Deliverables
Publications At least two technical articles are planned for publication in professional newspapers eg Fish Farming International andor magazines eg World Aquaculture or Aquaculture Europe summarizing the main results and outcomes of the project other than the scientific publications described in WP1
Individuation of indicators at different biological levels for early prediction of the onset and fate of skeletal anomalies in model species for marine (medaka) and freshwater (zebrafish) commercial fishESR4 Evaluation of skeletal anomalies requires a welldefined classification of the observed defects and an objective identification of the various types of defects
Primary effect of inappropriate P supply and function of Fgf23 on growth and development of bone tissue in Atlantic salmon.ESR12 Phosphate P is a limiting resource directly related with organic pollution whereas unbalanced diets may affect animal health and welfare with occurrence of anomalies P content and efficiency in fish feeds based on plant ingredients is frequently low A phosphorus deficient vertebral phenotype in juvenile salmon will be used to test the effect of different factors on bone in an in vivo model
Technical articlesOverview articles presenting and analysing combined results of several ESRs
Evaluation of risk and prediction of skeleton anomalies.ESR7 To precisely assess the burden of skeleton anomalies in European fish farms and to determine the socioeconomic impact regarding the prevention and treatment of skeleton anomalies in fish farms two main methodologies discrete choice analysis and risk assessment will be used
Biomedaqu Final workshop. All exploitation plans completed.Final workshop and final reports All activities finished
Physiological mechanisms of Zn, Mn and Se effect on bone development and mineralization.ESR6 Sustainable development of aquaculture asks for high quality ingredients to replace fishmeal and fish oil and fulfilling nutritional requirements This replacement presently leads to several skeletal alterations suggesting nutritional imbalances eg Zn Mn and Se are lower in plant ingredients Optimal dietary levels of Zn Mn and Se for skeletal health in seabream will be determined d14 M40 and the physiological mechanisms investigated through mutant fish models
Consortium AgreementConsortium Agreement finalized
Biomedaqu Training schools5 Summer Schools will be organized by different Beneficiaries under the leading management of ULG Each SS will be locally managed by the PI of the hosting Beneficiary The aim is to transfer skills in innovative tools to the recruited ESRs Partners will be actively involved in SS teaching As many as six Guidelines will be produced from SS
Recommendation of optimal levels and molecular forms of Zn, Mn and Se in commercial diets for gilthead seabream skeletal health.ESR6 Sustainable development of aquaculture asks for high quality ingredients to replace fishmeal and fish oil and fulfilling nutritional requirements This replacement presently leads to several skeletal alterations suggesting nutritional imbalances eg Zn Mn and Se are lower in plant ingredients Optimal dietary levels of Zn Mn and Se for skeletal health in seabream will be determined
Report on the effect of vitamin K and D on bone metabolism of osteoblastic- and chondroblastic-like skeletal derived cells.ESR8 The effects of VK and D supplementation on Ca metabolism bone development and mineralization and occurrence of skeletal anomalies will be investigated in gilthead seabream or meagre The involved physiological mechanisms will be studied through biochemical molecular cell culture and mutant fish studies
Satellite section in European Aquaculture Society Conference.Organisation and participation of a satellite meeting at the Conference of the European Aquaculture Society
Predictions of the effect of preventive measures when applied by fish farmers.Discrete choice experiments DCE have been used in many research fields to elicit preferences of decision makers regarding different products and services They involve the creation of hypothetical scenarios trying to mimic real markets which are defined to answer different research questions Thus it is possible to analyze the effect of important attributes over the outcomes of the experiment to quantify tradeoffs between attributes and to evaluate the willingness to pay for improving the quality of a product or service In our case different skeleton anomalies in form and severity will be defined and used Data will be obtained from a large number of companies and consumers within the consortium and through contacts from FEAP and API DCE provide rich data sources which have been widely used in health economics to evaluate preferences for healthcare products and services they allow researchers to obtain after the application of appropriate modelling methodologies such us discrete choice models merging their financial cost and revenues and their organizational consequences risks and controls to implement It will also provide essential inputs for the main economic evaluation techniques costbenefit analysis CBA and costutility analysis notably when coupled with riskcontrol matrix ULGCEPE
Dissemination and Outreach plan including website.Disseminate project activities and results (d6.1, M4), both to professionals (fish farmers, stakeholders, researchers) and the public. Public reports from the different WPs will also be made available through the site. A page on a social network (i.e., Facebook) will be created and coordinated, directed for a larger non-scientific audience
Practical recommendations for fish farms and feed producers on vitamins K and D dietary levels to avoid bone anomalies and pathological effects of Ca metabolism alterations.ESR8 Fatsoluble vitamins K VK and D VD play essential roles in Ca transport and tissue deposition and hence in bone development mineralization and remodelling Excessive VK and VD dietary levels can lead to bone anomalies there is a large variation in the content of these vitamins in live preys fed to marine fish larvae and their optimum levels during larval stages have not been yet determined for marine fish
In vivo and in vitro systems to test osteogenic activitiesAt the molecular level, skeletal formation and homeostasis depends on the presence of specific cells and their differentiation, proliferation and function in skeletal tissues influences extracellular matrix (ECM) and hydroxyapatite deposition. Osteoblast- and chondroblast-like skeletal derived cells from teleosts will be used as experimental model systems to assess the effects of micronutrients, at the cellular level, on the capacity to mineralize the ECM
BioMedAqC Supervisory Guidelines and ETN Training program.Set up SB, Recruitment guidelines, Satellite Meetings and supervision infrastructure
Description of cellular basis of spine repairESR14 Scoliosis a deviation of the normal line of the spine is one the main ecological threats to commercial fish farming Hence understanding what leads to malformations of the axial skeleton in fish is not only of scientific interest but also has considerable economical relevance The complete understanding of the underlying biology has been hampered by an inability to clearly identify the cells which are responsible for mineralizing the axial skeleton and by an inability to follow the dynamics of axial skeletogenesis at the level of gene expression We have recently shown that the extracellular Entpd5 an enzyme providing phosphate for the mineralization process is expressed in a segmental manner within chordoblastsnotochord sheath cells of the notochord Lleras Forero submitted and have furthermore demonstrated that these cells have the propensity to repair damage inflicted to the notochord Lopez Baez submitted Based on these findings it will now be possible to understand in detail how expression of Entpd5 is orchestrated by the embryo to form the larval axial skeleton during physiological conditions and to repair skeletal elements upon pathophysiological damage
2 oral communications /student (30).Publications At least two technical articles are planned for publication in professional newspapers eg Fish Farming International andor magazines eg World Aquaculture or Aquaculture Europe summarizing the main results and outcomes of the project other than the scientific publications described in WP1
Prediction model for early evaluation of skeletal quality in reared fish.ESR4 Evaluation of skeletal anomalies requires a welldefined classification of the observed defects and an objective identification of the various types of defects d32 M40 Anatomical analysis of whole skeletons and data analysis will be embedded into the consolidated use of new generation analytic tools ie Kohonens SelfOrganizing Maps SOMs particularly suited for the analysis data that are nonlinear complex and characterized by internal redundancy or noise Together with ESR5 this will contribute to a better prediction and understanding of the phenomena leading to developmental osteological deformities
Report on the recruitment for all ESR posts, Consortium agreement.Establishment of criteria for ESRs recruitment, announcement of ESR selection, selection and adoption in local Academic Doctorate Schools will be managed and coordinated as described in sec. 4.2. The lead partner is ULPGC, assisted in all steps by the SB
1 Conference proceedings (IAFSB).Collection reviewing and publication of IAFSB Conference Proceedings
Crowding and space effects on skeleton system in advanced teleosts and recommendations issued for commercial farm.ESR5 The use of large volumes and low densities have been demonstrated to be effective in lowering the incidence of skeletal anomalies in many marine reared species however the main cause driving these anomalies is unclear i smaller swimming space or ii the stress caused by too tight interactions among fish Identical batches of fish reared in two different volumes or at two different stocking densities ULPGCIPMAULG will be analyzed at the juvenile subadult and adult stage at anatomical UTV biomechanical INSERM histological UGent and biomolecular UALG WWU level in medaka and zebrafish and validated on commercial seabream
Cellular and molecular mechanisms of vertebral fusion in teleosts.Fusion of vertebral bodies is a common pathology in farmed fish At the same time during evolution fusion of vertebral bodies became a requirement to establish the teleost caudal fin endoskeleton Vertebral body fusion can be both an important process in the frame of regular skeletal development and a pathological process Previous studies analyzed in depth the ontogenetically required vertebral body fusion that occurs during zebrafish caudal fin endoskeleton development Exact data sets exist about the timeline of vertebral body fusion the variability of the process and the microanatomy of the fusion process Fusion occurs on two levels a early on the level of mineralization of the notochord sheath that establishes vertebral body identity b late on the level of intramembranous perinotochordal bone formation ESR11 will use the welldocumented ontogenetically required fusion of the caudal most vertebral bodies to understand developmental and molecular mechanisms that underlay pathological vertebral body fusion in other parts of the teleost vertebral column
PhD awards.All PhD awards granted
Tools to prevent pathological vertebral fusion in farmed fish.Fusion of vertebral bodies is a common pathology in farmed fish At the same time during evolution fusion of vertebral bodies became a requirement to establish the teleost caudal fin endoskeleton Vertebral body fusion can be both an important process in the frame of regular skeletal development and a pathological process Previous studies analyzed in depth the ontogenetically required vertebral body fusion that occurs during zebrafish caudal fin endoskeleton development Exact data sets exist about the timeline of vertebral body fusion the variability of the process and the microanatomy of the fusion process Fusion occurs on two levels a early on the level of mineralization of the notochord sheath that establishes vertebral body identity b late on the level of intramembranous perinotochordal bone formation ESR11 will use the welldocumented ontogenetically required fusion of the caudal most vertebral bodies to understand developmental and molecular mechanisms that underlay pathological vertebral body fusion in other parts of the teleost vertebral column d39 M36 as a prerequisite to ensure healthy vertebral column development in fast growing fish under farming conditions
Function of new candidate genes in zebrafish bone formation. Relevance for human (and general) skeletal pathology.ESR23 Zebrafish models have been proven relevant to study skeletal pathologies encountered in humans such as osteoporosis or scoliosis but possibly also in farmed fish ARS has identified the FIBULIN3 protein to be upregulated in serum of osteoarthritic patients UPD7 has identified several variants of genes in cohorts of young patients with osteoporosis osteoarthritis or ectopic mineral deposits in the cartilage such as chondrocalcinosis The function of these factors will be evaluated at the wholebody level by generating the zebrafish mutants in the genes of interest eg fbln1 fbln3 il11ra lrp5 wnt1 iftim5 plekhm1 using the CRISPR methodologies The mutant fish phenotype is characterized using established skeletal staining methods fluorescent transgenic lines microCT histomorphometric methods and by determining the expression of marker genes by in situ hybridization or RTPCR Variant proteins will be tested for proliferation in human and fish osteoblast cell culture Genes affecting skeletal development will be characterized in aquaculture species and their expression will be followed in challenging conditions that generate skeletal malformations including exposure to altered gravity conditions to evaluate their contribution to the defects
Biomedaqu workshopsAs many as 1 international and 5 national workshops will be organized to disseminate results obtained in this Marie Curie Action among stakeholders Only ESRs recruited in the country will attend the local workshops while all recruited ESRs will attend the final International Workshop Lead partner is UALG all PIs of the Beneficiaries will be local organizers Local workshops aim to reach a stakeholder audience in which results obtained from this action will be disseminated The International Workshop is oriented toward both academic and enterprise audiences
Influence of space availability and stocking density on the skeletal system in medaka, zebrafish, and seabream at anatomic (skeletal deformities), histological (transdifferentiation and modeling) and molecular (Gla protein) levels.ESR5 The use of large volumes and low densities have been demonstrated to be effective in lowering the incidence of skeletal anomalies in many marine reared species however the main cause driving these anomalies is unclear i smaller swimming space or ii the stress caused by too tight interactions among fish Identical batches of fish reared in two different volumes or at two different stocking densities ULPGCIPMAULG will be analyzed at the juvenile subadult and adult stage at anatomical UTV biomechanical INSERM histological UGent and biomolecular UALG WWU level in medaka and zebrafish and validated on commercial seabream
Supervisory BoardSupervisory board recruited.
An BioMedAqC web page will be prepared to disseminate project activities and results
Publications
Author(s):
Caetano da Silva C, Edouard T, Fradin M, Aubert-Mucca M, Ricquebourg M, Raman R, Salles JP, Charon V, Guggenbuhl P, Muller M, Cohen-Solal M, Collet C
Published in:
Human Molecular Genetics, Issue 31, 2021, Page(s) 1622-1634, ISSN 0964-6906
Publisher:
Oxford University Press
DOI:
10.1093/hmg/ddab349
Author(s):
Tonelli F, Leoni L, Daponte V, Gioia R, Cotti S, Fiedler IAK, Larionova D, Willaert A, Coucke PJ, Villani S, Busse B, Besio R, Rossi A, Witten PE, Forlino A
Published in:
Front Endocrinol (Lausanne), Issue 14, 2023, Page(s) 1002914, ISSN 1664-2392
Publisher:
Frontiers
DOI:
10.3389/fendo.2023.1002914
Author(s):
Sojan JM, Gundappa MK, Carletti A, Gaspar V, Gavaia P, Maradonna F, Carnevali O
Published in:
Front. Nutr., Issue 9, 2022, Page(s) 868805, ISSN 2296-861X
Publisher:
Frontiers Media
DOI:
10.3389/fnut.2022.868805
Author(s):
Alessio Carletti1,2†, Carlos Cardoso3,4†, Jorge Lobo-Arteaga5,6, Sabrina Sales3, Diana Juliao3, Inês Ferreira3, Paula Chainho6, Maria Ana Dionísio6, Maria J. Gaudêncio5, Cláudia Afonso3,4, Helena Lourenço3, M. Leonor Cancela1,2,7,8, Narcisa M. Bandarra3,4 and Paulo J. Gavaia1,2*
Published in:
Front. Nutr., Issue 9, 2022, Page(s) 888360, ISSN 2296-861X
Publisher:
Frontiers media S.A
DOI:
10.3389/fnut.2022.888360
Author(s):
Di Biagio C, Dellacqua Z, Martini A, Huysseune A, Scardi M, Witten PE, Boglione C
Published in:
Frontiers in Endocrinology - Sec. Bone Research, Issue 560, 738505, 2022, ISSN 1664-2392
Publisher:
Lausanne : Frontiers Research Foundation, 2010-
DOI:
10.3389/fendo.2022.893699
Author(s):
Lucia Drábiková, Per Gunnar Fjelldal, Adelbert De Clercq, M. Naveed Yousaf, Thea Morken, Charles McGurk, P. Eckhard Witten
Published in:
Aquaculture, Issue 541, 2021, Page(s) 736776, ISSN 0044-8486
Publisher:
Elsevier BV
DOI:
10.1016/j.aquaculture.2021.736776
Author(s):
Carletti A, Carlos Cardoso, Diana Juliao, Jorge L. Arteaga, Paula Chainho, Maria Ana Dionísio, Sabrina Sales, Maria J. Gaudêncio, Inês Ferreira, Cláudia Afonso, Helena Lourenço, M. Leonor Cancela, Narcisa M. Bandarra, Paulo J. Gavaia
Published in:
Proceedings, Issue 61, 2020, Page(s) 13, ISSN 2504-3900
Publisher:
MDPI
DOI:
10.3390/iecn2020-06994
Author(s):
Jerry Maria Sojan; Caterina Licini; Fabio Marcheggiani; Oliana Carnevali; Luca Tiano; Monica Mattioli-Belmonte; Francesca Maradonna
Published in:
Cells, Issue 12, 2023, Page(s) 364, ISSN 2073-4409
Publisher:
MDPI
DOI:
10.3390/cells12030364
Author(s):
Cantillo J, Van Caillie D
Published in:
Aquaculture Economics & Management, 2023, ISSN 1365-7305
Publisher:
International Association of Aquaculture Economics & Management
DOI:
10.1080/13657305.2022.2162625
Author(s):
Sunil Poudel, Gil Martins, M. Leonor Cancela, Paulo J. Gavaia
Published in:
Nutrients, Issue 14(23), 2022, Page(s) 4959, ISSN 2072-6643
Publisher:
Multidisciplinary Digital Publishing Institute (MDPI)
DOI:
10.3390/nu14234959
Author(s):
Sojan JM, Raman R, Muller M, Carnevali O, Renn J
Published in:
International Journal of Molecular Sciences, Issue 23, 2022, Page(s) 4748, ISSN 1422-0067
Publisher:
Multidisciplinary Digital Publishing Institute (MDPI)
DOI:
10.3390/ijms23094748
Author(s):
Dellacqua Z, Di Biagio C, Costa C, Pousão-Ferreira P, Ribeiro L, Barata M, Gavaia P, Mattei F, Fabris A, Izquierdo M, Boglione C
Published in:
Animals, Issue 13, 2023, Page(s) 557, ISSN 2076-2615
Publisher:
MDPI
DOI:
10.3390/ani13040557
Author(s):
Ana Rotter; Michéle Barbier; Francesco Bertoni; Francesco Bertoni; Atle M. Bones; M. Leonor Cancela; M. Leonor Cancela; Jens Carlsson; Maria F. Carvalho; Marta Cegłowska; Jerónimo Chirivella-Martorell; Meltem Conk Dalay; Mercedes Cueto; Thanos Dailianis; Irem Deniz; Ana R. Díaz-Marrero; Dragana Drakulovic; Arita Dubnika; Christine Edwards; Hjörleifur Einarsson; Ayşegül Erdoǧan; Orhan Tufan
Published in:
Frontiers in marine science, Lausanne : Frontiers Media S.A., 2021, vol. 8, art. no. 629629, p. 1-53, Issue 20, 2021, ISSN 2296-7745
Publisher:
Frontiers Media S.A
DOI:
10.3389/fmars.2021.629629
Author(s):
Javier Cantillo; Concepción Román; Juan Carlos Martin
Published in:
Aquaculture, Issue 15 January, 2023, Page(s) 738754, ISSN 0044-8486
Publisher:
Elsevier BV
DOI:
10.1016/j.aquaculture.2022.738754
Author(s):
Poudel S, Martins G, Cancela ML, Gavaia PJ.
Published in:
Int J Mol Sci, Issue 23(23), 2022, Page(s) 15160, ISSN 1422-0067
Publisher:
Multidisciplinary Digital Publishing Institute (MDPI)
DOI:
10.3390/ijms232315160
Author(s):
Sojan JM, Gioacchini G, Giorgini E, Orlando P, Tiano L, Maradonna F, Carnevali O
Published in:
Scientific Reports, Issue 12, 2022, Page(s) 8057, ISSN 2045-2322
Publisher:
Nature Publishing Group
DOI:
10.1038/s41598-022-12138-z
Author(s):
Javier Cantillo; Juan Carlos Martín; Concepción Román
Published in:
Aquaculture Research, Issue 53, 2022, Page(s) 136-160, ISSN 1355-557X
Publisher:
Blackwell Publishing Inc.
DOI:
10.1111/are.15560
Author(s):
Tseng Y, Dominguez D, Bravo J, Acosta F, Robaina L, Geraert PA, Kaushik S, Izquierdo M
Published in:
Animals, Issue 11, 2021, Page(s) 2877, ISSN 2076-2615
Publisher:
MDPI
DOI:
10.3390/ani11102877
Author(s):
Lucia Drábiková; Per Gunnar Fjelldal; Adelbert De Clercq; M. Naveed Yousaf; Thea Morken; Charles McGurk; P. Eckhard Witten
Published in:
Aquaculture, Issue 559, 2022, Page(s) 738430, ISSN 0044-8486
Publisher:
Elsevier BV
DOI:
10.1016/j.aquaculture.2022.738430
Author(s):
Tseng. Y, Eryalçın. K.M, Sivagurunathan U, Domínguez D, Hernández-Cruz C.M, Boglione C, Antony Jesu Prabhu P, Izquierdo M.
Published in:
Aquaculture, Issue 568, 2023, Page(s) 739319, ISSN 0044-8486
Publisher:
Elsevier BV
DOI:
10.1016/j.aquaculture.2023.739319
Author(s):
Caetano da Silva C, Ostertag A, Raman R, Muller M, Cohen-Solal M, Collet C
Published in:
Zebrafish, Issue 20, 2023, Page(s) 1-9, ISSN 1545-8547
Publisher:
Mary Ann Liebert Inc.
DOI:
10.1089/zeb.2022.0042
Author(s):
Javier Cantillo, Juan Carlos Martín, Concepción Román
Published in:
Food Quality and Preference, Issue 88, 2021, Page(s) 104085, ISSN 0950-3293
Publisher:
Pergamon Press
DOI:
10.1016/j.foodqual.2020.104085
Author(s):
Javier Cantillo, Juan Carlos Martín, Concepción Román
Published in:
Food Quality and Preference, Issue 84, 2020, Page(s) 103952, ISSN 0950-3293
Publisher:
Pergamon Press
DOI:
10.1016/j.foodqual.2020.103952
Author(s):
Sunil Poudel; Marisol Izquierdo; Maria Leonor Cancela; Paulo J. Gavaia
Published in:
Nutrients; Volume 14; Issue 6; Pages: 1154, Issue 6, 2022, ISSN 2072-6643
Publisher:
Multidisciplinary Digital Publishing Institute (MDPI)
DOI:
10.3390/nu14061154
Author(s):
Tonelli F, Cotti S, Leoni L, Besio R, Gioia R, Marchese L, Giorgetti S, Villani S, Gistelinck C, Wagener R, Kobbe B, Fiedler IAK, Larionova D, Busse B, Eyre D, Rossi A, Witten PE, Forlino A
Published in:
Matrix Biol, Issue 90, 2020, Page(s) 40-60, ISSN 0945-053X
Publisher:
Elsevier BV
DOI:
10.1016/j.matbio.2020.03.004
Author(s):
Silvia Cotti, Ann Huysseune, Wolfgang Koppe, Martin Rücklin, Federica Marone, Eva M. Wölfel, Imke A. K. Fiedler, Björn Busse, Antonella Forlino, P. Eckhard Witten
Published in:
International Journal of Molecular Sciences, Issue 21/15, 2020, Page(s) 5429, ISSN 1422-0067
Publisher:
Multidisciplinary Digital Publishing Institute (MDPI)
DOI:
10.3390/ijms21155429
Author(s):
Silvia Cotti; Ann Huysseune; Daria Larionova; Wolfgang Koppe; Antonella Forlino; Paul Eckhard Witten
Published in:
Front Endocrinol, Issue 13, 2022, Page(s) 851879, ISSN 2352-1872
Publisher:
Elsevier Inc.
DOI:
10.3389/fendo.2022.851879
Author(s):
Javier Cantillo, Juan Carlos Martín, Concepción Román
Published in:
Foods, Issue 10/1, 2021, Page(s) 90, ISSN 2304-8158
Publisher:
MDPI
DOI:
10.3390/foods10010090
Author(s):
Javier Cantillo, Juan Carlos Martín, Concepción Román
Published in:
Applied Sciences, Issue 11/1, 2021, Page(s) 112, ISSN 2076-3417
Publisher:
MDPI
DOI:
10.3390/app11010112
Author(s):
Caroline Caetano da Silva, Manon Ricquebourg, Philippe Orcel, Stéphanie Fabre, Thomas Funck‐Brentano, Martine Cohen‐Solal, Corinne Collet
Published in:
Molecular Genetics & Genomic Medicine, 2021, ISSN 2324-9269
Publisher:
Wiley
DOI:
10.1002/mgg3.1681
Author(s):
Javier Cantillo; Juan Carlos Martín; Concepción Román
Published in:
Marine Policy, Issue 128, 2021, Page(s) 104515, ISSN 0044-8486
Publisher:
Elsevier BV
DOI:
10.1016/j.marpol.2021.104515
Author(s):
U. Sivagurunathan; David Dominguez; Yiyen Tseng; Kamil Mert Eryalçın; Javier Roo; Clara Boglione; P. Antony Jesu Prabhu; Marisol Izquierdo
Published in:
Aquaculture, Issue 560, 2022, Page(s) 738505, ISSN 0044-8486
Publisher:
Elsevier BV
DOI:
10.1016/j.aquaculture.2022.738505
Author(s):
Javier Cantillo, Juan Carlos Martin, Concepción Román
Published in:
British Food Journal, Issue ahead-of-print/ahead-of-print, 2020, ISSN 0007-070X
Publisher:
British Food Journal, Ltd
DOI:
10.1108/bfj-12-2019-0884
Author(s):
Javier Cantillo; Juan Carlos Martín; Concepción Román
Published in:
Appetite, Issue 163, 2021, Page(s) 105216, ISSN 0195-6663
Publisher:
Elsevier BV
DOI:
10.1016/j.appet.2021.105216
Author(s):
Poudel, S, Izquierdo, M, M. Cancela, L, Gavaia, PJ
Published in:
Bone reports, Issue 14, 2021, Page(s) 100984, ISSN 2352-1872
Publisher:
Elsevier Inc.
DOI:
10.1016/j.bonr.2021.100984
Author(s):
Rosa J, Carelli A, Varela T, Gavaia PJ, Cancela ML, Laizé V
Published in:
Bone reports, Issue 14, 2021
Publisher:
Elsevier
DOI:
10.1016/j.bonr.2021.100985
Author(s):
Muller, Marc; Raman, Ratish; Guerrero Limon, Gustavo; Renn, Joerg
Published in:
The International CRISPR and Gene Editing Symposium, Issue 1, 2020
Publisher:
Mary Ann Liebert Inc.
Author(s):
Silvia Cotti; Ann Huysseune; Wolfgang Koppe; Martin Rücklin; Federica Marone; Eva M. Wölfel; Imke A.K. Fiedler; Björn Busse; Antonella Forlino; P. Eckhard Witten
Published in:
BONE REPORTS, Issue 16, 2020, Page(s) 59-60, ISSN 2352-1872
Publisher:
Elsevier Inc.
DOI:
10.1016/j.bonr.2022.101446
Author(s):
Navdeep Kumar; Alessio Carletti; Paulo J. Gavaia; Marc Muller; M. Leonor Cancela; Pierre Geurts; Raphaël Marée
Published in:
Computer Analysis of Images and Patterns ISBN: 9783030891275, Issue 18, 2021, ISBN 978-3-030-89128-2
Publisher:
Springer
DOI:
10.1007/978-3-030-89128-2_15
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