Project description
Merging metabolomics with magnetic resonance imaging to study human biology in the whole body
The EU-funded NICI project will introduce an innovative approach to studying human biology using non-invasive chemistry imaging (NICI). Developing magnetic resonance imaging (MRI) to detect recently discovered metabolic biomarkers will enable the dynamic mapping of biochemical processes in the whole body. The project will develop a new methodology using co-cultured 3D organoids as models for human organs. It will develop a platform integrating 7T MRI scanners and associated data acquisition approaches to create a 3D biochemical imaging system. The dynamic 3D chemical imaging approach and its predictive and prognostic value will be validated in the stratification strategy for patients with liver metastasis of gastrointestinal cancer.
Objective
The NICI project’s ambition is to lay the foundations of a new area of research: the study of human biology using non-invasive chemistry imaging. For this, NICI aims to unite two areas of research: metabolomics and magnetic resonance imaging (MRI). Metabolomics studies body functions through the measurement of metabolites; MRI, is able to provide 3D images of the body. By advancing MRI so that it can detect metabolic biomarkers and by discovering powerful new MRI-visible biomarkers, a non-invasive technology can be developed for dynamically mapping biochemical processes in the whole human body.
Vision: This new non-invasive technology for imaging biochemical processes in the human body will open a new and effective window for understanding human biology, diseases and their treatment.
Breakthroughs: I. Methodology for the discovery of discriminative biomarkers and II. Technological platform for full body biochemical imaging.
Novelty: Enabling a paradigm shift from morphologic imaging to biochemical understanding.
Foundational: Establishing the basis for a new research area, the study of human biochemistry using non-invasive biochemical imaging.
High-risk: i) The exact mechanisms of diseases are largely unknown and ii) Measuring specific metabolites is challenging.
Interdisciplinary: Bringing together physicists, biologists, chemists and clinicians.
The NICI project will develop a new methodology for the in vitro discovery of discriminant biomarkers using co-cultured 3D organoids as models for human organs. In addition, the project will develop a measurement platform, integrated with 7T MRI scanners and associated data acquisition approaches to adapt these MRI scanners into 3D biochemical imaging systems. NICI will validate the dynamic 3D chemical imaging approach and its predictive and prognostic value by researching a stratification strategy for patients with liver metastasis of gastrointestinal cancer. (This is one out of many possible applications.)
Fields of science
- medical and health sciencesclinical medicineinternal medicine
- medical and health sciencesclinical medicineoncology
- medical and health sciencesclinical medicinepaediatrics
- engineering and technologymedical engineeringdiagnostic imagingmagnetic resonance imaging
- engineering and technologyother engineering and technologiesmicrotechnologymolecular engineering
Programme(s)
Funding Scheme
RIA - Research and Innovation actionCoordinator
3584 CX Utrecht
Netherlands