

Modeling the cardiac electromechanical function: A mathematical journey

Author(s): Alfio Quarteroni; Luca Dedè; Francesco Regazzoni
Published in: Bulletin of the American Mathematical Society, Issue 59 (2022), 2022, Page(s) 371-403, ISSN 0273-0979
Publisher: American Mathematical Society
DOI: 10.1090/bull/1738

A stable loosely-coupled scheme for cardiac electro-fluid-structure interaction

Author(s): Michele Bucelli , Martin Geraint Gabriel , Alfio Quarteroni , Giacomo Gigante , Christian Vergara
Published in: Journal of Computational Physics, Issue Volume 490, 1 October 2023, 112326, 2023, ISSN 0021-9991
Publisher: Academic Press
DOI: 10.1016/j.jcp.2023.112326

Deep-HyROMnet: A Deep Learning-Based Operator Approximation for Hyper-Reduction of Nonlinear Parametrized PDEs

Author(s): Cicci, Ludovica; Fresca, Stefania; Manzoni, Andrea
Published in: Journal of Scientific Computing, Issue 93, Article number: 57 (2022), 2022, ISSN 0885-7474
Publisher: Kluwer Academic/Plenum Publishers
DOI: 10.1007/s10915-022-02001-8

Efficient and certified solution of parametrized one-way coupled problems through DEIM-based data projection across non-conforming interfaces

Author(s): Elena Zappon, Andrea Manzoni, Alfio Quarteroni
Published in: Advances in Computational Mathematics, Issue 49, 21, 2023, ISSN 1019-7168
Publisher: Kluwer Academic Publishers
DOI: 10.48550/arxiv.2203.09226

A cardiac electromechanical model coupled with a lumped-parameter model for closed-loop blood circulation

Author(s): F. Regazzoni; M. Salvador; P.C. Africa; M. Fedele; L. Dedè; A. Quarteroni
Published in: Journal of Computational Physics, Issue 4, 2022, ISSN 0021-9991
Publisher: Academic Press
DOI: 10.1016/j.jcp.2022.111083

Modeling cardiac muscle fibers in ventricular and atrial electrophysiology simulations

Author(s): Roberto Piersanti, Pasquale C. Africa, Marco Fedele, Christian Vergara, Luca Dedè, Antonio F. Corno, Alfio Quarteroni
Published in: Computer Methods in Applied Mechanics and Engineering, Issue 373, 2021, Page(s) 113468, ISSN 0045-7825
Publisher: Elsevier BV
DOI: 10.1016/j.cma.2020.113468

A geometric multiscale model for the numerical simulation of blood flow in the human left heart

Author(s): Alberto Zingaro; Ivan Fumagalli; Luca Dede; Marco Fedele; Pasquale C. Africa; Antonio F. Corno; Alfio Quarteroni
Published in: Discrete and Continuous Dynamical Systems - Series S, Issue 5, 2022, ISSN 1937-1632
Publisher: American Institute of Mathematical Sciences
DOI: 10.3934/dcdss.2022052

Book chapters (1)

Segregated algorithms for the numerical simulation of cardiac electromechanics in the left human ventricle

Author(s): L. Dede', A. Gerbi, A. Quarteroni
Published in: The Mathematics of Mechanobiology, 2020, Page(s) 81--116, ISBN 978-3-030-45196-7
Publisher: Springer Verlag
DOI: 10.1007/978-3-030-45197-4_3