Mimicking liver disease and regeneration in vitro for drug development and liver transplantation

Publicaciones

Prediction of Drug-Induced Hepatotoxicity Using Long-Term Stable Primary Hepatic 3D Spheroid Cultures in Chemically Defined Conditions

Autores: Sabine U Vorrink, Yitian Zhou, Magnus Ingelman-Sundberg, Volker M Lauschke
Publicado en: Toxicological Sciences, Edición 163/2, 2018, Página(s) 655-665, ISSN 1096-6080
Editor: Oxford University Press
DOI: 10.1093/toxsci/kfy058

3D primary hepatocyte culture systems for analyses of liver diseases, drug metabolism and toxicity: Emerging culture paradigms and applications

Autores: Volker M. Lauschke, Reza Zandi Shafagh, Delilah F. G. Hendriks, Magnus Ingelman‐Sundberg
Publicado en: Biotechnology Journal, 2019, Página(s) 1800347, ISSN 1860-6768
Editor: Wiley - VCH Verlag GmbH & CO. KGaA
DOI: 10.1002/biot.201800347

Comparison of Hepatic 2D Sandwich Cultures and 3D Spheroids for Long-term Toxicity Applications: A Multicenter Study

Autores: Catherine C Bell, Anita C A Dankers, Volker M Lauschke, Rowena Sison-Young, Roz Jenkins, Cliff Rowe, Chris E Goldring, Kevin Park, Sophie L Regan, Tracy Walker, Chris Schofield, Audrey Baze, Alison J Foster, Dominic P Williams, Amy W M van de Ven, Frank Jacobs, Jos van Houdt, Tuula Lähteenmäki, Jan Snoeys, Satu Juhila, Lysiane Richert, Magnus Ingelman-Sundberg
Publicado en: Toxicological Sciences, Edición 162/2, 2018, Página(s) 655-666, ISSN 1096-6080
Editor: Oxford University Press
DOI: 10.1093/toxsci/kfx289

AMP-activated protein kinase activation and NADPH oxidase inhibition by inorganic nitrate and nitrite prevent liver steatosis

Autores: Isabel Cordero-Herrera, Mikael Kozyra, Zhengbing Zhuge, Sarah McCann Haworth, Chiara Moretti, Maria Peleli, Mayara Caldeira-Dias, Arghavan Jahandideh, Han Huirong, Josiane de Campos Cruz, Andrei L. Kleschyov, Marcelo F. Montenegro, Magnus Ingelman-Sundberg, Eddie Weitzberg, Jon O. Lundberg, Mattias Carlstrom
Publicado en: Proceedings of the National Academy of Sciences, Edición 116/1, 2019, Página(s) 217-226, ISSN 0027-8424
Editor: National Academy of Sciences
DOI: 10.1073/pnas.1809406115

Novel genetic and epigenetic factors of importance for inter-individual differences in drug disposition, response and toxicity

Autores: Volker M. Lauschke, Yitian Zhou, Magnus Ingelman-Sundberg
Publicado en: Pharmacology & Therapeutics, 2019, ISSN 0163-7258
Editor: Pergamon Press
DOI: 10.1016/j.pharmthera.2019.01.002

Human Liver Spheroids as a Model to Study Aetiology and Treatment of Hepatic Fibrosis

Autores: Tracey Hurrell, Vlasia Kastrinou-Lampou, Achilleas Fardellas, Delilah F. G. Hendriks, Åsa Nordling, Inger Johansson, Audrey Baze, Céline Parmentier, Lysiane Richert, Magnus Ingelman-Sundberg
Publicado en: Cells, Edición 9/4, 2020, Página(s) 964, ISSN 2073-4409
Editor: MDPI
DOI: 10.3390/cells9040964

Managing the challenge of drug-induced liver injury: a roadmap for the development and deployment of preclinical predictive models

Autores: Richard J. Weaver, Eric A. Blomme, Amy E. Chadwick, Ian M. Copple, Helga H. J. Gerets, Christopher E. Goldring, Andre Guillouzo, Philip G. Hewitt, Magnus Ingelman-Sundberg, Klaus Gjervig Jensen, Satu Juhila, Ursula Klingmüller, Gilles Labbe, Michael J. Liguori, Cerys A. Lovatt, Paul Morgan, Dean J. Naisbitt, Raymond H. H. Pieters, Jan Snoeys, Bob van de Water, Dominic P. Williams, B. Kevin Park
Publicado en: Nature Reviews Drug Discovery, Edición 19/2, 2020, Página(s) 131-148, ISSN 1474-1776
Editor: Nature Publishing Group
DOI: 10.1038/s41573-019-0048-x

Impact of CYP2C19 genotype on sertraline exposure in 1200 Scandinavian patients

Autores: Line S. Bråten, Tore Haslemo, Marin M. Jukic, Magnus Ingelman-Sundberg, Espen Molden, Marianne K. Kringen
Publicado en: Neuropsychopharmacology, Edición 45/3, 2020, Página(s) 570-576, ISSN 0893-133X
Editor: Nature Publishing Group
DOI: 10.1038/s41386-019-0554-x

CYP3A5 is unlikely to mediate anticancer drug resistance in hepatocellular carcinoma

Autores: Volker M Lauschke, Åsa Nordling, Yitian Zhou, Sara Fontalva, Isabel Barragan, Magnus Ingelman-Sundberg
Publicado en: Pharmacogenomics, Edición 20/15, 2019, Página(s) 1085-1092, ISSN 1462-2416
Editor: Ashley Publications Ltd.
DOI: 10.2217/pgs-2019-0094

Mechanisms of Chronic Fialuridine Hepatotoxicity as Revealed in Primary Human Hepatocyte Spheroids

Autores: Delilah F G Hendriks, Tracey Hurrell, Julia Riede, Muriëlle van der Horst, Sarianna Tuovinen, Magnus Ingelman-Sundberg
Publicado en: Toxicological Sciences, Edición 171/2, 2019, Página(s) 385-395, ISSN 1096-6080
Editor: Oxford University Press
DOI: 10.1093/toxsci/kfz195

Calcium Signaling in Liver Injury and Regeneration

Autores: Nuria Oliva-Vilarnau, Simona Hankeova, Sabine U. Vorrink, Souren Mkrtchian, Emma R. Andersson, Volker M. Lauschke
Publicado en: Frontiers in Medicine, Edición 5, 2018, ISSN 2296-858X
Editor: Springer
DOI: 10.3389/fmed.2018.00192

The TM6SF2 E167K genetic variant induces lipid biosynthesis and reduces apolipoprotein B secretion in human hepatic 3D spheroids

Autores: Sebastian Prill, Andrea Caddeo, Guido Baselli, Oveis Jamialahmadi, Paola Dongiovanni, Raffaela Rametta, Kajsa P. Kanebratt, Arturo Pujia, Piero Pingitore, Rosellina Margherita Mancina, Daniel Lindén, Carl Whatling, Annika Janefeldt, Mikael Kozyra, Magnus Ingelman-Sundberg, Luca Valenti, Tommy B. Andersson, Stefano Romeo
Publicado en: Scientific Reports, Edición 9/1, 2019, ISSN 2045-2322
Editor: Nature Publishing Group
DOI: 10.1038/s41598-019-47737-w

Three-Dimensional Spheroid Primary Human Hepatocytes in Monoculture and Coculture with Nonparenchymal Cells

Autores: Audrey Baze, Céline Parmentier, Delilah F.G. Hendriks, Tracey Hurrell, Bruno Heyd, Philippe Bachellier, Catherine Schuster, Magnus Ingelman-Sundberg, Lysiane Richert
Publicado en: Tissue Engineering Part C: Methods, Edición 24/9, 2018, Página(s) 534-545, ISSN 1937-3384
Editor: Mary Ann Liebert Inc.
DOI: 10.1089/ten.tec.2018.0134

Inter-individual differences in the susceptibility of primary human hepatocytes towards drug-induced cholestasis are compound and time dependent

Autores: Céline Parmentier, Delilah F.G. Hendriks, Bruno Heyd, Philippe Bachellier, Magnus Ingelman-Sundberg, Lysiane Richert
Publicado en: Toxicology Letters, Edición 295, 2018, Página(s) 187-194, ISSN 0378-4274
Editor: Elsevier BV
DOI: 10.1016/j.toxlet.2018.06.1069

Characterisation of the NRF2 transcriptional network and its response to chemical insult in primary human hepatocytes: implications for prediction of drug-induced liver injury

Autores: Ian M. Copple, Wouter den Hollander, Giulia Callegaro, Fiona E. Mutter, James L. Maggs, Amy L. Schofield, Lucille Rainbow, Yongxiang Fang, Jeffrey J. Sutherland, Ewa C. Ellis, Magnus Ingelman-Sundberg, Stephen W. Fenwick, Christopher E. Goldring, Bob van de Water, James L. Stevens, B. Kevin Park
Publicado en: Archives of Toxicology, Edición 93/2, 2019, Página(s) 385-399, ISSN 0340-5761
Editor: Springer Verlag
DOI: 10.1007/s00204-018-2354-1

Clinically relevant CYP3A4 induction mechanisms and drug screening in 3D spheroid cultures of primary human hepatocytes

Autores: Delilah F.G. Hendriks, Sabine U. Vorrink, Tomas Smutny, Sarah C. Sim, Åsa Nordling, Shahid Ullah, Masaki Kumondai, Barry C. Jones, Inger Johansson, Tommy B. Andersson, Volker M. Lauschke, Magnus Ingelman‐Sundberg
Publicado en: Clinical Pharmacology & Therapeutics, 2020, ISSN 0009-9236
Editor: Nature Publishing Group
DOI: 10.1002/cpt.1860

Human hepatic 3D spheroids as a model for steatosis and insulin resistance

Autores: Mikael Kozyra, Inger Johansson, Åsa Nordling, Shahid Ullah, Volker M. Lauschke, Magnus Ingelman-Sundberg
Publicado en: Scientific Reports, Edición 8/1, 2018, ISSN 2045-2322
Editor: Nature Publishing Group
DOI: 10.1038/s41598-018-32722-6

Prediction of drug response and adverse drug reactions: From twin studies to Next Generation Sequencing

Autores: Volker M. Lauschke, Magnus Ingelman-Sundberg
Publicado en: European Journal of Pharmaceutical Sciences, Edición 130, 2019, Página(s) 65-77, ISSN 0928-0987
Editor: Elsevier BV
DOI: 10.1016/j.ejps.2019.01.024

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