Mimicking liver disease and regeneration in vitro for drug development and liver transplantation

Pubblicazioni

Prediction of Drug-Induced Hepatotoxicity Using Long-Term Stable Primary Hepatic 3D Spheroid Cultures in Chemically Defined Conditions

Autori: Sabine U Vorrink, Yitian Zhou, Magnus Ingelman-Sundberg, Volker M Lauschke
Pubblicato in: Toxicological Sciences, Numero 163/2, 2018, Pagina/e 655-665, ISSN 1096-6080
Editore: Oxford University Press
DOI: 10.1093/toxsci/kfy058

3D primary hepatocyte culture systems for analyses of liver diseases, drug metabolism and toxicity: Emerging culture paradigms and applications

Autori: Volker M. Lauschke, Reza Zandi Shafagh, Delilah F. G. Hendriks, Magnus Ingelman‐Sundberg
Pubblicato in: Biotechnology Journal, 2019, Pagina/e 1800347, ISSN 1860-6768
Editore: Wiley - VCH Verlag GmbH & CO. KGaA
DOI: 10.1002/biot.201800347

Comparison of Hepatic 2D Sandwich Cultures and 3D Spheroids for Long-term Toxicity Applications: A Multicenter Study

Autori: Catherine C Bell, Anita C A Dankers, Volker M Lauschke, Rowena Sison-Young, Roz Jenkins, Cliff Rowe, Chris E Goldring, Kevin Park, Sophie L Regan, Tracy Walker, Chris Schofield, Audrey Baze, Alison J Foster, Dominic P Williams, Amy W M van de Ven, Frank Jacobs, Jos van Houdt, Tuula Lähteenmäki, Jan Snoeys, Satu Juhila, Lysiane Richert, Magnus Ingelman-Sundberg
Pubblicato in: Toxicological Sciences, Numero 162/2, 2018, Pagina/e 655-666, ISSN 1096-6080
Editore: Oxford University Press
DOI: 10.1093/toxsci/kfx289

AMP-activated protein kinase activation and NADPH oxidase inhibition by inorganic nitrate and nitrite prevent liver steatosis

Autori: Isabel Cordero-Herrera, Mikael Kozyra, Zhengbing Zhuge, Sarah McCann Haworth, Chiara Moretti, Maria Peleli, Mayara Caldeira-Dias, Arghavan Jahandideh, Han Huirong, Josiane de Campos Cruz, Andrei L. Kleschyov, Marcelo F. Montenegro, Magnus Ingelman-Sundberg, Eddie Weitzberg, Jon O. Lundberg, Mattias Carlstrom
Pubblicato in: Proceedings of the National Academy of Sciences, Numero 116/1, 2019, Pagina/e 217-226, ISSN 0027-8424
Editore: National Academy of Sciences
DOI: 10.1073/pnas.1809406115

Novel genetic and epigenetic factors of importance for inter-individual differences in drug disposition, response and toxicity

Autori: Volker M. Lauschke, Yitian Zhou, Magnus Ingelman-Sundberg
Pubblicato in: Pharmacology & Therapeutics, 2019, ISSN 0163-7258
Editore: Pergamon Press
DOI: 10.1016/j.pharmthera.2019.01.002

Human Liver Spheroids as a Model to Study Aetiology and Treatment of Hepatic Fibrosis

Autori: Tracey Hurrell, Vlasia Kastrinou-Lampou, Achilleas Fardellas, Delilah F. G. Hendriks, Åsa Nordling, Inger Johansson, Audrey Baze, Céline Parmentier, Lysiane Richert, Magnus Ingelman-Sundberg
Pubblicato in: Cells, Numero 9/4, 2020, Pagina/e 964, ISSN 2073-4409
Editore: MDPI
DOI: 10.3390/cells9040964

Managing the challenge of drug-induced liver injury: a roadmap for the development and deployment of preclinical predictive models

Autori: Richard J. Weaver, Eric A. Blomme, Amy E. Chadwick, Ian M. Copple, Helga H. J. Gerets, Christopher E. Goldring, Andre Guillouzo, Philip G. Hewitt, Magnus Ingelman-Sundberg, Klaus Gjervig Jensen, Satu Juhila, Ursula Klingmüller, Gilles Labbe, Michael J. Liguori, Cerys A. Lovatt, Paul Morgan, Dean J. Naisbitt, Raymond H. H. Pieters, Jan Snoeys, Bob van de Water, Dominic P. Williams, B. Kevin Park
Pubblicato in: Nature Reviews Drug Discovery, Numero 19/2, 2020, Pagina/e 131-148, ISSN 1474-1776
Editore: Nature Publishing Group
DOI: 10.1038/s41573-019-0048-x

Impact of CYP2C19 genotype on sertraline exposure in 1200 Scandinavian patients

Autori: Line S. Bråten, Tore Haslemo, Marin M. Jukic, Magnus Ingelman-Sundberg, Espen Molden, Marianne K. Kringen
Pubblicato in: Neuropsychopharmacology, Numero 45/3, 2020, Pagina/e 570-576, ISSN 0893-133X
Editore: Nature Publishing Group
DOI: 10.1038/s41386-019-0554-x

CYP3A5 is unlikely to mediate anticancer drug resistance in hepatocellular carcinoma

Autori: Volker M Lauschke, Åsa Nordling, Yitian Zhou, Sara Fontalva, Isabel Barragan, Magnus Ingelman-Sundberg
Pubblicato in: Pharmacogenomics, Numero 20/15, 2019, Pagina/e 1085-1092, ISSN 1462-2416
Editore: Ashley Publications Ltd.
DOI: 10.2217/pgs-2019-0094

Mechanisms of Chronic Fialuridine Hepatotoxicity as Revealed in Primary Human Hepatocyte Spheroids

Autori: Delilah F G Hendriks, Tracey Hurrell, Julia Riede, Muriëlle van der Horst, Sarianna Tuovinen, Magnus Ingelman-Sundberg
Pubblicato in: Toxicological Sciences, Numero 171/2, 2019, Pagina/e 385-395, ISSN 1096-6080
Editore: Oxford University Press
DOI: 10.1093/toxsci/kfz195

Calcium Signaling in Liver Injury and Regeneration

Autori: Nuria Oliva-Vilarnau, Simona Hankeova, Sabine U. Vorrink, Souren Mkrtchian, Emma R. Andersson, Volker M. Lauschke
Pubblicato in: Frontiers in Medicine, Numero 5, 2018, ISSN 2296-858X
Editore: Springer
DOI: 10.3389/fmed.2018.00192

The TM6SF2 E167K genetic variant induces lipid biosynthesis and reduces apolipoprotein B secretion in human hepatic 3D spheroids

Autori: Sebastian Prill, Andrea Caddeo, Guido Baselli, Oveis Jamialahmadi, Paola Dongiovanni, Raffaela Rametta, Kajsa P. Kanebratt, Arturo Pujia, Piero Pingitore, Rosellina Margherita Mancina, Daniel Lindén, Carl Whatling, Annika Janefeldt, Mikael Kozyra, Magnus Ingelman-Sundberg, Luca Valenti, Tommy B. Andersson, Stefano Romeo
Pubblicato in: Scientific Reports, Numero 9/1, 2019, ISSN 2045-2322
Editore: Nature Publishing Group
DOI: 10.1038/s41598-019-47737-w

Three-Dimensional Spheroid Primary Human Hepatocytes in Monoculture and Coculture with Nonparenchymal Cells

Autori: Audrey Baze, Céline Parmentier, Delilah F.G. Hendriks, Tracey Hurrell, Bruno Heyd, Philippe Bachellier, Catherine Schuster, Magnus Ingelman-Sundberg, Lysiane Richert
Pubblicato in: Tissue Engineering Part C: Methods, Numero 24/9, 2018, Pagina/e 534-545, ISSN 1937-3384
Editore: Mary Ann Liebert Inc.
DOI: 10.1089/ten.tec.2018.0134

Inter-individual differences in the susceptibility of primary human hepatocytes towards drug-induced cholestasis are compound and time dependent

Autori: Céline Parmentier, Delilah F.G. Hendriks, Bruno Heyd, Philippe Bachellier, Magnus Ingelman-Sundberg, Lysiane Richert
Pubblicato in: Toxicology Letters, Numero 295, 2018, Pagina/e 187-194, ISSN 0378-4274
Editore: Elsevier BV
DOI: 10.1016/j.toxlet.2018.06.1069

Characterisation of the NRF2 transcriptional network and its response to chemical insult in primary human hepatocytes: implications for prediction of drug-induced liver injury

Autori: Ian M. Copple, Wouter den Hollander, Giulia Callegaro, Fiona E. Mutter, James L. Maggs, Amy L. Schofield, Lucille Rainbow, Yongxiang Fang, Jeffrey J. Sutherland, Ewa C. Ellis, Magnus Ingelman-Sundberg, Stephen W. Fenwick, Christopher E. Goldring, Bob van de Water, James L. Stevens, B. Kevin Park
Pubblicato in: Archives of Toxicology, Numero 93/2, 2019, Pagina/e 385-399, ISSN 0340-5761
Editore: Springer Verlag
DOI: 10.1007/s00204-018-2354-1

Clinically relevant CYP3A4 induction mechanisms and drug screening in 3D spheroid cultures of primary human hepatocytes

Autori: Delilah F.G. Hendriks, Sabine U. Vorrink, Tomas Smutny, Sarah C. Sim, Åsa Nordling, Shahid Ullah, Masaki Kumondai, Barry C. Jones, Inger Johansson, Tommy B. Andersson, Volker M. Lauschke, Magnus Ingelman‐Sundberg
Pubblicato in: Clinical Pharmacology & Therapeutics, 2020, ISSN 0009-9236
Editore: Nature Publishing Group
DOI: 10.1002/cpt.1860

Human hepatic 3D spheroids as a model for steatosis and insulin resistance

Autori: Mikael Kozyra, Inger Johansson, Åsa Nordling, Shahid Ullah, Volker M. Lauschke, Magnus Ingelman-Sundberg
Pubblicato in: Scientific Reports, Numero 8/1, 2018, ISSN 2045-2322
Editore: Nature Publishing Group
DOI: 10.1038/s41598-018-32722-6

Prediction of drug response and adverse drug reactions: From twin studies to Next Generation Sequencing

Autori: Volker M. Lauschke, Magnus Ingelman-Sundberg
Pubblicato in: European Journal of Pharmaceutical Sciences, Numero 130, 2019, Pagina/e 65-77, ISSN 0928-0987
Editore: Elsevier BV
DOI: 10.1016/j.ejps.2019.01.024

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